Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55871
Gene name	Zn regulated GTPase metalloprotein activator 1A
Gene symbol	ZNG1A
Synonyms (NCBI Gene)	CBWD1COBP
Chromosome	9
Chromosome location	9p24.3

187

Show/Hide all (187)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048672	hsa-miR-99a-5p	CLASH	23622248
MIRT047172	hsa-miR-182-3p	CLASH	23622248
MIRT043329	hsa-miR-331-3p	CLASH	23622248
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT499080	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503986	hsa-miR-4272	PAR-CLIP	21572407
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	21572407
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	21572407
MIRT499076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT499075	hsa-miR-421	PAR-CLIP	21572407
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT499073	hsa-miR-4658	PAR-CLIP	21572407
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT499069	hsa-miR-8081	PAR-CLIP	21572407
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT499080	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503986	hsa-miR-4272	PAR-CLIP	21572407
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	21572407
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	21572407
MIRT499076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT499075	hsa-miR-421	PAR-CLIP	21572407
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT499073	hsa-miR-4658	PAR-CLIP	21572407
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT499069	hsa-miR-8081	PAR-CLIP	21572407
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT499080	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503986	hsa-miR-4272	PAR-CLIP	23446348
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	23446348
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	23446348
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	23446348
MIRT499076	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT499075	hsa-miR-421	PAR-CLIP	23446348
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	23446348
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	23446348
MIRT499073	hsa-miR-4658	PAR-CLIP	23446348
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	23446348
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	23446348
MIRT499069	hsa-miR-8081	PAR-CLIP	23446348
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	24398324
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	24398324
MIRT499080	hsa-miR-511-3p	PAR-CLIP	24398324
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	24398324
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	24398324
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	24398324
MIRT499076	hsa-miR-505-3p	PAR-CLIP	24398324
MIRT499075	hsa-miR-421	PAR-CLIP	24398324
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	24398324
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	24398324
MIRT499073	hsa-miR-4658	PAR-CLIP	24398324
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	24398324
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	24398324
MIRT499069	hsa-miR-8081	PAR-CLIP	24398324
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT499080	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503986	hsa-miR-4272	PAR-CLIP	21572407
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	21572407
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	21572407
MIRT499076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT499075	hsa-miR-421	PAR-CLIP	21572407
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT499073	hsa-miR-4658	PAR-CLIP	21572407
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT499069	hsa-miR-8081	PAR-CLIP	21572407
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	21572407
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	21572407
MIRT499080	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT503986	hsa-miR-4272	PAR-CLIP	21572407
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	21572407
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	21572407
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	21572407
MIRT499076	hsa-miR-505-3p	PAR-CLIP	21572407
MIRT499075	hsa-miR-421	PAR-CLIP	21572407
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	21572407
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	21572407
MIRT499073	hsa-miR-4658	PAR-CLIP	21572407
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	21572407
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT499069	hsa-miR-8081	PAR-CLIP	21572407
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT499080	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT503986	hsa-miR-4272	PAR-CLIP	23446348
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	23446348
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	23446348
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	23446348
