Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55808
Gene name Gene Name - the full gene name approved by the HGNC.	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ST6GALNAC1
Synonyms (NCBI Gene) Gene synonyms aliases	HSY11339, SIAT7A, ST6GalNAcI, STYI
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17q25.1
Summary Summary of gene provided in NCBI Entrez Gene.	Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues.

Show/Hide all(36)

miRTarBase ID	miRNA	Experiments	Reference
MIRT016766	hsa-miR-335-5p	Microarray	18185580
MIRT650930	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT650929	hsa-miR-3155a	HITS-CLIP	23824327
MIRT650928	hsa-miR-3155b	HITS-CLIP	23824327
MIRT650927	hsa-miR-484	HITS-CLIP	23824327
MIRT650926	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT650925	hsa-miR-4673	HITS-CLIP	23824327
MIRT650924	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT650923	hsa-miR-3686	HITS-CLIP	23824327
MIRT650922	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT650921	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT650930	hsa-miR-605-5p	HITS-CLIP	23824327
MIRT650929	hsa-miR-3155a	HITS-CLIP	23824327
MIRT650928	hsa-miR-3155b	HITS-CLIP	23824327
MIRT650927	hsa-miR-484	HITS-CLIP	23824327
MIRT650926	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT650925	hsa-miR-4673	HITS-CLIP	23824327
MIRT650924	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT650923	hsa-miR-3686	HITS-CLIP	23824327
MIRT650922	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT650921	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT1393725	hsa-miR-3655	CLIP-seq
MIRT1393726	hsa-miR-4275	CLIP-seq
MIRT1393727	hsa-miR-4659a-5p	CLIP-seq
MIRT1393728	hsa-miR-4659b-5p	CLIP-seq
MIRT1393729	hsa-miR-4662a-5p	CLIP-seq
MIRT1393730	hsa-miR-4776-3p	CLIP-seq
MIRT1393731	hsa-miR-526b	CLIP-seq
MIRT1393732	hsa-miR-924	CLIP-seq
MIRT2634067	hsa-miR-4764-3p	CLIP-seq
MIRT2634068	hsa-miR-4777-5p	CLIP-seq
MIRT2634069	hsa-miR-518d-5p	CLIP-seq
MIRT2634070	hsa-miR-519b-5p	CLIP-seq
MIRT2634071	hsa-miR-519c-5p	CLIP-seq
MIRT2634072	hsa-miR-520c-5p	CLIP-seq
MIRT2634073	hsa-miR-526a	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA	21873635
GO:0006486	Process	Protein glycosylation	IEA
GO:0006486	Process	Protein glycosylation	NAS	10536037
GO:0008373	Function	Sialyltransferase activity	NAS	10536037
GO:0009312	Process	Oligosaccharide biosynthetic process	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0097503	Process	Sialylation	IEA

MIM	HGNC	e!Ensembl
610138	23614	ENSG00000070526

Protein

UniProt ID

Q9NSC7

Protein name

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (ST6GalNAc-I) (ST6GalNAcI) (hST6GalNAc-I) (Sialyltransferase 7A) (SIAT7-A)

Protein function

Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains l

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	302 → 589	Glycosyltransferase family 29 (sialyltransferase)	Family

Tissue specificity

TISSUE SPECIFICITY: Expression is restricted to the gastrointestinal tract (PubMed:16319059). Highly expressed in goblet cells (PubMed:35303419). Also expressed in various tumor cells (PubMed:16319059). {ECO:0000269|PubMed:16319059, ECO:0000269|PubMed:353

Sequence

MRSCLWRCRHLSQGVQWSLLLAVLVFFLFALPSFIKEPQTKPSRHQRTENIKERSLQSLA
KPKSQAPTRARRTTIYAEPVPENNALNTQTQPKAHTTGDRGKEANQAPPEEQDKVPHTAQ
RAAWKSPEKEKTMVNTLSPRGQDAGMASGRTEAQSWKSQDTKTTQGNGGQTRKLTASRTV
SEKHQGKAATTAKTLIPKSQHRMLAPTGAVSTRTRQKGVTTAVIPPKEKKPQATPPPAPF
QSPTTQRNQRLKAANFKSEPRWDFEEKYSFEIGGLQTTCPDSVKIKASKSLWLQKLFLPN
LTLFLDSRHFNQSEWDRLEHFAPPFGFMELNYSLVQKVVTRFPPVPQQQLLLASLPAGSL
RCITCAVVGNGGILNNSHMGQEIDSHDYVFRLSGALIKGYEQDVGTRTSFYGFTAFSLTQ
SLLILGNRGFKNVPLGKDVRYLHFLEGTRDYEWLEALLMNQTVMSKNLFWFRHRPQEAFR
EALHMDRYLLLHPDFLRYMKNRFLRSKTLDGAHWRIYRPTTGALLLLTALQLCDQVSAYG
FITEGHERFSDHYYDTSWKRLIFYINHDFKLEREVWKRLHDEGIIRLYQRPGPGTAKAKN

Sequence length

600

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Metabolic pathways		Sialic acid metabolism

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21908516

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis	Associate	32483203
Breast Neoplasms	Associate	19287074
Carcinoma Non Small Cell Lung	Associate	30396166
Colitis Associated Neoplasms	Stimulate	31831633
Colitis Ulcerative	Associate	31831633
Colorectal Neoplasms	Inhibit	39348343
Intestinal Diseases	Associate	25867765
Neoplasms	Associate	39348343
Prostatic Neoplasms	Associate	27428423
Prostatitis	Associate	27428423
Psychotic Disorders	Associate	21908516
Schizophrenia	Associate	21908516
Stomach Neoplasms	Stimulate	29729225
Urinary Bladder Neoplasms	Stimulate	24656965

ST6GALNAC1 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)