Gene Gene information from NCBI Gene database.
Entrez ID 55689
Gene name YEATS domain containing 2
Gene symbol YEATS2
Synonyms (NCBI Gene)
FAME4
Chromosome 3
Chromosome location 3q27.1
Summary Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [pr
miRNA miRNA information provided by mirtarbase database.
302
miRTarBase ID miRNA Experiments Reference
MIRT052158 hsa-let-7b-5p CLASH 23622248
MIRT043982 hsa-miR-378a-5p CLASH 23622248
MIRT042732 hsa-miR-345-5p CLASH 23622248
MIRT439274 hsa-miR-155-5p HITS-CLIP 22473208
MIRT439273 hsa-miR-205-5p HITS-CLIP 22473208
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 18838386
GO:0003714 Function Transcription corepressor activity IDA 18838386
GO:0005515 Function Protein binding IPI 18838386
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613373 25489 ENSG00000163872
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9ULM3
Protein name YEATS domain-containing protein 2
Protein function Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed:18838386, PubMed:19103755, PubMed:27103431). YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys
PDB 5IQL , 5XNV , 6LSD , 7EIE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03366 YEATS 231 313 YEATS family Domain
Sequence
MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHE
IEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPS
RSSSPANQRAETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRD
TSRITGSHKTEQRNADLTDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRG
SRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKR
IDIIHNLKLDRTY
TGLQTLGAETVVDVELHRHSLGEDCIYPQSSESDISDAPPSLPLTIP
APVKASSPIKQSHEPVPDTSVEKGFPASTEAERHTPFYALPSSLERTPTKMTTSQKVTFC
SHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPSPLPRTPT
STPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPSTGSPTNKISTASQVSQGTGSPVPK
IHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVIIKQEPGEAPH
VPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPSKVVGVPVGSALP
STVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKA
QVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQG
AILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGP
GGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLK
VISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPA
VALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVP
TPNPISGKATVSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSF
STSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNY
VIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMT
MRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSE
PECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKF
YLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAVGY
QTASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ
Sequence length 1422
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
21
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Breast ductal adenocarcinoma Uncertain significance rs376025260 RCV000207093
Epilepsy, familial adult myoclonic, 4 Benign; Likely benign; Uncertain significance; Conflicting classifications of pathogenicity rs116502703, rs3841649, rs262993, rs3830564, rs146705467, rs263042, rs1716550954, rs2108544825, rs377747123, rs754796241, rs376690006, rs779650841, rs34759333 RCV002245250
RCV002245251
RCV002245252
RCV002245253
RCV002245254
RCV002245255
RCV002275650
RCV002275659
RCV005399172
RCV003448572
RCV005392805
RCV005023549
RCV002503027
YEATS2-related disorder Uncertain significance; Likely benign rs138723729, rs370579078, rs776263149, rs779981836, rs947273346 RCV003963725
RCV003899661
RCV003951399
RCV003934305
RCV003969411
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 36503492
Carcinogenesis Associate 29057918
Carcinoma Hepatocellular Associate 38186679
Carcinoma Non Small Cell Lung Associate 29057918
Carcinoma Non Small Cell Lung Stimulate 34587874
Carcinoma Squamous Cell Associate 37469197
Liposarcoma Associate 29610390
Neoplasm Metastasis Associate 34587874
Neoplasms Associate 29057918
Pancreatic Neoplasms Associate 34587874, 40216980