Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55827
Gene name Gene Name - the full gene name approved by the HGNC.	DDB1 and CUL4 associated factor 6
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DCAF6
Synonyms (NCBI Gene) Gene synonyms aliases	1200006M05Rik, ARCAP, IQWD1, MSTP055, NRIP, PC326
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs145189179	G>A	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant

Show/Hide all(53)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051512	hsa-let-7e-5p	CLASH	23622248
MIRT048430	hsa-miR-100-5p	CLASH	23622248
MIRT048430	hsa-miR-100-5p	CLASH	23622248
MIRT925179	hsa-miR-188-3p	CLIP-seq
MIRT925180	hsa-miR-25	CLIP-seq
MIRT925181	hsa-miR-3162-5p	CLIP-seq
MIRT925182	hsa-miR-32	CLIP-seq
MIRT925183	hsa-miR-33a	CLIP-seq
MIRT925184	hsa-miR-33b	CLIP-seq
MIRT925185	hsa-miR-363	CLIP-seq
MIRT925186	hsa-miR-367	CLIP-seq
MIRT925187	hsa-miR-4325	CLIP-seq
MIRT925188	hsa-miR-4668-5p	CLIP-seq
MIRT925189	hsa-miR-483-3p	CLIP-seq
MIRT925190	hsa-miR-485-3p	CLIP-seq
MIRT925191	hsa-miR-493	CLIP-seq
MIRT925192	hsa-miR-532-3p	CLIP-seq
MIRT925193	hsa-miR-548al	CLIP-seq
MIRT925194	hsa-miR-561	CLIP-seq
MIRT925195	hsa-miR-602	CLIP-seq
MIRT925196	hsa-miR-640	CLIP-seq
MIRT925197	hsa-miR-92a	CLIP-seq
MIRT925198	hsa-miR-92b	CLIP-seq
MIRT925179	hsa-miR-188-3p	CLIP-seq
MIRT925180	hsa-miR-25	CLIP-seq
MIRT925181	hsa-miR-3162-5p	CLIP-seq
MIRT925182	hsa-miR-32	CLIP-seq
MIRT925183	hsa-miR-33a	CLIP-seq
MIRT925184	hsa-miR-33b	CLIP-seq
MIRT925185	hsa-miR-363	CLIP-seq
MIRT925186	hsa-miR-367	CLIP-seq
MIRT1974057	hsa-miR-421	CLIP-seq
MIRT925187	hsa-miR-4325	CLIP-seq
MIRT925188	hsa-miR-4668-5p	CLIP-seq
MIRT925189	hsa-miR-483-3p	CLIP-seq
MIRT925190	hsa-miR-485-3p	CLIP-seq
MIRT925192	hsa-miR-532-3p	CLIP-seq
MIRT925193	hsa-miR-548al	CLIP-seq
MIRT925195	hsa-miR-602	CLIP-seq
MIRT925196	hsa-miR-640	CLIP-seq
MIRT925197	hsa-miR-92a	CLIP-seq
MIRT925198	hsa-miR-92b	CLIP-seq
MIRT1974058	hsa-miR-944	CLIP-seq
MIRT2209627	hsa-miR-150	CLIP-seq
MIRT2209628	hsa-miR-300	CLIP-seq
MIRT2209629	hsa-miR-3065-5p	CLIP-seq
MIRT2209630	hsa-miR-381	CLIP-seq
MIRT2209631	hsa-miR-4666-3p	CLIP-seq
MIRT2209632	hsa-miR-4713-5p	CLIP-seq
MIRT2209633	hsa-miR-4760-3p	CLIP-seq
MIRT2209634	hsa-miR-4789-5p	CLIP-seq
MIRT2209635	hsa-miR-495	CLIP-seq
MIRT925192	hsa-miR-532-3p	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	15784617
GO:0005515	Function	Protein binding	IPI	16949367, 19966799, 26275350, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	15784617
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	IDA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IGI	15784617
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IBA
GO:0080008	Component	Cul4-RING E3 ubiquitin ligase complex	IDA	16949367

MIM	HGNC	e!Ensembl
610494	30002	ENSG00000143164

Protein

UniProt ID

Q58WW2

Protein name

DDB1- and CUL4-associated factor 6 (Androgen receptor complex-associated protein) (ARCAP) (IQ motif and WD repeat-containing protein 1) (Nuclear receptor interaction protein) (NRIP)

Protein function

Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:15784617, ECO:

PDB

3I7O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	41 → 77	WD domain, G-beta repeat	Repeat
PF00400	WD40	752 → 789	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland. {ECO:0000269|PubMed:15784617}.

Sequence

MSRGGSYPHLLWDVRKRSLGLEDPSRLRSRYLGRREFIQRLKLEATLNVHDGCVNTICWN
DTGEYILSGSDDTKLVISNPYSRKVLTTIRSGHRANIFSAKFLPCTNDKQIVSCSGDGVI
FYTNVEQDAETNRQCQFTCHYGTTYEIMTVPNDPYTFLSCGEDGTVRWFDTRIKTSCTKE
DCKDDILINCRRAATSVAICPPIPYYLAVGCSDSSVRIYDRRMLGTRATGNYAGRGTTGM
VARFIPSHLNNKSCRVTSLCYSEDGQEILVSYSSDYIYLFDPKDDTARELKTPSAEERRE
ELRQPPVKRLRLRGDWSDTGPRARPESERERDGEQSPNVSLMQRMSDMLSRWFEEASEVA
QSNRGRGRSRPRGGTSQSDISTLPTVPSSPDLEVSETAMEVDTPAEQFLQPSTSSTMSAQ
AHSTSSPTESPHSTPLLSSPDSEQRQSVEASGHHTHHQSDNNNEKLSPKPGTGEPVLSLH
YSTEGTTTSTIKLNFTDEWSSIASSSRGIGSHCKSEGQEESFVPQSSVQPPEGDSETKAP
EESSEDVTKYQEGVSAENPVENHINITQSDKFTAKPLDSNSGERNDLNLDRSCGVPEESA
SSEKAKEPETSDQTSTESATNENNTNPEPQFQTEATGPSAHEETSTRDSALQDTDDSDDD
PVLIPGARYRAGPGDRRSAVARIQEFFRRRKERKEMEELDTLNIRRPLVKMVYKGHRNSR
TMIKEANFWGANFVMSGSDCGHIFIWDRHTAEHLMLLEADNHVVNCLQPHPFDPILASSG
IDYDIKIWSPLEESRIFNRKLADEVITRNELMLEETRNTITVPASFMLRMLASLNHIRAD
RLEGDRSEGSGQENENEDEE

Sequence length

860

Interactions

View interactions

	Reactome
			Neddylation

DCAF6 (DDB1 and CUL4 associated factor 6)