Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55824
Gene name Gene Name - the full gene name approved by the HGNC.
Phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PAG1
Synonyms (NCBI Gene) Gene synonyms aliases
CBP, PAG
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CBP
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q21.13
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027134 hsa-miR-103a-3p Sequencing 20371350
MIRT030922 hsa-miR-21-5p Microarray 18591254
MIRT031726 hsa-miR-16-5p Sequencing 20371350
MIRT393570 hsa-miR-6867-5p HITS-CLIP 23706177
MIRT570563 hsa-miR-574-5p HITS-CLIP 23706177
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002250 Process Adaptive immune response IEA
GO:0005515 Function Protein binding IPI 10790433, 17911601, 18056706, 18070987, 23866081, 28514442
GO:0005886 Component Plasma membrane IDA 10790433
GO:0005886 Component Plasma membrane TAS
GO:0007165 Process Signal transduction TAS 10790433
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605767 30043 ENSG00000076641
Protein
UniProt ID Q9NWQ8
Protein name Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
Protein function Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15347 PAG 2 432 Phosphoprotein associated with glycosphingolipid-enriched Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level). {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:16160011}.
Sequence
Sequence length 432
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    GAB1 signalosome
Phosphorylation of CD3 and TCR zeta chains
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lymphoblastic leukemia Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699
View all (13 more)
23334668
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
21822266
Unknown
Disease term Disease name Evidence References Source
Breast Cancer Breast Cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Colorectal Cancer Colorectal Cancer In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Psoriatic Associate 35806402
Burkitt Lymphoma Associate 24667141
Carcinoma Hepatocellular Associate 37589508
COVID 19 Associate 35277538
Cytokine Release Syndrome Stimulate 31811760
Diabetes Mellitus Associate 32075680
Diabetic Nephropathies Associate 37988198
Drug Hypersensitivity Associate 26211970
Esophageal Neoplasms Associate 25684946
Familial cylindromatosis Associate 28728164