Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55825
Gene name	Peroxisomal trans-2-enoyl-CoA reductase
Gene symbol	PECR
Synonyms (NCBI Gene)	DCRRPHPDHASEHSA250303PVIARLSDR29C1TERP
Chromosome	2
Chromosome location	2q35

120

Show/Hide all (120)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023047	hsa-miR-124-3p	Microarray	18668037
MIRT719482	hsa-miR-548a-3p	HITS-CLIP	19536157
MIRT719481	hsa-miR-548ar-3p	HITS-CLIP	19536157
MIRT719480	hsa-miR-548az-3p	HITS-CLIP	19536157
MIRT719479	hsa-miR-548e-3p	HITS-CLIP	19536157
MIRT719478	hsa-miR-548f-3p	HITS-CLIP	19536157
MIRT719477	hsa-miR-5582-3p	HITS-CLIP	19536157
MIRT719476	hsa-miR-551b-5p	HITS-CLIP	19536157
MIRT719475	hsa-miR-6844	HITS-CLIP	19536157
MIRT719482	hsa-miR-548a-3p	HITS-CLIP	19536157
MIRT719481	hsa-miR-548ar-3p	HITS-CLIP	19536157
MIRT719480	hsa-miR-548az-3p	HITS-CLIP	19536157
MIRT719479	hsa-miR-548e-3p	HITS-CLIP	19536157
MIRT719478	hsa-miR-548f-3p	HITS-CLIP	19536157
MIRT719477	hsa-miR-5582-3p	HITS-CLIP	19536157
MIRT719476	hsa-miR-551b-5p	HITS-CLIP	19536157
MIRT719475	hsa-miR-6844	HITS-CLIP	19536157
MIRT1224586	hsa-miR-1343	CLIP-seq
MIRT1224587	hsa-miR-141	CLIP-seq
MIRT1224588	hsa-miR-1976	CLIP-seq
MIRT1224589	hsa-miR-200a	CLIP-seq
MIRT1224590	hsa-miR-2115	CLIP-seq
MIRT1224591	hsa-miR-4722-3p	CLIP-seq
MIRT1224592	hsa-miR-498	CLIP-seq
MIRT1224593	hsa-miR-516a-3p	CLIP-seq
MIRT1224594	hsa-miR-548a-5p	CLIP-seq
MIRT1224595	hsa-miR-548ab	CLIP-seq
MIRT1224596	hsa-miR-548ak	CLIP-seq
MIRT1224597	hsa-miR-548b-5p	CLIP-seq
MIRT1224598	hsa-miR-548c-5p	CLIP-seq
MIRT1224599	hsa-miR-548d-5p	CLIP-seq
MIRT1224600	hsa-miR-548h	CLIP-seq
MIRT1224601	hsa-miR-548i	CLIP-seq
MIRT1224602	hsa-miR-548j	CLIP-seq
MIRT1224603	hsa-miR-548n	CLIP-seq
MIRT1224604	hsa-miR-548w	CLIP-seq
MIRT1224605	hsa-miR-548y	CLIP-seq
MIRT1224606	hsa-miR-559	CLIP-seq
MIRT1224607	hsa-miR-587	CLIP-seq
MIRT1224608	hsa-miR-873	CLIP-seq
MIRT1224586	hsa-miR-1343	CLIP-seq
MIRT2065525	hsa-miR-150	CLIP-seq
MIRT1224588	hsa-miR-1976	CLIP-seq
MIRT1224590	hsa-miR-2115	CLIP-seq
MIRT2065526	hsa-miR-3176	CLIP-seq
MIRT2065527	hsa-miR-3922-3p	CLIP-seq
MIRT2065528	hsa-miR-4252	CLIP-seq
MIRT2065529	hsa-miR-4695-3p	CLIP-seq
MIRT2065530	hsa-miR-4716-5p	CLIP-seq
MIRT1224591	hsa-miR-4722-3p	CLIP-seq
MIRT2065531	hsa-miR-4757-5p	CLIP-seq
MIRT2065532	hsa-miR-4772-3p	CLIP-seq
MIRT2065533	hsa-miR-4781-3p	CLIP-seq
MIRT1224592	hsa-miR-498	CLIP-seq
MIRT1224593	hsa-miR-516a-3p	CLIP-seq
MIRT2065534	hsa-miR-619	CLIP-seq
MIRT2293304	hsa-miR-1234	CLIP-seq
MIRT1224586	hsa-miR-1343	CLIP-seq
MIRT2065525	hsa-miR-150	CLIP-seq
MIRT1224588	hsa-miR-1976	CLIP-seq
MIRT1224590	hsa-miR-2115	CLIP-seq
MIRT2293305	hsa-miR-3199	CLIP-seq
MIRT2293306	hsa-miR-3934	CLIP-seq
MIRT2065530	hsa-miR-4716-5p	CLIP-seq
MIRT1224591	hsa-miR-4722-3p	CLIP-seq
MIRT2065533	hsa-miR-4781-3p	CLIP-seq
MIRT1224592	hsa-miR-498	CLIP-seq
MIRT1224593	hsa-miR-516a-3p	CLIP-seq
MIRT2293307	hsa-miR-520g	CLIP-seq
MIRT2293308	hsa-miR-520h	CLIP-seq
MIRT2293309	hsa-miR-552	CLIP-seq
MIRT2065534	hsa-miR-619	CLIP-seq
MIRT2392377	hsa-miR-1269	CLIP-seq
MIRT2392378	hsa-miR-1269b	CLIP-seq
MIRT2392379	hsa-miR-1288	CLIP-seq
MIRT2392380	hsa-miR-3652	CLIP-seq
MIRT2392381	hsa-miR-378	CLIP-seq
MIRT2392382	hsa-miR-378b	CLIP-seq
MIRT2392383	hsa-miR-378c	CLIP-seq
MIRT2392384	hsa-miR-378d	CLIP-seq
MIRT2392385	hsa-miR-378e	CLIP-seq
MIRT2392386	hsa-miR-378f	CLIP-seq
