Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5579
Gene name Gene Name - the full gene name approved by the HGNC.	Protein kinase C beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRKCB
Synonyms (NCBI Gene) Gene synonyms aliases	PKC-beta, PKCB, PKCI(2), PKCbeta, PRKCB1, PRKCB2
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16p12.2-p12.1
Summary Summary of gene provided in NCBI Entrez Gene.	Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in d

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1131692056	G>T	Pathogenic	Coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022275	hsa-miR-124-3p	Microarray	18668037
MIRT718805	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT654742	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT718804	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT718803	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT718802	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT654756	hsa-miR-488-5p	HITS-CLIP	23824327
MIRT654755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT654754	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT654753	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT654751	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT654752	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654750	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT654749	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654747	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654748	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT654746	hsa-miR-6074	HITS-CLIP	23824327
MIRT654745	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT654744	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT654743	hsa-miR-1248	HITS-CLIP	23824327
MIRT654742	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT654741	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT608983	hsa-miR-3609	HITS-CLIP	24906430
MIRT608982	hsa-miR-548ah-5p	HITS-CLIP	24906430
MIRT608981	hsa-miR-106a-5p	HITS-CLIP	24906430
MIRT608980	hsa-miR-106b-5p	HITS-CLIP	24906430
MIRT608979	hsa-miR-17-5p	HITS-CLIP	24906430
MIRT608978	hsa-miR-20a-5p	HITS-CLIP	24906430
MIRT608977	hsa-miR-20b-5p	HITS-CLIP	24906430
MIRT608976	hsa-miR-519d-3p	HITS-CLIP	24906430
MIRT608975	hsa-miR-526b-3p	HITS-CLIP	24906430
MIRT608974	hsa-miR-93-5p	HITS-CLIP	24906430
MIRT395213	hsa-miR-4796-3p	HITS-CLIP	24906430
MIRT395211	hsa-miR-142-5p	HITS-CLIP	24906430
MIRT395214	hsa-miR-5590-3p	HITS-CLIP	24906430
MIRT608973	hsa-miR-4742-3p	HITS-CLIP	24906430
MIRT608972	hsa-miR-1537-5p	HITS-CLIP	24906430
MIRT608971	hsa-miR-4718	HITS-CLIP	24906430
MIRT608970	hsa-miR-4999-5p	HITS-CLIP	24906430
MIRT395212	hsa-miR-3650	HITS-CLIP	24906430
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608969	hsa-miR-4455	HITS-CLIP	24906430
MIRT608968	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT442227	hsa-miR-890	PAR-CLIP	22100165
MIRT442226	hsa-miR-300	PAR-CLIP	22100165
MIRT442225	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT442224	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT442223	hsa-miR-1261	PAR-CLIP	22100165
MIRT608981	hsa-miR-106a-5p	HITS-CLIP	27418678
MIRT608981	hsa-miR-106a-5p	HITS-CLIP	27418678
MIRT608980	hsa-miR-106b-5p	HITS-CLIP	27418678
MIRT608980	hsa-miR-106b-5p	HITS-CLIP	27418678
MIRT395211	hsa-miR-142-5p	HITS-CLIP	27418678
MIRT395211	hsa-miR-142-5p	HITS-CLIP	27418678
MIRT608972	hsa-miR-1537-5p	HITS-CLIP	27418678
MIRT608972	hsa-miR-1537-5p	HITS-CLIP	27418678
MIRT608979	hsa-miR-17-5p	HITS-CLIP	27418678
MIRT608979	hsa-miR-17-5p	HITS-CLIP	27418678
MIRT608978	hsa-miR-20a-5p	HITS-CLIP	27418678
MIRT608978	hsa-miR-20a-5p	HITS-CLIP	27418678
MIRT608977	hsa-miR-20b-5p	HITS-CLIP	27418678
MIRT608977	hsa-miR-20b-5p	HITS-CLIP	27418678
MIRT608983	hsa-miR-3609	HITS-CLIP	27418678
MIRT608983	hsa-miR-3609	HITS-CLIP	27418678
MIRT395212	hsa-miR-3650	HITS-CLIP	27418678
MIRT395212	hsa-miR-3650	HITS-CLIP	27418678
MIRT608969	hsa-miR-4455	HITS-CLIP	27418678
MIRT608969	hsa-miR-4455	HITS-CLIP	27418678
MIRT608971	hsa-miR-4718	HITS-CLIP	27418678
MIRT608971	hsa-miR-4718	HITS-CLIP	27418678
MIRT608973	hsa-miR-4742-3p	HITS-CLIP	27418678
MIRT395213	hsa-miR-4796-3p	HITS-CLIP	27418678
MIRT395213	hsa-miR-4796-3p	HITS-CLIP	27418678
MIRT608970	hsa-miR-4999-5p	HITS-CLIP	27418678
MIRT608970	hsa-miR-4999-5p	HITS-CLIP	27418678
MIRT608976	hsa-miR-519d-3p	HITS-CLIP	27418678
MIRT608976	hsa-miR-519d-3p	HITS-CLIP	27418678
MIRT608975	hsa-miR-526b-3p	HITS-CLIP	27418678
MIRT608975	hsa-miR-526b-3p	HITS-CLIP	27418678
MIRT608982	hsa-miR-548ah-5p	HITS-CLIP	27418678
MIRT608982	hsa-miR-548ah-5p	HITS-CLIP	27418678
MIRT395214	hsa-miR-5590-3p	HITS-CLIP	27418678
MIRT395214	hsa-miR-5590-3p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT576416	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT395216	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608974	hsa-miR-93-5p	HITS-CLIP	27418678
MIRT608974	hsa-miR-93-5p	HITS-CLIP	27418678
MIRT733514	hsa-miR-1200	Microarray	34164896
MIRT733514	hsa-miR-1200	Microarray	34164896
MIRT718805	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT654742	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT718804	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT718803	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT718802	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT654756	hsa-miR-488-5p	HITS-CLIP	23824327
MIRT654755	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT654754	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT654753	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT654751	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT654752	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT654750	hsa-miR-3180-5p	HITS-CLIP	23824327
MIRT654749	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT654747	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT654748	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT654746	hsa-miR-6074	HITS-CLIP	23824327
MIRT654745	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT654744	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT654743	hsa-miR-1248	HITS-CLIP	23824327
MIRT654742	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT654741	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT442227	hsa-miR-890	PAR-CLIP	22100165
MIRT442226	hsa-miR-300	PAR-CLIP	22100165
MIRT442225	hsa-miR-381-3p	PAR-CLIP	22100165
MIRT442224	hsa-miR-3614-5p	PAR-CLIP	22100165
MIRT442223	hsa-miR-1261	PAR-CLIP	22100165
MIRT1262987	hsa-miR-106a	CLIP-seq
MIRT1262988	hsa-miR-106b	CLIP-seq
MIRT1262989	hsa-miR-1237	CLIP-seq
MIRT1262990	hsa-miR-1238	CLIP-seq
MIRT1262991	hsa-miR-1297	CLIP-seq
MIRT1262992	hsa-miR-1324	CLIP-seq
MIRT1262993	hsa-miR-141	CLIP-seq
MIRT1262994	hsa-miR-17	CLIP-seq
MIRT1262995	hsa-miR-197	CLIP-seq
MIRT1262996	hsa-miR-200a	CLIP-seq
MIRT1262997	hsa-miR-20a	CLIP-seq
MIRT1262998	hsa-miR-20b	CLIP-seq
MIRT1262999	hsa-miR-26a	CLIP-seq
MIRT1263000	hsa-miR-26b	CLIP-seq
MIRT1263001	hsa-miR-3124-3p	CLIP-seq
MIRT1263002	hsa-miR-3165	CLIP-seq
MIRT1263003	hsa-miR-3183	CLIP-seq
MIRT1263004	hsa-miR-361-5p	CLIP-seq
MIRT1263005	hsa-miR-3617	CLIP-seq
MIRT1263006	hsa-miR-3646	CLIP-seq
MIRT1263007	hsa-miR-3690	CLIP-seq
MIRT1263008	hsa-miR-3942-3p	CLIP-seq
MIRT1263009	hsa-miR-3977	CLIP-seq
MIRT1263010	hsa-miR-4254	CLIP-seq
MIRT1263011	hsa-miR-4263	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263013	hsa-miR-431	CLIP-seq
MIRT1263014	hsa-miR-4330	CLIP-seq
MIRT1263015	hsa-miR-4434	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT1263017	hsa-miR-4465	CLIP-seq
MIRT1263018	hsa-miR-4491	CLIP-seq
MIRT1263019	hsa-miR-4516	CLIP-seq
MIRT1263020	hsa-miR-4529-5p	CLIP-seq
MIRT1263021	hsa-miR-4531	CLIP-seq
MIRT1263022	hsa-miR-4657	CLIP-seq
MIRT1263023	hsa-miR-4717-5p	CLIP-seq
MIRT1263024	hsa-miR-4723-3p	CLIP-seq
MIRT1263025	hsa-miR-500a	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263027	hsa-miR-511	CLIP-seq
MIRT1263028	hsa-miR-519d	CLIP-seq
MIRT1263029	hsa-miR-539	CLIP-seq
MIRT1263030	hsa-miR-548a-5p	CLIP-seq
MIRT1263031	hsa-miR-548aa	CLIP-seq
MIRT1263032	hsa-miR-548ab	CLIP-seq
MIRT1263033	hsa-miR-548ah	CLIP-seq
MIRT1263034	hsa-miR-548ak	CLIP-seq
MIRT1263035	hsa-miR-548b-5p	CLIP-seq
MIRT1263036	hsa-miR-548c-5p	CLIP-seq
MIRT1263037	hsa-miR-548d-5p	CLIP-seq
MIRT1263038	hsa-miR-548h	CLIP-seq
MIRT1263039	hsa-miR-548i	CLIP-seq
MIRT1263040	hsa-miR-548j	CLIP-seq
MIRT1263041	hsa-miR-548k	CLIP-seq
MIRT1263042	hsa-miR-548l	CLIP-seq
MIRT1263043	hsa-miR-548w	CLIP-seq
MIRT1263044	hsa-miR-548y	CLIP-seq
MIRT1263045	hsa-miR-559	CLIP-seq
MIRT1263046	hsa-miR-576-5p	CLIP-seq
MIRT1263047	hsa-miR-587	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263049	hsa-miR-640	CLIP-seq
MIRT1263050	hsa-miR-641	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq
MIRT1263052	hsa-miR-93	CLIP-seq
MIRT1263053	hsa-miR-939	CLIP-seq
MIRT2303967	hsa-miR-1914	CLIP-seq
MIRT2303968	hsa-miR-2355-3p	CLIP-seq
MIRT2303969	hsa-miR-4265	CLIP-seq
MIRT2303970	hsa-miR-4296	CLIP-seq
MIRT2303971	hsa-miR-4322	CLIP-seq
MIRT2303972	hsa-miR-4417	CLIP-seq
MIRT2303973	hsa-miR-4646-3p	CLIP-seq
MIRT2303974	hsa-miR-561	CLIP-seq
MIRT2303975	hsa-miR-676	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq
MIRT1262990	hsa-miR-1238	CLIP-seq
MIRT1262995	hsa-miR-197	CLIP-seq
MIRT1263001	hsa-miR-3124-3p	CLIP-seq
MIRT2600903	hsa-miR-361-3p	CLIP-seq
MIRT2600904	hsa-miR-3682-5p	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT2600905	hsa-miR-493	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263027	hsa-miR-511	CLIP-seq
MIRT2600906	hsa-miR-550b	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq
MIRT1262990	hsa-miR-1238	CLIP-seq
MIRT1262995	hsa-miR-197	CLIP-seq
MIRT1263001	hsa-miR-3124-3p	CLIP-seq
MIRT2600904	hsa-miR-3682-5p	CLIP-seq
MIRT1263012	hsa-miR-4302	CLIP-seq
MIRT1263016	hsa-miR-4436a	CLIP-seq
MIRT1263026	hsa-miR-508-5p	CLIP-seq
MIRT1263027	hsa-miR-511	CLIP-seq
MIRT2600906	hsa-miR-550b	CLIP-seq
MIRT1263048	hsa-miR-610	CLIP-seq
MIRT1263051	hsa-miR-665	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
MITF	Unknown	16411896

