Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5580
Gene name	Protein kinase C delta
Gene symbol	PRKCD
Synonyms (NCBI Gene)	ALPS3CVID9MAY1PKCDnPKC-delta
Chromosome	3
Chromosome location	3p21.1
Summary	The protein encoded by this gene is a member of the protein kinase C family of serine- and threonine-specific protein kinases. The encoded protein is activated by diacylglycerol and is both a tumor suppressor and a positive regulator of cell cycle progres

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SNP ID	Visualize variation	Clinical significance	Consequence
rs33911937	A>G	Conflicting-interpretations-of-pathogenicity	Intron variant, missense variant, coding sequence variant
rs398122958	G>A	Pathogenic	Splice donor variant
rs606231296	G>A	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs606231297	C>T	Pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs1295207359	A>G	Likely-pathogenic	Splice acceptor variant

195

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miRTarBase ID	miRNA	Experiments	Reference
MIRT041814	hsa-miR-484	CLASH	23622248
MIRT039609	hsa-miR-615-3p	CLASH	23622248
MIRT039609	hsa-miR-615-3p	CLASH	23622248
MIRT053097	hsa-miR-26a-5p	Luciferase reporter assayWestern blot	23525216
MIRT163342	hsa-miR-181a-5p	Luciferase reporter assay	24183997
MIRT163342	hsa-miR-181a-5p	Luciferase reporter assay	24183997
MIRT163342	hsa-miR-181a-5p	Luciferase reporter assay	24183997
MIRT163342	hsa-miR-181a-5p	Luciferase reporter assay	24183997
MIRT163378	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT163346	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT613705	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT163378	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT613708	hsa-miR-4268	HITS-CLIP	23824327
MIRT613707	hsa-miR-4448	HITS-CLIP	23824327
MIRT163346	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT613706	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT613705	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT163363	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT163384	hsa-miR-6856-3p	PAR-CLIP	21572407
MIRT163348	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT163380	hsa-miR-5692b	PAR-CLIP	21572407
MIRT163379	hsa-miR-5692c	PAR-CLIP	21572407
MIRT163350	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT163378	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515489	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT515488	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT163349	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT163358	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT163346	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT163369	hsa-miR-3924	PAR-CLIP	21572407
MIRT163363	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT163348	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT163380	hsa-miR-5692b	PAR-CLIP	23446348
MIRT163379	hsa-miR-5692c	PAR-CLIP	23446348
MIRT163350	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT163378	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515489	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT515488	hsa-miR-4796-5p	PAR-CLIP	23446348
MIRT163349	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT163358	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT163346	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT163369	hsa-miR-3924	PAR-CLIP	23446348
MIRT163362	hsa-miR-1305	PAR-CLIP	23446348
MIRT163253	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT163257	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT163254	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT163261	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT163342	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT163343	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT163344	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT163351	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT053097	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT163340	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT163342	hsa-miR-181a-5p	qRT-PCRLuciferase reporter assayWestern blot	25174404
