Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5577
Gene name Gene Name - the full gene name approved by the HGNC.	Protein kinase cAMP-dependent type II regulatory subunit beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRKAR2B
Synonyms (NCBI Gene) Gene synonyms aliases	PRKAR2, RII-BETA
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holo

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016228	hsa-miR-590-3p	Sequencing	20371350
MIRT1262833	hsa-miR-1272	CLIP-seq
MIRT1262834	hsa-miR-1305	CLIP-seq
MIRT1262835	hsa-miR-150	CLIP-seq
MIRT1262836	hsa-miR-188-3p	CLIP-seq
MIRT1262837	hsa-miR-2681	CLIP-seq
MIRT1262838	hsa-miR-296-3p	CLIP-seq
MIRT1262839	hsa-miR-2964a-3p	CLIP-seq
MIRT1262840	hsa-miR-297	CLIP-seq
MIRT1262841	hsa-miR-3140-3p	CLIP-seq
MIRT1262842	hsa-miR-3174	CLIP-seq
MIRT1262843	hsa-miR-3609	CLIP-seq
MIRT1262844	hsa-miR-361-5p	CLIP-seq
MIRT1262845	hsa-miR-3924	CLIP-seq
MIRT1262846	hsa-miR-4282	CLIP-seq
MIRT1262847	hsa-miR-431	CLIP-seq
MIRT1262848	hsa-miR-4643	CLIP-seq
MIRT1262849	hsa-miR-4653-3p	CLIP-seq
MIRT1262850	hsa-miR-4704-3p	CLIP-seq
MIRT1262851	hsa-miR-4713-5p	CLIP-seq
MIRT1262852	hsa-miR-4775	CLIP-seq
MIRT1262853	hsa-miR-4781-3p	CLIP-seq
MIRT1262854	hsa-miR-516b	CLIP-seq
MIRT1262855	hsa-miR-518a-5p	CLIP-seq
MIRT1262856	hsa-miR-520d-5p	CLIP-seq
MIRT1262857	hsa-miR-524-5p	CLIP-seq
MIRT1262858	hsa-miR-527	CLIP-seq
MIRT1262859	hsa-miR-532-3p	CLIP-seq
MIRT1262860	hsa-miR-548ah	CLIP-seq
MIRT1262861	hsa-miR-548c-3p	CLIP-seq
MIRT1262862	hsa-miR-552	CLIP-seq
MIRT1262863	hsa-miR-567	CLIP-seq
MIRT1262864	hsa-miR-606	CLIP-seq
MIRT1262865	hsa-miR-944	CLIP-seq
MIRT1262847	hsa-miR-431	CLIP-seq
MIRT2077392	hsa-miR-4318	CLIP-seq
MIRT2077393	hsa-miR-4693-5p	CLIP-seq
MIRT1262852	hsa-miR-4775	CLIP-seq
MIRT1262862	hsa-miR-552	CLIP-seq
MIRT2077394	hsa-miR-668	CLIP-seq
MIRT2077395	hsa-miR-892a	CLIP-seq
MIRT1262844	hsa-miR-361-5p	CLIP-seq
MIRT2303921	hsa-miR-3651	CLIP-seq
MIRT2303922	hsa-miR-3973	CLIP-seq
MIRT2303923	hsa-miR-3974	CLIP-seq
MIRT2303924	hsa-miR-4427	CLIP-seq
MIRT2303925	hsa-miR-4477a	CLIP-seq
MIRT2303926	hsa-miR-4680-3p	CLIP-seq
MIRT2303927	hsa-miR-491-3p	CLIP-seq
MIRT2303928	hsa-miR-520g	CLIP-seq
MIRT2303929	hsa-miR-520h	CLIP-seq
MIRT2303930	hsa-miR-622	CLIP-seq
MIRT2432273	hsa-miR-3065-5p	CLIP-seq
MIRT2432274	hsa-miR-3121-3p	CLIP-seq
MIRT2303927	hsa-miR-491-3p	CLIP-seq
MIRT2432275	hsa-miR-577	CLIP-seq
MIRT2600793	hsa-miR-137	CLIP-seq
MIRT2600794	hsa-miR-217	CLIP-seq
MIRT2600795	hsa-miR-25	CLIP-seq
MIRT2432273	hsa-miR-3065-5p	CLIP-seq
MIRT2600796	hsa-miR-3117-3p	CLIP-seq
MIRT2600797	hsa-miR-3163	CLIP-seq
MIRT2600798	hsa-miR-3169	CLIP-seq
MIRT2600799	hsa-miR-32	CLIP-seq
MIRT2600800	hsa-miR-3618	CLIP-seq
MIRT2600801	hsa-miR-363	CLIP-seq
MIRT2600802	hsa-miR-367	CLIP-seq
MIRT2600803	hsa-miR-376c	CLIP-seq
MIRT2600804	hsa-miR-448	CLIP-seq
MIRT2600805	hsa-miR-4633-5p	CLIP-seq
MIRT2600806	hsa-miR-4698	CLIP-seq
MIRT2600807	hsa-miR-4742-3p	CLIP-seq
MIRT2600808	hsa-miR-4759	CLIP-seq
MIRT1262855	hsa-miR-518a-5p	CLIP-seq
MIRT1262858	hsa-miR-527	CLIP-seq
MIRT2600809	hsa-miR-548a-3p	CLIP-seq
MIRT2600810	hsa-miR-548e	CLIP-seq
MIRT2600811	hsa-miR-548f	CLIP-seq
MIRT2600812	hsa-miR-561	CLIP-seq
MIRT2600813	hsa-miR-92a	CLIP-seq
MIRT2600814	hsa-miR-92b	CLIP-seq
MIRT2600815	hsa-miR-934	CLIP-seq