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0003682	Function	Chromatin binding	IDA	20228790
GO:0003713	Function	Transcription coactivator activity	IMP	20228790
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0004697	Function	Diacylglycerol-dependent serine/threonine kinase activity	EXP	12391145
GO:0004697	Function	Diacylglycerol-dependent serine/threonine kinase activity	IEA
GO:0004697	Function	Diacylglycerol-dependent serine/threonine kinase activity	TAS	3755548
GO:0004698	Function	Calcium,diacylglycerol-dependent serine/threonine kinase activity	IDA	25313067, 25982116
GO:0004698	Function	Calcium,diacylglycerol-dependent serine/threonine kinase activity	IEA
GO:0005080	Function	Protein kinase C binding	IPI	20228790
GO:0005246	Function	Calcium channel regulator activity	IEA
GO:0005515	Function	Protein binding	IPI	18162466, 20228790, 21044950, 25852190, 32707033, 32814053
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	20228790
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	15632189
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	15632189
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IMP	20228790
GO:0006468	Process	Protein phosphorylation	TAS	3755548
GO:0006816	Process	Calcium ion transport	IEA
GO:0006874	Process	Intracellular calcium ion homeostasis	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0007077	Process	Mitotic nuclear membrane disassembly	IEA
GO:0007077	Process	Mitotic nuclear membrane disassembly	TAS
GO:0007165	Process	Signal transduction	NAS	3755548
GO:0007207	Process	Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IEA
GO:0008091	Component	Spectrin	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0010827	Process	Regulation of D-glucose transmembrane transport	IDA	25982116
GO:0010829	Process	Negative regulation of D-glucose transmembrane transport	IEA
GO:0010829	Process	Negative regulation of D-glucose transmembrane transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030949	Process	Positive regulation of vascular endothelial growth factor receptor signaling pathway	IEA
GO:0030949	Process	Positive regulation of vascular endothelial growth factor receptor signaling pathway	ISS
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0035403	Function	Histone H3T6 kinase activity	IDA	20228790
GO:0035403	Function	Histone H3T6 kinase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0042113	Process	B cell activation	IEA
GO:0042113	Process	B cell activation	ISS
GO:0042393	Function	Histone binding	IDA	20228790
GO:0042953	Process	Lipoprotein transport	TAS	18981301
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	ISS
GO:0044305	Component	Calyx of Held	IEA
GO:0045766	Process	Positive regulation of angiogenesis	IEA
GO:0045766	Process	Positive regulation of angiogenesis	ISS
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0050681	Function	Nuclear androgen receptor binding	IDA	20228790
GO:0050853	Process	B cell receptor signaling pathway	IEA
GO:0050853	Process	B cell receptor signaling pathway	ISS
GO:0051049	Process	Regulation of transport	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070528	Process	Protein kinase C signaling	IDA	20228790
GO:0070528	Process	Protein kinase C signaling	IEA
GO:0071322	Process	Cellular response to carbohydrate stimulus	IEA
GO:0099171	Process	Presynaptic modulation of chemical synaptic transmission	IEA
GO:0099523	Component	Presynaptic cytosol	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IEA

MIM	HGNC	e!Ensembl
176970	9395	ENSG00000166501

Protein

UniProt ID

P05771

Protein name

Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)

Protein function

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen

PDB

2I0E , 8SG2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00130	C1_1	37 → 89	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00130	C1_1	102 → 154	Phorbol esters/diacylglycerol binding domain (C1 domain)	Domain
PF00168	C2	171 → 277	C2 domain	Domain
PF00069	Pkinase	342 → 600	Protein kinase domain	Domain
PF00433	Pkinase_C	622 → 662	Protein kinase C terminal domain	Family

Sequence

MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV

Sequence length

671

Interactions

View interactions

	KEGG		Reactome
	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Wnt signaling pathway VEGF signaling pathway Focal adhesion Gap junction Neutrophil extracellular trap formation Natural killer cell mediated cytotoxicity B cell receptor signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Circadian entrainment Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Melanogenesis Thyroid hormone synthesis Thyroid hormone signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion Parathyroid hormone synthesis, secretion and action GnRH secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Amphetamine addiction Morphine addiction Leishmaniasis African trypanosomiasis Amoebiasis Hepatitis B Human cytomegalovirus infection Influenza A Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Glioma Non-small cell lung cancer Hepatocellular carcinoma Choline metabolism in cancer Diabetic cardiomyopathy		Disinhibition of SNARE formation Activation of NF-kappaB in B cells Trafficking of GluR2-containing AMPA receptors Depolymerisation of the Nuclear Lamina WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

Show/Hide Unknown Diseases (7)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Biliary Cholangitis	Primary biliary cholangitis	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (79)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Acquired Immunodeficiency Syndrome	Associate	21997316
Adenocarcinoma of Lung	Associate	24369052, 30587197, 35567329
Alzheimer Disease	Associate	22982105, 26510741
Alzheimer Disease	Stimulate	24334724
Alzheimer Disease	Inhibit	33186918
Arthritis Psoriatic	Inhibit	7547380
Attention Deficit Disorder with Hyperactivity	Associate	30153408
Autism Spectrum Disorder	Associate	34562210
Autistic Disorder	Associate	30153408, 34562210
Bipolar Disorder	Associate	30153408
Breast Neoplasms	Associate	19324060, 32005108, 33760219, 36499753
Calcinosis Cutis	Associate	26121314
Carcinogenesis	Associate	12480928
Carcinoma Hepatocellular	Associate	18167130
Carcinoma Hepatocellular	Inhibit	19949911
Carcinoma Non Small Cell Lung	Associate	28422739, 37505453
Carcinoma Pancreatic Ductal	Associate	33593879
Cerebral Infarction	Associate	23963366
Choriocarcinoma	Associate	30140083
Chromosomal Instability	Associate	25486357
Colitis Ulcerative	Associate	35484353
Colorectal Neoplasms	Associate	24504536, 25486357
Colorectal Neoplasms	Inhibit	26989024
COVID 19	Associate	32805728, 35464051, 36736734
Crohn Disease	Associate	17522815
Diabetes Mellitus	Associate	19279131, 22965996, 29754148, 35592524, 36736734, 37460827
Diabetes Mellitus	Stimulate	22828147
Diabetes Mellitus Type 2	Associate	24455749, 25502755, 36736734
Diabetic Retinopathy	Associate	27509144
Drug Related Side Effects and Adverse Reactions	Associate	28246354, 31941829
Epilepsy Temporal Lobe	Associate	34722763
Glioblastoma	Associate	21649900, 29393370
Glioma	Associate	15842253, 30816530
Glut1 Deficiency Syndrome	Associate	23963366
Histiocytoma Benign Fibrous	Associate	26121314
Hyperglycemia	Stimulate	23963366
Hyperglycemic Hyperosmolar Nonketotic Coma	Associate	23963366
Ichthyosis X Linked	Associate	30816547
Immune System Diseases	Associate	18758661
Inflammation	Associate	36267464
Leukemia Lymphocytic Chronic B Cell	Associate	17003377, 20164467, 25001469
Leukemia Lymphoma Adult T Cell	Associate	29084771, 33426772
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	22141136
Leukemia Myeloid	Associate	9858570
Leukemia Myeloid Acute	Associate	19887445
Leukemia Prolymphocytic T Cell	Associate	28233872
Lung Diseases	Associate	29849902
Lupus Erythematosus Systemic	Inhibit	15379867
Lymphoma Follicular	Associate	17255358
Lymphoma Large B Cell Diffuse	Associate	15920548, 17255358, 20190733, 27835906
Lymphoma Non Hodgkin	Associate	21997316
Lymphoma T Cell Cutaneous	Associate	21471986, 28694326
Lymphoma T Cell Cutaneous	Inhibit	7547380
Melanoma	Associate	7678596
Mesothelioma Malignant	Associate	18765998
Mitochondrial Diseases	Associate	29849902
Muscle Hypotonia	Associate	34562210
Neoplasms	Associate	15920548, 17207890, 17255358, 21997316, 25802333, 26121314, 26510741, 28246354, 28422739, 29754148, 30904392, 35567329, 37474004, 37505453, 37551632, 8434650 View all (1 more)
Neoplasms	Stimulate	16508638
Neoplasms	Inhibit	26989024, 9916928
Neurodegenerative Diseases	Associate	37551632
Non alcoholic Fatty Liver Disease	Associate	37861538
Obesity	Associate	24455749
Osteoporosis	Associate	35990678
Ovarian Neoplasms	Associate	35464051
Pancreatic Neoplasms	Associate	32367578
Peri Implantitis	Associate	36267464
Periodontitis	Associate	35990678
Pre Eclampsia	Associate	30140083, 31138298
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	32394529
Prostatic Neoplasms	Associate	34198725, 35087237, 9916928
Prostatitis	Associate	22644296
Psoriasis	Inhibit	7547380
Pulmonary Disease Chronic Obstructive	Associate	29849902
Severe Acute Respiratory Syndrome	Associate	36466920
Spinocerebellar Ataxias	Associate	37551632
Urinary Bladder Neoplasms	Associate	28629334
Uterine Cervical Neoplasms	Associate	28246354
Uveal melanoma	Associate	22653968

PRKCB (protein kinase C beta)