MIRT163342	hsa-miR-181a-5p	qRT-PCRLuciferase reporter assayWestern blot	25174404
MIRT163344	hsa-miR-181c-5p	Luciferase reporter assay	26629004
MIRT163344	hsa-miR-181c-5p	Luciferase reporter assay	26629004
MIRT053097	hsa-miR-26a-5p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCRELISA	31907356
MIRT163340	hsa-miR-26b-5p	Luciferase reporter assayWestern blottingImmunoprecipitaion (IP)qRT-PCRELISA	31907356
MIRT163378	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT163346	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT613705	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT163378	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT613708	hsa-miR-4268	HITS-CLIP	23824327
MIRT613707	hsa-miR-4448	HITS-CLIP	23824327
MIRT163346	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT613706	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT613705	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT163363	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT163384	hsa-miR-6856-3p	PAR-CLIP	21572407
MIRT163348	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT163380	hsa-miR-5692b	PAR-CLIP	21572407
MIRT163379	hsa-miR-5692c	PAR-CLIP	21572407
MIRT163350	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT163378	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT515489	hsa-miR-654-3p	PAR-CLIP	21572407
MIRT515488	hsa-miR-4796-5p	PAR-CLIP	21572407
MIRT163349	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT163358	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT163346	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT163369	hsa-miR-3924	PAR-CLIP	21572407
MIRT163363	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT163348	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT163380	hsa-miR-5692b	PAR-CLIP	23446348
MIRT163379	hsa-miR-5692c	PAR-CLIP	23446348
MIRT163350	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT163378	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT515489	hsa-miR-654-3p	PAR-CLIP	23446348
MIRT515488	hsa-miR-4796-5p	PAR-CLIP	23446348
MIRT163349	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT163358	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT163346	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT163369	hsa-miR-3924	PAR-CLIP	23446348
MIRT163362	hsa-miR-1305	PAR-CLIP	23446348
MIRT1263054	hsa-miR-1207-5p	CLIP-seq
MIRT1263055	hsa-miR-1293	CLIP-seq
MIRT1263056	hsa-miR-3616-3p	CLIP-seq
MIRT1263057	hsa-miR-3665	CLIP-seq
MIRT1263058	hsa-miR-3934	CLIP-seq
MIRT1263059	hsa-miR-4436b-3p	CLIP-seq
MIRT1263060	hsa-miR-4483	CLIP-seq
MIRT1263061	hsa-miR-4763-3p	CLIP-seq
MIRT1263062	hsa-miR-1297	CLIP-seq
MIRT1263063	hsa-miR-181a	CLIP-seq
MIRT1263064	hsa-miR-181b	CLIP-seq
MIRT1263065	hsa-miR-181c	CLIP-seq
MIRT1263066	hsa-miR-181d	CLIP-seq
MIRT1263067	hsa-miR-26a	CLIP-seq
MIRT1263068	hsa-miR-26b	CLIP-seq
MIRT1263069	hsa-miR-4262	CLIP-seq
MIRT1263070	hsa-miR-4465	CLIP-seq
MIRT1263071	hsa-miR-494	CLIP-seq
MIRT1263072	hsa-miR-606	CLIP-seq
MIRT2077439	hsa-miR-374a	CLIP-seq
MIRT2077440	hsa-miR-374b	CLIP-seq
MIRT2077441	hsa-miR-3942-5p	CLIP-seq
MIRT2077442	hsa-miR-410	CLIP-seq
MIRT2077443	hsa-miR-4684-5p	CLIP-seq
MIRT2077444	hsa-miR-4703-5p	CLIP-seq
MIRT2077445	hsa-miR-4719	CLIP-seq
MIRT2077446	hsa-miR-4768-5p	CLIP-seq
MIRT2077447	hsa-miR-490-3p	CLIP-seq
MIRT2303976	hsa-miR-1226	CLIP-seq
MIRT1263055	hsa-miR-1293	CLIP-seq
MIRT2303977	hsa-miR-140-3p	CLIP-seq
MIRT2303978	hsa-miR-15a	CLIP-seq
MIRT2303979	hsa-miR-15b	CLIP-seq
MIRT2303980	hsa-miR-16	CLIP-seq
MIRT2303981	hsa-miR-1908	CLIP-seq
MIRT2303982	hsa-miR-195	CLIP-seq
MIRT2303983	hsa-miR-197	CLIP-seq
MIRT2303984	hsa-miR-224	CLIP-seq
