Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55760
Gene name	DEAH-box helicase 32 (putative)
Gene symbol	DHX32
Synonyms (NCBI Gene)	DDX32DHLP1
Chromosome	10
Chromosome location	10q26.2
Summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and m

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Show/Hide all (114)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018169	hsa-miR-335-5p	Microarray	18185580
MIRT2212244	hsa-miR-1302	CLIP-seq
MIRT2212245	hsa-miR-3122	CLIP-seq
MIRT2212246	hsa-miR-3157-5p	CLIP-seq
MIRT2212247	hsa-miR-338-3p	CLIP-seq
MIRT2212248	hsa-miR-3649	CLIP-seq
MIRT2212249	hsa-miR-370	CLIP-seq
MIRT2212250	hsa-miR-3913-5p	CLIP-seq
MIRT2212251	hsa-miR-4267	CLIP-seq
MIRT2212252	hsa-miR-4298	CLIP-seq
MIRT2212253	hsa-miR-4530	CLIP-seq
MIRT2212254	hsa-miR-4691-3p	CLIP-seq
MIRT2212255	hsa-miR-4725-5p	CLIP-seq
MIRT2212256	hsa-miR-504	CLIP-seq
MIRT2448201	hsa-miR-1273g	CLIP-seq
MIRT2448202	hsa-miR-133a	CLIP-seq
MIRT2448203	hsa-miR-133b	CLIP-seq
MIRT2448204	hsa-miR-140-5p	CLIP-seq
MIRT2448205	hsa-miR-3185	CLIP-seq
MIRT2448206	hsa-miR-3942-3p	CLIP-seq
MIRT2448207	hsa-miR-4282	CLIP-seq
MIRT2448208	hsa-miR-4328	CLIP-seq
MIRT2448209	hsa-miR-4422	CLIP-seq
MIRT2448210	hsa-miR-4481	CLIP-seq
MIRT2448211	hsa-miR-4494	CLIP-seq
MIRT2448212	hsa-miR-4745-5p	CLIP-seq
MIRT2448213	hsa-miR-4758-5p	CLIP-seq
MIRT2448214	hsa-miR-499a-5p	CLIP-seq
MIRT2448215	hsa-miR-520d-5p	CLIP-seq
MIRT2448216	hsa-miR-524-5p	CLIP-seq
MIRT2448217	hsa-miR-548ac	CLIP-seq
MIRT2448218	hsa-miR-548ae	CLIP-seq
MIRT2448219	hsa-miR-548aj	CLIP-seq
MIRT2448220	hsa-miR-548am	CLIP-seq
MIRT2448221	hsa-miR-548d-3p	CLIP-seq
MIRT2448222	hsa-miR-548x	CLIP-seq
MIRT2448223	hsa-miR-548z	CLIP-seq
MIRT2448224	hsa-miR-563	CLIP-seq
MIRT2448225	hsa-miR-642b	CLIP-seq
MIRT2448201	hsa-miR-1273g	CLIP-seq
MIRT2448202	hsa-miR-133a	CLIP-seq
MIRT2448203	hsa-miR-133b	CLIP-seq
MIRT2448204	hsa-miR-140-5p	CLIP-seq
MIRT2448205	hsa-miR-3185	CLIP-seq
MIRT2448207	hsa-miR-4282	CLIP-seq
MIRT2448208	hsa-miR-4328	CLIP-seq
MIRT2448209	hsa-miR-4422	CLIP-seq
MIRT2448210	hsa-miR-4481	CLIP-seq
MIRT2448212	hsa-miR-4745-5p	CLIP-seq
MIRT2448213	hsa-miR-4758-5p	CLIP-seq
MIRT2448215	hsa-miR-520d-5p	CLIP-seq
MIRT2448216	hsa-miR-524-5p	CLIP-seq
MIRT2448217	hsa-miR-548ac	CLIP-seq
MIRT2448218	hsa-miR-548ae	CLIP-seq
MIRT2448219	hsa-miR-548aj	CLIP-seq
MIRT2448220	hsa-miR-548am	CLIP-seq
MIRT2448221	hsa-miR-548d-3p	CLIP-seq
MIRT2448222	hsa-miR-548x	CLIP-seq
MIRT2448223	hsa-miR-548z	CLIP-seq
MIRT2448224	hsa-miR-563	CLIP-seq
MIRT2448225	hsa-miR-642b	CLIP-seq
MIRT2448201	hsa-miR-1273g	CLIP-seq
MIRT2515946	hsa-miR-1283	CLIP-seq
MIRT2448202	hsa-miR-133a	CLIP-seq
MIRT2448203	hsa-miR-133b	CLIP-seq
MIRT2448204	hsa-miR-140-5p	CLIP-seq
MIRT2515947	hsa-miR-186	CLIP-seq
MIRT2515948	hsa-miR-3133	CLIP-seq
MIRT2448205	hsa-miR-3185	CLIP-seq
MIRT2448207	hsa-miR-4282	CLIP-seq
MIRT2515949	hsa-miR-4326	CLIP-seq
MIRT2448208	hsa-miR-4328	CLIP-seq
MIRT2448209	hsa-miR-4422	CLIP-seq
MIRT2448210	hsa-miR-4481	CLIP-seq
MIRT2515950	hsa-miR-4511	CLIP-seq
MIRT2448212	hsa-miR-4745-5p	CLIP-seq
MIRT2448213	hsa-miR-4758-5p	CLIP-seq
MIRT2448215	hsa-miR-520d-5p	CLIP-seq
MIRT2448216	hsa-miR-524-5p	CLIP-seq
MIRT2448217	hsa-miR-548ac	CLIP-seq
MIRT2448218	hsa-miR-548ae	CLIP-seq
MIRT2448219	hsa-miR-548aj	CLIP-seq
MIRT2448220	hsa-miR-548am	CLIP-seq
MIRT2448221	hsa-miR-548d-3p	CLIP-seq
MIRT2515951	hsa-miR-548n	CLIP-seq
MIRT2448222	hsa-miR-548x	CLIP-seq
MIRT2448223	hsa-miR-548z	CLIP-seq
MIRT2448224	hsa-miR-563	CLIP-seq
MIRT2448225	hsa-miR-642b	CLIP-seq
MIRT2448201	hsa-miR-1273g	CLIP-seq
MIRT2515946	hsa-miR-1283	CLIP-seq
MIRT2448202	hsa-miR-133a	CLIP-seq
MIRT2448203	hsa-miR-133b	CLIP-seq
MIRT2448204	hsa-miR-140-5p	CLIP-seq
MIRT2448205	hsa-miR-3185	CLIP-seq
MIRT2448207	hsa-miR-4282	CLIP-seq
MIRT2515949	hsa-miR-4326	CLIP-seq
MIRT2448208	hsa-miR-4328	CLIP-seq
MIRT2448209	hsa-miR-4422	CLIP-seq
MIRT2448210	hsa-miR-4481	CLIP-seq
MIRT2448212	hsa-miR-4745-5p	CLIP-seq
MIRT2448213	hsa-miR-4758-5p	CLIP-seq
MIRT2448215	hsa-miR-520d-5p	CLIP-seq
MIRT2448216	hsa-miR-524-5p	CLIP-seq
MIRT2448217	hsa-miR-548ac	CLIP-seq
MIRT2448218	hsa-miR-548ae	CLIP-seq
MIRT2448219	hsa-miR-548aj	CLIP-seq
MIRT2448220	hsa-miR-548am	CLIP-seq
MIRT2448221	hsa-miR-548d-3p	CLIP-seq
MIRT2515951	hsa-miR-548n	CLIP-seq
MIRT2448222	hsa-miR-548x	CLIP-seq
MIRT2448223	hsa-miR-548z	CLIP-seq
MIRT2448224	hsa-miR-563	CLIP-seq
MIRT2448225	hsa-miR-642b	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003723	Function	RNA binding	IBA
GO:0003724	Function	RNA helicase activity	IEA
GO:0004386	Function	Helicase activity	IBA
GO:0004386	Function	Helicase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 27107012, 31515488, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005681	Component	Spliceosomal complex	IBA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA

MIM	HGNC	e!Ensembl
607960	16717	ENSG00000089876

Q7L7V1

Protein name

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04408	HA2	458 → 547	Helicase associated domain (HA2)	Domain
PF07717	OB_NTP_bind	616 → 696	Oligonucleotide/oligosaccharide-binding (OB)-fold	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes. {ECO:0000269|PubMed:12163057, E

Sequence

MEEEGLECPNSSSEKRYFPESLDSSDGDEEEVLACEDLELNPFDGLPYSSRYYKLLKERE
DLPIWKEKYSFMENLLQNQIVIVSGDAKCGKSAQVPQWCAEYCLSIHYQHGGVICTQVHK
QTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLQREMMSNPFLGSYG
VIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNVPVIEVKNK
HPVEVVYLSEAQKDSFESILRLIFEIHHSGEKGDIVVFLACEQDIEKVCETVYQGSNLNP
DLGELVVVPLYPKEKCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRFVIDVGV
ERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKDMTPLKPAE
MQEANLTSMVLFMKRIDIAGLGHCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGII
MSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEEAALTCWKTFLHP
EGDHFTLISIYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIEL
PYAEPAFGSKENTLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGYSITKK
MPEWVLFHKFSISENNYIRITSEISPELFMQLVPQYYFSNLPPSESKDILQQVVDHLSPV
STMNKEQQMCETCPETEQRCTLQ

Sequence length

743

Interactions

View interactions

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Abnormal circulating immunoglobulin concentration	Uncertain significance	rs2134053537	RCV001849811
Cervical cancer	Benign	rs140070899	RCV005921032
Clear cell carcinoma of kidney	Benign	rs140070899	RCV005921033
Familial cancer of breast	Benign	rs140070899	RCV005921030
Hepatocellular carcinoma	Benign	rs140070899	RCV005921031
Lung cancer	Benign	rs140070899	RCV005921034
Thyroid tumor	Uncertain significance	rs2134053360	RCV001849810
Uterine corpus endometrial carcinoma	Benign	rs140070899	RCV005921035

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arthritis Rheumatoid	Associate	25848939
Carcinoma Hepatocellular	Stimulate	33729094
Colorectal Neoplasms	Associate	19161603
Colorectal Neoplasms	Stimulate	25782664
Leukemia Myeloid Acute	Associate	30760869
Lymphatic Metastasis	Associate	19161603
Neoplasm Metastasis	Associate	25782664
Neoplasms	Associate	19161603
Neoplasms	Stimulate	33729094
Precursor Cell Lymphoblastic Leukemia Lymphoma	Inhibit	16080506

DHX32 (DEAH-box helicase 32 (putative))