KIF16B (kinesin family member 16B)

Gene

• Entrez ID: 55614
• Gene name: Kinesin family member 16B
• Gene symbol: KIF16B
• Synonyms (NCBI Gene): C20orf23, KISC20ORF, SNX23
• Chromosome: 20
• Chromosome location: 20p12.1
• Summary: The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022782	hsa-miR-124-3p	Microarray	18668037
MIRT025863	hsa-miR-7-5p	Microarray	17612493
MIRT046881	hsa-miR-221-3p	CLASH	23622248
MIRT1093424	hsa-miR-1183	CLIP-seq
MIRT1093425	hsa-miR-1827	CLIP-seq
MIRT1093426	hsa-miR-214	CLIP-seq
MIRT1093427	hsa-miR-3120-5p	CLIP-seq
MIRT1093428	hsa-miR-3180-5p	CLIP-seq
MIRT1093429	hsa-miR-323b-3p	CLIP-seq
MIRT1093430	hsa-miR-330-3p	CLIP-seq
MIRT1093431	hsa-miR-3607-3p	CLIP-seq
MIRT1093432	hsa-miR-3612	CLIP-seq
MIRT1093433	hsa-miR-3619-5p	CLIP-seq
MIRT1093434	hsa-miR-3686	CLIP-seq
MIRT1093435	hsa-miR-4291	CLIP-seq
MIRT1093436	hsa-miR-4328	CLIP-seq
MIRT1093437	hsa-miR-4459	CLIP-seq
MIRT1093438	hsa-miR-4672	CLIP-seq
MIRT1093439	hsa-miR-4693-5p	CLIP-seq
MIRT1093440	hsa-miR-4695-5p	CLIP-seq
MIRT1093441	hsa-miR-4722-5p	CLIP-seq
MIRT1093442	hsa-miR-4778-5p	CLIP-seq
MIRT1093443	hsa-miR-548g	CLIP-seq
MIRT1093444	hsa-miR-650	CLIP-seq
MIRT1093445	hsa-miR-654-3p	CLIP-seq
MIRT1093446	hsa-miR-761	CLIP-seq
MIRT1093447	hsa-miR-765	CLIP-seq
MIRT1093448	hsa-miR-922	CLIP-seq
MIRT1093449	hsa-miR-4293	CLIP-seq
MIRT1093450	hsa-miR-4682	CLIP-seq
MIRT1093451	hsa-miR-498	CLIP-seq
MIRT1093452	hsa-miR-3662	CLIP-seq
MIRT1093453	hsa-miR-4666-3p	CLIP-seq
MIRT1922804	hsa-miR-130a	CLIP-seq
MIRT1922805	hsa-miR-130b	CLIP-seq
MIRT1922806	hsa-miR-221	CLIP-seq
MIRT1922807	hsa-miR-222	CLIP-seq
MIRT1922808	hsa-miR-301a	CLIP-seq
MIRT1922809	hsa-miR-301b	CLIP-seq
MIRT1922810	hsa-miR-323-3p	CLIP-seq
MIRT1922811	hsa-miR-3666	CLIP-seq
MIRT1922812	hsa-miR-4295	CLIP-seq
MIRT1922813	hsa-miR-454	CLIP-seq
MIRT1922814	hsa-miR-519a	CLIP-seq
MIRT1922815	hsa-miR-519b-3p	CLIP-seq
MIRT1922816	hsa-miR-519c-3p	CLIP-seq
MIRT1922817	hsa-miR-548v	CLIP-seq
MIRT1093424	hsa-miR-1183	CLIP-seq
MIRT1093430	hsa-miR-330-3p	CLIP-seq
MIRT1093436	hsa-miR-4328	CLIP-seq
MIRT1093438	hsa-miR-4672	CLIP-seq
MIRT1093439	hsa-miR-4693-5p	CLIP-seq
MIRT1093424	hsa-miR-1183	CLIP-seq
MIRT2256153	hsa-miR-2113	CLIP-seq
MIRT2256154	hsa-miR-218	CLIP-seq
MIRT2256155	hsa-miR-30a	CLIP-seq
MIRT2256156	hsa-miR-30b	CLIP-seq
MIRT2256157	hsa-miR-30c	CLIP-seq
MIRT2256158	hsa-miR-30d	CLIP-seq
MIRT2256159	hsa-miR-30e	CLIP-seq
MIRT2256160	hsa-miR-410	CLIP-seq
MIRT2256161	hsa-miR-4302	CLIP-seq
MIRT2256162	hsa-miR-4514	CLIP-seq
MIRT2256163	hsa-miR-4524	CLIP-seq
MIRT2256164	hsa-miR-4692	CLIP-seq
MIRT1093442	hsa-miR-4778-5p	CLIP-seq
MIRT2256165	hsa-miR-579	CLIP-seq
MIRT2256166	hsa-miR-636	CLIP-seq
MIRT2256163	hsa-miR-4524	CLIP-seq
MIRT2256165	hsa-miR-579	CLIP-seq
MIRT1093424	hsa-miR-1183	CLIP-seq
MIRT1093430	hsa-miR-330-3p	CLIP-seq
MIRT1093436	hsa-miR-4328	CLIP-seq
MIRT1093438	hsa-miR-4672	CLIP-seq
MIRT1093439	hsa-miR-4693-5p	CLIP-seq
MIRT2452573	hsa-miR-146b-3p	CLIP-seq
MIRT2452574	hsa-miR-22	CLIP-seq
MIRT2452575	hsa-miR-3173-5p	CLIP-seq
MIRT2452576	hsa-miR-4300	CLIP-seq
MIRT2452577	hsa-miR-558	CLIP-seq
MIRT2452578	hsa-miR-874	CLIP-seq
MIRT2452579	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001704	Process	Formation of primary germ layer	ISS
GO:0001919	Process	Regulation of receptor recycling	IMP	15882625
GO:0003777	Function	Microtubule motor activity	IBA	21873635
GO:0005524	Function	ATP binding	IEA
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	15882625, 17641687
GO:0005737	Component	Cytoplasm	IDA	18445686
GO:0005768	Component	Endosome	IDA	17641687
GO:0005769	Component	Early endosome	IDA	15882625
GO:0005819	Component	Spindle	IDA	18445686
GO:0005829	Component	Cytosol	IEA
GO:0005871	Component	Kinesin complex	IBA	21873635
GO:0005874	Component	Microtubule	IBA	21873635
GO:0006895	Process	Golgi to endosome transport	ISS
GO:0007018	Process	Microtubule-based movement	IBA	21873635
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IMP	15882625
GO:0007492	Process	Endoderm development	ISS
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0008543	Process	Fibroblast growth factor receptor signaling pathway	ISS
GO:0008574	Function	ATP-dependent microtubule motor activity, plus-end-directed	IBA	21873635
GO:0008574	Function	ATP-dependent microtubule motor activity, plus-end-directed	IDA	15882625
GO:0016887	Function	ATPase activity	IBA	21873635
GO:0031901	Component	Early endosome membrane	IEA
GO:0032266	Function	Phosphatidylinositol-3-phosphate binding	IDA	15882625
GO:0032801	Process	Receptor catabolic process	IMP	15882625
GO:0043325	Function	Phosphatidylinositol-3,4-bisphosphate binding	IDA	15882625, 17641687
GO:0045022	Process	Early endosome to late endosome transport	IMP	15882625
GO:0080025	Function	Phosphatidylinositol-3,5-bisphosphate binding	IDA	17641687

