Gene Gene information from NCBI Gene database.
Entrez ID 55662
Gene name Hypoxia inducible factor 1 subunit alpha inhibitor
Gene symbol HIF1AN
Synonyms (NCBI Gene)
FIH1
Chromosome 10
Chromosome location 10q24.31
miRNA miRNA information provided by mirtarbase database.
1802
miRTarBase ID miRNA Experiments Reference
MIRT006468 hsa-miR-31-5p Northern blotqRT-PCRWestern blot 22532441
MIRT006468 hsa-miR-31-5p Northern blotqRT-PCRWestern blot 22532441
MIRT006468 hsa-miR-31-5p Northern blotqRT-PCRWestern blot 22532441
MIRT006468 hsa-miR-31-5p Northern blotqRT-PCRWestern blot 22532441
MIRT019390 hsa-miR-148b-3p Microarray 17612493
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
39
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 19071119
GO:0003714 Function Transcription corepressor activity IDA 11641274, 12080085
GO:0005112 Function Notch binding IPI 17573339, 18299578
GO:0005515 Function Protein binding IPI 11641274, 12446723, 16189514, 17003112, 17573339, 19060904, 19071119, 19726677, 21251231, 25609649, 26751287, 26752685, 26948053, 26972000, 28514442, 29426014, 31515488, 32296183, 32707033, 33961781
GO:0005634 Component Nucleus IDA 18299578
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606615 17113 ENSG00000166135
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NWT6
Protein name Hypoxia-inducible factor 1-alpha inhibitor (EC 1.14.11.30) (EC 1.14.11.n4) (Factor inhibiting HIF-1) (FIH-1) (Hypoxia-inducible factor asparagine hydroxylase)
Protein function Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p
PDB 1H2K , 1H2L , 1H2M , 1H2N , 1IZ3 , 1MZE , 1MZF , 1YCI , 2CGN , 2CGO , 2ILM , 2W0X , 2WA3 , 2WA4 , 2XUM , 2Y0I , 2YC0 , 2YDE , 3D8C , 3KCX , 3KCY , 3OD4 , 3P3N , 3P3P , 4AI8 , 4B7E , 4B7K , 4BIO , 4JAA , 4NR1 , 4Z1V , 4Z2W , 5JWK , 5JWL , 5JWP , 5OP6 , 5OP8 , 5OPC , 6H9J , 6HA6 , 6HC8 , 6HKP , 6HL5 , 6HL6 , 6RUJ , 7A1J , 7A1K , 7A1L , 7A1M , 7A1N , 7A1O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13621 Cupin_8 48 302 Cupin-like domain Domain
Sequence
Sequence length 349
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Cellular response to hypoxia