ARFGAP1 (ARF GTPase activating protein 1)

Gene

• Entrez ID: 55738
• Gene name: ARF GTPase activating protein 1
• Gene symbol: ARFGAP1
• Synonyms (NCBI Gene): ARF1GAP, HRIHFB2281
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required f

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047930	hsa-miR-30c-5p	CLASH	23622248
MIRT042628	hsa-miR-423-3p	CLASH	23622248
MIRT038909	hsa-miR-93-3p	CLASH	23622248
MIRT792746	hsa-miR-1343	CLIP-seq
MIRT792747	hsa-miR-1908	CLIP-seq
MIRT792748	hsa-miR-1909	CLIP-seq
MIRT792749	hsa-miR-3135b	CLIP-seq
MIRT792750	hsa-miR-3189-5p	CLIP-seq
MIRT792751	hsa-miR-3622b-5p	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT792753	hsa-miR-3944-5p	CLIP-seq
MIRT792754	hsa-miR-4283	CLIP-seq
MIRT792755	hsa-miR-4323	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT792757	hsa-miR-4436b-3p	CLIP-seq
MIRT792758	hsa-miR-4489	CLIP-seq
MIRT792759	hsa-miR-4492	CLIP-seq
MIRT792760	hsa-miR-4498	CLIP-seq
MIRT792761	hsa-miR-4633-3p	CLIP-seq
MIRT792762	hsa-miR-4642	CLIP-seq
MIRT792763	hsa-miR-4793-5p	CLIP-seq
MIRT792764	hsa-miR-663	CLIP-seq
MIRT792765	hsa-miR-762	CLIP-seq
MIRT792766	hsa-miR-105	CLIP-seq
MIRT792747	hsa-miR-1908	CLIP-seq
MIRT792748	hsa-miR-1909	CLIP-seq
MIRT792767	hsa-miR-1910	CLIP-seq
MIRT792768	hsa-miR-2114	CLIP-seq
MIRT792769	hsa-miR-214	CLIP-seq
MIRT792770	hsa-miR-296-3p	CLIP-seq
MIRT792771	hsa-miR-3120-3p	CLIP-seq
MIRT792772	hsa-miR-3154	CLIP-seq
MIRT792773	hsa-miR-3158-5p	CLIP-seq
MIRT792774	hsa-miR-3166	CLIP-seq
MIRT792775	hsa-miR-3173-3p	CLIP-seq
MIRT792776	hsa-miR-3179	CLIP-seq
MIRT792750	hsa-miR-3189-5p	CLIP-seq
MIRT792777	hsa-miR-3202	CLIP-seq
MIRT792778	hsa-miR-342-3p	CLIP-seq
MIRT792779	hsa-miR-342-5p	CLIP-seq
MIRT792780	hsa-miR-3619-5p	CLIP-seq
MIRT792751	hsa-miR-3622b-5p	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT792781	hsa-miR-3665	CLIP-seq
MIRT792782	hsa-miR-3689d	CLIP-seq
MIRT792783	hsa-miR-377	CLIP-seq
MIRT792784	hsa-miR-3909	CLIP-seq
MIRT792785	hsa-miR-3922-5p	CLIP-seq
MIRT792786	hsa-miR-3926	CLIP-seq
MIRT792753	hsa-miR-3944-5p	CLIP-seq
MIRT792787	hsa-miR-4256	CLIP-seq
MIRT792788	hsa-miR-4270	CLIP-seq
MIRT792755	hsa-miR-4323	CLIP-seq
MIRT792789	hsa-miR-4418	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT792757	hsa-miR-4436b-3p	CLIP-seq
MIRT792790	hsa-miR-4438	CLIP-seq
MIRT792791	hsa-miR-4441	CLIP-seq
MIRT792792	hsa-miR-4475	CLIP-seq
MIRT792793	hsa-miR-4520a-3p	CLIP-seq
MIRT792794	hsa-miR-4533	CLIP-seq
MIRT792795	hsa-miR-4638-3p	CLIP-seq
MIRT792762	hsa-miR-4642	CLIP-seq
MIRT792796	hsa-miR-4648	CLIP-seq
MIRT792797	hsa-miR-4651	CLIP-seq
MIRT792798	hsa-miR-4656	CLIP-seq
MIRT792799	hsa-miR-4664-5p	CLIP-seq
MIRT792800	hsa-miR-4694-3p	CLIP-seq
MIRT792801	hsa-miR-4710	CLIP-seq
MIRT792802	hsa-miR-4753-5p	CLIP-seq
MIRT792803	hsa-miR-4765	CLIP-seq
MIRT792804	hsa-miR-4771	CLIP-seq
MIRT792805	hsa-miR-4795-5p	CLIP-seq
MIRT792806	hsa-miR-509-3-5p	CLIP-seq
MIRT792807	hsa-miR-509-5p	CLIP-seq
MIRT792808	hsa-miR-542-5p	CLIP-seq
MIRT792809	hsa-miR-548s	CLIP-seq
MIRT792810	hsa-miR-604	CLIP-seq
MIRT792811	hsa-miR-608	CLIP-seq
MIRT792812	hsa-miR-628-5p	CLIP-seq
MIRT792813	hsa-miR-635	CLIP-seq
MIRT792814	hsa-miR-647	CLIP-seq
MIRT792764	hsa-miR-663	CLIP-seq
MIRT792815	hsa-miR-759	CLIP-seq
MIRT792816	hsa-miR-761	CLIP-seq
MIRT792817	hsa-miR-885-3p	CLIP-seq
MIRT1933927	hsa-miR-4455	CLIP-seq
MIRT1933928	hsa-miR-4474-3p	CLIP-seq
MIRT1933929	hsa-miR-644	CLIP-seq
MIRT1933930	hsa-miR-1	CLIP-seq
MIRT1933931	hsa-miR-1321	CLIP-seq
MIRT792767	hsa-miR-1910	CLIP-seq
MIRT1933932	hsa-miR-206	CLIP-seq
MIRT1933933	hsa-miR-296-5p	CLIP-seq