Other IDs

• MIM: 618171
• HGNC: 15869
• e!Ensembl: ENSG00000089177

Protein

• UniProt ID: Q96L93
• Protein name: Kinesin-like protein KIF16B (Sorting nexin-23)
• Protein function: Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such a
• PDB: 2V14, 6EE0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	9 → 358	Kinesin motor domain	Domain
  PF00498	FHA	478 → 544	FHA domain	Family
  PF00787	PX	1209 → 1283	PX domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Primarily expressed in brain. Also present in kidney, liver, intestine, placenta, leukocytes, heart and skeletal muscle (at protein level). {ECO:0000269|PubMed:15882625}.
• Sequence:

  MASVKVAVRVRPMNRREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERTKTFTYDF
  SFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSG
  LIPRICEGLFSRINETTRWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKE
  GPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFDSEM
  PCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTL
  AKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATISPADVNYGETLSTLRYANRAKNIIN
  KPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEARVQELTK
  EWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYV
  GRDDASTEQDIVLHGLDLESEHCIFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAV
  ILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYNPGLEFER
  QQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKR
  RSFHIENKLKDLLAEKEKFEEERLREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEK
  AEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQEMIQLLR
  RGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLE
  KDLVQQKDILKKEVQEEQEILECLKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEY
  RLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKEEQLAQYQ
  ANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQ
  RHSTLGMEIEEQRQKLASLNSGSREQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYE
  VDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDLHRVISEG
  CSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDA
  HFEFEVKITVLDETWTVFRRYSRFREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAER
  RSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSSHGTG

• Sequence length: 1317

Pathways

KEGG:

Motor proteins

Reactome:

COPI-dependent Golgi-to-ER retrograde traffic
Kinesins

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Asthma		27611488	ClinVar, GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	26573232
Carcinoma Non Small Cell Lung	Associate	31618441
Colorectal Neoplasms	Associate	35487942
Neoplasms	Associate	21139019
Ovarian Diseases	Associate	31618441
Stomach Neoplasms	Associate	35715463