ZCCHC8 (zinc finger CCHC-type containing 8)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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55596 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Zinc finger CCHC-type containing 8 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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ZCCHC8 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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PFBMFT5 |
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Chromosome
Chromosome number
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12 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q24.31 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which pro |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q6NZY4 | |||||||||||||||
| Protein name | Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8) | |||||||||||||||
| Protein function | Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex that is involved in the surveillance and turnover of aberrant transcripts and non-coding RNAs (PubMed:27871484). NEXT functions as an RNA exosome cofactor that directs | |||||||||||||||
| PDB | 5LXR , 5LXY , 6C90 , 7S7B , 7S7C , 7Z4Y , 7Z4Z , 7Z52 | |||||||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 707 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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