Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	5569
Gene name	CAMP-dependent protein kinase inhibitor alpha
Gene symbol	PKIA
Synonyms (NCBI Gene)	PRKACN1
Chromosome	8
Chromosome location	8q21.13
Summary	The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spl

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Show/Hide all (259)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006214	hsa-miR-155-5p	ChIP-seqImmunoblotLuciferase reporter assayqRT-PCR	22473996
MIRT006214	hsa-miR-155-5p	ChIP-seqImmunoblotLuciferase reporter assayqRT-PCR	22473996
MIRT006214	hsa-miR-155-5p	ChIP-seqImmunoblotLuciferase reporter assayqRT-PCR	22473996
MIRT030340	hsa-miR-26b-5p	Microarray	19088304
MIRT713148	hsa-miR-548ac	HITS-CLIP	19536157
MIRT713147	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT713146	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT713145	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT713144	hsa-miR-548z	HITS-CLIP	19536157
MIRT713143	hsa-miR-548ae-3p	HITS-CLIP	19536157
MIRT713142	hsa-miR-548ah-3p	HITS-CLIP	19536157
MIRT713141	hsa-miR-548aj-3p	HITS-CLIP	19536157
MIRT713140	hsa-miR-548am-3p	HITS-CLIP	19536157
MIRT713139	hsa-miR-548aq-3p	HITS-CLIP	19536157
MIRT713138	hsa-miR-548j-3p	HITS-CLIP	19536157
MIRT713137	hsa-miR-548x-3p	HITS-CLIP	19536157
MIRT713136	hsa-miR-4524a-3p	HITS-CLIP	19536157
MIRT713135	hsa-miR-6804-5p	HITS-CLIP	19536157
MIRT713134	hsa-miR-139-3p	HITS-CLIP	19536157
MIRT655071	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT655070	hsa-miR-1283	HITS-CLIP	23824327
MIRT655069	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT655068	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT655067	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT655071	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT655070	hsa-miR-1283	HITS-CLIP	23824327
MIRT655069	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT655068	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT655067	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT655066	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT655065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT655064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT655063	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT655062	hsa-miR-5696	HITS-CLIP	23824327
MIRT655061	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT655060	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT655059	hsa-miR-6753-3p	HITS-CLIP	23824327
MIRT569022	hsa-miR-654-3p	PAR-CLIP	20371350
MIRT535214	hsa-miR-4762-5p	PAR-CLIP	20371350
MIRT535213	hsa-miR-200c-5p	PAR-CLIP	20371350
MIRT535212	hsa-miR-550a-3p	PAR-CLIP	20371350
MIRT535211	hsa-miR-6844	PAR-CLIP	20371350
MIRT535210	hsa-miR-147b	PAR-CLIP	20371350
MIRT535209	hsa-miR-210-3p	PAR-CLIP	20371350
MIRT535205	hsa-miR-2113	PAR-CLIP	20371350
MIRT535214	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT535213	hsa-miR-200c-5p	PAR-CLIP	22012620
MIRT535212	hsa-miR-550a-3p	PAR-CLIP	22012620
MIRT393524	hsa-miR-4684-5p	PAR-CLIP	22012620
