Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55800
Gene name	Sodium voltage-gated channel beta subunit 3
Gene symbol	SCN3B
Synonyms (NCBI Gene)	ATFB16BRGDA7HSA243396SCNB3
Chromosome	11
Chromosome location	11q24.1
Summary	Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gen

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SNP ID	Visualize variation	Clinical significance	Consequence
rs147205617	C>T	Likely-benign, uncertain-significance, pathogenic, conflicting-interpretations-of-pathogenicity	Missense variant, coding sequence variant
rs587777556	G>A,T	Pathogenic, uncertain-significance	Coding sequence variant, missense variant
rs587777557	A>G	Pathogenic	Coding sequence variant, missense variant
rs771342044	A>C	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant
rs879253730	G>C	Pathogenic	Missense variant, coding sequence variant

340

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018656	hsa-miR-335-5p	Microarray	18185580
MIRT680912	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT680911	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT680910	hsa-miR-4257	HITS-CLIP	23706177
MIRT680909	hsa-miR-4537	HITS-CLIP	23706177
MIRT680908	hsa-miR-1827	HITS-CLIP	23706177
MIRT680907	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT680906	hsa-miR-6086	HITS-CLIP	23706177
MIRT680905	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT680904	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT680903	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT680902	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT680908	hsa-miR-1827	PAR-CLIP	27292025
MIRT680908	hsa-miR-1827	PAR-CLIP	27292025
MIRT680912	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT680912	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT680905	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT680905	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT680907	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT680907	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT680910	hsa-miR-4257	PAR-CLIP	27292025
MIRT680910	hsa-miR-4257	PAR-CLIP	27292025
MIRT680909	hsa-miR-4537	PAR-CLIP	27292025
MIRT680909	hsa-miR-4537	PAR-CLIP	27292025
MIRT680903	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT680903	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT680906	hsa-miR-6086	PAR-CLIP	27292025
MIRT680906	hsa-miR-6086	PAR-CLIP	27292025
MIRT680904	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT680904	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT680911	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT680911	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT680902	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT680902	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT680912	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT680911	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT680910	hsa-miR-4257	HITS-CLIP	23706177