MIRT2303985	hsa-miR-27a	CLIP-seq
MIRT2303986	hsa-miR-27b	CLIP-seq
MIRT2303987	hsa-miR-298	CLIP-seq
MIRT2303988	hsa-miR-3125	CLIP-seq
MIRT2303989	hsa-miR-3150a-3p	CLIP-seq
MIRT2303990	hsa-miR-3156-3p	CLIP-seq
MIRT2303991	hsa-miR-3175	CLIP-seq
MIRT2303992	hsa-miR-3180	CLIP-seq
MIRT2303993	hsa-miR-3180-3p	CLIP-seq
MIRT2303994	hsa-miR-3196	CLIP-seq
MIRT2303995	hsa-miR-361-3p	CLIP-seq
MIRT1263057	hsa-miR-3665	CLIP-seq
MIRT2303996	hsa-miR-3677-3p	CLIP-seq
MIRT2303997	hsa-miR-377	CLIP-seq
MIRT2303998	hsa-miR-3907	CLIP-seq
MIRT2303999	hsa-miR-3916	CLIP-seq
MIRT1263058	hsa-miR-3934	CLIP-seq
MIRT2304000	hsa-miR-3940-3p	CLIP-seq
MIRT2077441	hsa-miR-3942-5p	CLIP-seq
MIRT2304001	hsa-miR-424	CLIP-seq
MIRT2304002	hsa-miR-4301	CLIP-seq
MIRT1263060	hsa-miR-4483	CLIP-seq
MIRT2304003	hsa-miR-4530	CLIP-seq
MIRT2304004	hsa-miR-4640-5p	CLIP-seq
MIRT2077443	hsa-miR-4684-5p	CLIP-seq
MIRT2077444	hsa-miR-4703-5p	CLIP-seq
MIRT2304005	hsa-miR-4712-3p	CLIP-seq
MIRT2304006	hsa-miR-4726-5p	CLIP-seq
MIRT2304007	hsa-miR-4733-3p	CLIP-seq
MIRT2304008	hsa-miR-4736	CLIP-seq
MIRT2077446	hsa-miR-4768-5p	CLIP-seq
MIRT2304009	hsa-miR-491-5p	CLIP-seq
MIRT2304010	hsa-miR-497	CLIP-seq
MIRT2304011	hsa-miR-513a-5p	CLIP-seq
MIRT2304012	hsa-miR-548q	CLIP-seq
MIRT2304013	hsa-miR-663	CLIP-seq
MIRT2304014	hsa-miR-744	CLIP-seq
MIRT2304015	hsa-miR-922	CLIP-seq
MIRT2304016	hsa-miR-939	CLIP-seq
MIRT2303985	hsa-miR-27a	CLIP-seq
MIRT2303986	hsa-miR-27b	CLIP-seq
MIRT2303988	hsa-miR-3125	CLIP-seq
MIRT2303997	hsa-miR-377	CLIP-seq
MIRT2303999	hsa-miR-3916	CLIP-seq
MIRT2304011	hsa-miR-513a-5p	CLIP-seq
MIRT2303985	hsa-miR-27a	CLIP-seq
MIRT2303986	hsa-miR-27b	CLIP-seq
MIRT2303988	hsa-miR-3125	CLIP-seq
MIRT2303997	hsa-miR-377	CLIP-seq
MIRT2303999	hsa-miR-3916	CLIP-seq
MIRT2304000	hsa-miR-3940-3p	CLIP-seq
MIRT2304005	hsa-miR-4712-3p	CLIP-seq
MIRT2304011	hsa-miR-513a-5p	CLIP-seq
MIRT2303985	hsa-miR-27a	CLIP-seq
MIRT2303986	hsa-miR-27b	CLIP-seq
MIRT2303988	hsa-miR-3125	CLIP-seq
MIRT2303997	hsa-miR-377	CLIP-seq
MIRT2303999	hsa-miR-3916	CLIP-seq
MIRT2304000	hsa-miR-3940-3p	CLIP-seq
MIRT2077441	hsa-miR-3942-5p	CLIP-seq
MIRT2077444	hsa-miR-4703-5p	CLIP-seq
MIRT2304005	hsa-miR-4712-3p	CLIP-seq
MIRT2304011	hsa-miR-513a-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IDA	24008408, 34593629
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10770950, 18285462, 19059439
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004697	Function	Diacylglycerol-dependent serine/threonine kinase activity	EXP	12391145, 18285462
GO:0004697	Function	Diacylglycerol-dependent serine/threonine kinase activity	IEA
GO:0004697	Function	Diacylglycerol-dependent serine/threonine kinase activity	TAS
GO:0004699	Function	Diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IEA
GO:0004699	Function	Diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	ISS
GO:0004699	Function	Diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	TAS	14583092
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004715	Function	Non-membrane spanning protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	9139733, 10383400, 10948194, 12628935, 12649167, 12721299, 15591124, 16377624, 16611985, 16940418, 19059439, 22465666, 22528498, 23814099, 24396867, 24996056, 25241761, 26112605, 32814053, 34593629
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IDA	15632189, 15774464, 16611985, 18285462
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	15632189, 16611985, 18285462
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA	15774464, 18556656
GO:0005829	Component	Cytosol	IDA	10770950, 15774464, 17303575
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	10770950, 15632189, 17303575
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	IEA
GO:0006468	Process	Protein phosphorylation	IDA	12649167, 16611985
GO:0006915	Process	Apoptotic process	IDA	10770950, 12649167
GO:0006915	Process	Apoptotic process	IEA
