IL26 (interleukin 26)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55801
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 26
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL26
Synonyms (NCBI Gene) Gene synonyms aliases
AK155, IL-26
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q15
Summary Summary of gene provided in NCBI Entrez Gene.
This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(7)
miRTarBase ID miRNA Experiments Reference
MIRT2015379 hsa-miR-151-3p CLIP-seq
MIRT2015380 hsa-miR-3152-3p CLIP-seq
MIRT2015381 hsa-miR-340 CLIP-seq
MIRT2015382 hsa-miR-4463 CLIP-seq
MIRT2015383 hsa-miR-4499 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0001819 Process Positive regulation of cytokine production IDA 18483078
GO:0005125 Function Cytokine activity IDA 18483078
GO:0005576 Component Extracellular region TAS
GO:0005615 Component Extracellular space IDA 18483078
GO:0005829 Component Cytosol IDA 18483078
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605679 17119 ENSG00000111536
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9NPH9
Protein name Interleukin-26 (IL-26) (Protein AK155)
Protein function May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alph
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00726 IL10 6 → 168 Interleukin 10 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn'
Sequence
Sequence length 171
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway 		  Interleukin-20 family signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Ulcerative colitis Ulcerative colitis GWAS
Show/Hide Text Mining Associations (36)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Associate 34572149
Arthritis Rheumatoid Associate 14558082, 31831038
Arthritis Rheumatoid Stimulate 23055831
Asthma Associate 35188435
Bacterial Infections Associate 34777376
Bronchitis Chronic Stimulate 29780024
Carcinoma Renal Cell Stimulate 40612864
Colitis Ulcerative Associate 20176734
Colonic Neoplasms Associate 15178681
COVID 19 Associate 36466824