PKIB (cAMP-dependent protein kinase inhibitor beta)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5570
Gene name Gene Name - the full gene name approved by the HGNC.
CAMP-dependent protein kinase inhibitor beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PKIB
Synonyms (NCBI Gene) Gene synonyms aliases
PRKACN2
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q22.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role i
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(27)
miRTarBase ID miRNA Experiments Reference
MIRT1237515 hsa-miR-1324 CLIP-seq
MIRT1237516 hsa-miR-148a CLIP-seq
MIRT1237517 hsa-miR-148b CLIP-seq
MIRT1237518 hsa-miR-152 CLIP-seq
MIRT1237519 hsa-miR-205 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(7)
GO ID Ontology Definition Evidence Reference
GO:0004860 Function Protein kinase inhibitor activity IEA
GO:0004862 Function CAMP-dependent protein kinase inhibitor activity IBA
GO:0004862 Function CAMP-dependent protein kinase inhibitor activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606914 9018 ENSG00000135549
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9C010
Protein name cAMP-dependent protein kinase inhibitor beta (PKI-beta)
Protein function Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02827 PKI 9 → 77 cAMP-dependent protein kinase inhibitor Family
Sequence
Sequence length 78
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
Breast Cancer Breast cancer N/A N/A GWAS
Prostate cancer Prostate cancer, Prostate cancer (late onset) N/A N/A GWAS
Show/Hide Text Mining Associations (8)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 28387904
Carcinogenesis Associate 27325557
Carcinoma Non Small Cell Lung Associate 27325557
Colorectal Neoplasms Associate 35817785
Genomic Instability Associate 35817785
Neoplasm Metastasis Associate 27325557
Neoplasms Associate 27325557, 28387904
Triple Negative Breast Neoplasms Associate 28387904