Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55616
Gene name Gene Name - the full gene name approved by the HGNC.
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ASAP3
Synonyms (NCBI Gene) Gene synonyms aliases
ACAP4, CENTB6, DDEFL1, UPLC1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf pr
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018191 hsa-miR-335-5p Microarray 18185580
MIRT539081 hsa-miR-3667-5p PAR-CLIP 22012620
MIRT539080 hsa-miR-548ao-3p PAR-CLIP 22012620
MIRT539078 hsa-miR-6814-5p PAR-CLIP 22012620
MIRT539079 hsa-miR-208a-3p PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle IBA 21873635
GO:0001726 Component Ruffle IDA 18400762
GO:0005096 Function GTPase activator activity IBA 21873635
GO:0005096 Function GTPase activator activity IDA 18400762
GO:0005515 Function Protein binding IPI 19380743, 25416956, 26871637, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616594 14987 ENSG00000088280
Protein
UniProt ID Q8TDY4
Protein name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (Development and differentiation-enhancing factor-like 1) (Protein up-regulated in liver cancer 1)
Protein function Promotes cell proliferation.
PDB 2B0O , 3LVQ , 3LVR
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16746 BAR_3 32 261 Domain
PF00169 PH 303 394 PH domain Domain
PF01412 ArfGap 426 544 Putative GTPase activating protein for Arf Domain
PF12796 Ank_2 590 682 Ankyrin repeats (3 copies) Repeat
Tissue specificity TISSUE SPECIFICITY: Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes. {ECO:0000269|PubMed:14654939}.
Sequence
MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR
AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL
NNIVSFPLDSLMKGQLRDGRQDSKKQLEKAWKDYEAKMAKLEKERDRARVTGGIPGEVAQ
DMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFI
EKLAASVHALHQAQEDELQKL
TQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQ
FGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVRPNPEEK
KCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKD
EALSSAFLGEPSAGPGSWGSAGHDGE
PHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQS
LTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRF
ARRC
TPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQA
SLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALD
IARKKHHKECEELLEQAQAGTF
AFPLHVDYSWVISTEPGSDSEEDEEEKRCLLKLPAQAH
WASGRLDISNKTYETVASLGAATPQGESEDCPPPLPVKNSSRTLVQGCARHASGDRSEVS
SLSSEAPETPESLGSPASSSSLMSPLEPGDPSQAPPNSEEGLREPPGTSRPSLTSGTTPS
EMYLPVRFSSESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSLPASSVQL
LQD
Sequence length 903
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Endocytosis
Fc gamma R-mediated phagocytosis
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 36829221
Carcinoma Non Small Cell Lung Associate 24078447
Colorectal Neoplasms Associate 30536996
Lymphatic Metastasis Stimulate 24078447
Neoplasm Metastasis Associate 30536996
Neoplasms Associate 24078447
Tertiary Lymphoid Structures Associate 30536996