MIRT535211	hsa-miR-6844	PAR-CLIP	22012620
MIRT535210	hsa-miR-147b	PAR-CLIP	22012620
MIRT535209	hsa-miR-210-3p	PAR-CLIP	22012620
MIRT535208	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT535207	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT535206	hsa-miR-6809-3p	PAR-CLIP	22012620
MIRT535205	hsa-miR-2113	PAR-CLIP	22012620
MIRT713148	hsa-miR-548ac	HITS-CLIP	19536157
MIRT713147	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT713146	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT713145	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT713144	hsa-miR-548z	HITS-CLIP	19536157
MIRT713143	hsa-miR-548ae-3p	HITS-CLIP	19536157
MIRT713142	hsa-miR-548ah-3p	HITS-CLIP	19536157
MIRT713141	hsa-miR-548aj-3p	HITS-CLIP	19536157
MIRT713140	hsa-miR-548am-3p	HITS-CLIP	19536157
MIRT713139	hsa-miR-548aq-3p	HITS-CLIP	19536157
MIRT713138	hsa-miR-548j-3p	HITS-CLIP	19536157
MIRT713137	hsa-miR-548x-3p	HITS-CLIP	19536157
MIRT713136	hsa-miR-4524a-3p	HITS-CLIP	19536157
MIRT713135	hsa-miR-6804-5p	HITS-CLIP	19536157
MIRT713134	hsa-miR-139-3p	HITS-CLIP	19536157
MIRT655071	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT655070	hsa-miR-1283	HITS-CLIP	23824327
MIRT655069	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT655068	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT655067	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT655071	hsa-miR-7849-3p	HITS-CLIP	23824327
MIRT655070	hsa-miR-1283	HITS-CLIP	23824327
MIRT655069	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT655068	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT655067	hsa-miR-4652-3p	HITS-CLIP	23824327
MIRT655066	hsa-miR-6728-3p	HITS-CLIP	23824327
MIRT655065	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT655064	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT655063	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT655062	hsa-miR-5696	HITS-CLIP	23824327
MIRT655061	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT655060	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT655059	hsa-miR-6753-3p	HITS-CLIP	23824327
MIRT569022	hsa-miR-654-3p	PAR-CLIP	20371350
MIRT535214	hsa-miR-4762-5p	PAR-CLIP	20371350
MIRT535213	hsa-miR-200c-5p	PAR-CLIP	20371350
MIRT535212	hsa-miR-550a-3p	PAR-CLIP	20371350
MIRT535211	hsa-miR-6844	PAR-CLIP	20371350
MIRT535210	hsa-miR-147b	PAR-CLIP	20371350
MIRT535209	hsa-miR-210-3p	PAR-CLIP	20371350
MIRT535205	hsa-miR-2113	PAR-CLIP	20371350
MIRT535214	hsa-miR-4762-5p	PAR-CLIP	22012620
MIRT535213	hsa-miR-200c-5p	PAR-CLIP	22012620
MIRT535212	hsa-miR-550a-3p	PAR-CLIP	22012620
MIRT393524	hsa-miR-4684-5p	PAR-CLIP	22012620
MIRT535211	hsa-miR-6844	PAR-CLIP	22012620
MIRT535210	hsa-miR-147b	PAR-CLIP	22012620
MIRT535209	hsa-miR-210-3p	PAR-CLIP	22012620
MIRT535208	hsa-miR-4768-5p	PAR-CLIP	22012620
MIRT535207	hsa-miR-6833-3p	PAR-CLIP	22012620
MIRT535206	hsa-miR-6809-3p	PAR-CLIP	22012620
MIRT535205	hsa-miR-2113	PAR-CLIP	22012620
MIRT1237484	hsa-miR-128	CLIP-seq
MIRT1237485	hsa-miR-1305	CLIP-seq
MIRT1237486	hsa-miR-27a	CLIP-seq