MIRT680909	hsa-miR-4537	HITS-CLIP	23706177
MIRT680908	hsa-miR-1827	HITS-CLIP	23706177
MIRT680907	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT680906	hsa-miR-6086	HITS-CLIP	23706177
MIRT680905	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT680904	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT680903	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT680902	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT1329987	hsa-miR-1228	CLIP-seq
MIRT1329988	hsa-miR-1253	CLIP-seq
MIRT1329989	hsa-miR-1273	CLIP-seq
MIRT1329990	hsa-miR-1293	CLIP-seq
MIRT1329991	hsa-miR-1304	CLIP-seq
MIRT1329992	hsa-miR-2114	CLIP-seq
MIRT1329993	hsa-miR-2467-5p	CLIP-seq
MIRT1329994	hsa-miR-31	CLIP-seq
MIRT1329995	hsa-miR-3124-3p	CLIP-seq
MIRT1329996	hsa-miR-3153	CLIP-seq
MIRT1329997	hsa-miR-3183	CLIP-seq
MIRT1329998	hsa-miR-3188	CLIP-seq
MIRT1329999	hsa-miR-323-5p	CLIP-seq
MIRT1330000	hsa-miR-3655	CLIP-seq
MIRT1330001	hsa-miR-3679-3p	CLIP-seq
MIRT1330002	hsa-miR-3683	CLIP-seq
MIRT1330003	hsa-miR-3975	CLIP-seq
MIRT1330004	hsa-miR-4278	CLIP-seq
MIRT1330005	hsa-miR-4292	CLIP-seq
MIRT1330006	hsa-miR-4308	CLIP-seq
MIRT1330007	hsa-miR-4426	CLIP-seq
MIRT1330008	hsa-miR-4433	CLIP-seq
MIRT1330009	hsa-miR-4434	CLIP-seq
MIRT1330010	hsa-miR-4459	CLIP-seq
MIRT1330011	hsa-miR-4483	CLIP-seq
MIRT1330012	hsa-miR-4486	CLIP-seq
MIRT1330013	hsa-miR-4516	CLIP-seq
MIRT1330014	hsa-miR-4531	CLIP-seq
MIRT1330015	hsa-miR-4534	CLIP-seq
MIRT1330016	hsa-miR-4646-3p	CLIP-seq
MIRT1330017	hsa-miR-4646-5p	CLIP-seq
MIRT1330018	hsa-miR-4647	CLIP-seq
MIRT1330019	hsa-miR-4649-5p	CLIP-seq
MIRT1330020	hsa-miR-4662a-5p	CLIP-seq
MIRT1330021	hsa-miR-4662b	CLIP-seq
MIRT1330022	hsa-miR-4668-5p	CLIP-seq
MIRT1330023	hsa-miR-4676-5p	CLIP-seq
MIRT1330024	hsa-miR-4720-3p	CLIP-seq
MIRT1330025	hsa-miR-4723-3p	CLIP-seq
MIRT1330026	hsa-miR-4755-3p	CLIP-seq
MIRT1330027	hsa-miR-4768-3p	CLIP-seq
MIRT1330028	hsa-miR-4804-3p	CLIP-seq
MIRT1330029	hsa-miR-485-5p	CLIP-seq
MIRT1330030	hsa-miR-486-3p	CLIP-seq
MIRT1330031	hsa-miR-490-3p	CLIP-seq
MIRT1330032	hsa-miR-548g	CLIP-seq
MIRT1330033	hsa-miR-575	CLIP-seq
MIRT1330034	hsa-miR-579	CLIP-seq
MIRT1330035	hsa-miR-619	CLIP-seq
MIRT1330036	hsa-miR-661	CLIP-seq
MIRT1330037	hsa-miR-665	CLIP-seq
MIRT1330038	hsa-miR-759	CLIP-seq
MIRT1330039	hsa-miR-876-3p	CLIP-seq
MIRT1330040	hsa-miR-935	CLIP-seq
MIRT1330041	hsa-miR-10a	CLIP-seq
MIRT1330042	hsa-miR-10b	CLIP-seq
MIRT1330043	hsa-miR-1225-3p	CLIP-seq
MIRT1329987	hsa-miR-1228	CLIP-seq
MIRT1330044	hsa-miR-1233	CLIP-seq
MIRT1330045	hsa-miR-1251	CLIP-seq
MIRT1330046	hsa-miR-1255a	CLIP-seq