MIRT499076	hsa-miR-505-3p	PAR-CLIP	23446348
MIRT499075	hsa-miR-421	PAR-CLIP	23446348
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	23446348
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	23446348
MIRT499073	hsa-miR-4658	PAR-CLIP	23446348
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	23446348
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	23446348
MIRT499069	hsa-miR-8081	PAR-CLIP	23446348
MIRT499082	hsa-miR-7-1-3p	PAR-CLIP	24398324
MIRT499081	hsa-miR-7-2-3p	PAR-CLIP	24398324
MIRT499080	hsa-miR-511-3p	PAR-CLIP	24398324
MIRT499079	hsa-miR-3065-5p	PAR-CLIP	24398324
MIRT499078	hsa-miR-1909-5p	PAR-CLIP	24398324
MIRT499077	hsa-miR-7159-5p	PAR-CLIP	24398324
MIRT499076	hsa-miR-505-3p	PAR-CLIP	24398324
MIRT499075	hsa-miR-421	PAR-CLIP	24398324
MIRT499074	hsa-miR-1238-5p	PAR-CLIP	24398324
MIRT499072	hsa-miR-4758-5p	PAR-CLIP	24398324
MIRT499073	hsa-miR-4658	PAR-CLIP	24398324
MIRT499071	hsa-miR-6790-5p	PAR-CLIP	24398324
MIRT499070	hsa-miR-5089-3p	PAR-CLIP	24398324
MIRT499069	hsa-miR-8081	PAR-CLIP	24398324
MIRT2497428	hsa-miR-1207-3p	CLIP-seq
MIRT2497429	hsa-miR-2113	CLIP-seq
MIRT2497430	hsa-miR-2276	CLIP-seq
MIRT2497431	hsa-miR-30a	CLIP-seq
MIRT2497432	hsa-miR-30b	CLIP-seq
MIRT2497433	hsa-miR-30c	CLIP-seq
MIRT2497434	hsa-miR-30d	CLIP-seq
MIRT2497435	hsa-miR-30e	CLIP-seq
MIRT2497436	hsa-miR-3117-5p	CLIP-seq
MIRT2497437	hsa-miR-3145-3p	CLIP-seq
MIRT2497438	hsa-miR-3145-5p	CLIP-seq
MIRT2497439	hsa-miR-3152-3p	CLIP-seq
MIRT2497440	hsa-miR-3168	CLIP-seq
MIRT2497441	hsa-miR-340	CLIP-seq
MIRT2497442	hsa-miR-3611	CLIP-seq
MIRT2497443	hsa-miR-3662	CLIP-seq
MIRT2497444	hsa-miR-3675-3p	CLIP-seq
MIRT2497445	hsa-miR-380	CLIP-seq
MIRT2497446	hsa-miR-382	CLIP-seq
MIRT2497447	hsa-miR-409-3p	CLIP-seq
MIRT2497448	hsa-miR-410	CLIP-seq
MIRT2497449	hsa-miR-4263	CLIP-seq
MIRT2497450	hsa-miR-4282	CLIP-seq
MIRT2497451	hsa-miR-4495	CLIP-seq
MIRT2497452	hsa-miR-4528	CLIP-seq
MIRT2497453	hsa-miR-4670-3p	CLIP-seq
MIRT2497454	hsa-miR-4772-3p	CLIP-seq
MIRT2497455	hsa-miR-4795-3p	CLIP-seq
MIRT2497456	hsa-miR-488	CLIP-seq
MIRT2497457	hsa-miR-581	CLIP-seq
MIRT2497458	hsa-miR-607	CLIP-seq
MIRT2497459	hsa-miR-653	CLIP-seq
MIRT2497460	hsa-miR-656	CLIP-seq
MIRT2497461	hsa-miR-758	CLIP-seq
MIRT2497428	hsa-miR-1207-3p	CLIP-seq
MIRT2497429	hsa-miR-2113	CLIP-seq
MIRT2497430	hsa-miR-2276	CLIP-seq
MIRT2497431	hsa-miR-30a	CLIP-seq
MIRT2497432	hsa-miR-30b	CLIP-seq
MIRT2497433	hsa-miR-30c	CLIP-seq
MIRT2497434	hsa-miR-30d	CLIP-seq
MIRT2497435	hsa-miR-30e	CLIP-seq
MIRT2497436	hsa-miR-3117-5p	CLIP-seq
MIRT2497437	hsa-miR-3145-3p	CLIP-seq
MIRT2497438	hsa-miR-3145-5p	CLIP-seq
MIRT2497439	hsa-miR-3152-3p	CLIP-seq
MIRT2497440	hsa-miR-3168	CLIP-seq
MIRT2497441	hsa-miR-340	CLIP-seq
MIRT2497442	hsa-miR-3611	CLIP-seq
MIRT2497443	hsa-miR-3662	CLIP-seq
MIRT2497444	hsa-miR-3675-3p	CLIP-seq
MIRT2497445	hsa-miR-380	CLIP-seq
MIRT2497446	hsa-miR-382	CLIP-seq
MIRT2497447	hsa-miR-409-3p	CLIP-seq
MIRT2497449	hsa-miR-4263	CLIP-seq
MIRT2497450	hsa-miR-4282	CLIP-seq
MIRT2497451	hsa-miR-4495	CLIP-seq
MIRT2497452	hsa-miR-4528	CLIP-seq
MIRT2497453	hsa-miR-4670-3p	CLIP-seq
MIRT2497454	hsa-miR-4772-3p	CLIP-seq
MIRT2497455	hsa-miR-4795-3p	CLIP-seq
MIRT2497456	hsa-miR-488	CLIP-seq
MIRT2497457	hsa-miR-581	CLIP-seq
MIRT2497458	hsa-miR-607	CLIP-seq
MIRT2497459	hsa-miR-653	CLIP-seq
MIRT2497461	hsa-miR-758	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001822	Process	Kidney development	IMP	31862704
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
611078	17134	ENSG00000172785

Q9BRT8

Protein name

Zinc-regulated GTPase metalloprotein activator 1A (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 1) (COBW domain-containing protein 1) (NPC-A-6 COBW domain-containing protein 1) (NPC-A-6)

Protein function

Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from po

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02492	cobW	43 → 231	CobW/HypB/UreG, nucleotide-binding domain	Domain
PF07683	CobW_C	274 → 377	Cobalamin synthesis protein cobW C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Up-regulated in cultured astrocytes treated with dopamine. {ECO:0000269|PubMed:15233989}.

Sequence

MLPAVGSADEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLN
YILTEQHSKRVAVILNEFGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDSGLRAI
ENLMQKKGKFDYILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTE
EKPDGLINEATRQVALADAILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLS
NVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWE
KNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLL
GRNLDKDILKQLFIATVTETEKQWTTRFQEDQVCT

Sequence length

395

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARPAL TUNNEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNG1A (Zn regulated GTPase metalloprotein activator 1A)