GO:0006974	Process	DNA damage response	IMP	17938203
GO:0007165	Process	Signal transduction	TAS	8357834
GO:0008047	Function	Enzyme activator activity	IDA	16611985
GO:0008270	Function	Zinc ion binding	IEA
GO:0008631	Process	Intrinsic apoptotic signaling pathway in response to oxidative stress	TAS	24522549
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016064	Process	Immunoglobulin mediated immune response	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	18285462
GO:0018107	Process	Peptidyl-threonine phosphorylation	IDA	10770950
GO:0019899	Function	Enzyme binding	IPI	16611985, 18556656
GO:0019901	Function	Protein kinase binding	IPI	10713049, 28428613
GO:0023021	Process	Termination of signal transduction	IMP	19279008
GO:0030296	Function	Protein tyrosine kinase activator activity	IDA	10713049
GO:0030837	Process	Negative regulation of actin filament polymerization	IEA
GO:0030837	Process	Negative regulation of actin filament polymerization	ISS
GO:0032079	Process	Positive regulation of endodeoxyribonuclease activity	IMP	19059439
GO:0032930	Process	Positive regulation of superoxide anion generation	IMP	19801500
GO:0032956	Process	Regulation of actin cytoskeleton organization	IMP	22554282
GO:0034351	Process	Negative regulation of glial cell apoptotic process	IMP	15774464
GO:0034644	Process	Cellular response to UV	IDA	17303575
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0036019	Component	Endolysosome	IDA	17303575
GO:0038096	Process	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS
GO:0042100	Process	B cell proliferation	IEA
GO:0042119	Process	Neutrophil activation	IDA	10770950
GO:0042307	Process	Positive regulation of protein import into nucleus	IMP	19059439
GO:0042742	Process	Defense response to bacterium	IEA
GO:0042742	Process	Defense response to bacterium	ISS
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	IMP	19279008
GO:0043488	Process	Regulation of mRNA stability	TAS
GO:0043560	Function	Insulin receptor substrate binding	IEA
GO:0043560	Function	Insulin receptor substrate binding	ISS
GO:0043687	Process	Post-translational protein modification	IDA	19059439
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	ISS	14583092
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IMP	19279008
GO:0050821	Process	Protein stabilization	NAS	16611985
GO:0051054	Process	Positive regulation of DNA metabolic process	IEA
GO:0051490	Process	Negative regulation of filopodium assembly	IEA
GO:0051490	Process	Negative regulation of filopodium assembly	ISS
GO:0060326	Process	Cell chemotaxis	IEA
GO:0060326	Process	Cell chemotaxis	IMP	24008408
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070301	Process	Cellular response to hydrogen peroxide	IDA	10713049
GO:0070528	Process	Protein kinase C signaling	IEA
GO:0071398	Process	Cellular response to fatty acid	TAS	14583092
GO:0071447	Process	Cellular response to hydroperoxide	IDA	19059439
GO:0090331	Process	Negative regulation of platelet aggregation	IEA
GO:0090331	Process	Negative regulation of platelet aggregation	ISS
GO:0090398	Process	Cellular senescence	IMP	15282327
GO:0106310	Function	Protein serine kinase activity	IDA	17303575
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0141212	Process	Phospholipase C/protein kinase C signal transduction	IDA	10713049
GO:1900163	Process	Positive regulation of phospholipid scramblase activity	IMP	10770950
GO:1904385	Process	Cellular response to angiotensin	IDA	18285462
GO:2000303	Process	Regulation of ceramide biosynthetic process	IDA	17303575
GO:2000304	Process	Positive regulation of ceramide biosynthetic process	IMP	19279011
GO:2000753	Process	Positive regulation of glucosylceramide catabolic process	IMP	19279011
GO:2000755	Process	Positive regulation of sphingomyelin catabolic process	IMP	19279011
GO:2001235	Process	Positive regulation of apoptotic signaling pathway	IEA

