Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55638
Gene name	Syntabulin
Gene symbol	SYBU
Synonyms (NCBI Gene)	GOLSYNOCSYNSNPHL
Chromosome	8
Chromosome location	8q23.2
Summary	Syntabulin/GOLSYN is part of a kinesin motor-adaptor complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (Cai et al., 2007 [PubMed 1

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Show/Hide all (206)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020241	hsa-miR-130b-3p	Sequencing	20371350
MIRT027999	hsa-miR-93-5p	Sequencing	20371350
MIRT028295	hsa-miR-32-5p	Sequencing	20371350
MIRT031204	hsa-miR-19b-3p	Sequencing	20371350
MIRT1405006	hsa-miR-1200	CLIP-seq
MIRT1405007	hsa-miR-1236	CLIP-seq
MIRT1405008	hsa-miR-1243	CLIP-seq
MIRT1405009	hsa-miR-1271	CLIP-seq
MIRT1405010	hsa-miR-1273g	CLIP-seq
MIRT1405011	hsa-miR-1276	CLIP-seq
MIRT1405012	hsa-miR-1302	CLIP-seq
MIRT1405013	hsa-miR-130a	CLIP-seq
MIRT1405014	hsa-miR-130b	CLIP-seq
MIRT1405015	hsa-miR-136	CLIP-seq
MIRT1405016	hsa-miR-147	CLIP-seq
MIRT1405017	hsa-miR-19a	CLIP-seq
MIRT1405018	hsa-miR-19b	CLIP-seq
MIRT1405019	hsa-miR-301a	CLIP-seq
MIRT1405020	hsa-miR-301b	CLIP-seq
MIRT1405021	hsa-miR-3140-5p	CLIP-seq
MIRT1405022	hsa-miR-331-3p	CLIP-seq
MIRT1405023	hsa-miR-3616-5p	CLIP-seq
MIRT1405024	hsa-miR-3617	CLIP-seq
MIRT1405025	hsa-miR-3647-5p	CLIP-seq
MIRT1405026	hsa-miR-3654	CLIP-seq
MIRT1405027	hsa-miR-3666	CLIP-seq
MIRT1405028	hsa-miR-3671	CLIP-seq
MIRT1405029	hsa-miR-3673	CLIP-seq
MIRT1405030	hsa-miR-3911	CLIP-seq
MIRT1405031	hsa-miR-3941	CLIP-seq
MIRT1405032	hsa-miR-409-5p	CLIP-seq
MIRT1405033	hsa-miR-4272	CLIP-seq
MIRT1405034	hsa-miR-4275	CLIP-seq
MIRT1405035	hsa-miR-4295	CLIP-seq
MIRT1405036	hsa-miR-4298	CLIP-seq
MIRT1405037	hsa-miR-4311	CLIP-seq
MIRT1405038	hsa-miR-4438	CLIP-seq
MIRT1405039	hsa-miR-454	CLIP-seq
MIRT1405040	hsa-miR-4645-3p	CLIP-seq
MIRT1405041	hsa-miR-466	CLIP-seq
MIRT1405042	hsa-miR-4666-5p	CLIP-seq
MIRT1405043	hsa-miR-4671-3p	CLIP-seq
MIRT1405044	hsa-miR-4672	CLIP-seq
MIRT1405045	hsa-miR-4684-5p	CLIP-seq
MIRT1405046	hsa-miR-4717-3p	CLIP-seq
MIRT1405047	hsa-miR-4719	CLIP-seq
MIRT1405048	hsa-miR-4728-3p	CLIP-seq
MIRT1405049	hsa-miR-4731-3p	CLIP-seq
MIRT1405050	hsa-miR-4753-3p	CLIP-seq
MIRT1405051	hsa-miR-4768-5p	CLIP-seq
MIRT1405052	hsa-miR-4778-3p	CLIP-seq
MIRT1405053	hsa-miR-4795-5p	CLIP-seq
MIRT1405054	hsa-miR-4801	CLIP-seq
MIRT1405055	hsa-miR-501-3p	CLIP-seq
MIRT1405056	hsa-miR-502-3p	CLIP-seq
MIRT1405057	hsa-miR-532-5p	CLIP-seq
MIRT1405058	hsa-miR-548ad	CLIP-seq
MIRT1405059	hsa-miR-548p	CLIP-seq
MIRT1405060	hsa-miR-573	CLIP-seq
MIRT1405061	hsa-miR-582-5p	CLIP-seq
MIRT1405062	hsa-miR-583	CLIP-seq
MIRT1405063	hsa-miR-595	CLIP-seq
MIRT1405064	hsa-miR-617	CLIP-seq
MIRT1405065	hsa-miR-619	CLIP-seq
MIRT1405066	hsa-miR-641	CLIP-seq
MIRT1405067	hsa-miR-642b	CLIP-seq
MIRT1405068	hsa-miR-644	CLIP-seq
MIRT1405069	hsa-miR-659	CLIP-seq