MIRT1330047	hsa-miR-1255b	CLIP-seq
MIRT1330048	hsa-miR-1290	CLIP-seq
MIRT1329991	hsa-miR-1304	CLIP-seq
MIRT1330049	hsa-miR-1322	CLIP-seq
MIRT1329993	hsa-miR-2467-5p	CLIP-seq
MIRT1330050	hsa-miR-2964a-3p	CLIP-seq
MIRT1330051	hsa-miR-302f	CLIP-seq
MIRT1330052	hsa-miR-3120-5p	CLIP-seq
MIRT1330053	hsa-miR-3135	CLIP-seq
MIRT1330054	hsa-miR-3140-3p	CLIP-seq
MIRT1330055	hsa-miR-3162-5p	CLIP-seq
MIRT1329998	hsa-miR-3188	CLIP-seq
MIRT1330056	hsa-miR-320e	CLIP-seq
MIRT1329999	hsa-miR-323-5p	CLIP-seq
MIRT1330057	hsa-miR-339-5p	CLIP-seq
MIRT1330058	hsa-miR-3622b-5p	CLIP-seq
MIRT1330003	hsa-miR-3975	CLIP-seq
MIRT1330059	hsa-miR-4421	CLIP-seq
MIRT1330008	hsa-miR-4433	CLIP-seq
MIRT1330060	hsa-miR-4464	CLIP-seq
MIRT1330061	hsa-miR-4645-5p	CLIP-seq
MIRT1330020	hsa-miR-4662a-5p	CLIP-seq
MIRT1330062	hsa-miR-4673	CLIP-seq
MIRT1330023	hsa-miR-4676-5p	CLIP-seq
MIRT1330063	hsa-miR-4680-3p	CLIP-seq
MIRT1330024	hsa-miR-4720-3p	CLIP-seq
MIRT1330064	hsa-miR-4729	CLIP-seq
MIRT1330065	hsa-miR-4748	CLIP-seq
MIRT1330026	hsa-miR-4755-3p	CLIP-seq
MIRT1330066	hsa-miR-4793-3p	CLIP-seq
MIRT1330067	hsa-miR-4797-5p	CLIP-seq
MIRT1330028	hsa-miR-4804-3p	CLIP-seq
MIRT1330029	hsa-miR-485-5p	CLIP-seq
MIRT1330030	hsa-miR-486-3p	CLIP-seq
MIRT1330031	hsa-miR-490-3p	CLIP-seq
MIRT1330068	hsa-miR-542-3p	CLIP-seq
MIRT1330069	hsa-miR-548c-3p	CLIP-seq
MIRT1330033	hsa-miR-575	CLIP-seq
MIRT1330034	hsa-miR-579	CLIP-seq
MIRT1330070	hsa-miR-580	CLIP-seq
MIRT1330036	hsa-miR-661	CLIP-seq
MIRT1330037	hsa-miR-665	CLIP-seq
MIRT1330039	hsa-miR-876-3p	CLIP-seq
MIRT2097779	hsa-miR-1972	CLIP-seq
MIRT2097780	hsa-miR-198	CLIP-seq
MIRT2097781	hsa-miR-2964a-5p	CLIP-seq
MIRT2097782	hsa-miR-3180-5p	CLIP-seq
MIRT2097783	hsa-miR-520a-5p	CLIP-seq
MIRT2097784	hsa-miR-525-5p	CLIP-seq
MIRT1329987	hsa-miR-1228	CLIP-seq
MIRT1330045	hsa-miR-1251	CLIP-seq
MIRT1329989	hsa-miR-1273	CLIP-seq
MIRT1329990	hsa-miR-1293	CLIP-seq
MIRT1329991	hsa-miR-1304	CLIP-seq
MIRT1329992	hsa-miR-2114	CLIP-seq
MIRT2322082	hsa-miR-3065-3p	CLIP-seq
MIRT2322083	hsa-miR-3122	CLIP-seq
MIRT1330053	hsa-miR-3135	CLIP-seq
MIRT2322084	hsa-miR-3192	CLIP-seq
MIRT1329999	hsa-miR-323-5p	CLIP-seq
MIRT2322085	hsa-miR-3614-5p	CLIP-seq
MIRT1330002	hsa-miR-3683	CLIP-seq
MIRT2322086	hsa-miR-3689a-3p	CLIP-seq
MIRT2322087	hsa-miR-3689c	CLIP-seq
MIRT2322088	hsa-miR-3913-5p	CLIP-seq
MIRT2322089	hsa-miR-3929	CLIP-seq
MIRT2322090	hsa-miR-4282	CLIP-seq
MIRT2322091	hsa-miR-4293	CLIP-seq
MIRT2322092	hsa-miR-4419b	CLIP-seq
MIRT1330008	hsa-miR-4433	CLIP-seq
MIRT1330009	hsa-miR-4434	CLIP-seq
MIRT1330010	hsa-miR-4459	CLIP-seq
MIRT2322093	hsa-miR-4478	CLIP-seq
MIRT1330011	hsa-miR-4483	CLIP-seq
MIRT1330012	hsa-miR-4486	CLIP-seq
MIRT2322094	hsa-miR-4488	CLIP-seq
MIRT1330013	hsa-miR-4516	CLIP-seq
