Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	55602
Gene name	CDKN2A interacting protein
Gene symbol	CDKN2AIP
Synonyms (NCBI Gene)	-
Chromosome	4
Chromosome location	4q35.1
Summary	The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022595	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT025391	hsa-miR-34a-5p	Proteomics	21566225
MIRT039491	hsa-miR-652-3p	CLASH	23622248
MIRT356241	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT356240	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT659635	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT659634	hsa-miR-5696	HITS-CLIP	23824327
MIRT659633	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT659632	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT659631	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT659630	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT659629	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT571270	hsa-miR-548aa	PAR-CLIP	20371350
MIRT571269	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT571268	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT571267	hsa-miR-548as-3p	PAR-CLIP	20371350
MIRT571266	hsa-miR-548at-3p	PAR-CLIP	20371350
MIRT571265	hsa-miR-548ay-3p	PAR-CLIP	20371350
MIRT571264	hsa-miR-323a-3p	PAR-CLIP	20371350
MIRT356240	hsa-miR-153-5p	PAR-CLIP	20371350
MIRT356239	hsa-miR-196a-3p	PAR-CLIP	20371350
MIRT551585	hsa-miR-1-5p	PAR-CLIP	21572407
MIRT551584	hsa-miR-5707	PAR-CLIP	21572407
MIRT551583	hsa-miR-6731-3p	PAR-CLIP	21572407
MIRT551582	hsa-miR-636	PAR-CLIP	21572407
MIRT551581	hsa-miR-337-3p	PAR-CLIP	21572407
MIRT551580	hsa-miR-202-5p	PAR-CLIP	21572407
MIRT551579	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT551578	hsa-miR-3685	PAR-CLIP	21572407
MIRT551577	hsa-miR-384	PAR-CLIP	21572407
MIRT450237	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT450236	hsa-miR-219b-5p	PAR-CLIP	22100165
MIRT356241	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT356240	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT659635	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT659634	hsa-miR-5696	HITS-CLIP	23824327
MIRT659633	hsa-miR-579-3p	HITS-CLIP	23824327
MIRT659632	hsa-miR-664b-3p	HITS-CLIP	23824327
MIRT659631	hsa-miR-6509-3p	HITS-CLIP	23824327
MIRT659630	hsa-miR-4436b-5p	HITS-CLIP	23824327
MIRT659629	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT571270	hsa-miR-548aa	PAR-CLIP	20371350
MIRT571269	hsa-miR-548ap-3p	PAR-CLIP	20371350
MIRT571268	hsa-miR-548t-3p	PAR-CLIP	20371350
MIRT571267	hsa-miR-548as-3p	PAR-CLIP	20371350
MIRT571266	hsa-miR-548at-3p	PAR-CLIP	20371350
MIRT571265	hsa-miR-548ay-3p	PAR-CLIP	20371350
MIRT571264	hsa-miR-323a-3p	PAR-CLIP	20371350
MIRT356240	hsa-miR-153-5p	PAR-CLIP	20371350
MIRT356239	hsa-miR-196a-3p	PAR-CLIP	20371350
MIRT551585	hsa-miR-1-5p	PAR-CLIP	21572407
MIRT551584	hsa-miR-5707	PAR-CLIP	21572407
MIRT551583	hsa-miR-6731-3p	PAR-CLIP	21572407
MIRT551582	hsa-miR-636	PAR-CLIP	21572407
MIRT551581	hsa-miR-337-3p	PAR-CLIP	21572407
MIRT551580	hsa-miR-202-5p	PAR-CLIP	21572407
MIRT551579	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT551578	hsa-miR-3685	PAR-CLIP	21572407
MIRT551577	hsa-miR-384	PAR-CLIP	21572407
MIRT450237	hsa-miR-548c-3p	PAR-CLIP	22100165
MIRT450236	hsa-miR-219b-5p	PAR-CLIP	22100165
MIRT881808	hsa-miR-126	CLIP-seq
MIRT881809	hsa-miR-3121-3p	CLIP-seq
MIRT881810	hsa-miR-4643	CLIP-seq
MIRT881811	hsa-miR-466	CLIP-seq
MIRT881812	hsa-miR-4789-3p	CLIP-seq
MIRT881813	hsa-miR-487b	CLIP-seq
MIRT1961228	hsa-miR-3177-5p	CLIP-seq
MIRT1961229	hsa-miR-3671	CLIP-seq
MIRT2197980	hsa-miR-181a	CLIP-seq
MIRT2197981	hsa-miR-181b	CLIP-seq
MIRT2197982	hsa-miR-181c	CLIP-seq
MIRT2197983	hsa-miR-181d	CLIP-seq
MIRT2197984	hsa-miR-297	CLIP-seq
MIRT2197985	hsa-miR-3145-3p	CLIP-seq
MIRT2197986	hsa-miR-3149	CLIP-seq
MIRT2197987	hsa-miR-323-3p	CLIP-seq
MIRT1961229	hsa-miR-3671	CLIP-seq
MIRT2197988	hsa-miR-3689a-5p	CLIP-seq
MIRT2197989	hsa-miR-3689b	CLIP-seq
MIRT2197990	hsa-miR-3689e	CLIP-seq
MIRT2197991	hsa-miR-3689f	CLIP-seq
MIRT2197992	hsa-miR-421	CLIP-seq
MIRT2197993	hsa-miR-4262	CLIP-seq
MIRT2197994	hsa-miR-499a-5p	CLIP-seq
MIRT2197995	hsa-miR-543	CLIP-seq
MIRT2197996	hsa-miR-607	CLIP-seq
MIRT2197980	hsa-miR-181a	CLIP-seq
MIRT2197981	hsa-miR-181b	CLIP-seq
MIRT2197982	hsa-miR-181c	CLIP-seq
MIRT2197983	hsa-miR-181d	CLIP-seq
MIRT2501228	hsa-miR-200b	CLIP-seq
MIRT2501229	hsa-miR-200c	CLIP-seq
MIRT2501230	hsa-miR-204	CLIP-seq
MIRT2501231	hsa-miR-211	CLIP-seq
MIRT2501232	hsa-miR-3124-3p	CLIP-seq
MIRT2197987	hsa-miR-323-3p	CLIP-seq
MIRT1961229	hsa-miR-3671	CLIP-seq
MIRT2197992	hsa-miR-421	CLIP-seq
MIRT2197993	hsa-miR-4262	CLIP-seq
MIRT2501233	hsa-miR-4281	CLIP-seq
MIRT2501234	hsa-miR-429	CLIP-seq
MIRT2501235	hsa-miR-4318	CLIP-seq
MIRT2501236	hsa-miR-4693-5p	CLIP-seq
MIRT2197994	hsa-miR-499a-5p	CLIP-seq
MIRT2197995	hsa-miR-543	CLIP-seq
MIRT2197996	hsa-miR-607	CLIP-seq
MIRT2501237	hsa-miR-892a	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001652	Component	Granular component	IDA	12154087
GO:0002039	Function	P53 binding	IDA	15109303
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	12581788, 24825908, 26496610, 33961781, 34591612
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA	12154087
GO:0005654	Component	Nucleoplasm	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	12154087
GO:0006974	Process	DNA damage response	IDA	24825908
GO:0009967	Process	Positive regulation of signal transduction	IMP	15109303
GO:0030307	Process	Positive regulation of cell growth	IMP	24825908
GO:0030308	Process	Negative regulation of cell growth	IMP	12154087, 15109303
GO:0031647	Process	Regulation of protein stability	IMP	12154087

