Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	55669
Gene name	Mitofusin 1
Gene symbol	MFN1
Synonyms (NCBI Gene)	hfzo1hfzo2
Chromosome	3
Chromosome location	3q26.33
Summary	The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondri

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miRTarBase ID	miRNA	Experiments	Reference
MIRT522523	hsa-miR-520b	PAR-CLIP	23446348
MIRT522522	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT522521	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT522520	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT522519	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT522518	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT522517	hsa-miR-520e	PAR-CLIP	23446348
MIRT522516	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT522515	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT522514	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT522513	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT522512	hsa-miR-302e	PAR-CLIP	23446348
MIRT522511	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT522510	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT522509	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT522508	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT522507	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT522506	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT522505	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT522504	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT522503	hsa-miR-7153-3p	PAR-CLIP	23446348
MIRT522502	hsa-miR-3186-5p	PAR-CLIP	23446348
MIRT522501	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT522500	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT522499	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT522498	hsa-miR-5009-3p	PAR-CLIP	23446348
MIRT522497	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT522496	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT522495	hsa-miR-6791-3p	PAR-CLIP	23446348
MIRT522494	hsa-miR-6829-3p	PAR-CLIP	23446348
MIRT522493	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT522492	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT522491	hsa-miR-7158-3p	PAR-CLIP	23446348
MIRT522490	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT161819	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT161829	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT161818	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT522523	hsa-miR-520b	PAR-CLIP	23446348
MIRT522522	hsa-miR-302c-3p	PAR-CLIP	23446348
MIRT522521	hsa-miR-302b-3p	PAR-CLIP	23446348
MIRT522520	hsa-miR-372-3p	PAR-CLIP	23446348
MIRT522519	hsa-miR-520d-3p	PAR-CLIP	23446348
MIRT522518	hsa-miR-302d-3p	PAR-CLIP	23446348
MIRT522517	hsa-miR-520e	PAR-CLIP	23446348
MIRT522516	hsa-miR-373-3p	PAR-CLIP	23446348
MIRT522515	hsa-miR-520a-3p	PAR-CLIP	23446348
MIRT522514	hsa-miR-520c-3p	PAR-CLIP	23446348
MIRT522513	hsa-miR-302a-3p	PAR-CLIP	23446348
MIRT522512	hsa-miR-302e	PAR-CLIP	23446348
MIRT522511	hsa-miR-20b-5p	PAR-CLIP	23446348
MIRT522510	hsa-miR-519d-3p	PAR-CLIP	23446348
MIRT522509	hsa-miR-106a-5p	PAR-CLIP	23446348
MIRT522508	hsa-miR-106b-5p	PAR-CLIP	23446348
MIRT522507	hsa-miR-17-5p	PAR-CLIP	23446348