MIRT2392387	hsa-miR-378h	CLIP-seq
MIRT2392388	hsa-miR-378i	CLIP-seq
MIRT2392389	hsa-miR-422a	CLIP-seq
MIRT2392390	hsa-miR-4418	CLIP-seq
MIRT2392391	hsa-miR-4430	CLIP-seq
MIRT2392392	hsa-miR-4515	CLIP-seq
MIRT2392393	hsa-miR-4740-5p	CLIP-seq
MIRT2392394	hsa-miR-509-3-5p	CLIP-seq
MIRT2392395	hsa-miR-509-5p	CLIP-seq
MIRT1224586	hsa-miR-1343	CLIP-seq
MIRT1224588	hsa-miR-1976	CLIP-seq
MIRT1224590	hsa-miR-2115	CLIP-seq
MIRT2591315	hsa-miR-3187-3p	CLIP-seq
MIRT2591316	hsa-miR-3194-5p	CLIP-seq
MIRT2591317	hsa-miR-4435	CLIP-seq
MIRT2591318	hsa-miR-4701-5p	CLIP-seq
MIRT2065530	hsa-miR-4716-5p	CLIP-seq
MIRT1224591	hsa-miR-4722-3p	CLIP-seq
MIRT2065533	hsa-miR-4781-3p	CLIP-seq
MIRT1224592	hsa-miR-498	CLIP-seq
MIRT1224593	hsa-miR-516a-3p	CLIP-seq
MIRT2591319	hsa-miR-548s	CLIP-seq
MIRT2591320	hsa-miR-588	CLIP-seq
MIRT1224586	hsa-miR-1343	CLIP-seq
MIRT2065525	hsa-miR-150	CLIP-seq
MIRT1224588	hsa-miR-1976	CLIP-seq
MIRT1224590	hsa-miR-2115	CLIP-seq
MIRT2591315	hsa-miR-3187-3p	CLIP-seq
MIRT2591316	hsa-miR-3194-5p	CLIP-seq
MIRT2591317	hsa-miR-4435	CLIP-seq
MIRT2591318	hsa-miR-4701-5p	CLIP-seq
MIRT2065530	hsa-miR-4716-5p	CLIP-seq
MIRT1224591	hsa-miR-4722-3p	CLIP-seq
MIRT2065533	hsa-miR-4781-3p	CLIP-seq
MIRT1224592	hsa-miR-498	CLIP-seq
MIRT1224593	hsa-miR-516a-3p	CLIP-seq
MIRT2591319	hsa-miR-548s	CLIP-seq
MIRT2591320	hsa-miR-588	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005102	Function	Signaling receptor binding	IPI	11669066
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005777	Component	Peroxisome	IBA
GO:0005777	Component	Peroxisome	IDA	11669066
GO:0005777	Component	Peroxisome	IEA
GO:0005778	Component	Peroxisomal membrane	ISS	10811639
GO:0005778	Component	Peroxisomal membrane	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IEA
GO:0008670	Function	2,4-dienoyl-CoA reductase (NADPH) activity	IDA	11669066
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0019166	Function	Trans-2-enoyl-CoA reductase (NADPH) activity	IBA
GO:0019166	Function	Trans-2-enoyl-CoA reductase (NADPH) activity	IDA	16546181
GO:0019166	Function	Trans-2-enoyl-CoA reductase (NADPH) activity	IEA
GO:0033306	Process	Phytol metabolic process	IBA
GO:0033306	Process	Phytol metabolic process	IDA	16546181

MIM	HGNC	e!Ensembl
605843	18281	ENSG00000115425

Q9BY49

Protein name

Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP) (HPDHase) (Short chain dehydrogenase/reductase family 29C member 1) (pVI-ARL)

Protein function

Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity. {ECO:0000269|PubMed:10811

PDB

1YXM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13561	adh_short_C2	25 → 266		Domain

Sequence

MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAAD
ELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHIS
SKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYN
LTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVS
SVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEK
AKL

Sequence length

303

Interactions

View interactions

	KEGG		Reactome
	Peroxisome		Alpha-oxidation of phytanate Peroxisomal protein import

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INTELLECTUAL DISABILITY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Pain	Stimulate	29156912	★★★★★ ★☆☆☆☆ Found in Text Mining only

PECR (peroxisomal trans-2-enoyl-CoA reductase)