MIM	HGNC	e!Ensembl
615914	24325	ENSG00000168564

Q9NXV6

Protein name

CDKN2A-interacting protein (Collaborator of ARF)

Protein function

Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11952	XTBD	19 → 124	XRN-Two Binding Domain, XTBD	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:12581788}.

Sequence

MAQEVSEYLSQNPRVAAWVEALRCDGETDKHWRHRRDFLLRNAGDLAPAGGAASASTDEA
ADAESGTRNRQLQQLISFSMAWANHVFLGCRYPQKVMDKILSMAEGIKVTDAPTYTTRDE
LVAKVKKRGISSSNEGVEEPSKKRVIEGKNSSAVEQDHAKTSAKTERASAQQENSSTCIG
SAIKSESGNSARSSGISSQNSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKHG
SASFVSLLKSSVNSHMTQSTDSRQQSGSPKKSALEGSSASASQSSSEIEVPLLGSSGSSE
VELPLLSSKPSSETASSGLTSKTSSEASVSSSVAKNSSSSGTSLLTPKSSSSTNTSLLTS
KSTSQVAASLLASKSSSQTSGSLVSKSTSLASVSQLASKSSSQTSTSQLPSKSTSQSSES
SVKFSCKLTNEDVKQKQPFFNRLYKTVAWKLVAVGGFSPNVNHGELLNAAIEALKATLDV
FFVPLKELADLPQNKSSQESIVCELRCKSVYLGTGCGKSKENAKAVASREALKLFLKKKV
VVKICKRKYRGSEIEDLVLLDEESRPVNLPPALKHPQELL

Sequence length

580

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Aneuploidy	Inhibit	24825908	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	19457610	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chemical and Drug Induced Liver Injury	Associate	39596320	★★★★★ ★☆☆☆☆ Found in Text Mining only
DNA Virus Infections	Stimulate	24825908	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	25881029	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	24825908	★★★★★ ★☆☆☆☆ Found in Text Mining only

CDKN2AIP (CDKN2A interacting protein)