G2E3 (G2/M-phase specific E3 ubiquitin protein ligase)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 55632 |
| Gene name | G2/M-phase specific E3 ubiquitin protein ligase |
| Gene symbol | G2E3 |
| Synonyms (NCBI Gene) |
KIAA1333PHF7B
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| Chromosome | 14 |
| Chromosome location | 14q12 |
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miRNA
miRNA information provided by mirtarbase database.
362
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q7L622 | |||||||||||||||
| Protein name | G2/M phase-specific E3 ubiquitin-protein ligase (EC 2.3.2.26) (G2/M phase-specific HECT-type E3 ubiquitin transferase) | |||||||||||||||
| Protein function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptoti | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Predominantly expressed in brain, liver, kidney, testes and ovary. {ECO:0000269|PubMed:10718198}. | |||||||||||||||
| Sequence |
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| Sequence length | 706 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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