MIRT522506	hsa-miR-93-5p	PAR-CLIP	23446348
MIRT522505	hsa-miR-20a-5p	PAR-CLIP	23446348
MIRT522504	hsa-miR-526b-3p	PAR-CLIP	23446348
MIRT522503	hsa-miR-7153-3p	PAR-CLIP	23446348
MIRT522502	hsa-miR-3186-5p	PAR-CLIP	23446348
MIRT522501	hsa-miR-512-3p	PAR-CLIP	23446348
MIRT522500	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT522499	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT522498	hsa-miR-5009-3p	PAR-CLIP	23446348
MIRT522497	hsa-miR-619-5p	PAR-CLIP	23446348
MIRT522496	hsa-miR-6506-5p	PAR-CLIP	23446348
MIRT522495	hsa-miR-6791-3p	PAR-CLIP	23446348
MIRT522494	hsa-miR-6829-3p	PAR-CLIP	23446348
MIRT522493	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT522492	hsa-miR-5589-5p	PAR-CLIP	23446348
MIRT522491	hsa-miR-7158-3p	PAR-CLIP	23446348
MIRT522490	hsa-miR-5089-5p	PAR-CLIP	23446348
MIRT1146219	hsa-miR-10a	CLIP-seq
MIRT1146220	hsa-miR-10b	CLIP-seq
MIRT1146221	hsa-miR-1238	CLIP-seq
MIRT1146222	hsa-miR-125a-5p	CLIP-seq
MIRT1146223	hsa-miR-125b	CLIP-seq
MIRT1146224	hsa-miR-1279	CLIP-seq
MIRT1146225	hsa-miR-216b	CLIP-seq
MIRT1146226	hsa-miR-2681	CLIP-seq
MIRT1146227	hsa-miR-3158-3p	CLIP-seq
MIRT1146228	hsa-miR-3189-3p	CLIP-seq
MIRT1146229	hsa-miR-323-5p	CLIP-seq
MIRT1146230	hsa-miR-330-3p	CLIP-seq
MIRT1146231	hsa-miR-331-5p	CLIP-seq
MIRT1146232	hsa-miR-338-3p	CLIP-seq
MIRT1146233	hsa-miR-3908	CLIP-seq
MIRT1146234	hsa-miR-4319	CLIP-seq
MIRT1146235	hsa-miR-4324	CLIP-seq
MIRT1146236	hsa-miR-4329	CLIP-seq
MIRT1146237	hsa-miR-4530	CLIP-seq
MIRT1146238	hsa-miR-4643	CLIP-seq
MIRT1146239	hsa-miR-466	CLIP-seq
MIRT1146240	hsa-miR-4672	CLIP-seq
MIRT1146241	hsa-miR-4691-5p	CLIP-seq
MIRT1146242	hsa-miR-4699-3p	CLIP-seq
MIRT1146243	hsa-miR-4760-3p	CLIP-seq
MIRT1146244	hsa-miR-4789-3p	CLIP-seq
MIRT1146245	hsa-miR-483-3p	CLIP-seq
MIRT1146246	hsa-miR-582-5p	CLIP-seq
MIRT1146247	hsa-miR-876-3p	CLIP-seq
MIRT2041573	hsa-miR-1236	CLIP-seq
MIRT1146221	hsa-miR-1238	CLIP-seq
MIRT2041574	hsa-miR-128	CLIP-seq
MIRT2041575	hsa-miR-2110	CLIP-seq
MIRT1146226	hsa-miR-2681	CLIP-seq
MIRT2041576	hsa-miR-3692	CLIP-seq
MIRT2041577	hsa-miR-4271	CLIP-seq
MIRT1146241	hsa-miR-4691-5p	CLIP-seq
MIRT2041578	hsa-miR-4725-3p	CLIP-seq
MIRT1146243	hsa-miR-4760-3p	CLIP-seq
MIRT2041579	hsa-miR-491-5p	CLIP-seq
MIRT1146224	hsa-miR-1279	CLIP-seq
MIRT2271180	hsa-miR-134	CLIP-seq
MIRT2271181	hsa-miR-153	CLIP-seq
MIRT2271182	hsa-miR-3118	CLIP-seq
MIRT1146227	hsa-miR-3158-3p	CLIP-seq
MIRT2271183	hsa-miR-3164	CLIP-seq
MIRT1146228	hsa-miR-3189-3p	CLIP-seq
MIRT1146229	hsa-miR-323-5p	CLIP-seq
MIRT1146231	hsa-miR-331-5p	CLIP-seq
MIRT1146232	hsa-miR-338-3p	CLIP-seq
MIRT2041576	hsa-miR-3692	CLIP-seq
MIRT2271184	hsa-miR-369-3p	CLIP-seq
MIRT2271185	hsa-miR-374c	CLIP-seq
MIRT1146233	hsa-miR-3908	CLIP-seq
MIRT2271186	hsa-miR-3938	CLIP-seq
MIRT2271187	hsa-miR-4422	CLIP-seq
MIRT2271188	hsa-miR-448	CLIP-seq
MIRT2271189	hsa-miR-4496	CLIP-seq
MIRT1146237	hsa-miR-4530	CLIP-seq
MIRT1146240	hsa-miR-4672	CLIP-seq
MIRT2271190	hsa-miR-4698	CLIP-seq
MIRT1146243	hsa-miR-4760-3p	CLIP-seq
MIRT1146245	hsa-miR-483-3p	CLIP-seq
MIRT2271191	hsa-miR-499-3p	CLIP-seq
MIRT2271192	hsa-miR-499a-3p	CLIP-seq
MIRT1146246	hsa-miR-582-5p	CLIP-seq
MIRT2271193	hsa-miR-655	CLIP-seq
MIRT1146247	hsa-miR-876-3p	CLIP-seq
MIRT2271194	hsa-miR-9	CLIP-seq