MIRT1330014	hsa-miR-4531	CLIP-seq
MIRT2322095	hsa-miR-4535	CLIP-seq
MIRT1330019	hsa-miR-4649-5p	CLIP-seq
MIRT2322096	hsa-miR-4656	CLIP-seq
MIRT1330020	hsa-miR-4662a-5p	CLIP-seq
MIRT1330023	hsa-miR-4676-5p	CLIP-seq
MIRT2322097	hsa-miR-4697-5p	CLIP-seq
MIRT2322098	hsa-miR-4728-5p	CLIP-seq
MIRT1330026	hsa-miR-4755-3p	CLIP-seq
MIRT1330027	hsa-miR-4768-3p	CLIP-seq
MIRT2322099	hsa-miR-4776-5p	CLIP-seq
MIRT1330066	hsa-miR-4793-3p	CLIP-seq
MIRT1330067	hsa-miR-4797-5p	CLIP-seq
MIRT1330029	hsa-miR-485-5p	CLIP-seq
MIRT2322100	hsa-miR-492	CLIP-seq
MIRT1330033	hsa-miR-575	CLIP-seq
MIRT1330034	hsa-miR-579	CLIP-seq
MIRT2322101	hsa-miR-589	CLIP-seq
MIRT2322102	hsa-miR-596	CLIP-seq
MIRT1330035	hsa-miR-619	CLIP-seq
MIRT2322103	hsa-miR-637	CLIP-seq
MIRT1330036	hsa-miR-661	CLIP-seq
MIRT1330037	hsa-miR-665	CLIP-seq
MIRT2322104	hsa-miR-668	CLIP-seq
MIRT2322105	hsa-miR-767-5p	CLIP-seq
MIRT1330039	hsa-miR-876-3p	CLIP-seq
MIRT2322106	hsa-miR-890	CLIP-seq
MIRT1330040	hsa-miR-935	CLIP-seq
MIRT1329993	hsa-miR-2467-5p	CLIP-seq
MIRT1329998	hsa-miR-3188	CLIP-seq
MIRT1330003	hsa-miR-3975	CLIP-seq
MIRT2322107	hsa-miR-4455	CLIP-seq
MIRT1329987	hsa-miR-1228	CLIP-seq
MIRT1330045	hsa-miR-1251	CLIP-seq
MIRT1329991	hsa-miR-1304	CLIP-seq
MIRT1330050	hsa-miR-2964a-3p	CLIP-seq
MIRT1330051	hsa-miR-302f	CLIP-seq
MIRT1330053	hsa-miR-3135	CLIP-seq
MIRT2394090	hsa-miR-370	CLIP-seq
MIRT2394091	hsa-miR-3926	CLIP-seq
MIRT2322091	hsa-miR-4293	CLIP-seq
MIRT1330008	hsa-miR-4433	CLIP-seq
MIRT1330010	hsa-miR-4459	CLIP-seq
MIRT1330027	hsa-miR-4768-3p	CLIP-seq
MIRT1330066	hsa-miR-4793-3p	CLIP-seq
MIRT1330068	hsa-miR-542-3p	CLIP-seq
MIRT2394092	hsa-miR-548s	CLIP-seq
MIRT1330034	hsa-miR-579	CLIP-seq
MIRT1330070	hsa-miR-580	CLIP-seq
MIRT2322102	hsa-miR-596	CLIP-seq
MIRT1330036	hsa-miR-661	CLIP-seq
MIRT1330041	hsa-miR-10a	CLIP-seq
MIRT1330042	hsa-miR-10b	CLIP-seq
MIRT1330045	hsa-miR-1251	CLIP-seq
MIRT1329988	hsa-miR-1253	CLIP-seq
MIRT1329989	hsa-miR-1273	CLIP-seq
MIRT1329990	hsa-miR-1293	CLIP-seq
MIRT2097779	hsa-miR-1972	CLIP-seq
MIRT1329992	hsa-miR-2114	CLIP-seq
MIRT2618491	hsa-miR-214	CLIP-seq
MIRT2618492	hsa-miR-216a	CLIP-seq
MIRT2618493	hsa-miR-216b	CLIP-seq
MIRT1329993	hsa-miR-2467-5p	CLIP-seq
MIRT2322082	hsa-miR-3065-3p	CLIP-seq
MIRT1329994	hsa-miR-31	CLIP-seq
MIRT1330052	hsa-miR-3120-5p	CLIP-seq
MIRT2322083	hsa-miR-3122	CLIP-seq
MIRT1329998	hsa-miR-3188	CLIP-seq
MIRT1330057	hsa-miR-339-5p	CLIP-seq
MIRT2618494	hsa-miR-3613-3p	CLIP-seq
MIRT2618495	hsa-miR-3619-5p	CLIP-seq
MIRT2618496	hsa-miR-3672	CLIP-seq
MIRT1330002	hsa-miR-3683	CLIP-seq
MIRT2322086	hsa-miR-3689a-3p	CLIP-seq
MIRT2322087	hsa-miR-3689c	CLIP-seq
MIRT2618497	hsa-miR-371-5p	CLIP-seq
MIRT2618498	hsa-miR-371b-5p	CLIP-seq
MIRT2322088	hsa-miR-3913-5p	CLIP-seq
MIRT2322089	hsa-miR-3929	CLIP-seq