MIRT1405070	hsa-miR-671-3p	CLIP-seq
MIRT1405071	hsa-miR-96	CLIP-seq
MIRT1554357	hsa-miR-3658	CLIP-seq
MIRT1405008	hsa-miR-1243	CLIP-seq
MIRT1405009	hsa-miR-1271	CLIP-seq
MIRT1405012	hsa-miR-1302	CLIP-seq
MIRT2121529	hsa-miR-1303	CLIP-seq
MIRT2121530	hsa-miR-3123	CLIP-seq
MIRT1405022	hsa-miR-331-3p	CLIP-seq
MIRT1405026	hsa-miR-3654	CLIP-seq
MIRT2121531	hsa-miR-3925-5p	CLIP-seq
MIRT1405031	hsa-miR-3941	CLIP-seq
MIRT1405032	hsa-miR-409-5p	CLIP-seq
MIRT1405034	hsa-miR-4275	CLIP-seq
MIRT1405036	hsa-miR-4298	CLIP-seq
MIRT1405041	hsa-miR-466	CLIP-seq
MIRT1405044	hsa-miR-4672	CLIP-seq
MIRT1405045	hsa-miR-4684-5p	CLIP-seq
MIRT2121532	hsa-miR-4699-3p	CLIP-seq
MIRT1405046	hsa-miR-4717-3p	CLIP-seq
MIRT1405049	hsa-miR-4731-3p	CLIP-seq
MIRT1405051	hsa-miR-4768-5p	CLIP-seq
MIRT1405054	hsa-miR-4801	CLIP-seq
MIRT1405055	hsa-miR-501-3p	CLIP-seq
MIRT1405056	hsa-miR-502-3p	CLIP-seq
MIRT1405061	hsa-miR-582-5p	CLIP-seq
MIRT1405064	hsa-miR-617	CLIP-seq
MIRT1405065	hsa-miR-619	CLIP-seq
MIRT1405067	hsa-miR-642b	CLIP-seq
MIRT1405069	hsa-miR-659	CLIP-seq
MIRT1405071	hsa-miR-96	CLIP-seq
MIRT2343553	hsa-miR-1	CLIP-seq
MIRT2343554	hsa-miR-106a	CLIP-seq
MIRT2343555	hsa-miR-106b	CLIP-seq
MIRT1405006	hsa-miR-1200	CLIP-seq
MIRT1405007	hsa-miR-1236	CLIP-seq
MIRT1405008	hsa-miR-1243	CLIP-seq
MIRT1405009	hsa-miR-1271	CLIP-seq
MIRT1405011	hsa-miR-1276	CLIP-seq
MIRT2343556	hsa-miR-1287	CLIP-seq
MIRT1405012	hsa-miR-1302	CLIP-seq
MIRT1405013	hsa-miR-130a	CLIP-seq
MIRT1405014	hsa-miR-130b	CLIP-seq
MIRT2343557	hsa-miR-132	CLIP-seq
MIRT1405015	hsa-miR-136	CLIP-seq
MIRT2343558	hsa-miR-17	CLIP-seq
MIRT1405017	hsa-miR-19a	CLIP-seq
MIRT1405018	hsa-miR-19b	CLIP-seq
MIRT2343559	hsa-miR-206	CLIP-seq
MIRT2343560	hsa-miR-20a	CLIP-seq
MIRT2343561	hsa-miR-20b	CLIP-seq
MIRT2343562	hsa-miR-212	CLIP-seq
MIRT1405019	hsa-miR-301a	CLIP-seq
MIRT1405020	hsa-miR-301b	CLIP-seq
MIRT2343563	hsa-miR-30a	CLIP-seq
MIRT2343564	hsa-miR-30b	CLIP-seq
MIRT2343565	hsa-miR-30c	CLIP-seq
MIRT2343566	hsa-miR-30d	CLIP-seq
MIRT2343567	hsa-miR-30e	CLIP-seq
MIRT2121530	hsa-miR-3123	CLIP-seq
MIRT2343568	hsa-miR-3135b	CLIP-seq
MIRT1405021	hsa-miR-3140-5p	CLIP-seq
MIRT2343569	hsa-miR-323b-3p	CLIP-seq
MIRT1405022	hsa-miR-331-3p	CLIP-seq
MIRT1405024	hsa-miR-3617	CLIP-seq
MIRT2343570	hsa-miR-3653	CLIP-seq
MIRT1405026	hsa-miR-3654	CLIP-seq
MIRT1554357	hsa-miR-3658	CLIP-seq
MIRT1405027	hsa-miR-3666	CLIP-seq
MIRT1405028	hsa-miR-3671	CLIP-seq
MIRT1405029	hsa-miR-3673	CLIP-seq
MIRT2121531	hsa-miR-3925-5p	CLIP-seq
MIRT1405031	hsa-miR-3941	CLIP-seq
MIRT1405032	hsa-miR-409-5p	CLIP-seq
MIRT2343571	hsa-miR-410	CLIP-seq
MIRT1405033	hsa-miR-4272	CLIP-seq
MIRT1405034	hsa-miR-4275	CLIP-seq
MIRT1405035	hsa-miR-4295	CLIP-seq
MIRT1405036	hsa-miR-4298	CLIP-seq
MIRT2343572	hsa-miR-431	CLIP-seq
MIRT1405037	hsa-miR-4311	CLIP-seq
MIRT1405038	hsa-miR-4438	CLIP-seq
MIRT2343573	hsa-miR-4511	CLIP-seq
