Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55663
Gene name	Zinc finger protein 446
Gene symbol	ZNF446
Synonyms (NCBI Gene)	ZKSCAN20ZSCAN30ZSCAN52
Chromosome	19
Chromosome location	19q13.43

140

Show/Hide all (140)

miRTarBase ID	miRNA	Experiments	Reference
MIRT694132	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT694131	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT694130	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT694129	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT694128	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT694127	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT694126	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT694125	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT694124	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT694123	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT694122	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT694121	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT694120	hsa-miR-302e	HITS-CLIP	23313552
MIRT694119	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT694118	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT694117	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT694116	hsa-miR-520b	HITS-CLIP	23313552
MIRT694115	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT694114	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT694113	hsa-miR-520e	HITS-CLIP	23313552
MIRT694112	hsa-miR-4700-3p	HITS-CLIP	23313552
MIRT694111	hsa-miR-4433b-3p	HITS-CLIP	23313552
MIRT694110	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT694109	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT694108	hsa-miR-3973	HITS-CLIP	23313552
MIRT694107	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT694106	hsa-miR-520h	HITS-CLIP	23313552
MIRT694105	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT694104	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT694103	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT694102	hsa-miR-6889-3p	HITS-CLIP	23313552
MIRT694101	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT694100	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT694099	hsa-miR-5095	HITS-CLIP	23313552
MIRT694098	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT694097	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT647123	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT647124	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647122	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT647121	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT647120	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT647119	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647118	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647117	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT694108	hsa-miR-3973	HITS-CLIP	27418678
MIRT694107	hsa-miR-520g-3p	HITS-CLIP	27418678
MIRT694106	hsa-miR-520h	HITS-CLIP	27418678
MIRT694132	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT694131	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT694130	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT694129	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT694128	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT694127	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT694126	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT694125	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT694124	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT694123	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT694122	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT694121	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT694120	hsa-miR-302e	HITS-CLIP	23313552
MIRT694119	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT694118	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT694117	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT694116	hsa-miR-520b	HITS-CLIP	23313552
MIRT694115	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT694114	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT694113	hsa-miR-520e	HITS-CLIP	23313552
MIRT694112	hsa-miR-4700-3p	HITS-CLIP	23313552
MIRT694111	hsa-miR-4433b-3p	HITS-CLIP	23313552
MIRT694110	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT694109	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT694108	hsa-miR-3973	HITS-CLIP	23313552
MIRT694107	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT694106	hsa-miR-520h	HITS-CLIP	23313552
MIRT694105	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT694104	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT694103	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT694102	hsa-miR-6889-3p	HITS-CLIP	23313552
MIRT694101	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT694100	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT694099	hsa-miR-5095	HITS-CLIP	23313552
MIRT694098	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT694097	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT647123	hsa-miR-6768-3p	HITS-CLIP	23824327
MIRT647124	hsa-miR-4753-5p	HITS-CLIP	23824327
MIRT647122	hsa-miR-4717-5p	HITS-CLIP	23824327
MIRT647121	hsa-miR-1306-5p	HITS-CLIP	23824327
MIRT647120	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT647119	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT647118	hsa-miR-6780b-3p	HITS-CLIP	23824327
MIRT647117	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT1525373	hsa-miR-1207-5p	CLIP-seq
MIRT1525374	hsa-miR-1827	CLIP-seq
MIRT1525375	hsa-miR-1909	CLIP-seq
MIRT1525376	hsa-miR-31	CLIP-seq
MIRT1525377	hsa-miR-3612	CLIP-seq
MIRT1525378	hsa-miR-4266	CLIP-seq
MIRT1525379	hsa-miR-4688	CLIP-seq
MIRT1525380	hsa-miR-4695-5p	CLIP-seq
MIRT1525381	hsa-miR-4763-3p	CLIP-seq
MIRT1525382	hsa-miR-4779	CLIP-seq
MIRT1525383	hsa-miR-650	CLIP-seq
MIRT1525384	hsa-miR-940	CLIP-seq
MIRT2378191	hsa-miR-4270	CLIP-seq
MIRT2378192	hsa-miR-4441	CLIP-seq
MIRT2378193	hsa-miR-4722-5p	CLIP-seq
MIRT2378194	hsa-miR-4768-3p	CLIP-seq
MIRT2378195	hsa-miR-4786-5p	CLIP-seq
MIRT2670478	hsa-miR-1224-3p	CLIP-seq
MIRT2670479	hsa-miR-124	CLIP-seq
MIRT1525374	hsa-miR-1827	CLIP-seq
MIRT2670480	hsa-miR-1972	CLIP-seq
MIRT2670481	hsa-miR-3130-3p	CLIP-seq
MIRT2670482	hsa-miR-3173-3p	CLIP-seq
MIRT2670483	hsa-miR-3622a-3p	CLIP-seq
MIRT2670484	hsa-miR-3622b-3p	CLIP-seq
MIRT2670485	hsa-miR-4328	CLIP-seq
MIRT2670486	hsa-miR-4481	CLIP-seq
MIRT2670487	hsa-miR-4649-3p	CLIP-seq
MIRT2670488	hsa-miR-4650-5p	CLIP-seq
MIRT2670489	hsa-miR-4745-5p	CLIP-seq
MIRT2670490	hsa-miR-4747-5p	CLIP-seq
MIRT2378195	hsa-miR-4786-5p	CLIP-seq
MIRT2670491	hsa-miR-4793-3p	CLIP-seq
MIRT2670492	hsa-miR-506	CLIP-seq
MIRT2670493	hsa-miR-544b	CLIP-seq
MIRT2670494	hsa-miR-769-5p	CLIP-seq
MIRT2670478	hsa-miR-1224-3p	CLIP-seq
MIRT1525374	hsa-miR-1827	CLIP-seq
MIRT2670480	hsa-miR-1972	CLIP-seq
MIRT2670481	hsa-miR-3130-3p	CLIP-seq
MIRT2670483	hsa-miR-3622a-3p	CLIP-seq
MIRT2670484	hsa-miR-3622b-3p	CLIP-seq
MIRT2670485	hsa-miR-4328	CLIP-seq
MIRT2670487	hsa-miR-4649-3p	CLIP-seq
MIRT2670488	hsa-miR-4650-5p	CLIP-seq
MIRT2378195	hsa-miR-4786-5p	CLIP-seq
MIRT2670491	hsa-miR-4793-3p	CLIP-seq
MIRT2670493	hsa-miR-544b	CLIP-seq
MIRT2670494	hsa-miR-769-5p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 20211142, 25416956, 25910212, 26871637, 28514442, 30886144, 31403225, 31515488, 32296183, 32814053, 33961781
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9NWS9