MIRT2618499	hsa-miR-3974	CLIP-seq
MIRT1330003	hsa-miR-3975	CLIP-seq
MIRT2322090	hsa-miR-4282	CLIP-seq
MIRT2618500	hsa-miR-4291	CLIP-seq
MIRT2322092	hsa-miR-4419b	CLIP-seq
MIRT1330059	hsa-miR-4421	CLIP-seq
MIRT1330009	hsa-miR-4434	CLIP-seq
MIRT2322093	hsa-miR-4478	CLIP-seq
MIRT1330011	hsa-miR-4483	CLIP-seq
MIRT1330012	hsa-miR-4486	CLIP-seq
MIRT1330013	hsa-miR-4516	CLIP-seq
MIRT1330014	hsa-miR-4531	CLIP-seq
MIRT2618501	hsa-miR-4649-3p	CLIP-seq
MIRT1330019	hsa-miR-4649-5p	CLIP-seq
MIRT2618502	hsa-miR-4650-5p	CLIP-seq
MIRT2618503	hsa-miR-4670-3p	CLIP-seq
MIRT2618504	hsa-miR-4696	CLIP-seq
MIRT2322098	hsa-miR-4728-5p	CLIP-seq
MIRT2618505	hsa-miR-4761-5p	CLIP-seq
MIRT1330066	hsa-miR-4793-3p	CLIP-seq
MIRT1330029	hsa-miR-485-5p	CLIP-seq
MIRT2618506	hsa-miR-493	CLIP-seq
MIRT1330069	hsa-miR-548c-3p	CLIP-seq
MIRT1330070	hsa-miR-580	CLIP-seq
MIRT1330035	hsa-miR-619	CLIP-seq
MIRT1330036	hsa-miR-661	CLIP-seq
MIRT2618507	hsa-miR-761	CLIP-seq
MIRT2618508	hsa-miR-922	CLIP-seq
MIRT1330040	hsa-miR-935	CLIP-seq
MIRT1330041	hsa-miR-10a	CLIP-seq
MIRT1330042	hsa-miR-10b	CLIP-seq
MIRT1330045	hsa-miR-1251	CLIP-seq
MIRT1329988	hsa-miR-1253	CLIP-seq
MIRT1329990	hsa-miR-1293	CLIP-seq
MIRT2097779	hsa-miR-1972	CLIP-seq
MIRT2618491	hsa-miR-214	CLIP-seq
MIRT2618492	hsa-miR-216a	CLIP-seq
MIRT2618493	hsa-miR-216b	CLIP-seq
MIRT1329993	hsa-miR-2467-5p	CLIP-seq
MIRT2322082	hsa-miR-3065-3p	CLIP-seq
MIRT1330052	hsa-miR-3120-5p	CLIP-seq
MIRT2322083	hsa-miR-3122	CLIP-seq
MIRT1330053	hsa-miR-3135	CLIP-seq
MIRT1329998	hsa-miR-3188	CLIP-seq
MIRT1330057	hsa-miR-339-5p	CLIP-seq
MIRT2618494	hsa-miR-3613-3p	CLIP-seq
MIRT2618495	hsa-miR-3619-5p	CLIP-seq
MIRT2618496	hsa-miR-3672	CLIP-seq
MIRT2322086	hsa-miR-3689a-3p	CLIP-seq
MIRT2322087	hsa-miR-3689c	CLIP-seq
MIRT2618497	hsa-miR-371-5p	CLIP-seq
MIRT2618498	hsa-miR-371b-5p	CLIP-seq
MIRT2322088	hsa-miR-3913-5p	CLIP-seq
MIRT2322089	hsa-miR-3929	CLIP-seq
MIRT2618499	hsa-miR-3974	CLIP-seq
MIRT1330003	hsa-miR-3975	CLIP-seq
MIRT2322090	hsa-miR-4282	CLIP-seq
MIRT2618500	hsa-miR-4291	CLIP-seq
MIRT2322092	hsa-miR-4419b	CLIP-seq
MIRT1330059	hsa-miR-4421	CLIP-seq
MIRT1330009	hsa-miR-4434	CLIP-seq
MIRT2322093	hsa-miR-4478	CLIP-seq
MIRT1330011	hsa-miR-4483	CLIP-seq
MIRT1330013	hsa-miR-4516	CLIP-seq
MIRT1330014	hsa-miR-4531	CLIP-seq
MIRT2618501	hsa-miR-4649-3p	CLIP-seq
MIRT2618502	hsa-miR-4650-5p	CLIP-seq
MIRT2618503	hsa-miR-4670-3p	CLIP-seq
MIRT2322098	hsa-miR-4728-5p	CLIP-seq
MIRT2618505	hsa-miR-4761-5p	CLIP-seq
MIRT1330066	hsa-miR-4793-3p	CLIP-seq
MIRT1330029	hsa-miR-485-5p	CLIP-seq
MIRT2618506	hsa-miR-493	CLIP-seq
MIRT1330068	hsa-miR-542-3p	CLIP-seq
MIRT1330069	hsa-miR-548c-3p	CLIP-seq
MIRT1330070	hsa-miR-580	CLIP-seq
MIRT2618507	hsa-miR-761	CLIP-seq
MIRT2618508	hsa-miR-922	CLIP-seq

