Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55677
Gene name	Interacts with SUPT6H, CTD assembly factor 1
Gene symbol	IWS1
Synonyms (NCBI Gene)	-
Chromosome	2
Chromosome location	2q14.3

119

Show/Hide all (119)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031971	hsa-miR-16-5p	Proteomics	18668040
MIRT041528	hsa-miR-193b-3p	CLASH	23622248
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560972	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560972	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT571303	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT571302	hsa-miR-5698	PAR-CLIP	20371350
MIRT571301	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT571300	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560972	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT440416	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440416	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560972	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560972	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT571303	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT571302	hsa-miR-5698	PAR-CLIP	20371350
MIRT571301	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT571300	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT560980	hsa-miR-4428	PAR-CLIP	20371350
MIRT560978	hsa-miR-4476	PAR-CLIP	20371350
MIRT560979	hsa-miR-6876-5p	PAR-CLIP	20371350
MIRT560977	hsa-miR-5584-3p	PAR-CLIP	20371350
MIRT560976	hsa-miR-4533	PAR-CLIP	20371350
MIRT560975	hsa-miR-5192	PAR-CLIP	20371350
MIRT560974	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT560973	hsa-miR-7106-5p	PAR-CLIP	20371350
MIRT560972	hsa-miR-6825-5p	PAR-CLIP	20371350
MIRT560971	hsa-miR-6844	PAR-CLIP	20371350
MIRT560970	hsa-miR-599	PAR-CLIP	20371350
MIRT1075717	hsa-miR-425	CLIP-seq
MIRT1075718	hsa-miR-515-5p	CLIP-seq
MIRT1075719	hsa-miR-539	CLIP-seq
MIRT1075720	hsa-miR-549	CLIP-seq
MIRT1075721	hsa-miR-561	CLIP-seq
MIRT1075722	hsa-miR-590-3p	CLIP-seq
MIRT2250702	hsa-miR-3121-5p	CLIP-seq
MIRT2250703	hsa-miR-3973	CLIP-seq
MIRT2250704	hsa-miR-520d-5p	CLIP-seq
MIRT2250705	hsa-miR-524-5p	CLIP-seq
MIRT2250706	hsa-miR-548k	CLIP-seq
MIRT2554195	hsa-miR-4307	CLIP-seq
MIRT2554196	hsa-miR-4778-3p	CLIP-seq
MIRT1075718	hsa-miR-515-5p	CLIP-seq
MIRT2554197	hsa-miR-548c-3p	CLIP-seq
MIRT2554198	hsa-miR-603	CLIP-seq
MIRT2554195	hsa-miR-4307	CLIP-seq
MIRT2554196	hsa-miR-4778-3p	CLIP-seq
MIRT1075718	hsa-miR-515-5p	CLIP-seq
MIRT2554197	hsa-miR-548c-3p	CLIP-seq
MIRT2554198	hsa-miR-603	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0005515	Function	Protein binding	IPI	17234882, 19141475, 25689719, 26245978, 29997176
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	17234882
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006338	Process	Chromatin remodeling	IMP	19141475
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0010793	Process	Regulation of mRNA export from nucleus	IMP	17234882
GO:0016973	Process	Poly(A)+ mRNA export from nucleus	IBA
GO:0050684	Process	Regulation of mRNA processing	IMP	17234882
GO:0051028	Process	MRNA transport	IEA
GO:0140673	Process	Transcription elongation-coupled chromatin remodeling	IMP	19141475

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q96ST2

Protein name

Protein IWS1 homolog (IWS1-like protein)

Protein function

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to th

PDB

6EMR , 6ZV1 , 6ZV4 , 9EGX , 9EGY , 9EGZ , 9EH0 , 9EH1 , 9EH2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08711	Med26	636 → 689	TFIIS helical bundle-like domain	Domain

Sequence

MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL
PKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDS
ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP
QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE
ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS
DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF
HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS
DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGES
GDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMS
GKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKK
QDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRA
VMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMNS
TGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQAT
SKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL

Sequence length

819

Interactions

View interactions

	Reactome
			Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DISORDER OF DEVELOPMENT OR MORPHOGENESIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Thyroid Cancer Papillary	Associate	30278442	★★★★★ ★☆☆☆☆ Found in Text Mining only

IWS1 (interacts with SUPT6H, CTD assembly factor 1)