Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55591
Gene name Gene Name - the full gene name approved by the HGNC.
Vezatin, adherens junctions transmembrane protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
VEZT
Synonyms (NCBI Gene) Gene synonyms aliases
VEZATIN
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004780 hsa-miR-30a-3p Luciferase reporter assay, qRT-PCR, Western blot 16239240
MIRT019856 hsa-miR-375 Microarray 20215506
MIRT027075 hsa-miR-103a-3p Sequencing 20371350
MIRT027346 hsa-miR-101-3p Sequencing 20371350
MIRT004780 hsa-miR-30a-3p qRT-PCR 16239240
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001669 Component Acrosomal vesicle IEA
GO:0002142 Component Stereocilia ankle link complex ISS
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619749 18258 ENSG00000028203
Protein
UniProt ID Q9HBM0
Protein name Vezatin
Protein function Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. ; (Microbia
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12632 Vezatin 150 438 Mysoin-binding motif of peroxisomes Family
Sequence
MTPEFDEEVVFENSPLYQYLQDLGHTDFEICSSLSPKTEKCTTEGQQKPPTRVLPKQGIL
LKVAETIKSWIFFSQCNKKDDLLHKLDIGFRLDSLHTILQQEVLLQEDVELIELLDPSIL
SAGQSQQQENGHLPTLCSLATPNIWDLSMLFAFISLLVMLPTWWIVSSWLVWGVILFVYL
VIRALRLWRTAKLQVTLKKYSVHLEDMATNSRAFTNLVRKALRLIQETEVISRGFTLVSA
ACPFNKAGQHPSQHLIGLRKAVYRTLRANFQAARLATLYMLKNYPLNSESDNVTNYICVV
PFKELGLGLSEEQISEEEAHNFTDGFSLPALKVLFQLWVAQSSEFFRRLALLLSTANSPP
GPLLTPALLPHRILSDVTQGLPHAHSACLEELKRSYEFYRYFETQHQSVPQCLSKTQQKS
RELNNVHTAVRSLQLHLK
ALLNEVIILEDELEKLVCTKETQELVSEAYPILEQKLKLIQP
HVQASNNCWEEAISQVDKLLRRNTDKKGKPEIACENPHCTVVPLKQPTLHIADKDPIPEE
QELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQ
KWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISR
TEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQP
SIKQRLARLQLSPDFTFTAGLAAEVAARSLSFTTMQEQTFGGEEEEQIIEENKNEIEEK
Sequence length 779
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Endometriosis Endometriosis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Endometriosis Associate 28901453, 30061686
Lymphatic Metastasis Associate 25792470
Neoplasms Inhibit 25792470
Obesity Associate 32071425
Stomach Neoplasms Inhibit 25792470
Usher Syndromes Associate 25404053