Show/Hide all (53)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001518	Component	Voltage-gated sodium channel complex	IBA
GO:0001518	Component	Voltage-gated sodium channel complex	IDA	20042427, 21051419, 24567321
GO:0001518	Component	Voltage-gated sodium channel complex	IEA
GO:0001518	Component	Voltage-gated sodium channel complex	TAS	21895525
GO:0005272	Function	Sodium channel activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781, 35301303
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA	24567321
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006814	Process	Sodium ion transport	NAS	10688874
GO:0007399	Process	Nervous system development	IEA
GO:0010460	Process	Positive regulation of heart rate	IEA
GO:0010460	Process	Positive regulation of heart rate	ISS
GO:0010765	Process	Positive regulation of sodium ion transport	IDA	20042427
GO:0010765	Process	Positive regulation of sodium ion transport	IMP	21051419
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10688874
GO:0017080	Function	Sodium channel regulator activity	IDA	20226894
GO:0017080	Function	Sodium channel regulator activity	IEA
GO:0017080	Function	Sodium channel regulator activity	IMP	20042427, 21051419
GO:0019871	Function	Sodium channel inhibitor activity	IBA
GO:0030018	Component	Z disc	IEA
GO:0030018	Component	Z disc	ISS
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IBA
GO:0035725	Process	Sodium ion transmembrane transport	IDA	20226894
GO:0044325	Function	Transmembrane transporter binding	IBA
GO:0044325	Function	Transmembrane transporter binding	IEA
GO:0044325	Function	Transmembrane transporter binding	IPI	20042427
GO:0051899	Process	Membrane depolarization	IDA	21051419
GO:0060048	Process	Cardiac muscle contraction	IMP	20042427, 21051419
GO:0060371	Process	Regulation of atrial cardiac muscle cell membrane depolarization	IEA
GO:0060371	Process	Regulation of atrial cardiac muscle cell membrane depolarization	IMP	21051419
GO:0060373	Process	Regulation of ventricular cardiac muscle cell membrane depolarization	IMP	20042427
GO:0061337	Process	Cardiac conduction	IEA
GO:0072659	Process	Protein localization to plasma membrane	IMP	20042427
GO:0086002	Process	Cardiac muscle cell action potential involved in contraction	IMP	21051419
GO:0086005	Process	Ventricular cardiac muscle cell action potential	IBA
GO:0086005	Process	Ventricular cardiac muscle cell action potential	IEA
GO:0086005	Process	Ventricular cardiac muscle cell action potential	IMP	20042427
GO:0086006	Function	Voltage-gated sodium channel activity involved in cardiac muscle cell action potential	IEA
GO:0086010	Process	Membrane depolarization during action potential	IDA	20042427, 20226894
GO:0086010	Process	Membrane depolarization during action potential	IMP	21051419
GO:0086012	Process	Membrane depolarization during cardiac muscle cell action potential	IBA
GO:0086012	Process	Membrane depolarization during cardiac muscle cell action potential	IMP	21051419
GO:0086014	Process	Atrial cardiac muscle cell action potential	IMP	21051419
GO:0086015	Process	SA node cell action potential	IEA
GO:0086015	Process	SA node cell action potential	ISS
GO:0086091	Process	Regulation of heart rate by cardiac conduction	IBA
GO:0086091	Process	Regulation of heart rate by cardiac conduction	IMP	20042427, 21051419

