Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5578
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase C alpha
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRKCA
Synonyms (NCBI Gene) Gene synonyms aliases
AAG6, PKC-alpha, PKCA, PKCI+/-, PKCalpha, PRKACA
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q24.2
Summary Summary of gene provided in NCBI Entrez Gene.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs16960228 G>A Drug-response Intron variant, genic downstream transcript variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006882 mmu-miR-24-2-5p Luciferase reporter assay, qRT-PCR, Western blot 22911661
MIRT020045 hsa-miR-375 Microarray 20215506
MIRT050756 hsa-miR-17-3p CLASH 23622248
MIRT049636 hsa-miR-92a-3p CLASH 23622248
MIRT041382 hsa-miR-193b-3p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
RARA Activation 11525643
TFAP2A Activation 12269829
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 11909826
GO:0002159 Process Desmosome assembly IMP 18474624
GO:0004672 Function Protein kinase activity IDA 10770950
GO:0004674 Function Protein serine/threonine kinase activity EXP 7520444, 7539802, 12391145, 17392515
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
176960 9393 ENSG00000154229
Protein
UniProt ID P17252
Protein name Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Protein function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, ca
PDB 2ELI , 3IW4 , 4DNL , 4RA4 , 8U37 , 8UAK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00130 C1_1 37 89 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00130 C1_1 102 154 Phorbol esters/diacylglycerol binding domain (C1 domain) Domain
PF00168 C2 171 277 C2 domain Domain
PF00069 Pkinase 339 597 Protein kinase domain Domain
PF00433 Pkinase_C 623 658 Protein kinase C terminal domain Family
Sequence
Sequence length 672
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Axon guidance
VEGF signaling pathway
Focal adhesion
Gap junction
Neutrophil extracellular trap formation
Natural killer cell mediated cytotoxicity
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone synthesis and secretion
Relaxin signaling pathway
Parathyroid hormone synthesis, secretion and action
GnRH secretion
AGE-RAGE signaling pathway in diabetic complications
Growth hormone synthesis, secretion and action
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Human cytomegalovirus infection
Influenza A
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
Glioma
Non-small cell lung cancer
Hepatocellular carcinoma
Choline metabolism in cancer
Diabetic cardiomyopathy
Lipid and atherosclerosis
  Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
WNT5A-dependent internalization of FZD4
VEGFR2 mediated cell proliferation
RHO GTPases Activate NADPH Oxidases
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Adenocarcinoma of large intestine rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Diabetes insipidus Acquired Nephrogenic Diabetes Insipidus rs781942628, rs104894747, rs104894748, rs104894749, rs104894750, rs28935496, rs2147483647, rs104894751, rs104894752, rs104894753, rs104894754, rs104894755, rs1569545523, rs104894756, rs104894757
View all (33 more)
25006961
Glioblastoma Glioblastoma Multiforme rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Nephrogenic diabetes insipidus Nephrogenic Diabetes Insipidus, Congenital Nephrogenic Diabetes Insipidus, Nephrogenic Diabetes Insipidus, Type I, Nephrogenic Diabetes Insipidus, Type II, ADH-Resistant Diabetes Insipidus rs104894749, rs104894756, rs104894760, rs104894328, rs104894329, rs104894334, rs104894341, rs193922494, rs193922495, rs193922496, rs193922112, rs193922113, rs104894761, rs193922114, rs193922115
View all (10 more)
25006961
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma, Occupational 27504716 ClinVar
Neuroticism Neuroticism GWAS
Gout Gout GWAS
Bipolar Disorder Bipolar Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abruptio Placentae Associate 30194050
Acrocephalosyndactylia Associate 11315998
Adenocarcinoma Associate 30170437, 37010714
Adenocarcinoma of Lung Associate 31420605, 36263632, 39630579
Adenoma Associate 8434650
Adrenocortical Carcinoma Associate 37895143
Alzheimer Disease Associate 18336728, 22982105, 37010714
Arthritis Rheumatoid Associate 17530707
Arthropathy progressive pseudorheumatoid of childhood Associate 17200207
Asthma Associate 19576566, 20426528, 27504716