Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5562
Gene name Gene Name - the full gene name approved by the HGNC.
Protein kinase AMP-activated catalytic subunit alpha 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PRKAA1
Synonyms (NCBI Gene) Gene synonyms aliases
AMPK, AMPK alpha 1, AMPKa1
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p13.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5`-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT006742 hsa-miR-19b-3p Luciferase reporter assay 20190740
MIRT019393 hsa-miR-148b-3p Microarray 17612493
MIRT020218 hsa-miR-130b-3p Sequencing 20371350
MIRT021937 hsa-miR-128-3p Microarray 17612493
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000187 Process Activation of MAPK activity NAS 11546797
GO:0001666 Process Response to hypoxia NAS 8557660
GO:0003682 Function Chromatin binding ISS
GO:0004672 Function Protein kinase activity IDA 17028174
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602739 9376 ENSG00000132356
Protein
UniProt ID Q13131
Protein name 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11
Protein function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:17307971, PubMed:17712357, PubMed:24563466, PubMed:37821951). In response to reducti
PDB 4RED , 4RER , 4REW , 5EZV , 6C9F , 6C9G , 6C9H , 6C9J , 7JHG , 7JHH , 7JIJ , 7M74
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 27 279 Protein kinase domain Domain
PF16579 AdenylateSensor 406 503 Adenylate sensor of SNF1-like protein kinase Domain
Sequence
Sequence length 559
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  FoxO signaling pathway
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Apelin signaling pathway
Tight junction
Circadian rhythm
Thermogenesis
Insulin signaling pathway
Adipocytokine signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Insulin resistance
Non-alcoholic fatty liver disease
Alcoholic liver disease
Hypertrophic cardiomyopathy
Fluid shear stress and atherosclerosis
  Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Gastric cancer Hereditary Diffuse Gastric Cancer rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802
View all (244 more)
26098866
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
22037555
Unknown
Disease term Disease name Evidence References Source
Gastric ulcer Gastric ulcer GWAS
Duodenal Ulcer Duodenal Ulcer GWAS
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Associate 35414794
Adenocarcinoma Inhibit 37670284
Adenocarcinoma of Lung Associate 24048094, 26715839, 28336923, 38203624, 38242874
Alzheimer Disease Associate 32444538, 34992508, 36035305
Arthritis Rheumatoid Associate 32692720
Ataxia Telangiectasia Associate 23800068
Atherosclerosis Associate 25354528
Birt Hogg Dube Syndrome Associate 19850877, 34031471
Breast Neoplasms Associate 19483724, 22363791, 22562547, 24359639, 24403860, 24488910, 26616021, 30653260, 31870119, 33632157, 34584194, 35674458, 37906431
Carcinogenesis Associate 22363791, 22801477, 24829520, 33219302, 33752745