MIRT1933934	hsa-miR-3065-3p	CLIP-seq
MIRT1933935	hsa-miR-323-5p	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT1933936	hsa-miR-3673	CLIP-seq
MIRT1933937	hsa-miR-3925-3p	CLIP-seq
MIRT792786	hsa-miR-3926	CLIP-seq
MIRT792788	hsa-miR-4270	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT792791	hsa-miR-4441	CLIP-seq
MIRT1933938	hsa-miR-4499	CLIP-seq
MIRT1933939	hsa-miR-4505	CLIP-seq
MIRT1933940	hsa-miR-4739	CLIP-seq
MIRT1933941	hsa-miR-4756-5p	CLIP-seq
MIRT1933942	hsa-miR-508-5p	CLIP-seq
MIRT792809	hsa-miR-548s	CLIP-seq
MIRT792810	hsa-miR-604	CLIP-seq
MIRT1933943	hsa-miR-613	CLIP-seq
MIRT1933944	hsa-miR-626	CLIP-seq
MIRT792814	hsa-miR-647	CLIP-seq
MIRT792815	hsa-miR-759	CLIP-seq
MIRT1933945	hsa-miR-765	CLIP-seq
MIRT792817	hsa-miR-885-3p	CLIP-seq
MIRT1933946	hsa-miR-937	CLIP-seq
MIRT2173778	hsa-miR-125a-3p	CLIP-seq
MIRT2173779	hsa-miR-2277-3p	CLIP-seq
MIRT2173780	hsa-miR-3621	CLIP-seq
MIRT792752	hsa-miR-3652	CLIP-seq
MIRT2173781	hsa-miR-3660	CLIP-seq
MIRT792786	hsa-miR-3926	CLIP-seq
MIRT2173782	hsa-miR-3934	CLIP-seq
MIRT792756	hsa-miR-4430	CLIP-seq
MIRT1933939	hsa-miR-4505	CLIP-seq
MIRT2173783	hsa-miR-4526	CLIP-seq
MIRT792809	hsa-miR-548s	CLIP-seq
MIRT2173784	hsa-miR-764	CLIP-seq
MIRT792768	hsa-miR-2114	CLIP-seq
MIRT2477407	hsa-miR-298	CLIP-seq
MIRT1933934	hsa-miR-3065-3p	CLIP-seq
MIRT792771	hsa-miR-3120-3p	CLIP-seq
MIRT2477408	hsa-miR-3153	CLIP-seq
MIRT792772	hsa-miR-3154	CLIP-seq
MIRT792773	hsa-miR-3158-5p	CLIP-seq
MIRT792774	hsa-miR-3166	CLIP-seq
MIRT792776	hsa-miR-3179	CLIP-seq
MIRT792779	hsa-miR-342-5p	CLIP-seq
MIRT792783	hsa-miR-377	CLIP-seq
MIRT792788	hsa-miR-4270	CLIP-seq
MIRT2477409	hsa-miR-4428	CLIP-seq
MIRT2477410	hsa-miR-4433	CLIP-seq
MIRT792791	hsa-miR-4441	CLIP-seq
MIRT792796	hsa-miR-4648	CLIP-seq
MIRT792797	hsa-miR-4651	CLIP-seq
MIRT792798	hsa-miR-4656	CLIP-seq
MIRT792799	hsa-miR-4664-5p	CLIP-seq
MIRT792802	hsa-miR-4753-5p	CLIP-seq
MIRT792804	hsa-miR-4771	CLIP-seq
MIRT792805	hsa-miR-4795-5p	CLIP-seq
MIRT2477411	hsa-miR-512-3p	CLIP-seq
MIRT792811	hsa-miR-608	CLIP-seq
MIRT2477412	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IBA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	22423108
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	22363216, 25416956, 25910212, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0030100	Process	Regulation of endocytosis	IBA
GO:0032012	Process	Regulation of ARF protein signal transduction	IBA
GO:0045202	Component	Synapse	IDA	22423108
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 608377
• HGNC: 15852
• e!Ensembl: ENSG00000101199

Protein

• UniProt ID: Q8N6T3
• Protein name: ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
• Protein function: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golg
• PDB: 3DWD, 3O47
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01412	ArfGap	7 → 120	Putative GTPase activating protein for Arf	Domain

• Sequence:

  MASPRTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVR
  SVTMDKWKDIELEKMKAGGNAKFREFLESQEDYDPCWSLQEKYNSRAAALFRDKVVALAE
  GREWSLESSPAQNWTPPQPRTLPSMVHRVSGQPQSVTASSDKAFEDWLNDDLGSYQGAQG
  NRYVGFGNTPPPQKKEDDFLNNAMSSLYSGWSSFTTGASRFASAAKEGATKFGSQASQKA
  SELGHSLNENVLKPAQEKVKEGKIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEG
  PLDSPSEGHSYQNSGLDHFQNSNIDQSFWETFGSAEPTKTRKSPSSDSWTCADTSTERRS
  SDSWEVWGSASTNRNSNSDGGEGGEGTKKAVPPAVPTDDGWDNQNW

• Sequence length: 406

Pathways

KEGG:

Endocytosis

Reactome:

XBP1(S) activates chaperone genes
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Clathrin-mediated endocytosis