MIM	HGNC	e!Ensembl
176977	9399	ENSG00000163932

Q05655

Protein name

Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SD

Protein function

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but

PDB

1YRK , 2YUU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00130	C1_1	159 → 211	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00130	C1_1	231 → 283	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00069	Pkinase	349 → 603	Protein kinase domain	Domain
PF00433	Pkinase_C	624 → 665	Protein kinase C terminal domain	Family

Sequence

MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
AGFSFVNPKFEHLLED

Sequence length

676

Interactions

View interactions

	KEGG		Reactome
	Chemokine signaling pathway Autophagy - animal Vascular smooth muscle contraction NOD-like receptor signaling pathway C-type lectin receptor signaling pathway Fc gamma R-mediated phagocytosis Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels GnRH signaling pathway Estrogen signaling pathway Type II diabetes mellitus Insulin resistance AGE-RAGE signaling pathway in diabetic complications Prion disease Shigellosis Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy		Apoptotic cleavage of cellular proteins Calmodulin induced events Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis HuR (ELAVL1) binds and stabilizes mRNA VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Interferon gamma signaling

477

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Autoimmune lymphoproliferative syndrome, type III caused by mutation in PRKCD	Pathogenic; Likely pathogenic	rs781824115, rs2107263484, rs1553669486, rs2107267894, rs2107257357, rs1559629912, rs606231296, rs2471106746, rs2471094850, rs2471099139, rs1703450134, rs1295207359, rs576747810, rs398122958	RCV001385018 RCV001776307 RCV001776308 RCV001776309 RCV001960700 RCV001972817 RCV000144965 RCV002863475 RCV002974924 RCV003057564 RCV003745147 RCV000651930 RCV001231375 RCV000074607
Lymphoma	Pathogenic	rs576747810, rs398122958	RCV005909094 RCV005890427

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs782588098	RCV004557904
PRKCD-related disorder	Likely benign; Benign	rs2471085779, rs782032884, rs180706867, rs782735766, rs141412493, rs529176751, rs149751382, rs782548097, rs201862364, rs200076653	RCV003947349 RCV003983574 RCV003925697 RCV003935520 RCV003920735 RCV004758751 RCV003950566 RCV003942879 RCV003960499 RCV003972957
See cases	Uncertain significance	rs782059592	RCV002252915
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs140359417	RCV005908989

