Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55781
Gene name Gene Name - the full gene name approved by the HGNC.	RIO kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	RIOK2
Synonyms (NCBI Gene) Gene synonyms aliases	RIO2
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q15

Show/Hide all(135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020827	hsa-miR-155-5p	Proteomics	18668040
MIRT027348	hsa-miR-101-3p	Sequencing	20371350
MIRT032368	hsa-let-7b-5p	Proteomics	18668040
MIRT048452	hsa-miR-100-5p	CLASH	23622248
MIRT047511	hsa-miR-10a-5p	CLASH	23622248
MIRT042078	hsa-miR-484	CLASH	23622248
MIRT1307451	hsa-miR-124	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT1307454	hsa-miR-217	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT1307457	hsa-miR-3149	CLIP-seq
MIRT1307458	hsa-miR-3714	CLIP-seq
MIRT1307459	hsa-miR-3910	CLIP-seq
MIRT1307460	hsa-miR-4328	CLIP-seq
MIRT1307461	hsa-miR-4418	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT1307463	hsa-miR-4477b	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307465	hsa-miR-4772-3p	CLIP-seq
MIRT1307466	hsa-miR-506	CLIP-seq
MIRT1307467	hsa-miR-509-3-5p	CLIP-seq
MIRT1307468	hsa-miR-509-5p	CLIP-seq
MIRT1307469	hsa-miR-9	CLIP-seq
MIRT1307470	hsa-miR-101	CLIP-seq
MIRT1307471	hsa-miR-125a-3p	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307472	hsa-miR-144	CLIP-seq
MIRT1307473	hsa-miR-146a	CLIP-seq
MIRT1307474	hsa-miR-146b-5p	CLIP-seq
MIRT1307475	hsa-miR-2053	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT1307476	hsa-miR-3074-5p	CLIP-seq
MIRT1307477	hsa-miR-3124-3p	CLIP-seq
MIRT1307478	hsa-miR-331-5p	CLIP-seq
MIRT1307479	hsa-miR-3687	CLIP-seq
MIRT1307480	hsa-miR-3924	CLIP-seq
MIRT1307481	hsa-miR-3934	CLIP-seq
MIRT1307482	hsa-miR-4442	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT1307483	hsa-miR-4503	CLIP-seq
MIRT1307484	hsa-miR-4678	CLIP-seq
MIRT1307485	hsa-miR-4709-3p	CLIP-seq
MIRT1307486	hsa-miR-513c	CLIP-seq
MIRT1307487	hsa-miR-514b-5p	CLIP-seq
MIRT1307488	hsa-miR-582-5p	CLIP-seq
MIRT1307489	hsa-miR-587	CLIP-seq
MIRT1307490	hsa-miR-589	CLIP-seq
MIRT1307491	hsa-miR-764	CLIP-seq
MIRT2091117	hsa-miR-1207-5p	CLIP-seq
MIRT2091118	hsa-miR-1271	CLIP-seq
MIRT2091119	hsa-miR-182	CLIP-seq
MIRT2091120	hsa-miR-340	CLIP-seq
MIRT2091121	hsa-miR-371b-5p	CLIP-seq
MIRT1307480	hsa-miR-3924	CLIP-seq
MIRT2091122	hsa-miR-3935	CLIP-seq
MIRT2091123	hsa-miR-411	CLIP-seq
MIRT2091124	hsa-miR-4282	CLIP-seq
MIRT2091125	hsa-miR-4729	CLIP-seq
MIRT2091126	hsa-miR-4736	CLIP-seq
MIRT2091127	hsa-miR-4763-3p	CLIP-seq
MIRT2091128	hsa-miR-579	CLIP-seq
MIRT2091129	hsa-miR-591	CLIP-seq
MIRT2091130	hsa-miR-888	CLIP-seq
MIRT2091131	hsa-miR-944	CLIP-seq
MIRT2091132	hsa-miR-96	CLIP-seq
MIRT2315870	hsa-miR-122	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT1307454	hsa-miR-217	CLIP-seq
MIRT2315871	hsa-miR-3135b	CLIP-seq
MIRT2315872	hsa-miR-3652	CLIP-seq
MIRT1307461	hsa-miR-4418	CLIP-seq
MIRT2315873	hsa-miR-4430	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307465	hsa-miR-4772-3p	CLIP-seq
MIRT1307467	hsa-miR-509-3-5p	CLIP-seq
MIRT1307468	hsa-miR-509-5p	CLIP-seq
MIRT2315870	hsa-miR-122	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307454	hsa-miR-217	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2315871	hsa-miR-3135b	CLIP-seq
MIRT2315872	hsa-miR-3652	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307461	hsa-miR-4418	CLIP-seq
MIRT2315873	hsa-miR-4430	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307465	hsa-miR-4772-3p	CLIP-seq
MIRT1307467	hsa-miR-509-3-5p	CLIP-seq
MIRT1307468	hsa-miR-509-5p	CLIP-seq
MIRT2393773	hsa-miR-622	CLIP-seq
MIRT2439915	hsa-miR-22	CLIP-seq
MIRT2439916	hsa-miR-3607-3p	CLIP-seq
MIRT2439915	hsa-miR-22	CLIP-seq
MIRT2439916	hsa-miR-3607-3p	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT2393773	hsa-miR-622	CLIP-seq
MIRT1307452	hsa-miR-1297	CLIP-seq
MIRT1307453	hsa-miR-1915	CLIP-seq
MIRT2393769	hsa-miR-1976	CLIP-seq
MIRT1307455	hsa-miR-26a	CLIP-seq
MIRT1307456	hsa-miR-26b	CLIP-seq
MIRT2393770	hsa-miR-4264	CLIP-seq
MIRT2393771	hsa-miR-4279	CLIP-seq
MIRT1307462	hsa-miR-4465	CLIP-seq
MIRT2393772	hsa-miR-4722-3p	CLIP-seq
MIRT1307464	hsa-miR-4726-3p	CLIP-seq
MIRT2393773	hsa-miR-622	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	21880710
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IMP	19564402
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0007049	Process	Cell cycle	IEA
GO:0030071	Process	Regulation of mitotic metaphase/anaphase transition	IMP	21880710
GO:0030490	Process	Maturation of SSU-rRNA	IBA	21873635
GO:0030490	Process	Maturation of SSU-rRNA	IMP	19564402
GO:0030688	Component	Preribosome, small subunit precursor	IBA	21873635
GO:0030688	Component	Preribosome, small subunit precursor	IDA	19564402
GO:0042274	Process	Ribosomal small subunit biogenesis	IMP	19564402
GO:0046777	Process	Protein autophosphorylation	IMP	21880710
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:2000208	Process	Positive regulation of ribosomal small subunit export from nucleus	IMP	19564402
GO:2000234	Process	Positive regulation of rRNA processing	IDA	19564402