MIRT1405039	hsa-miR-454	CLIP-seq
MIRT2343574	hsa-miR-4635	CLIP-seq
MIRT1405040	hsa-miR-4645-3p	CLIP-seq
MIRT1405041	hsa-miR-466	CLIP-seq
MIRT1405043	hsa-miR-4671-3p	CLIP-seq
MIRT1405044	hsa-miR-4672	CLIP-seq
MIRT1405045	hsa-miR-4684-5p	CLIP-seq
MIRT2121532	hsa-miR-4699-3p	CLIP-seq
MIRT2343575	hsa-miR-4699-5p	CLIP-seq
MIRT2343576	hsa-miR-4709-3p	CLIP-seq
MIRT1405046	hsa-miR-4717-3p	CLIP-seq
MIRT1405050	hsa-miR-4753-3p	CLIP-seq
MIRT2343577	hsa-miR-4762-5p	CLIP-seq
MIRT1405051	hsa-miR-4768-5p	CLIP-seq
MIRT2343578	hsa-miR-4777-3p	CLIP-seq
MIRT1405052	hsa-miR-4778-3p	CLIP-seq
MIRT2343579	hsa-miR-488	CLIP-seq
MIRT2343580	hsa-miR-491-3p	CLIP-seq
MIRT2343581	hsa-miR-495	CLIP-seq
MIRT1405055	hsa-miR-501-3p	CLIP-seq
MIRT1405056	hsa-miR-502-3p	CLIP-seq
MIRT2343582	hsa-miR-518a-5p	CLIP-seq
MIRT2343583	hsa-miR-519a	CLIP-seq
MIRT2343584	hsa-miR-519b-3p	CLIP-seq
MIRT2343585	hsa-miR-519c-3p	CLIP-seq
MIRT2343586	hsa-miR-519d	CLIP-seq
MIRT2343587	hsa-miR-527	CLIP-seq
MIRT1405057	hsa-miR-532-5p	CLIP-seq
MIRT1405058	hsa-miR-548ad	CLIP-seq
MIRT2343588	hsa-miR-548b-3p	CLIP-seq
MIRT1405059	hsa-miR-548p	CLIP-seq
MIRT1405061	hsa-miR-582-5p	CLIP-seq
MIRT1405062	hsa-miR-583	CLIP-seq
MIRT2343589	hsa-miR-613	CLIP-seq
MIRT1405064	hsa-miR-617	CLIP-seq
MIRT1405065	hsa-miR-619	CLIP-seq
MIRT2343590	hsa-miR-626	CLIP-seq
MIRT1405066	hsa-miR-641	CLIP-seq
MIRT1405067	hsa-miR-642b	CLIP-seq
MIRT1405069	hsa-miR-659	CLIP-seq
MIRT2343591	hsa-miR-875-5p	CLIP-seq
MIRT2343592	hsa-miR-888	CLIP-seq
MIRT2343593	hsa-miR-93	CLIP-seq
MIRT1405071	hsa-miR-96	CLIP-seq
MIRT2637248	hsa-miR-1245b-3p	CLIP-seq
MIRT1405009	hsa-miR-1271	CLIP-seq
MIRT1405012	hsa-miR-1302	CLIP-seq
MIRT1405036	hsa-miR-4298	CLIP-seq
MIRT1405045	hsa-miR-4684-5p	CLIP-seq
MIRT1405046	hsa-miR-4717-3p	CLIP-seq
MIRT1405051	hsa-miR-4768-5p	CLIP-seq
MIRT1405064	hsa-miR-617	CLIP-seq
MIRT1405065	hsa-miR-619	CLIP-seq
MIRT1405067	hsa-miR-642b	CLIP-seq
MIRT1405071	hsa-miR-96	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0005515	Function	Protein binding	IPI	15459722, 16713569, 17043677, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005794	Component	Golgi apparatus	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IDA	15459722
GO:0005874	Component	Microtubule	IEA
GO:0005881	Component	Cytoplasmic microtubule	IBA
GO:0016020	Component	Membrane	IEA
GO:0019896	Process	Axonal transport of mitochondrion	IBA
GO:0019896	Process	Axonal transport of mitochondrion	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031982	Component	Vesicle	IDA	15459722
GO:0031982	Component	Vesicle	IEA
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0060025	Process	Regulation of synaptic activity	IEA
GO:0060074	Process	Synapse maturation	IBA
GO:0060074	Process	Synapse maturation	IEA
GO:1904115	Component	Axon cytoplasm	IEA
GO:1990048	Process	Anterograde neuronal dense core vesicle transport	IEA