MIM	HGNC	e!Ensembl
608214	20665	ENSG00000166257

Q9NY72

Protein name

Sodium channel regulatory subunit beta-3

Protein function

Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by swi

PDB

4L1D , 7TJ8 , 7TJ9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	28 → 143	Immunoglobulin V-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the atrium. {ECO:0000269|PubMed:21051419}.

Sequence

MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE

Sequence length

215

Interactions

View interactions

	Reactome
			Phase 0 - rapid depolarisation

260

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Atrial fibrillation, familial, 16	Pathogenic	rs587777557, rs587777558	RCV000128814 RCV000128815

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Brugada syndrome	Conflicting classifications of pathogenicity; Uncertain significance	rs121918282, rs765294617, rs867302682, rs886047904, rs886047906, rs72553907, rs544984224, rs776449566, rs80017720, rs762633602	RCV000171567 RCV000266188 RCV000292638 RCV000289193 RCV000406653 RCV000366696 RCV000320548 RCV000358241 RCV000280076 RCV001089637
Brugada syndrome 7	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs369522500, rs2137236047, rs758915355, rs115752338, rs527845801, rs879253730, rs2137247053, rs754476318, rs575419664, rs201049075, rs746888620, rs775194985, rs36016311, rs1020414330, rs1955806072 View all (89 more)	RCV001352405 RCV001365529 RCV001404110 RCV001413945 RCV001432490 RCV001445493 RCV001429114 RCV001443488 RCV001462087 RCV001474970 RCV001494209 RCV001480394 RCV001517234 RCV002032825 RCV002025962 RCV001991573 RCV001923548 RCV002028622 RCV001982351 RCV001890935 RCV001971282 RCV001951768 RCV000471206 RCV001942991 RCV001949029 RCV002005812 RCV001885810 RCV002030565 RCV002001999 RCV001243331 RCV001320720 RCV002131833 RCV002109236 RCV002183190 RCV000002574 RCV002298983 RCV003094326 RCV003096864 RCV003096710 RCV003101175 RCV003101996 RCV003497959 RCV003102152 RCV003102978 RCV003085692 RCV002054024 RCV000463466 RCV001221228 RCV001087315 RCV000233030 RCV003088062 RCV003073476 RCV002615698 RCV002624558 RCV003117084 RCV002582703 RCV002631545 RCV002653265 RCV002716022 RCV002700690 RCV002691176 RCV002880794 RCV002943950 RCV002953109 RCV002953520 RCV003019218 RCV003055261 RCV002515579 RCV005101019 RCV005101374 RCV000860457 RCV001521817 RCV000461565 RCV005104236 RCV003499112 RCV003499841 RCV003497547 RCV003604961 RCV003604990 RCV003603695 RCV003820262 RCV001303529 RCV002487351 RCV003860115 RCV002522416 RCV000476588 RCV002489198 RCV001372816 RCV000554297 RCV002066736 RCV000983797 RCV001510932 RCV001855267 RCV000695978 RCV000706863 RCV001441804 RCV000795798 RCV000798076 RCV000800514 RCV001807357 RCV000861375 RCV000917949 RCV005056728 RCV001221947 RCV001229539 RCV003770397 RCV001302904