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	IBA
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	IDA	21812984
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	17148597, 20007971, 23455922, 24605759, 25477193, 25920809, 26496610, 26871637, 27107012, 28514442, 32296183, 32707033, 33058759, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IDA	21423175
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	21399614
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	21423175
GO:0005886	Component	Plasma membrane	IEA
GO:0005952	Component	CAMP-dependent protein kinase complex	IBA
GO:0005952	Component	CAMP-dependent protein kinase complex	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007612	Process	Learning	IEA
GO:0008603	Function	CAMP-dependent protein kinase regulator activity	IDA	21812984
GO:0008603	Function	CAMP-dependent protein kinase regulator activity	IEA
GO:0008603	Function	CAMP-dependent protein kinase regulator activity	TAS	2851102
GO:0016020	Component	Membrane	IEA
GO:0019901	Function	Protein kinase binding	IEA
GO:0019904	Function	Protein domain specific binding	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030552	Function	CAMP binding	IBA
GO:0030552	Function	CAMP binding	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IDA	21423175
GO:0034236	Function	Protein kinase A catalytic subunit binding	IBA
GO:0034236	Function	Protein kinase A catalytic subunit binding	IEA
GO:0034236	Function	Protein kinase A catalytic subunit binding	IPI	21812984
GO:0035556	Process	Intracellular signal transduction	TAS	2851102
GO:0043025	Component	Neuronal cell body	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043197	Component	Dendritic spine	ISS
GO:0043198	Component	Dendritic shaft	IEA
GO:0043198	Component	Dendritic shaft	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0097332	Process	Response to antipsychotic drug	IEA
GO:0097546	Component	Ciliary base	IEA
GO:0097546	Component	Ciliary base	TAS
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IDA	21812984
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IEA

MIM	HGNC	e!Ensembl
176912	9392	ENSG00000005249

Protein

UniProt ID

P31323

Protein name

cAMP-dependent protein kinase type II-beta regulatory subunit

Protein function

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02197	RIIa	7 → 44	Regulatory subunit of type II PKA R-subunit	Domain
PF00027	cNMP_binding	172 → 259	Cyclic nucleotide-binding domain	Domain
PF00027	cNMP_binding	294 → 387	Cyclic nucleotide-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Sequence

MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGD
LGAAAGGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAY
NPDEEEDDAESRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEH
VIDQGDDGDNFYVIDRGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATS
PGALWGLDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDG
EQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKP
RAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYEEQLVALFGTNMDIVEPTA

Sequence length

418

Interactions

View interactions

	KEGG		Reactome
	Insulin signaling pathway		PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes, Triglyceride levels in non-type 2 diabetes	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (18)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adrenocortical Carcinoma	Associate	25268545
Aneuploidy	Associate	18056771
Breast Neoplasms	Associate	26336805
Carcinoma	Stimulate	25393625
Congenital chloride diarrhea	Associate	8963897
Hypertension	Associate	32888289
Hypoxia	Inhibit	32111982
Lupus Erythematosus Systemic	Associate	10946316
Lymphoma	Associate	18544528, 37569769
Neoplasms	Associate	1689049, 2000408, 33960436
Neoplasms	Inhibit	22461635
Obesity	Inhibit	20975297
Osteosarcoma	Associate	22355351
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	18544528
Prostatic Neoplasms	Associate	22355351, 28800317, 31986411
Prostatic Neoplasms Castration Resistant	Associate	31986411
Pulmonary Disease Chronic Obstructive	Associate	30361509
Thyroid Neoplasms	Associate	25393625

PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta)