Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	55759
Gene name	WD repeat domain 12
Gene symbol	WDR12
Synonyms (NCBI Gene)	YTM1
Chromosome	2
Chromosome location	2q33.2
Summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein com

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Show/Hide all (242)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028635	hsa-miR-30a-5p	Proteomics	18668040
MIRT041501	hsa-miR-193b-3p	CLASH	23622248
MIRT707780	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707781	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707779	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT680445	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680444	hsa-miR-764	HITS-CLIP	23824327
MIRT680443	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT680442	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT680441	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT680440	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT680439	hsa-miR-640	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT664814	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT664813	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664812	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT119354	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT649856	hsa-miR-4279	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT649855	hsa-miR-3122	HITS-CLIP	23824327
MIRT649854	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT621081	hsa-miR-125b-1-3p	HITS-CLIP	23824327
MIRT621080	hsa-miR-3615	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT542396	hsa-miR-4432	PAR-CLIP	21572407
MIRT542395	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT542394	hsa-miR-451b	PAR-CLIP	21572407
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT542392	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542391	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542389	hsa-miR-4696	PAR-CLIP	21572407
MIRT542390	hsa-miR-3135a	PAR-CLIP	21572407
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	21572407
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	27292025
MIRT542390	hsa-miR-3135a	PAR-CLIP	27292025
MIRT542390	hsa-miR-3135a	PAR-CLIP	27292025
MIRT542396	hsa-miR-4432	PAR-CLIP	27292025
MIRT542396	hsa-miR-4432	PAR-CLIP	27292025
MIRT542394	hsa-miR-451b	PAR-CLIP	27292025
MIRT542394	hsa-miR-451b	PAR-CLIP	27292025
MIRT542389	hsa-miR-4696	PAR-CLIP	27292025
MIRT542389	hsa-miR-4696	PAR-CLIP	27292025
MIRT542395	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	27292025
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	27292025
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT542391	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT542391	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT707780	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707781	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707779	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT680445	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT680444	hsa-miR-764	HITS-CLIP	23824327
MIRT680443	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT680442	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT680441	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT680440	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT680439	hsa-miR-640	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT664814	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT664813	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT664812	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT119354	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT649861	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT649860	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT649859	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT649858	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT649857	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT649856	hsa-miR-4279	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT649855	hsa-miR-3122	HITS-CLIP	23824327
MIRT649854	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT621093	hsa-miR-890	HITS-CLIP	23824327
MIRT621092	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT621091	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT621090	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT621089	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT621088	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT621087	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT621086	hsa-miR-1976	HITS-CLIP	23824327
MIRT621085	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT621084	hsa-miR-3649	HITS-CLIP	23824327
MIRT621083	hsa-miR-1302	HITS-CLIP	23824327
MIRT621082	hsa-miR-4298	HITS-CLIP	23824327
MIRT621081	hsa-miR-125b-1-3p	HITS-CLIP	23824327
MIRT621080	hsa-miR-3615	HITS-CLIP	23824327
MIRT621079	hsa-miR-2682-3p	HITS-CLIP	23824327
MIRT621078	hsa-miR-6781-3p	HITS-CLIP	23824327
MIRT621077	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT542396	hsa-miR-4432	PAR-CLIP	21572407
MIRT542395	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT542394	hsa-miR-451b	PAR-CLIP	21572407
MIRT542393	hsa-miR-6501-3p	PAR-CLIP	21572407
MIRT542392	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT542391	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT542389	hsa-miR-4696	PAR-CLIP	21572407
MIRT542390	hsa-miR-3135a	PAR-CLIP	21572407
MIRT542388	hsa-miR-196a-3p	PAR-CLIP	21572407
MIRT542387	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT542386	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT1489724	hsa-miR-1297	CLIP-seq
MIRT1489725	hsa-miR-26a	CLIP-seq
MIRT1489726	hsa-miR-26b	CLIP-seq
MIRT1489727	hsa-miR-3064-3p	CLIP-seq
MIRT1489728	hsa-miR-3123	CLIP-seq
MIRT1489729	hsa-miR-3149	CLIP-seq
MIRT1489730	hsa-miR-340	CLIP-seq
MIRT1489731	hsa-miR-380	CLIP-seq
MIRT1489732	hsa-miR-3925-5p	CLIP-seq
MIRT1489733	hsa-miR-3976	CLIP-seq
MIRT1489734	hsa-miR-4328	CLIP-seq
MIRT1489735	hsa-miR-4465	CLIP-seq
MIRT1489736	hsa-miR-4495	CLIP-seq
MIRT1489737	hsa-miR-4714-3p	CLIP-seq
MIRT1489738	hsa-miR-4775	CLIP-seq
MIRT1489739	hsa-miR-498	CLIP-seq
MIRT1489740	hsa-miR-544	CLIP-seq
MIRT1489741	hsa-miR-568	CLIP-seq
MIRT2147680	hsa-miR-2117	CLIP-seq
MIRT2147681	hsa-miR-4684-5p	CLIP-seq
MIRT1489724	hsa-miR-1297	CLIP-seq
MIRT1489725	hsa-miR-26a	CLIP-seq
MIRT1489726	hsa-miR-26b	CLIP-seq
MIRT1489729	hsa-miR-3149	CLIP-seq
MIRT1489733	hsa-miR-3976	CLIP-seq
MIRT1489734	hsa-miR-4328	CLIP-seq
MIRT1489735	hsa-miR-4465	CLIP-seq
MIRT1489738	hsa-miR-4775	CLIP-seq
MIRT1489739	hsa-miR-498	CLIP-seq
MIRT1489741	hsa-miR-568	CLIP-seq
MIRT2147680	hsa-miR-2117	CLIP-seq
MIRT2661538	hsa-miR-216a	CLIP-seq
MIRT2661539	hsa-miR-216b	CLIP-seq
MIRT2661540	hsa-miR-3160-5p	CLIP-seq
MIRT2661541	hsa-miR-3179	CLIP-seq
MIRT2661542	hsa-miR-3675-3p	CLIP-seq
MIRT1489731	hsa-miR-380	CLIP-seq
MIRT2661543	hsa-miR-410	CLIP-seq
MIRT1489736	hsa-miR-4495	CLIP-seq
MIRT2661544	hsa-miR-4528	CLIP-seq
MIRT2147681	hsa-miR-4684-5p	CLIP-seq
MIRT2661545	hsa-miR-4729	CLIP-seq
MIRT1489740	hsa-miR-544	CLIP-seq
MIRT2661546	hsa-miR-570	CLIP-seq
MIRT2661547	hsa-miR-579	CLIP-seq
MIRT2147680	hsa-miR-2117	CLIP-seq
MIRT2661538	hsa-miR-216a	CLIP-seq
MIRT2661539	hsa-miR-216b	CLIP-seq
MIRT2661540	hsa-miR-3160-5p	CLIP-seq
MIRT2661541	hsa-miR-3179	CLIP-seq
MIRT1489731	hsa-miR-380	CLIP-seq
MIRT2661543	hsa-miR-410	CLIP-seq
MIRT1489736	hsa-miR-4495	CLIP-seq
MIRT2661544	hsa-miR-4528	CLIP-seq
MIRT2147681	hsa-miR-4684-5p	CLIP-seq
MIRT2661545	hsa-miR-4729	CLIP-seq
MIRT1489740	hsa-miR-544	CLIP-seq
MIRT2661546	hsa-miR-570	CLIP-seq
MIRT2661547	hsa-miR-579	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	16043514, 17353269
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	16043514
GO:0005515	Function	Protein binding	IPI	16043514, 16738141, 17353269, 28514442, 30021884, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	16043514
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	16043514
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0007219	Process	Notch signaling pathway	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA
GO:0030687	Component	Preribosome, large subunit precursor	IDA	17353269
GO:0030687	Component	Preribosome, large subunit precursor	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IC	16043514, 17353269
GO:0042273	Process	Ribosomal large subunit biogenesis	IEA
GO:0043021	Function	Ribonucleoprotein complex binding	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	16043514
GO:0070545	Component	PeBoW complex	IBA
GO:0070545	Component	PeBoW complex	IDA	16043514, 16738141, 17353269

MIM	HGNC	e!Ensembl
616620	14098	ENSG00000138442

Q9GZL7

Protein name

Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)

Protein function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

PDB

6N31 , 6P0Q , 8FKY

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08154	NLE	4 → 70	NLE (NUC135) domain	Domain
PF00400	WD40	130 → 171	WD domain, G-beta repeat	Repeat
PF00400	WD40	179 → 217	WD domain, G-beta repeat	Repeat
PF00400	WD40	247 → 284	WD domain, G-beta repeat	Repeat
PF00400	WD40	288 → 325	WD domain, G-beta repeat	Repeat
PF00400	WD40	334 → 371	WD domain, G-beta repeat	Repeat

Sequence

MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQ
FLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYD
KTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVK
ALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKT
EQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVF
NCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLIS
GSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSH
VGA

Sequence length

423

Interactions

View interactions

	Reactome
			Major pathway of rRNA processing in the nucleolus and cytosol

WDR12 (WD repeat domain 12)