MIM	HGNC	e!Ensembl
611568	26011	ENSG00000147642

Q9NX95

Protein name

Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein)

Protein function

Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development. {ECO:0000250, ECO:0000269|PubMed:1545

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15290	Syntaphilin	211 → 507	Golgi-localised syntaxin-1-binding clamp	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 3, isoform 4 and isoform 5 are expressed in HeLa cell line (at protein level). Isoform 3 is expressed in fetal and adult brain. Isoform 4 is expressed in numerous fetal tissues (brain, kidney, liver, lung, and thymus) and in ad

Sequence

MGPLRESKKEHRVQHHDKEISRSRIPRLILRPHMPQQQHKVSPASESPFSEEESREFNPS
SSGRSARTVSSNSFCSDDTGCPSSQSVSPVKTPSDAGNSPIGFCPGSDEGFTRKKCTIGM
VGEGSIQSSRYKKESKSGLVKPGSEADFSSSSSTGSISAPEVHMSTAGSKRSSSSRNRGP
HGRSNGASSHKPGSSPSSPREKDLLSMLCRNQLSPVNIHPSYAPSSPSSSNSGSYKGSDC
SPIMRRSGRYMSCGENHGVRPPNPEQYLTPLQQKEVTVRHLKTKLKESERRLHERESEIV
ELKSQLARMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMRSSLADKDKGIQKYFV
DINIQNKKLESLLQSMEMAHSGSLRDELCLDFPCDSPEKSLTLNPPLDTMADGLSLEEQV
TGEGADRELLVGDSIANSTDLFDEIVTATTTESGDLELVHSTPGANVLELLPIVMGQEEG
SVVVERAVQTDVVPYSPAISELIQSVLQKLQDPCPSSLASPDESEPDSMESFPESLSALV
VDLTPRNPNSAILLSPVETPYANVDAEVHANRLMRELDFAACVEERLDGVIPLARGGVVR
QYWSSSFLVDLLAVAAPVVPTVLWAFSTQRGGTDPVYNIGALLRGCCVVALHSLRRTAFR
IKT

Sequence length

663

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE DERMATOMYOSITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Cognition Disorders	Associate	29324989	★★★★★ ★☆☆☆☆ Found in Text Mining only
Death	Associate	29324989	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Inhibit	29324989	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Stimulate	38243290	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thymic epithelial tumor	Associate	33161413	★★★★★ ★☆☆☆☆ Found in Text Mining only

SYBU (syntabulin)