MIRT1237487	hsa-miR-27b	CLIP-seq
MIRT1237488	hsa-miR-3152-3p	CLIP-seq
MIRT1237489	hsa-miR-3153	CLIP-seq
MIRT1237490	hsa-miR-3662	CLIP-seq
MIRT1237491	hsa-miR-377	CLIP-seq
MIRT1237492	hsa-miR-4659a-5p	CLIP-seq
MIRT1237493	hsa-miR-4659b-5p	CLIP-seq
MIRT1237494	hsa-miR-4661-3p	CLIP-seq
MIRT1237495	hsa-miR-4666-3p	CLIP-seq
MIRT1237496	hsa-miR-4698	CLIP-seq
MIRT1237497	hsa-miR-4775	CLIP-seq
MIRT1237498	hsa-miR-488	CLIP-seq
MIRT1237499	hsa-miR-499-3p	CLIP-seq
MIRT1237500	hsa-miR-499a-3p	CLIP-seq
MIRT1237501	hsa-miR-513a-5p	CLIP-seq
MIRT1237502	hsa-miR-548c-3p	CLIP-seq
MIRT1237503	hsa-miR-548p	CLIP-seq
MIRT1237504	hsa-miR-548u	CLIP-seq
MIRT1237505	hsa-miR-556-3p	CLIP-seq
MIRT1237506	hsa-miR-590-3p	CLIP-seq
MIRT1237507	hsa-miR-944	CLIP-seq
MIRT1237508	hsa-miR-144	CLIP-seq
MIRT1237509	hsa-miR-3163	CLIP-seq
MIRT1237510	hsa-miR-3673	CLIP-seq
MIRT1237491	hsa-miR-377	CLIP-seq
MIRT1237511	hsa-miR-4328	CLIP-seq
MIRT1237512	hsa-miR-4668-3p	CLIP-seq
MIRT1237513	hsa-miR-513b	CLIP-seq
MIRT1237514	hsa-miR-580	CLIP-seq
MIRT1237507	hsa-miR-944	CLIP-seq
MIRT1237491	hsa-miR-377	CLIP-seq
MIRT1237507	hsa-miR-944	CLIP-seq
MIRT2069865	hsa-miR-3653	CLIP-seq
MIRT2069866	hsa-miR-369-3p	CLIP-seq
MIRT1237511	hsa-miR-4328	CLIP-seq
MIRT2297170	hsa-miR-1294	CLIP-seq
MIRT1237485	hsa-miR-1305	CLIP-seq
MIRT1237508	hsa-miR-144	CLIP-seq
MIRT2297171	hsa-miR-200b	CLIP-seq
MIRT2297172	hsa-miR-200c	CLIP-seq
MIRT2297173	hsa-miR-203	CLIP-seq
MIRT2297174	hsa-miR-221	CLIP-seq
MIRT2297175	hsa-miR-222	CLIP-seq
MIRT2297176	hsa-miR-3143	CLIP-seq
MIRT2297177	hsa-miR-3154	CLIP-seq
MIRT1237509	hsa-miR-3163	CLIP-seq
MIRT2297178	hsa-miR-3184	CLIP-seq
MIRT1237490	hsa-miR-3662	CLIP-seq
MIRT2297179	hsa-miR-3688-3p	CLIP-seq
MIRT2069866	hsa-miR-369-3p	CLIP-seq
MIRT2297180	hsa-miR-3941	CLIP-seq
MIRT2297181	hsa-miR-423-5p	CLIP-seq
MIRT2297182	hsa-miR-4289	CLIP-seq
MIRT2297183	hsa-miR-429	CLIP-seq
MIRT2297184	hsa-miR-4316	CLIP-seq
MIRT2297185	hsa-miR-4640-5p	CLIP-seq
MIRT2297186	hsa-miR-466	CLIP-seq
MIRT2297187	hsa-miR-4672	CLIP-seq
MIRT2297188	hsa-miR-4700-3p	CLIP-seq
MIRT2297189	hsa-miR-4719	CLIP-seq
MIRT2297190	hsa-miR-4726-5p	CLIP-seq
MIRT2297191	hsa-miR-4731-3p	CLIP-seq
MIRT2297192	hsa-miR-4758-5p	CLIP-seq
MIRT2297193	hsa-miR-4801	CLIP-seq
MIRT2297194	hsa-miR-520f	CLIP-seq
MIRT2297195	hsa-miR-548ae	CLIP-seq
MIRT2297196	hsa-miR-548aj	CLIP-seq
MIRT2297197	hsa-miR-548am	CLIP-seq
MIRT1237502	hsa-miR-548c-3p	CLIP-seq
MIRT2297198	hsa-miR-548n	CLIP-seq
MIRT2297199	hsa-miR-548t	CLIP-seq
MIRT2297200	hsa-miR-548v	CLIP-seq
MIRT2297201	hsa-miR-548x	CLIP-seq
MIRT1237505	hsa-miR-556-3p	CLIP-seq
MIRT2297202	hsa-miR-561	CLIP-seq
MIRT2297203	hsa-miR-586	CLIP-seq
MIRT2297204	hsa-miR-607	CLIP-seq
MIRT1237508	hsa-miR-144	CLIP-seq
MIRT2297176	hsa-miR-3143	CLIP-seq
MIRT1237509	hsa-miR-3163	CLIP-seq
MIRT1237490	hsa-miR-3662	CLIP-seq
MIRT2069866	hsa-miR-369-3p	CLIP-seq
MIRT2297205	hsa-miR-4252	CLIP-seq
MIRT2297186	hsa-miR-466	CLIP-seq
MIRT2297206	hsa-miR-4691-3p	CLIP-seq
MIRT2297195	hsa-miR-548ae	CLIP-seq