Protein name

Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20)

Protein function

May be involved in transcriptional regulation.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02023	SCAN	22 → 110	SCAN domain	Domain
PF01352	KRAB	208 → 238	KRAB box	Family
PF00096	zf-C2H2	395 → 417	Zinc finger, C2H2 type	Domain

Sequence

MPSPLGPPCLPVMDPETTLEEPETARLRFRGFCYQEVAGPREALARLRELCCQWLQPEAH
SKEQMLEMLVLEQFLGTLPPEIQAWVRGQRPGSPEEAAALVEGLQHDPGQLLGWITAHVL
KQEVLPAAQKTEEPLGSPHPSGTVESPGEGPQDTRIEGSVQLSCSVKEEPNVDGQEVAPS
SPPLAAQSPEGNHGHQEPASTSFHPPRIQEEWGLLDRSQKELYWDAMLEKYGTVVSLGLP
PHQPEAQAQSELGMLLTGTGVCRSLRSGNESEGPPGCPEAQPPQGPGPAAWEGLSGAATP
APTVRPGTPPVPTQPTPAETRLEPAATPRKPYTCEQCGRGFDWKSVFVIHHRTHTSGPGV
QSPGLATGESTEKPPQGEVAFPHHPRRSLTGPRSYPCEECGCSFSWKSQLVIHRKSHTGQ
RRHFCSDCGRAFDWKSQLVIHRKGHRPEVP

Sequence length

450

Interactions

View interactions

	Reactome
			Generic Transcription Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Short stature	Pathogenic	rs776780438	RCV000736169	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ZNF446 (zinc finger protein 446)