CCAR1 (cell division cycle and apoptosis regulator 1)

Gene

• Entrez ID: 55749
• Gene name: Cell division cycle and apoptosis regulator 1
• Gene symbol: CCAR1
• Synonyms (NCBI Gene): uc.285+
• Chromosome: 10
• Chromosome location: 10q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030489	hsa-miR-24-3p	Microarray	19748357
MIRT049109	hsa-miR-92a-3p	CLASH	23622248
MIRT045240	hsa-miR-186-5p	CLASH	23622248
MIRT737269	hsa-miR-627-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32945522
MIRT1957361	hsa-miR-323-3p	CLIP-seq
MIRT1957362	hsa-miR-3591-3p	CLIP-seq
MIRT1957363	hsa-miR-656	CLIP-seq
MIRT2497695	hsa-miR-181a	CLIP-seq
MIRT2497696	hsa-miR-181b	CLIP-seq
MIRT2497697	hsa-miR-181c	CLIP-seq
MIRT2497698	hsa-miR-181d	CLIP-seq
MIRT2497699	hsa-miR-23a	CLIP-seq
MIRT2497700	hsa-miR-23b	CLIP-seq
MIRT2497701	hsa-miR-23c	CLIP-seq
MIRT2497702	hsa-miR-2681	CLIP-seq
MIRT2497703	hsa-miR-3074-3p	CLIP-seq
MIRT2497704	hsa-miR-3545-3p	CLIP-seq
MIRT2497705	hsa-miR-4262	CLIP-seq
MIRT2497706	hsa-miR-433	CLIP-seq
MIRT2497707	hsa-miR-4668-3p	CLIP-seq
MIRT2497708	hsa-miR-4711-5p	CLIP-seq
MIRT2497709	hsa-miR-4729	CLIP-seq
MIRT2497710	hsa-miR-4789-5p	CLIP-seq
MIRT2497711	hsa-miR-499-3p	CLIP-seq
MIRT2497712	hsa-miR-499a-3p	CLIP-seq
MIRT2497713	hsa-miR-543	CLIP-seq
MIRT2497714	hsa-miR-548a-3p	CLIP-seq
MIRT2497715	hsa-miR-548e	CLIP-seq
MIRT2497716	hsa-miR-548f	CLIP-seq
MIRT2497717	hsa-miR-579	CLIP-seq
MIRT2497695	hsa-miR-181a	CLIP-seq
MIRT2497696	hsa-miR-181b	CLIP-seq
MIRT2497697	hsa-miR-181c	CLIP-seq
MIRT2497698	hsa-miR-181d	CLIP-seq
MIRT2497699	hsa-miR-23a	CLIP-seq
MIRT2497700	hsa-miR-23b	CLIP-seq
MIRT2497701	hsa-miR-23c	CLIP-seq
MIRT2497704	hsa-miR-3545-3p	CLIP-seq
MIRT2497705	hsa-miR-4262	CLIP-seq
MIRT2497709	hsa-miR-4729	CLIP-seq
MIRT2497710	hsa-miR-4789-5p	CLIP-seq
MIRT2497711	hsa-miR-499-3p	CLIP-seq
MIRT2497712	hsa-miR-499a-3p	CLIP-seq
MIRT2497714	hsa-miR-548a-3p	CLIP-seq
MIRT2497715	hsa-miR-548e	CLIP-seq
MIRT2497716	hsa-miR-548f	CLIP-seq
MIRT2497717	hsa-miR-579	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	24245781
GO:0003713	Function	Transcription coactivator activity	IDA	24245781
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IGI	18722177
GO:0003713	Function	Transcription coactivator activity	IMP	23887938
GO:0003714	Function	Transcription corepressor activity	IMP	23887938
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	18157088, 20594350, 22365833, 23887938, 24245781, 25416956, 32296183, 35271311, 39251607
GO:0005634	Component	Nucleus	IBA
GO:0005641	Component	Nuclear envelope lumen	IDA	12816952
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006915	Process	Apoptotic process	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	23887938
GO:0016567	Process	Protein ubiquitination	IBA
GO:0030335	Process	Positive regulation of cell migration	IMP	23887938
GO:0043065	Process	Positive regulation of apoptotic process	IDA	12816952
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA

Other IDs

• MIM: 612569
• HGNC: 24236
• e!Ensembl: ENSG00000060339

Protein

• UniProt ID: Q8IX12
• Protein name: Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)
• Protein function: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14444	S1-like	147 → 204	S1-like	Domain
  PF14443	DBC1	479 → 604	DBC1	Domain
  PF02037	SAP	636 → 670	SAP domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors. {ECO:0000269|PubMed:12816952}.
• Sequence:

  MAQFGGQKNPPWATQFTATAVSQPAALGVQQPSLLGASPTIYTQQTALAAAGLTTQTPAN
  YQLTQTAALQQQAAAAAAALQQQYSQPQQALYSVQQQLQQPQQTLLTQPAVALPTSLSLS
  TPQPTAQITVSYPTPRSSQQQTQPQKQRVFTGVVTKLHDTFGFVDEDVFFQLSAVKGKTP
  QVGDRVLVEATYNPNMPFKWNAQRIQTLPNQNQSQTQPLLKTPPAVLQPIAPQTTFGVQT
  QPQPQSLLQAQISAASITPLLQTQPQPLLQQPQQKAGLLQPPVRIVSQPQPARRLDPPSR
  FSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQRKRSRERSPRRERERSPRRVRRVVP
  RYTVQFSKFSLDCPSCDMMELRRRYQNLYIPSDFFDAQFTWVDAFPLSRPFQLGNYCNFY
  VMHREVESLEKNMAILDPPDADHLYSAKVMLMASPSMEDLYHKSCALAEDPQELRDGFQH
  PARLVKFLVGMKGKDEAMAIGGHWSPSLDGPDPEKDPSVLIKTAIRCCKALTGIDLSVCT
  QWYRFAEIRYHRPEETHKGRTVPAHVETVVLFFPDVWHCLPTRSEWETLSRGYKQQLVEK
  LQGERKEADGEQDEEEKDDGEAKEISTPTHWSKLDPKTMKVNDLRKELESRALSSKGLKS
  QLIARLTKQLKVEEQKEEQKELEKSEKEEDEDDDRKSEDDKEEEERKRQEEIERQRRERR
  YILPDEPAIIVHPNWAAKSGKFDCSIMSLSVLLDYRLEDNKEHSFEVSLFAELFNEMLQR
  DFGVRIYKSLLSLPEKEDKKEKDKKSKKDERKDKKEERDDETDEPKPKRRKSGDDKDKKE
  DRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRDDKRDIN
  RYCKERPSKDKEKEKTQMITINRDLLMAFVYFDQSHCGYLLEKDLEEILYTLGLHLSRAQ
  VKKLLNKVVLRESCFYRKLTDTSKDEENHEESESLQEDMLGNRLLLPTPTVKQESKDVEE
  NVGLIVYNGAMVDVGSLLQKLEKSEKVRAEVEQKLQLLEEKTDEDEKTILNLENSNKSLS
  GELREVKKDLSQLQENLKISENMNLQFENQMNKTIRNLSTVMDEIHTVLKKDNVKNEDKD
  QKSKENGASV

• Sequence length: 1150

Pathways

Reactome:

mRNA Splicing - Major Pathway