MIRT2297196	hsa-miR-548aj	CLIP-seq
MIRT2297197	hsa-miR-548am	CLIP-seq
MIRT1237502	hsa-miR-548c-3p	CLIP-seq
MIRT2297201	hsa-miR-548x	CLIP-seq
MIRT1237505	hsa-miR-556-3p	CLIP-seq
MIRT2297204	hsa-miR-607	CLIP-seq
MIRT2432134	hsa-miR-1265	CLIP-seq
MIRT2432135	hsa-miR-2392	CLIP-seq
MIRT2432136	hsa-miR-4517	CLIP-seq
MIRT2432137	hsa-miR-4642	CLIP-seq
MIRT2432138	hsa-miR-4781-3p	CLIP-seq
MIRT1237490	hsa-miR-3662	CLIP-seq
MIRT1237494	hsa-miR-4661-3p	CLIP-seq
MIRT2594531	hsa-let-7a	CLIP-seq
MIRT2594532	hsa-let-7b	CLIP-seq
MIRT2594533	hsa-let-7c	CLIP-seq
MIRT2594534	hsa-let-7d	CLIP-seq
MIRT2594535	hsa-let-7e	CLIP-seq
MIRT2594536	hsa-let-7f	CLIP-seq
MIRT2594537	hsa-let-7g	CLIP-seq
MIRT2594538	hsa-let-7i	CLIP-seq
MIRT2594539	hsa-miR-1184	CLIP-seq
MIRT2297170	hsa-miR-1294	CLIP-seq
MIRT2594540	hsa-miR-1913	CLIP-seq
MIRT2297171	hsa-miR-200b	CLIP-seq
MIRT2297172	hsa-miR-200c	CLIP-seq
MIRT2297174	hsa-miR-221	CLIP-seq
MIRT2297175	hsa-miR-222	CLIP-seq
MIRT2594541	hsa-miR-3074-5p	CLIP-seq
MIRT2297176	hsa-miR-3143	CLIP-seq
MIRT2297178	hsa-miR-3184	CLIP-seq
MIRT2594542	hsa-miR-324-3p	CLIP-seq
MIRT2594543	hsa-miR-346	CLIP-seq
MIRT2069865	hsa-miR-3653	CLIP-seq
MIRT2069866	hsa-miR-369-3p	CLIP-seq
MIRT2297180	hsa-miR-3941	CLIP-seq
MIRT2297181	hsa-miR-423-5p	CLIP-seq
MIRT2594544	hsa-miR-4257	CLIP-seq
MIRT2297182	hsa-miR-4289	CLIP-seq
MIRT2297183	hsa-miR-429	CLIP-seq
MIRT2594545	hsa-miR-4290	CLIP-seq
MIRT2297184	hsa-miR-4316	CLIP-seq
MIRT2594546	hsa-miR-4458	CLIP-seq
MIRT2594547	hsa-miR-4468	CLIP-seq
MIRT2594548	hsa-miR-4500	CLIP-seq
MIRT2297185	hsa-miR-4640-5p	CLIP-seq
MIRT2297186	hsa-miR-466	CLIP-seq
MIRT2594549	hsa-miR-4668-5p	CLIP-seq
MIRT2297187	hsa-miR-4672	CLIP-seq
MIRT2297206	hsa-miR-4691-3p	CLIP-seq
MIRT2297188	hsa-miR-4700-3p	CLIP-seq
MIRT2297189	hsa-miR-4719	CLIP-seq
MIRT2297190	hsa-miR-4726-5p	CLIP-seq
MIRT2594550	hsa-miR-4763-5p	CLIP-seq
MIRT2297195	hsa-miR-548ae	CLIP-seq
MIRT2297196	hsa-miR-548aj	CLIP-seq
MIRT2297197	hsa-miR-548am	CLIP-seq
MIRT2297200	hsa-miR-548v	CLIP-seq
MIRT2297201	hsa-miR-548x	CLIP-seq
MIRT2594551	hsa-miR-587	CLIP-seq
MIRT2594552	hsa-miR-657	CLIP-seq
MIRT2594553	hsa-miR-98	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0004860	Function	Protein kinase inhibitor activity	IEA
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	IBA
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	IDA	7905001, 21812984
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	IEA
GO:0004862	Function	CAMP-dependent protein kinase inhibitor activity	TAS	1710219
GO:0005515	Function	Protein binding	IPI	20485264, 20972448, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	IEA
GO:0034236	Function	Protein kinase A catalytic subunit binding	IEA
GO:0034236	Function	Protein kinase A catalytic subunit binding	IPI	21812984
GO:0042308	Process	Negative regulation of protein import into nucleus	IEA
GO:0141162	Process	Negative regulation of cAMP/PKA signal transduction	IDA	21812984
GO:2000480	Process	Negative regulation of cAMP-dependent protein kinase activity	IDA	7905001

