DEPDC1B (DEP domain containing 1B)

Gene

• Entrez ID: 55789
• Gene name: DEP domain containing 1B
• Gene symbol: DEPDC1B
• Synonyms (NCBI Gene): BRCC3, XTP1
• Chromosome: 5
• Chromosome location: 5q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020076	hsa-miR-361-5p	Sequencing	20371350
MIRT564279	hsa-miR-548ac	PAR-CLIP	20371350
MIRT564278	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT564277	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT564276	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT564275	hsa-miR-548z	PAR-CLIP	20371350
MIRT564274	hsa-miR-548ae-3p	PAR-CLIP	20371350
MIRT564273	hsa-miR-548ah-3p	PAR-CLIP	20371350
MIRT564272	hsa-miR-548aj-3p	PAR-CLIP	20371350
MIRT564271	hsa-miR-548am-3p	PAR-CLIP	20371350
MIRT564270	hsa-miR-548aq-3p	PAR-CLIP	20371350
MIRT564269	hsa-miR-548j-3p	PAR-CLIP	20371350
MIRT564268	hsa-miR-548x-3p	PAR-CLIP	20371350
MIRT564267	hsa-miR-548a-3p	PAR-CLIP	20371350
MIRT564266	hsa-miR-548ar-3p	PAR-CLIP	20371350
MIRT564265	hsa-miR-548az-3p	PAR-CLIP	20371350
MIRT564264	hsa-miR-548e-3p	PAR-CLIP	20371350
MIRT564263	hsa-miR-548f-3p	PAR-CLIP	20371350
MIRT313866	hsa-miR-4282	PAR-CLIP	20371350
MIRT564262	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT564261	hsa-miR-641	PAR-CLIP	20371350
MIRT564260	hsa-miR-3942-5p	PAR-CLIP	20371350
MIRT564259	hsa-miR-4703-5p	PAR-CLIP	20371350
MIRT564258	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT564257	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT564256	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT564255	hsa-miR-107	PAR-CLIP	20371350
MIRT564254	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT564253	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT564279	hsa-miR-548ac	PAR-CLIP	20371350
MIRT564278	hsa-miR-548bb-3p	PAR-CLIP	20371350
MIRT564277	hsa-miR-548d-3p	PAR-CLIP	20371350
MIRT564276	hsa-miR-548h-3p	PAR-CLIP	20371350
MIRT564275	hsa-miR-548z	PAR-CLIP	20371350
MIRT564274	hsa-miR-548ae-3p	PAR-CLIP	20371350
MIRT564273	hsa-miR-548ah-3p	PAR-CLIP	20371350
MIRT564272	hsa-miR-548aj-3p	PAR-CLIP	20371350
MIRT564271	hsa-miR-548am-3p	PAR-CLIP	20371350
MIRT564270	hsa-miR-548aq-3p	PAR-CLIP	20371350
MIRT564269	hsa-miR-548j-3p	PAR-CLIP	20371350
MIRT564268	hsa-miR-548x-3p	PAR-CLIP	20371350
MIRT564267	hsa-miR-548a-3p	PAR-CLIP	20371350
MIRT564266	hsa-miR-548ar-3p	PAR-CLIP	20371350
MIRT564265	hsa-miR-548az-3p	PAR-CLIP	20371350
MIRT564264	hsa-miR-548e-3p	PAR-CLIP	20371350
MIRT564263	hsa-miR-548f-3p	PAR-CLIP	20371350
MIRT313866	hsa-miR-4282	PAR-CLIP	20371350
MIRT564262	hsa-miR-3617-5p	PAR-CLIP	20371350
MIRT564261	hsa-miR-641	PAR-CLIP	20371350
MIRT564260	hsa-miR-3942-5p	PAR-CLIP	20371350
MIRT564259	hsa-miR-4703-5p	PAR-CLIP	20371350
MIRT564258	hsa-miR-455-5p	PAR-CLIP	20371350
MIRT564257	hsa-miR-95-5p	PAR-CLIP	20371350
MIRT564256	hsa-miR-103a-3p	PAR-CLIP	20371350
MIRT564255	hsa-miR-107	PAR-CLIP	20371350
MIRT564254	hsa-miR-3944-5p	PAR-CLIP	20371350
MIRT564253	hsa-miR-143-5p	PAR-CLIP	20371350
MIRT932937	hsa-miR-101	CLIP-seq
MIRT932938	hsa-miR-128	CLIP-seq
MIRT932939	hsa-miR-132	CLIP-seq
MIRT932940	hsa-miR-1912	CLIP-seq
MIRT932941	hsa-miR-194	CLIP-seq
MIRT932942	hsa-miR-199a-5p	CLIP-seq
MIRT932943	hsa-miR-199b-5p	CLIP-seq
MIRT932944	hsa-miR-212	CLIP-seq
MIRT932945	hsa-miR-224	CLIP-seq
MIRT932946	hsa-miR-27a	CLIP-seq
MIRT932947	hsa-miR-27b	CLIP-seq
MIRT932948	hsa-miR-3130-5p	CLIP-seq
MIRT932949	hsa-miR-4482	CLIP-seq
MIRT932950	hsa-miR-4700-3p	CLIP-seq
MIRT932951	hsa-miR-4711-3p	CLIP-seq
