Gene Gene information from NCBI Gene database.
Entrez ID 55635
Gene name DEP domain containing 1
Gene symbol DEPDC1
Synonyms (NCBI Gene)
DEP.8DEPDC1-V2DEPDC1ASDP35
Chromosome 1
Chromosome location 1p31.3
miRNA miRNA information provided by mirtarbase database.
357
miRTarBase ID miRNA Experiments Reference
MIRT019599 hsa-miR-340-5p Sequencing 20371350
MIRT021182 hsa-miR-186-5p Sequencing 20371350
MIRT002615 hsa-miR-124-3p Microarray 15685193
MIRT002615 hsa-miR-124-3p Microarray 18668037
MIRT024325 hsa-miR-215-5p Microarray 19074876
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0005096 Function GTPase activator activity IEA
GO:0005515 Function Protein binding IPI 20587513
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 20587513
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612002 22949 ENSG00000024526
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5TB30
Protein name DEP domain-containing protein 1A
Protein function May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein
PDB 2YSR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00610 DEP 27 106 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in testis. Up-regulated in bladder cancer cells (at protein level). {ECO:0000269|PubMed:17452976}.
Sequence
MESQGVPPGPYRATKLWNEVTTSFRAGMPLRKHRQHFKKYGNCFTAGEAVDWLYDLLRNN
SNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSENVDDNNQLFRF
PATSPLKTLPRRYP
ELRKNNIENFSKDKDSIFKLRNLSRRTPKRHGLHLSQENGEKIKHEIINEDQENAIDNRE
LSQEDVEEVWRYVILIYLQTILGVPSLEEVINPKQVIPQYIMYNMANTSKRGVVILQNKS
DDLPHWVLSAMKCLANWPRSNDMNNPTYVGFERDVFRTIADYFLDLPEPLLTFEYYELFV
NILVVCGYITVSDRSSGIHKIQDDPQSSKFLHLNNLNSFKSTECLLLSLLHREKNKEESD
STERLQISNPGFQERCAKKMQLVNLRNRRVSANDIMGGSCHNLIGLSNMHDLSSNSKPRC
CSLEGIVDVPGNSSKEASSVFHQSFPNIEGQNNKLFLESKPKQEFLLNLHSEENIQKPFS
AGFKRTSTLTVQDQEELCNGKCKSKQLCRSQSLLLRSSTRRNSYINTPVAEIIMKPNVGQ
GSTSVQTAMESELGESSATINKRLCKSTIELSENSLLPASSMLTGTQSLLQPHLERVAID
ALQLCCLLLPPPNRRKLQLLMRMISRMSQNVDMPKLHDAMGTRSLMIHTFSRCVLCCAEE
VDLDELLAGRLVSFLMDHHQEILQVPSYLQTAVEKHLDYLKKGHIENPGDGLFAPLPTYS
YCKQISAQEFDEQKVSTSQAAIAELLENIIKNRSLPLKEKRKKLKQFQKEYPLIYQKRFP
TTESEAALFGDKPTIKQPMLILRKPKFRSLR
Sequence length 811
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Aganglionic megacolon Uncertain significance rs1571197028 RCV000984784
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 33021072, 35466755
Breast Neoplasms Associate 31162714, 34172056
Carcinogenesis Associate 25902835, 33140894, 33361586
Carcinoma Hepatocellular Associate 25605201, 31322256, 34556750, 36785674
Carcinoma Renal Cell Associate 33287763
Colorectal Neoplasms Stimulate 33140894
Colorectal Neoplasms Associate 36309731
Esophageal Neoplasms Associate 32500232
Lupus Erythematosus Systemic Associate 37072474
Lymphatic Metastasis Associate 36768316