Show/Hide Text Mining Associations (110)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	17608772
Adenocarcinoma of Lung	Associate	16055435, 36254009, 38186574
Adenoma	Associate	25371776
Alzheimer Disease	Associate	18336728, 37418137
Aortic Dissection	Associate	33083483
Arthritis Rheumatoid	Associate	27915349
Arthropathy progressive pseudorheumatoid of childhood	Associate	17200207
Atherosclerosis	Associate	27910925
Autoimmune Diseases	Associate	36782298
Bone Diseases Metabolic	Associate	25420887
Breast Neoplasms	Associate	17371872, 17965220, 19002183, 19279008, 19833733, 21720730, 26083392, 27036017, 29036789, 31843498, 35301803, 36732634, 40722182
Calcinosis Cutis	Associate	26121314
Carcinogenesis	Associate	25225290, 26121314, 26918447, 36851883
Carcinoma Hepatocellular	Associate	33307168, 33778066, 34609335, 37241771, 37674210
Carcinoma Non Small Cell Lung	Associate	26918447, 30537515, 35039611, 36482371
Carcinoma Renal Cell	Associate	10748176, 16669786, 17760843, 20459627, 21233420, 9346879
Cardiovascular Diseases	Associate	27910925
Cartilage Diseases	Associate	24385683
Cell Transformation Neoplastic	Associate	21886838
Chondrosarcoma	Associate	23320110, 24992595
Colonic Neoplasms	Associate	17760565, 17965192
Colorectal Neoplasms	Associate	14527959, 15601585, 16052516, 17965192, 36851883, 36982784
Cystic Fibrosis	Associate	10634929, 24223826
Dermatitis Atopic	Associate	29498756
Diabetes Mellitus	Associate	35628588
Diabetes Mellitus Type 2	Associate	29036789
Diabetic Nephropathies	Stimulate	25371776
Disease	Associate	23454274
Drug Related Side Effects and Adverse Reactions	Stimulate	21326872
Drug Related Side Effects and Adverse Reactions	Associate	30194076
Dystonic Disorders	Inhibit	35585372
Dystonic Disorders	Associate	35585372
Endocrine System Diseases	Associate	17965220
Endometrial Neoplasms	Associate	17959229, 21079811
Esophageal Squamous Cell Carcinoma	Associate	30361064
Fever	Associate	20569108
Genetic Diseases Inborn	Associate	23666743
Glioblastoma	Associate	15618223, 20669099, 36732634
Granulomatous Disease Chronic	Associate	35585372
Heart Diseases	Associate	25420887
Hepatitis B	Inhibit	35301803
Histiocytoma Benign Fibrous	Associate	26121314
Hyperglycemia	Associate	29036789
Hypoxia	Stimulate	17608772
Hypoxia	Associate	24500281, 29272263
Hypoxia Brain	Associate	24500281
Immunologic Deficiency Syndromes	Stimulate	23319571
Inflammation	Associate	18650365, 22048166, 23826267, 35409338, 36782298
Insulin Resistance	Associate	33308192
Kidney Diseases	Associate	25371776
Kidney Failure Chronic	Associate	30212930
Leukemia	Associate	15308560, 19662097, 19995395, 22356114, 33556471
Leukemia B Cell	Associate	23319571
Leukemia Erythroblastic Acute	Associate	31545282
Leukemia Lymphocytic Chronic B Cell	Associate	12393602
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	14670960, 15850832
Leukemia Myeloid Acute	Associate	15845901, 20472553, 35895896
Leukemia Prolymphocytic T Cell	Associate	19995395
Leukemia Promyelocytic Acute	Associate	22356114
Liver Failure	Stimulate	26212029
Lung Diseases	Associate	18342628, 24500281, 29849902
Lung Injury	Associate	27442243
Lung Neoplasms	Associate	26918447, 28368426, 30537515, 36482371
Lupus Erythematosus Systemic	Inhibit	15379867
Lupus Erythematosus Systemic	Associate	17911642, 22549474, 23285258, 23666743, 27915349, 29177435, 30257684
Lymphoma	Inhibit	25991819
Lymphoma T Cell Cutaneous	Associate	33922439
Malformations of Cortical Development Group I	Inhibit	19833733
Malformations of Cortical Development Group I	Associate	29048618
Melanoma	Associate	24506253
Mitochondrial Diseases	Associate	29849902
Multiple Myeloma	Associate	11485567, 12786795, 22435755
Multiple Sclerosis	Associate	23469041
Neoplasm Invasiveness	Associate	17200207
Neoplasm Metastasis	Associate	26847170
Neoplasms	Inhibit	12097319, 14699137, 15601585, 17959229, 35039611
Neoplasms	Stimulate	16508638
Neoplasms	Associate	17760843, 19002183, 19549763, 19632318, 22848562, 24030148, 25104022, 25372487, 25420887, 26121314, 26918447, 31843498, 36217175, 36482371, 36732634, 36851883, 36982784, 40722182 View all (3 more)
Nerve Degeneration	Associate	25590633
Neuroblastoma	Associate	15189345, 21326872
Neurologic Manifestations	Associate	25590633
Non alcoholic Fatty Liver Disease	Associate	29046367, 29341352
Ophthalmoplegia Chronic Progressive External	Associate	19477272
Osteoarthritis	Associate	17311929
Osteosarcoma	Associate	28339053
Ovarian Neoplasms	Associate	28081739
Ovarian Neoplasms	Stimulate	40269926
Pancreatic Neoplasms	Associate	17374730, 19190347
Pituitary Neoplasms	Associate	37233978
Plasma Cell Granuloma Pulmonary	Associate	27442243
Post Infectious Disorders	Associate	22048166
Primary Immunodeficiency Diseases	Associate	38644452
Primary Myelofibrosis	Associate	27081176
Prostatic Neoplasms	Associate	12824193, 16183650, 17553165, 19117992, 19667069, 20566643, 23559010, 23826267, 27196755, 29048618, 32427575
Prostatitis	Associate	27196755
Protein C Deficiency	Inhibit	23319571
Protein C Deficiency	Associate	30257684
Pulmonary Disease Chronic Obstructive	Associate	29849902
Seizures	Associate	38166692
Sepsis	Associate	27442243
Spinocerebellar Ataxia 10	Associate	20548952
Stomach Neoplasms	Associate	16055706, 26811494
Thrombocythemia Essential	Associate	27081176
Thrombocytopenia	Associate	30257684
Thyroid Cancer Papillary	Associate	36217175
Triple Negative Breast Neoplasms	Associate	33411917
Urethral Neoplasms	Associate	36862682
Uveal melanoma	Associate	22653968
Uveomeningoencephalitic Syndrome	Associate	36782298
Vitiligo	Associate	28129744

PRKCD (protein kinase C delta)