MIRT932952	hsa-miR-4768-3p	CLIP-seq
MIRT932953	hsa-miR-539	CLIP-seq
MIRT932954	hsa-miR-802	CLIP-seq
MIRT932937	hsa-miR-101	CLIP-seq
MIRT932955	hsa-miR-1251	CLIP-seq
MIRT932956	hsa-miR-1273d	CLIP-seq
MIRT932938	hsa-miR-128	CLIP-seq
MIRT932957	hsa-miR-1297	CLIP-seq
MIRT932939	hsa-miR-132	CLIP-seq
MIRT932958	hsa-miR-1323	CLIP-seq
MIRT932959	hsa-miR-145	CLIP-seq
MIRT932960	hsa-miR-186	CLIP-seq
MIRT932940	hsa-miR-1912	CLIP-seq
MIRT932941	hsa-miR-194	CLIP-seq
MIRT932942	hsa-miR-199a-5p	CLIP-seq
MIRT932943	hsa-miR-199b-5p	CLIP-seq
MIRT932944	hsa-miR-212	CLIP-seq
MIRT932945	hsa-miR-224	CLIP-seq
MIRT932961	hsa-miR-26a	CLIP-seq
MIRT932962	hsa-miR-26b	CLIP-seq
MIRT932946	hsa-miR-27a	CLIP-seq
MIRT932947	hsa-miR-27b	CLIP-seq
MIRT932963	hsa-miR-29a	CLIP-seq
MIRT932964	hsa-miR-29b	CLIP-seq
MIRT932965	hsa-miR-29c	CLIP-seq
MIRT932948	hsa-miR-3130-5p	CLIP-seq
MIRT932966	hsa-miR-33a	CLIP-seq
MIRT932967	hsa-miR-33b	CLIP-seq
MIRT932968	hsa-miR-3545-5p	CLIP-seq
MIRT932969	hsa-miR-371b-5p	CLIP-seq
MIRT932970	hsa-miR-4257	CLIP-seq
MIRT932971	hsa-miR-4272	CLIP-seq
MIRT932972	hsa-miR-4465	CLIP-seq
MIRT932949	hsa-miR-4482	CLIP-seq
MIRT932973	hsa-miR-4521	CLIP-seq
MIRT932974	hsa-miR-4709-5p	CLIP-seq
MIRT932951	hsa-miR-4711-3p	CLIP-seq
MIRT932975	hsa-miR-4789-5p	CLIP-seq
MIRT932976	hsa-miR-511	CLIP-seq
MIRT932977	hsa-miR-548o	CLIP-seq
MIRT932978	hsa-miR-660	CLIP-seq
MIRT932954	hsa-miR-802	CLIP-seq
MIRT932979	hsa-miR-888	CLIP-seq
MIRT932975	hsa-miR-4789-5p	CLIP-seq
MIRT932937	hsa-miR-101	CLIP-seq
MIRT2211630	hsa-miR-124	CLIP-seq
MIRT2211631	hsa-miR-1265	CLIP-seq
MIRT932938	hsa-miR-128	CLIP-seq
MIRT932957	hsa-miR-1297	CLIP-seq
MIRT932939	hsa-miR-132	CLIP-seq
MIRT932958	hsa-miR-1323	CLIP-seq
MIRT2211632	hsa-miR-142-5p	CLIP-seq
MIRT932940	hsa-miR-1912	CLIP-seq
MIRT932941	hsa-miR-194	CLIP-seq
MIRT2211633	hsa-miR-199a-3p	CLIP-seq
MIRT932942	hsa-miR-199a-5p	CLIP-seq
MIRT2211634	hsa-miR-199b-3p	CLIP-seq
MIRT932943	hsa-miR-199b-5p	CLIP-seq
MIRT932944	hsa-miR-212	CLIP-seq
MIRT932945	hsa-miR-224	CLIP-seq
MIRT2211635	hsa-miR-2392	CLIP-seq
MIRT932961	hsa-miR-26a	CLIP-seq
MIRT932962	hsa-miR-26b	CLIP-seq
MIRT932946	hsa-miR-27a	CLIP-seq
MIRT932947	hsa-miR-27b	CLIP-seq
MIRT2211636	hsa-miR-3074-3p	CLIP-seq
MIRT2211637	hsa-miR-3129-5p	CLIP-seq
MIRT932948	hsa-miR-3130-5p	CLIP-seq
MIRT2211638	hsa-miR-3171	CLIP-seq
MIRT2211639	hsa-miR-340	CLIP-seq
MIRT2211640	hsa-miR-3714	CLIP-seq
MIRT932969	hsa-miR-371b-5p	CLIP-seq
MIRT2211641	hsa-miR-3910	CLIP-seq
MIRT932971	hsa-miR-4272	CLIP-seq
MIRT932972	hsa-miR-4465	CLIP-seq
MIRT2211642	hsa-miR-4474-5p	CLIP-seq
MIRT932949	hsa-miR-4482	CLIP-seq
MIRT932951	hsa-miR-4711-3p	CLIP-seq
MIRT932975	hsa-miR-4789-5p	CLIP-seq
MIRT2211643	hsa-miR-491-3p	CLIP-seq
MIRT2211644	hsa-miR-506	CLIP-seq
MIRT932976	hsa-miR-511	CLIP-seq
MIRT2211645	hsa-miR-548ae	CLIP-seq
MIRT2211646	hsa-miR-548aj	CLIP-seq
MIRT2211647	hsa-miR-548am	CLIP-seq
MIRT932977	hsa-miR-548o	CLIP-seq
MIRT2211648	hsa-miR-548x	CLIP-seq
MIRT932954	hsa-miR-802	CLIP-seq
MIRT932979	hsa-miR-888	CLIP-seq
MIRT2211649	hsa-miR-936	CLIP-seq
MIRT932958	hsa-miR-1323	CLIP-seq
MIRT932969	hsa-miR-371b-5p	CLIP-seq
MIRT932977	hsa-miR-548o	CLIP-seq
MIRT932979	hsa-miR-888	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0016477	Process	Cell migration	IMP	24971537
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IBA
GO:0030177	Process	Positive regulation of Wnt signaling pathway	IMP	24971537
GO:0035556	Process	Intracellular signal transduction	IEA

