Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55757
Gene name Gene Name - the full gene name approved by the HGNC.	UDP-glucose glycoprotein glucosyltransferase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	UGGT2
Synonyms (NCBI Gene) Gene synonyms aliases	HUGT2, UGCGL2, UGT2
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q32.1
Summary Summary of gene provided in NCBI Entrez Gene.	UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 200

Show/Hide all(23)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023666	hsa-miR-1-3p	Proteomics	18668040
MIRT439346	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439346	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1473267	hsa-miR-3074-5p	CLIP-seq
MIRT1473268	hsa-miR-3160-5p	CLIP-seq
MIRT1473269	hsa-miR-4421	CLIP-seq
MIRT1473270	hsa-miR-4736	CLIP-seq
MIRT1473271	hsa-miR-657	CLIP-seq
MIRT2142592	hsa-miR-1909	CLIP-seq
MIRT2142593	hsa-miR-214	CLIP-seq
MIRT2142594	hsa-miR-3619-5p	CLIP-seq
MIRT2142595	hsa-miR-4283	CLIP-seq
MIRT2142596	hsa-miR-499a-5p	CLIP-seq
MIRT2142597	hsa-miR-617	CLIP-seq
MIRT2142598	hsa-miR-761	CLIP-seq
MIRT2142592	hsa-miR-1909	CLIP-seq
MIRT2142593	hsa-miR-214	CLIP-seq
MIRT2142594	hsa-miR-3619-5p	CLIP-seq
MIRT2142595	hsa-miR-4283	CLIP-seq
MIRT2363080	hsa-miR-4291	CLIP-seq
MIRT2142597	hsa-miR-617	CLIP-seq
MIRT2142598	hsa-miR-761	CLIP-seq
MIRT2363081	hsa-miR-922	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003980	Function	UDP-glucose:glycoprotein glucosyltransferase activity	IBA	21873635
GO:0003980	Function	UDP-glucose:glycoprotein glucosyltransferase activity	ISS
GO:0005515	Function	Protein binding	IPI	23349634, 25416956
GO:0005783	Component	Endoplasmic reticulum	IBA	21873635
GO:0005788	Component	Endoplasmic reticulum lumen	ISS
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0018279	Process	Protein N-linked glycosylation via asparagine	IBA	21873635
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0051082	Function	Unfolded protein binding	IBA	21873635
GO:0071712	Process	ER-associated misfolded protein catabolic process	IBA	21873635
GO:0097359	Process	UDP-glucosylation	IEA
GO:1904380	Process	Endoplasmic reticulum mannose trimming	TAS

MIM	HGNC	e!Ensembl
605898	15664	ENSG00000102595

Protein

UniProt ID

Q9NYU1

Protein name

UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1)

Protein function

Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18400	Thioredoxin_12	45 → 226	Thioredoxin-like domain	Domain
PF18401	Thioredoxin_13	296 → 433	Thioredoxin-like domain	Domain
PF18402	Thioredoxin_14	437 → 686	Thioredoxin-like domain	Domain
PF18403	Thioredoxin_15	710 → 933	Thioredoxin-like domain	Domain
PF06427	UDP-g_GGTase	1093 → 1200	UDP-glucose:Glycoprotein Glucosyltransferase	Domain
PF18404	Glyco_transf_24	1231 → 1498	Glucosyltransferase 24	Domain

Tissue specificity

TISSUE SPECIFICITY: Higher levels in kidney, pancreas, heart, and skeletal muscle. {ECO:0000269|PubMed:10694380}.

Sequence

MAPAKATNVVRLLLGSTALWLSQLGSGTVAASKSVTAHLAAKWPETPLLLEASEFMAEES
NEKFWQFLETVQELAIYKQTESDYSYYNLILKKAGQFLDNLHINLLKFAFSIRAYSPAIQ
MFQQIAADEPPPDGCNAFVVIHKKHTCKINEIKKLLKKAASRTRPYLFKGDHKFPTNKEN
LPVVILYAEMGTRTFSAFHKVLSEKAQNEEILYVLRHYIQKPSSRKMYLSGYGVELAIKS
TEYKALDDTQVKTVTNTTVEDETETNEVQGFLFGKLKEIYSDLRDNLTAFQKYLIESNKQ
MMPLKVWELQDLSFQAASQIMSAPVYDSIKLMKDISQNFPIKARSLTRIAVNQHMREEIK
ENQKDLQVRFKIQPGDARLFINGLRVDMDVYDAFSILDMLKLEGKMMNGLRNLGINGEDM
SKFLKLNSHIWEYTYVLDIRHSSIMWINDLENDDLYITWPTSCQKLLKPVFPGSVPSIRR
NFHNLVLFIDPAQEYTLDFIKLADVFYSHEVPLRIGFVFILNTDDEVDGANDAGVALWRA
FNYIAEEFDISEAFISIVHMYQKVKKDQNILTVDNVKSVLQNTFPHANIWDILGIHSKYD
EERKAGASFYKMTGLGPLPQALYNGEPFKHEEMNIKELKMAVLQRMMDASVYLQREVFLG
TLNDRTNAIDFLMDRNNVVPRINTLILRTNQQYLNLISTSVTADVEDFSTFFFLDSQDKS
AVIAKNMYYLTQDDESIISAVTLWIIADFDKPSGRKLLFNALKHMKTSVHSRLGIIYNPT
SKINEENTAISRGILAAFLTQKNMFLRSFLGQLAKEEIATAIYSGDKIKTFLIEGMDKNA
FEKKYNTVGVNIFRTHQLFCQDVLKLRPGEMGIVSNGRFLGPLDEDFYAEDFYLLEKITF
SNLGEKIKGIVENMGINANNMSDFIMKVDALMSSVPKRASRYDVTFLRENHSVIKTNPQE
NDMFFNVIAIVDPLTREAQKMAQLLVVLGKIINMKIKLFMNCRGRLSEAPLESFYRFVLE
PELMSGANDVSSLGPVAKFLDIPESPLLILNMITPEGWLVETVHSNCDLDNIHLKDTEKT
VTAEYELEYLLLEGQCFDKVTEQPPRGLQFTLGTKNKPAVVDTIVMAHHGYFQLKANPGA
WILRLHQGKSEDIYQIVGHEGTDSQADLEDIIVVLNSFKSKILKVKVKKETDKIKEDILT
DEDEKTKGLWDSIKSFTVSLHKENKKEKDVLNIFSVASGHLYERFLRIMMLSVLRNTKTP
VKFWLLKNYLSPTFKEVIPHMAKEYGFRYELVQYRWPRWLRQQTERQRIIWGYKILFLDV
LFPLAVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWAS
HLLRRKYHISALYVVDLKKFRRIGAGDRLRSQYQALSQDPNSLSNLDQDLPNNMIYQVAI
KSLPQDWLWCETWCDDESKQRAKTIDLCNNPKTKESKLKAAARIVPEWVEYDAEIRQLLD
HLENKKQDTILTHDEL

Sequence length

1516

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum		ER Quality Control Compartment (ERQC)

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Myocardial infarction	Myocardial Infarction	21211798	ClinVar
Schizophrenia	Schizophrenia		GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining
Basal Cell Nevus Syndrome	Associate	29081410
Colorectal Neoplasms	Associate	30809968
Essential Hypertension	Associate	25695618

UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2)