MIM	HGNC	e!Ensembl
606059	9017	ENSG00000171033

P61925

Protein name

cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform)

Protein function

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

PDB

1CMK , 1JLU , 1Q8T , 1VEB , 1XH4 , 1XH5 , 1XH6 , 1XH7 , 1XH8 , 1XH9 , 1XHA , 1YDR , 2C1A , 2C1B , 2F7E , 2GNI , 2JDS , 2JDT , 2JDV , 2L1L , 2UVX , 2UVY , 2UVZ , 2UW0 , 2UW3 , 2UW4 , 2UW5 , 2UW6 , 2UW7 , 2UW8 , 2VNW , 2VNY , 2VO0 , 2VO3 , 2VO6 , 2VO7 , 3AMA , 3AMB , 3L9L , 3L9M , 3L9N , 3MVJ , 3NX8 , 3OOG , 3OVV , 3OWP , 3OXT , 3P0M , 3POO , 3VQH , 3WYG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02827	PKI	2 → 70	cAMP-dependent protein kinase inhibitor	Family

Sequence

MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAGLDINKTEGEEDAQRSS
TEQSGEAQGEAAKSES

Sequence length

Interactions

View interactions

	KEGG
	Alcoholism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PULMONARY ARTERIAL HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	37644544	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Associate	29203642	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	36204642	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esotropia	Associate	21738391	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Stimulate	33885249	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Stimulate	18586957	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	29203642, 38565949	★★★★★ ★☆☆☆☆ Found in Text Mining only
Strabismus	Associate	21738391	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Associate	32793117	★★★★★ ★☆☆☆☆ Found in Text Mining only

PKIA (cAMP-dependent protein kinase inhibitor alpha)