Other IDs

• MIM: 616073
• HGNC: 24902
• e!Ensembl: ENSG00000035499

Protein

• UniProt ID: Q8WUY9
• Protein name: DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00610	DEP	27 → 106	Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)	Domain
  PF00620	RhoGAP	266 → 346	RhoGAP domain	Domain

• Sequence:

  MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCS
  QNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYRFPPSSPLKPYPKKPP
  NQKDVIKFPEWNDLPPGTSQENIPVRPVVMNSEMWYKRHSIAIGEVPACRLVHRRQLTEA
  NVEEIWKSMTLSYLQKILGLDSLEEVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELP
  HWVLSAMKCLANWPNCSDLKQPMYLGFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLG
  LLQKEKVAVEAFQICCLLLPPENRRKLQLLMRMMARICLNKEMPPLCDGFGTRTLMVQTF
  SRCILCSKDEVDLDELLAARLVTFLMDNYQEILKVPLALQTSIEERVAHLRRVQIKYPGA
  DMDITLSAPSFCRQISPEEFEYQRSYGSQEPLAALLEEVITDAKLSNKEKKKKLKQFQKS
  YPEVYQERFPTPESAALLFPEKPKPKPQLLMWALKKPFQPFQRTRSFRM

• Sequence length: 529

Pathways

Reactome:

Rho GTPase cycle