Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55662
Gene name Gene Name - the full gene name approved by the HGNC.
Hypoxia inducible factor 1 subunit alpha inhibitor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HIF1AN
Synonyms (NCBI Gene) Gene synonyms aliases
FIH1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
FIH1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q24.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006468 hsa-miR-31-5p Northern blot, qRT-PCR, Western blot 22532441
MIRT006468 hsa-miR-31-5p Northern blot, qRT-PCR, Western blot 22532441
MIRT006468 hsa-miR-31-5p Northern blot, qRT-PCR, Western blot 22532441
MIRT006468 hsa-miR-31-5p Northern blot, qRT-PCR, Western blot 22532441
MIRT019390 hsa-miR-148b-3p Microarray 17612493
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005112 Function Notch binding IPI 17573339, 18299578
GO:0005515 Function Protein binding IPI 11641274, 12446723, 16189514, 17003112, 17573339, 19060904, 19071119, 19726677, 21251231, 25609649, 26751287, 26752685, 26948053, 26972000, 28514442, 29426014, 31515488, 32296183
GO:0005634 Component Nucleus IDA 18299578
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606615 17113 ENSG00000166135
Protein
UniProt ID Q9NWT6
Protein name Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase)
Protein function Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p
PDB 1H2K , 1H2L , 1H2M , 1H2N , 1IZ3 , 1MZE , 1MZF , 1YCI , 2CGN , 2CGO , 2ILM , 2W0X , 2WA3 , 2WA4 , 2XUM , 2Y0I , 2YC0 , 2YDE , 3D8C , 3KCX , 3KCY , 3OD4 , 3P3N , 3P3P , 4AI8 , 4B7E , 4B7K , 4BIO , 4JAA , 4NR1 , 4Z1V , 4Z2W , 5JWK , 5JWL , 5JWP , 5OP6 , 5OP8 , 5OPC , 6H9J , 6HA6 , 6HC8 , 6HKP , 6HL5 , 6HL6 , 6RUJ , 7A1J , 7A1K , 7A1L , 7A1M , 7A1N , 7A1O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13621 Cupin_8 48 302 Cupin-like domain Domain
Sequence
Sequence length 349
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Cellular response to hypoxia
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Mitochondrial complex deficiency MITOCHONDRIAL COMPLEX I DEFICIENCY, NUCLEAR TYPE 32 rs267606829, rs267606830, rs587776513, rs121918134, rs121918135, rs121918136, rs137853192, rs137853193, rs183973249, rs137853184, rs118203929, rs267606689, rs11544803, rs63751061, rs137852863
View all (210 more)
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Metabolic Syndrome Metabolic Syndrome GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 21751195
Altitude Sickness Associate 25431923
Breast Neoplasms Associate 18096060, 21732131, 25907805
Carcinoma Renal Cell Associate 21386837
Colorectal Neoplasms Associate 26749281
Esophageal Neoplasms Associate 34046994
Esophageal Squamous Cell Carcinoma Associate 34046994
Gastroesophageal Reflux Associate 21751195
Hypoxia Associate 28476026
Hypoxia Brain Associate 18174379