MINDY1 (MINDY lysine 48 deubiquitinase 1)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein
Entrez ID 55793
Gene name MINDY lysine 48 deubiquitinase 1
Gene symbol MINDY1
Synonyms (NCBI Gene)
FAM63AMINDY-1
Chromosome 1
Chromosome location 1q21.3
miRNA miRNA information provided by mirtarbase database.
14
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all (14)
miRTarBase ID miRNA Experiments Reference
MIRT623979 hsa-miR-483-5p HITS-CLIP 23824327
MIRT623976 hsa-miR-411-5p HITS-CLIP 23824327
MIRT623978 hsa-miR-193b-5p HITS-CLIP 23824327
MIRT623977 hsa-miR-6832-5p HITS-CLIP 23824327
MIRT623976 hsa-miR-411-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0004843 Function Cysteine-type deubiquitinase activity IEA
GO:0005515 Function Protein binding IPI 25416956, 32296183, 32814053
GO:0005654 Component Nucleoplasm IDA
GO:0006508 Process Proteolysis IEA
GO:0008233 Function Peptidase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
618407 25648 ENSG00000143409
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N5J2
Protein name Ubiquitin carboxyl-terminal hydrolase MINDY-1 (EC 3.4.19.12) (Deubiquitinating enzyme MINDY-1) (Protein FAM63A)
Protein function Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. {ECO:00002
PDB 5JKN , 5JQS , 5MN9 , 6TUV , 6TXB , 6Y6R , 6YJG , 6Z90
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04424 MINDY_DUB 143 → 266 MINDY deubiquitinase Family
Sequence 
MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDADGEAREREPADQALLPS
QCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIP
WKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQ
EKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGW
LVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLC
ELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFC
DSDFHLSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQ
QEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL
Sequence length 469
Interactions View interactions