MIM	HGNC	e!Ensembl
617754	18999	ENSG00000058729

Protein

UniProt ID

Q9BVS4

Protein name

Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)

Protein function

Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required

PDB

5DHF , 6FDM , 6FDN , 6FDO , 6G18 , 6G51 , 6HK6 , 7VBT , 7WU0 , 9F81

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09202	Rio2_N	9 → 91	Rio2, N-terminal	Domain
PF01163	RIO1	108 → 284		Family

Sequence

MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHK
LIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQF
ALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPID
YNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESD
HITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEV
SASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLE
ESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEK
NRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTR
TLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNI
KSSLEAASFWGE

Sequence length

552

Interactions

View interactions

	KEGG		Reactome
	Ribosome biogenesis in eukaryotes		Major pathway of rRNA processing in the nucleolus and cytosol

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Renal carcinoma	Conventional (Clear Cell) Renal Cell Carcinoma	rs121913668, rs121913670, rs121913243, rs786202724

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Amyotrophic lateral sclerosis 1	Inhibit	37838312
Carcinoma Non Small Cell Lung	Associate	27346559
Glioma	Associate	32125767
Lymphatic Metastasis	Associate	27346559
Neoplasm Metastasis	Associate	27346559
Neoplasms	Associate	27346559, 36661680
Squamous Cell Carcinoma of Head and Neck	Associate	36661680

RIOK2 (RIO kinase 2)