Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55752
Gene name Gene Name - the full gene name approved by the HGNC.
Septin 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SEPTIN11
Synonyms (NCBI Gene) Gene synonyms aliases
SEPT11, Septin-11
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001725 Component Stress fiber IDA 15485874
GO:0003924 Function GTPase activity IBA 21873635
GO:0005515 Function Protein binding IPI 15485874, 16767699, 18330356, 18443421, 32296183
GO:0005525 Function GTP binding IEA
GO:0005940 Component Septin ring IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612887 25589 ENSG00000138758
Protein
UniProt ID Q9NVA2
Protein name Septin-11
Protein function Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity).
PDB 6UPQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00735 Septin 38 311 Septin Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, except in leukocytes. {ECO:0000269|PubMed:15196925, ECO:0000269|PubMed:15915442}.
Sequence
Sequence length 429
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Bacterial invasion of epithelial cells
Shigellosis
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
21536977
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 20419844
Insulin Resistance Associate 27866222
Obesity Associate 27866222
Retinitis Associate 17625225
Thyroid Neoplasms Associate 28703219