Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55619
Gene name Gene Name - the full gene name approved by the HGNC.	Dedicator of cytokinesis 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DOCK10
Synonyms (NCBI Gene) Gene synonyms aliases	DRIP2, Nbla10300, ZIZ3
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q36.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the

Show/Hide all(111)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021604	hsa-miR-142-3p	Microarray	17612493
MIRT021826	hsa-miR-132-3p	Microarray	17612493
MIRT029588	hsa-miR-26b-5p	Microarray	19088304
MIRT030887	hsa-miR-21-5p	Microarray	18591254
MIRT440785	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440785	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT942758	hsa-miR-181a	CLIP-seq
MIRT942759	hsa-miR-181b	CLIP-seq
MIRT942760	hsa-miR-181c	CLIP-seq
MIRT942761	hsa-miR-181d	CLIP-seq
MIRT942762	hsa-miR-193a-5p	CLIP-seq
MIRT942763	hsa-miR-2467-3p	CLIP-seq
MIRT942764	hsa-miR-3117-3p	CLIP-seq
MIRT942765	hsa-miR-3158-5p	CLIP-seq
MIRT942766	hsa-miR-3169	CLIP-seq
MIRT942767	hsa-miR-3177-5p	CLIP-seq
MIRT942768	hsa-miR-3678-3p	CLIP-seq
MIRT942769	hsa-miR-4262	CLIP-seq
MIRT942770	hsa-miR-4420	CLIP-seq
MIRT942771	hsa-miR-4502	CLIP-seq
MIRT942772	hsa-miR-4515	CLIP-seq
MIRT942773	hsa-miR-4643	CLIP-seq
MIRT942774	hsa-miR-466	CLIP-seq
MIRT942775	hsa-miR-4720-3p	CLIP-seq
MIRT942776	hsa-miR-4759	CLIP-seq
MIRT942777	hsa-miR-4789-3p	CLIP-seq
MIRT942778	hsa-miR-4804-3p	CLIP-seq
MIRT942779	hsa-miR-520d-5p	CLIP-seq
MIRT942780	hsa-miR-524-5p	CLIP-seq
MIRT942781	hsa-miR-610	CLIP-seq
MIRT942758	hsa-miR-181a	CLIP-seq
MIRT942759	hsa-miR-181b	CLIP-seq
MIRT942760	hsa-miR-181c	CLIP-seq
MIRT942761	hsa-miR-181d	CLIP-seq
MIRT942769	hsa-miR-4262	CLIP-seq
MIRT942773	hsa-miR-4643	CLIP-seq
MIRT942774	hsa-miR-466	CLIP-seq
MIRT942777	hsa-miR-4789-3p	CLIP-seq
MIRT942779	hsa-miR-520d-5p	CLIP-seq
MIRT942780	hsa-miR-524-5p	CLIP-seq
MIRT2214269	hsa-miR-141	CLIP-seq
MIRT2214270	hsa-miR-200a	CLIP-seq
MIRT942764	hsa-miR-3117-3p	CLIP-seq
MIRT942766	hsa-miR-3169	CLIP-seq
MIRT942767	hsa-miR-3177-5p	CLIP-seq
MIRT942772	hsa-miR-4515	CLIP-seq
MIRT942773	hsa-miR-4643	CLIP-seq
MIRT942774	hsa-miR-466	CLIP-seq
MIRT942776	hsa-miR-4759	CLIP-seq
MIRT942777	hsa-miR-4789-3p	CLIP-seq
MIRT2214271	hsa-miR-767-3p	CLIP-seq
MIRT942764	hsa-miR-3117-3p	CLIP-seq
MIRT942766	hsa-miR-3169	CLIP-seq
MIRT942767	hsa-miR-3177-5p	CLIP-seq
MIRT942772	hsa-miR-4515	CLIP-seq
MIRT942776	hsa-miR-4759	CLIP-seq
MIRT2428331	hsa-miR-3140-3p	CLIP-seq
MIRT2428332	hsa-miR-3200-5p	CLIP-seq
MIRT942773	hsa-miR-4643	CLIP-seq
MIRT942774	hsa-miR-466	CLIP-seq
MIRT2428333	hsa-miR-4719	CLIP-seq
MIRT2428334	hsa-miR-4731-3p	CLIP-seq
MIRT942777	hsa-miR-4789-3p	CLIP-seq
MIRT2428335	hsa-miR-4801	CLIP-seq
MIRT2428336	hsa-miR-889	CLIP-seq
MIRT2214269	hsa-miR-141	CLIP-seq
MIRT942758	hsa-miR-181a	CLIP-seq
MIRT942759	hsa-miR-181b	CLIP-seq
MIRT942760	hsa-miR-181c	CLIP-seq
MIRT942761	hsa-miR-181d	CLIP-seq
MIRT2214270	hsa-miR-200a	CLIP-seq
MIRT2518607	hsa-miR-2277-3p	CLIP-seq
MIRT2518608	hsa-miR-296-3p	CLIP-seq
MIRT2518609	hsa-miR-3120-3p	CLIP-seq
MIRT2518610	hsa-miR-33a	CLIP-seq
MIRT2518611	hsa-miR-33b	CLIP-seq
MIRT942769	hsa-miR-4262	CLIP-seq
MIRT2518612	hsa-miR-4272	CLIP-seq
MIRT942770	hsa-miR-4420	CLIP-seq
MIRT2518613	hsa-miR-4470	CLIP-seq
MIRT942773	hsa-miR-4643	CLIP-seq
MIRT942774	hsa-miR-466	CLIP-seq
MIRT2518614	hsa-miR-4714-3p	CLIP-seq
MIRT942777	hsa-miR-4789-3p	CLIP-seq
MIRT2518615	hsa-miR-490-3p	CLIP-seq
MIRT2518616	hsa-miR-545	CLIP-seq
MIRT942781	hsa-miR-610	CLIP-seq
MIRT2214271	hsa-miR-767-3p	CLIP-seq
MIRT2214269	hsa-miR-141	CLIP-seq
MIRT942758	hsa-miR-181a	CLIP-seq
MIRT942759	hsa-miR-181b	CLIP-seq
MIRT942760	hsa-miR-181c	CLIP-seq
MIRT942761	hsa-miR-181d	CLIP-seq
MIRT2214270	hsa-miR-200a	CLIP-seq
MIRT2518607	hsa-miR-2277-3p	CLIP-seq
MIRT2518608	hsa-miR-296-3p	CLIP-seq
MIRT2518609	hsa-miR-3120-3p	CLIP-seq
MIRT2518610	hsa-miR-33a	CLIP-seq
MIRT2518611	hsa-miR-33b	CLIP-seq
MIRT942769	hsa-miR-4262	CLIP-seq
MIRT2518612	hsa-miR-4272	CLIP-seq
MIRT942770	hsa-miR-4420	CLIP-seq
MIRT2518613	hsa-miR-4470	CLIP-seq
MIRT942773	hsa-miR-4643	CLIP-seq
MIRT942774	hsa-miR-466	CLIP-seq
MIRT2518614	hsa-miR-4714-3p	CLIP-seq
MIRT942777	hsa-miR-4789-3p	CLIP-seq
MIRT2518615	hsa-miR-490-3p	CLIP-seq
MIRT2518616	hsa-miR-545	CLIP-seq
MIRT942781	hsa-miR-610	CLIP-seq
MIRT2214271	hsa-miR-767-3p	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001782	Process	B cell homeostasis	IEA
GO:0001782	Process	B cell homeostasis	ISS
GO:0002315	Process	Marginal zone B cell differentiation	IEA
GO:0002315	Process	Marginal zone B cell differentiation	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005634	Component	Nucleus	IDA	18499258
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	18499258
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0030334	Process	Regulation of cell migration	IBA
GO:0030334	Process	Regulation of cell migration	IDA	18835169
GO:0031267	Function	Small GTPase binding	IEA
GO:0035023	Process	Regulation of Rho protein signal transduction	IBA
GO:0042995	Component	Cell projection	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043197	Component	Dendritic spine	ISS
GO:0043547	Process	Positive regulation of GTPase activity	ISS
GO:0045202	Component	Synapse	IEA
GO:0060997	Process	Dendritic spine morphogenesis	IBA
GO:0060997	Process	Dendritic spine morphogenesis	IEA
GO:0060997	Process	Dendritic spine morphogenesis	ISS
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA

MIM	HGNC	e!Ensembl
611518	23479	ENSG00000135905

Protein

UniProt ID

Q96BY6

Protein name

Dedicator of cytokinesis protein 10 (Zizimin-3)

Protein function

Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell

PDB

6TKY , 6TKZ , 6TM1 , 7Q43

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11878	DUF3398	45 → 155	Domain of unknown function (DUF3398)	Domain
PF00169	PH	182 → 290	PH domain	Domain
PF14429	DOCK-C2	668 → 859	C2 domain in Dock180 and Zizimin proteins	Domain
PF06920	DHR-2	1592 → 2143	Dock homology region 2	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells. {ECO:0000269|PubMed:18499258, ECO:0000269|PubMed:21514340, ECO:0

Sequence

MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEEL
EKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQW
HVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGT
GVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIF
LDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGR
RSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMERLNLF
SLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNI
EPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHI
KGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKIL
KSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSD
YRRADRISKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEFVYD
STKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKP
GGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKK
EALETSVGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGK
PLFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMS
FLPIILNQLFKVLVQNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKE
RTVHEELAKNVTGLLKSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFP
ESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYI
SMFSSGDLKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPE
YSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQ
IASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDT
SFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLI
GSTLRFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQNFR
YLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQT
LPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQT
HQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADL
CGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIAD
AGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEM
LVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYW
KVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQ
DTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSY
LKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADK
FGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFE
TPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKV
SELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEI
FRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVMNEQITGRDDLSKRGV
DQTCTRVISKATPALPTVSISSSAEV

Sequence length

2186

Interactions

View interactions

	Reactome
			Factors involved in megakaryocyte development and platelet production

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Dementia	Dementia	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus	N/A	N/A	GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Autism Spectrum Disorder	Associate	23632794
Melanoma	Associate	18835169
Mood Disorders	Associate	33828235
Parkinson Disease	Associate	26510930

DOCK10 (dedicator of cytokinesis 10)