Cardiac arrhythmia	Uncertain significance	rs879253730, rs371558196	RCV001842965 RCV001841980
Cardiomyopathy	Conflicting classifications of pathogenicity	rs147205617	RCV000852659
Cardiovascular phenotype	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	rs369522500, rs758915355, rs115752338, rs754476318, rs575419664, rs201049075, rs746888620, rs775194985, rs36016311, rs1020414330, rs587777556, rs1955806072, rs767074394, rs371050389, rs148484744 View all (94 more)	RCV002395785 RCV002357339 RCV002420931 RCV003160785 RCV002350939 RCV002405122 RCV002343663 RCV003375317 RCV002405211 RCV002421252 RCV004040854 RCV002425402 RCV003170489 RCV002425309 RCV000253821 RCV002449576 RCV003164240 RCV003303576 RCV002442904 RCV002399507 RCV004046499 RCV000250087 RCV002325975 RCV002339727 RCV002349076 RCV002326584 RCV002327951 RCV002333575 RCV002333706 RCV002320567 RCV002338432 RCV002349920 RCV002353915 RCV002368731 RCV002353956 RCV002330799 RCV002340406 RCV002347028 RCV002345075 RCV002330344 RCV002337870 RCV002342841 RCV002434891 RCV002427919 RCV002380526 RCV002364742 RCV002423651 RCV002413147 RCV002443686 RCV002437089 RCV002450319 RCV002428796 RCV002437470 RCV002453233 RCV002444312 RCV002435861 RCV005483318 RCV003165348 RCV000622088 RCV002326936 RCV000621217 RCV000249174 RCV002354424 RCV004983224 RCV003377806 RCV003168307 RCV003181803 RCV003181804 RCV003181805 RCV003181806 RCV003216614 RCV000241560 RCV000245661 RCV000250033 RCV000242852 RCV003301647 RCV003301648 RCV003301649 RCV004348604 RCV003380368 RCV003380369 RCV003380370 RCV004374202 RCV002374517 RCV004524253 RCV004524254 RCV004524255 RCV004524256 RCV004524257 RCV004524258 RCV004524259 RCV004524260 RCV004022303 RCV002339079 RCV002446906 RCV002356802 RCV004023335 RCV002431667 RCV002457956 RCV000620529 RCV000617294 RCV000621836 RCV000618849 RCV000619211 RCV002386276 RCV002360869 RCV002352331 RCV004027942 RCV002352355 RCV002372396 RCV002327222 RCV005268985 RCV002384364
Death in infancy	Conflicting classifications of pathogenicity	rs147205617	RCV000234992
Long QT syndrome	Uncertain significance	rs140381249	RCV003318378
Ovarian serous cystadenocarcinoma	Likely benign	rs72552169	RCV005902243
Sarcoma	Benign; Likely benign	rs34964168	RCV005889664
SCN3B-related disorder	Likely benign; Conflicting classifications of pathogenicity	rs746888620, rs147205617, rs199937307	RCV003908768 RCV003937532 RCV003932762
Sudden cardiac death	Uncertain significance	rs777776827	RCV000208160

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Atrial Fibrillation	Associate	20558140, 30821358
Brain Neoplasms	Associate	31610812
Brugada Syndrome	Associate	20031595, 39761910
Edema	Stimulate	27487831
Epilepsy	Associate	26742644
Glioma	Associate	35581384
Hypoxia	Associate	31610812
Renal Insufficiency Chronic	Associate	32354559

SCN3B (sodium voltage-gated channel beta subunit 3)