Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55683
Gene name Gene Name - the full gene name approved by the HGNC.	KAT8 regulatory NSL complex subunit 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	KANSL3
Synonyms (NCBI Gene) Gene synonyms aliases	KIAA1310, NSL3, Rcd1
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q11.2

Show/Hide all(36)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030314	hsa-miR-26b-5p	Microarray	19088304
MIRT051184	hsa-miR-16-5p	CLASH	23622248
MIRT049440	hsa-miR-92a-3p	CLASH	23622248
MIRT041753	hsa-miR-484	CLASH	23622248
MIRT038818	hsa-miR-93-3p	CLASH	23622248
MIRT036963	hsa-miR-877-3p	CLASH	23622248
MIRT712977	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT712976	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712975	hsa-miR-8073	HITS-CLIP	19536157
MIRT712974	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT712973	hsa-miR-3128	HITS-CLIP	19536157
MIRT712972	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT712971	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT643614	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT643612	hsa-miR-4705	HITS-CLIP	23824327
MIRT643613	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT643611	hsa-miR-4301	HITS-CLIP	23824327
MIRT643610	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT643609	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643608	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643607	hsa-miR-3156-3p	HITS-CLIP	23824327
MIRT712977	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT712976	hsa-miR-221-5p	HITS-CLIP	19536157
MIRT712975	hsa-miR-8073	HITS-CLIP	19536157
MIRT712974	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT712973	hsa-miR-3128	HITS-CLIP	19536157
MIRT712972	hsa-miR-7106-3p	HITS-CLIP	19536157
MIRT712971	hsa-miR-196a-3p	HITS-CLIP	19536157
MIRT643614	hsa-miR-141-5p	HITS-CLIP	23824327
MIRT643612	hsa-miR-4705	HITS-CLIP	23824327
MIRT643613	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT643611	hsa-miR-4301	HITS-CLIP	23824327
MIRT643610	hsa-miR-188-3p	HITS-CLIP	23824327
MIRT643609	hsa-miR-1260a	HITS-CLIP	23824327
MIRT643608	hsa-miR-1260b	HITS-CLIP	23824327
MIRT643607	hsa-miR-3156-3p	HITS-CLIP	23824327

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000123	Component	Histone acetyltransferase complex	IDA	20018852
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA	27768893
GO:0005739	Component	Mitochondrion	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0044545	Component	NSL complex	IBA
GO:0044545	Component	NSL complex	IDA	20018852, 27768893
GO:0044545	Component	NSL complex	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	24842875
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:1903108	Process	Regulation of mitochondrial transcription	IDA	27768893

MIM	HGNC	e!Ensembl
617742	25473	ENSG00000114982

Protein

UniProt ID

Q9P2N6

Protein name

KAT8 regulatory NSL complex subunit 3 (NSL complex protein NSL3) (Non-specific lethal 3 homolog) (Serum inhibited-related protein) (Testis development protein PRTD)

Protein function

Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (Pub

Family and domains

Sequence

MAHRGGERDFQTSARRMGTSLLFQLSVHERELDLVFLDHSYAKPWSAHPDASSARPTRML
FVTPRRQHESTIESDVPIDVETVTSTPMPLYDNQKARSVMNECERHVIFARTDADAPPPP
EDWEEHVNRTGWTMAQNKLFNKILKALQSDRLARLANEGACNEPVLRRVAVDKCARRVRQ
ALASVSWDTKLIQWLHTTLVETLSLPMLAAYLDALQTLKGKIPTLIDRMLVSSNTKTGAA
GAEALSLLLKRPWDPAVGVLSHNKPSKLPGSPLILIASSGPSSSVFPTSRRHRFWQSQLS
CLGKVIPVATHLLNNGSGVGVLQCLEHMIGAVRSKVLEIHSHFPHKPIILIGWNTGALVA
CHVSVMEYVTAVVCLGFPLLTVDGPRGDVDDPLLDMKTPVLFVIGQNSLQCHPEAMEDFR
EKIRAENSLVVVGGADDNLRISKAKKKSEGLTQSMVDRCIQDEIVDFLTGVLTRAEGHMG
SEPRDQDAEKKKKPRDVARRDLAFEVPERGSRPASPAAKLPASPSGSEDLSSVSSSPTSS
PKTKVTTVTSAQKSSQIGSSQLLKRHVQRTEAVLTHKQAQAQFAAFLKQNMLVRKALPPG
TSSCLFVPISSEPPEEGEKEDLRVQLKRHHPSSPLPGSKTSKRPKIKVSLISQGDTAGGP
CAPSQGSAPEAAGGKPITMTLGQASAGAKELTGLLTTAKSSSSEGGVSASPVPSVVSSST
APSALHTLQSRLVATSPGSSLPGATSASSLLQGLSFSLQDISSKTSGLPANPSPGPAPQA
TSVKLPTPMQSLGAITTGTSTIVRTIPVATTLSSLGATPGGKPTAIHQLLTNGGLAKLAS
SLPGLAQISNQASGLKVPTTITLTLRGQPSRITTLSPMGSGAAPSEESSSQVLPSSSQRL
PPAP

Sequence length

904

Interactions

View interactions

	Reactome
			HATs acetylate histones

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Hypothyroidism	Hypothyroidism	N/A	N/A	GWAS
Sarcoidosis	Sarcoidosis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Lung Neoplasms	Associate	31881804
Lymphoma Non Hodgkin	Associate	37161535
Triple Negative Breast Neoplasms	Associate	35973998

KANSL3 (KAT8 regulatory NSL complex subunit 3)