MIRT2271195	hsa-miR-943	CLIP-seq
MIRT2390850	hsa-miR-452	CLIP-seq
MIRT2390851	hsa-miR-4676-3p	CLIP-seq
MIRT2271194	hsa-miR-9	CLIP-seq
MIRT1146224	hsa-miR-1279	CLIP-seq
MIRT1146231	hsa-miR-331-5p	CLIP-seq
MIRT1146243	hsa-miR-4760-3p	CLIP-seq
MIRT2431109	hsa-miR-548a-5p	CLIP-seq
MIRT2431110	hsa-miR-548ab	CLIP-seq
MIRT2431111	hsa-miR-548ak	CLIP-seq
MIRT2431112	hsa-miR-548b-5p	CLIP-seq
MIRT2431113	hsa-miR-548c-5p	CLIP-seq
MIRT2431114	hsa-miR-548d-5p	CLIP-seq
MIRT2431115	hsa-miR-548h	CLIP-seq
MIRT2431116	hsa-miR-548i	CLIP-seq
MIRT2431117	hsa-miR-548j	CLIP-seq
MIRT2431118	hsa-miR-548k	CLIP-seq
MIRT2431119	hsa-miR-548l	CLIP-seq
MIRT2431120	hsa-miR-548w	CLIP-seq
MIRT2431121	hsa-miR-548y	CLIP-seq
MIRT2431122	hsa-miR-559	CLIP-seq
MIRT1146246	hsa-miR-582-5p	CLIP-seq
MIRT2438573	hsa-miR-3591-5p	CLIP-seq
MIRT1146240	hsa-miR-4672	CLIP-seq
MIRT2438574	hsa-miR-4729	CLIP-seq
MIRT2431109	hsa-miR-548a-5p	CLIP-seq
MIRT2431110	hsa-miR-548ab	CLIP-seq
MIRT2438575	hsa-miR-548ac	CLIP-seq
MIRT2438576	hsa-miR-548ae	CLIP-seq
MIRT2438577	hsa-miR-548aj	CLIP-seq
MIRT2431111	hsa-miR-548ak	CLIP-seq
MIRT2438578	hsa-miR-548am	CLIP-seq
MIRT2431112	hsa-miR-548b-5p	CLIP-seq
MIRT2431113	hsa-miR-548c-5p	CLIP-seq
MIRT2438579	hsa-miR-548d-3p	CLIP-seq
MIRT2431114	hsa-miR-548d-5p	CLIP-seq
MIRT2431115	hsa-miR-548h	CLIP-seq
MIRT2431116	hsa-miR-548i	CLIP-seq
MIRT2431117	hsa-miR-548j	CLIP-seq
MIRT2438580	hsa-miR-548n	CLIP-seq
MIRT2431120	hsa-miR-548w	CLIP-seq
MIRT2438581	hsa-miR-548x	CLIP-seq
MIRT2431121	hsa-miR-548y	CLIP-seq
MIRT2438582	hsa-miR-548z	CLIP-seq
MIRT2431122	hsa-miR-559	CLIP-seq
MIRT1146224	hsa-miR-1279	CLIP-seq
MIRT2271180	hsa-miR-134	CLIP-seq
MIRT2271181	hsa-miR-153	CLIP-seq
MIRT2570313	hsa-miR-23a	CLIP-seq
MIRT2570314	hsa-miR-23b	CLIP-seq
MIRT2570315	hsa-miR-23c	CLIP-seq
MIRT2271182	hsa-miR-3118	CLIP-seq
MIRT1146227	hsa-miR-3158-3p	CLIP-seq
MIRT2271183	hsa-miR-3164	CLIP-seq
MIRT1146231	hsa-miR-331-5p	CLIP-seq
MIRT2438573	hsa-miR-3591-5p	CLIP-seq
MIRT2271184	hsa-miR-369-3p	CLIP-seq
MIRT2271185	hsa-miR-374c	CLIP-seq
MIRT2570316	hsa-miR-4255	CLIP-seq
MIRT2570317	hsa-miR-4328	CLIP-seq
MIRT2271188	hsa-miR-448	CLIP-seq
MIRT1146240	hsa-miR-4672	CLIP-seq
MIRT2570318	hsa-miR-4681	CLIP-seq
MIRT2438574	hsa-miR-4729	CLIP-seq
MIRT1146243	hsa-miR-4760-3p	CLIP-seq
MIRT2271191	hsa-miR-499-3p	CLIP-seq
MIRT2271192	hsa-miR-499a-3p	CLIP-seq
MIRT2431109	hsa-miR-548a-5p	CLIP-seq
MIRT2431110	hsa-miR-548ab	CLIP-seq
MIRT2438575	hsa-miR-548ac	CLIP-seq
MIRT2438576	hsa-miR-548ae	CLIP-seq
MIRT2438577	hsa-miR-548aj	CLIP-seq
MIRT2431111	hsa-miR-548ak	CLIP-seq
MIRT2438578	hsa-miR-548am	CLIP-seq
MIRT2431112	hsa-miR-548b-5p	CLIP-seq
MIRT2570319	hsa-miR-548c-3p	CLIP-seq
MIRT2431113	hsa-miR-548c-5p	CLIP-seq
MIRT2438579	hsa-miR-548d-3p	CLIP-seq
MIRT2431114	hsa-miR-548d-5p	CLIP-seq
MIRT2431115	hsa-miR-548h	CLIP-seq
MIRT2431116	hsa-miR-548i	CLIP-seq
MIRT2431117	hsa-miR-548j	CLIP-seq
MIRT2431118	hsa-miR-548k	CLIP-seq
MIRT2431119	hsa-miR-548l	CLIP-seq
MIRT2438580	hsa-miR-548n	CLIP-seq
MIRT2431120	hsa-miR-548w	CLIP-seq
MIRT2438581	hsa-miR-548x	CLIP-seq
MIRT2431121	hsa-miR-548y	CLIP-seq
MIRT2438582	hsa-miR-548z	CLIP-seq
MIRT2431122	hsa-miR-559	CLIP-seq
MIRT1146246	hsa-miR-582-5p	CLIP-seq
MIRT2570320	hsa-miR-600	CLIP-seq
