Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5563
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase AMP-activated catalytic subunit alpha 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRKAA2
Synonyms (NCBI Gene) Gene synonyms aliases
AMPK, AMPK2, AMPKa2, PRKAA
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p32.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026874 hsa-miR-192-5p Microarray 19074876
MIRT027841 hsa-miR-98-5p Microarray 19088304
MIRT052107 hsa-let-7b-5p CLASH 23622248
MIRT047217 hsa-miR-182-5p CLASH 23622248
MIRT700623 hsa-miR-495-5p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003682 Function Chromatin binding ISS
GO:0004672 Function Protein kinase activity TAS 7959015
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity ISS
GO:0004679 Function AMP-activated protein kinase activity IDA 18439900
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600497 9377 ENSG00000162409
Protein
UniProt ID P54646
Protein name 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31)
Protein function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357). In response to reduction of intracellular ATP levels, AM
PDB 2H6D , 2LTU , 2YZA , 3AQV , 4CFE , 4CFF , 4ZHX , 5EZV , 5ISO , 6B1U , 6B2E , 6BX6 , 7MYJ , 8BIK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 16 268 Protein kinase domain Domain
PF16579 AdenylateSensor 401 495 Adenylate sensor of SNF1-like protein kinase Domain
Sequence
Sequence length 552
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  FoxO signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Apelin signaling pathway
Tight junction
Circadian rhythm
Thermogenesis
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease
Alcoholic liver disease
Hypertrophic cardiomyopathy
Fluid shear stress and atherosclerosis
  Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Cardiomyopathy Cardiomyopathies, Primary, Cardiomyopathies rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)
21037199
Gastric cancer Gastric Adenocarcinoma rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 25798539
Adenoma Oxyphilic Stimulate 26655904
Adenosine monophosphate deaminase deficiency Associate 15766830
Alzheimer Disease Associate 33942972
Amyotrophic Lateral Sclerosis Associate 28213588
Arrhythmias Cardiac Associate 12747836
Arthritis Rheumatoid Associate 30100905, 36661308
Breast Neoplasms Associate 19723334, 24406729, 25427448, 25651975, 26752181, 26919657, 27145268, 29702405, 31507133, 31907353, 35864962, 37542585, 39512680, 40427554
Carcinogenesis Associate 25017332
Carcinoma Basal Cell Associate 27367504