MIRT2271193	hsa-miR-655	CLIP-seq
MIRT1146224	hsa-miR-1279	CLIP-seq
MIRT1146227	hsa-miR-3158-3p	CLIP-seq
MIRT1146231	hsa-miR-331-5p	CLIP-seq
MIRT2570317	hsa-miR-4328	CLIP-seq
MIRT1146240	hsa-miR-4672	CLIP-seq
MIRT2570318	hsa-miR-4681	CLIP-seq
MIRT1146243	hsa-miR-4760-3p	CLIP-seq
MIRT2271191	hsa-miR-499-3p	CLIP-seq
MIRT2271192	hsa-miR-499a-3p	CLIP-seq
MIRT1146246	hsa-miR-582-5p	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	27920125
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	IMP	28114303
GO:0005515	Function	Protein binding	IPI	19052620, 20019757, 25008184, 28514442, 33961781, 35271311
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	20871098, 27920125
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IBA
GO:0005741	Component	Mitochondrial outer membrane	IDA	12759376
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0007005	Process	Mitochondrion organization	IEA
GO:0008053	Process	Mitochondrial fusion	IBA
GO:0008053	Process	Mitochondrial fusion	IDA	20436456
GO:0008053	Process	Mitochondrial fusion	IEA
GO:0008053	Process	Mitochondrial fusion	IEA
GO:0008053	Process	Mitochondrial fusion	IMP	12759376, 23921378, 27920125, 28114303
GO:0010918	Process	Positive regulation of mitochondrial membrane potential	IEA
GO:0016020	Component	Membrane	IDA	27920125
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	29483649
GO:0046039	Process	GTP metabolic process	IDA	27920125
GO:0051646	Process	Mitochondrion localization	IBA
GO:0051646	Process	Mitochondrion localization	IMP	12759376
GO:0098799	Component	Outer mitochondrial membrane protein complex	IDA	12759376

MIM	HGNC	e!Ensembl
608506	18262	ENSG00000171109

Q8IWA4

Protein name

Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)

Protein function

Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major re

PDB

5GNR , 5GNS , 5GNT , 5GNU , 5GO4 , 5GOE , 5GOF , 5GOM , 5YEW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00350	Dynamin_N	78 → 238	Dynamin family	Domain
PF04799	Fzo_mitofusin	575 → 735	fzo-like conserved region	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors,

Sequence

MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGY
KDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDG
DKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSP
GTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD
ASASEPEYMEDVRRQHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMP
ESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNL
AAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRL
SVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENL
KPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRN
AQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLVTGLASVTSRTSMGII
IVGGVIWKTIGWKLLSVSLTMYGALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSS
TSANCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAV
QLENELENFTKQFLPSSNEES

Sequence length

741

Interactions

View interactions

	KEGG		Reactome
	Mitophagy - animal NOD-like receptor signaling pathway Parkinson disease Pathways of neurodegeneration - multiple diseases		Pink/Parkin Mediated Mitophagy Factors involved in megakaryocyte development and platelet production

MFN1 (mitofusin 1)