Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55589
Gene name	BMP2 inducible kinase
Gene symbol	BMP2K
Synonyms (NCBI Gene)	BIKEHRIHFB2017
Chromosome	4
Chromosome location	4q21.21
Summary	This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is

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Show/Hide all (199)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026511	hsa-miR-192-5p	Microarray	19074876
MIRT027518	hsa-miR-98-5p	Microarray	19088304
MIRT051629	hsa-let-7e-5p	CLASH	23622248
MIRT054907	hsa-miR-1228-3p	qRT-PCR	23362149
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT538948	hsa-miR-606	PAR-CLIP	20371350
MIRT568265	hsa-miR-1245a	PAR-CLIP	20371350
MIRT568264	hsa-miR-8079	PAR-CLIP	20371350
MIRT568263	hsa-miR-8062	PAR-CLIP	20371350
MIRT568262	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT568261	hsa-miR-5697	PAR-CLIP	20371350
MIRT568260	hsa-miR-1297	PAR-CLIP	20371350
MIRT568259	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT568258	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT568257	hsa-miR-4465	PAR-CLIP	20371350
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT538960	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT538959	hsa-miR-4643	PAR-CLIP	22012620
MIRT538958	hsa-miR-610	PAR-CLIP	22012620
MIRT538957	hsa-miR-3941	PAR-CLIP	22012620
MIRT538955	hsa-miR-4672	PAR-CLIP	22012620
MIRT538956	hsa-miR-466	PAR-CLIP	22012620
MIRT538954	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT538953	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT538952	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT538951	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT538950	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT538949	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT538948	hsa-miR-606	PAR-CLIP	22012620
MIRT538947	hsa-miR-3145-5p	PAR-CLIP	22012620
MIRT538946	hsa-miR-508-5p	PAR-CLIP	22012620
MIRT538945	hsa-miR-4477a	PAR-CLIP	22012620
MIRT538944	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT538943	hsa-miR-4311	PAR-CLIP	22012620
MIRT538942	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT538941	hsa-miR-4693-3p	PAR-CLIP	22012620
MIRT538940	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524746	hsa-miR-6885-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT512220	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT512219	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT512218	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT524746	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT538948	hsa-miR-606	PAR-CLIP	20371350
MIRT568265	hsa-miR-1245a	PAR-CLIP	20371350
MIRT568264	hsa-miR-8079	PAR-CLIP	20371350
MIRT568263	hsa-miR-8062	PAR-CLIP	20371350
MIRT568262	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT568261	hsa-miR-5697	PAR-CLIP	20371350
MIRT568260	hsa-miR-1297	PAR-CLIP	20371350
MIRT568259	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT568258	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT568257	hsa-miR-4465	PAR-CLIP	20371350
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	21572407
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT538960	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT538959	hsa-miR-4643	PAR-CLIP	22012620
MIRT538958	hsa-miR-610	PAR-CLIP	22012620
MIRT538957	hsa-miR-3941	PAR-CLIP	22012620
MIRT538955	hsa-miR-4672	PAR-CLIP	22012620
MIRT538956	hsa-miR-466	PAR-CLIP	22012620
MIRT538954	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT538953	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT538952	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT538951	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT538950	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT538949	hsa-miR-5582-3p	PAR-CLIP	22012620
MIRT538948	hsa-miR-606	PAR-CLIP	22012620
MIRT538947	hsa-miR-3145-5p	PAR-CLIP	22012620
MIRT538946	hsa-miR-508-5p	PAR-CLIP	22012620
MIRT538945	hsa-miR-4477a	PAR-CLIP	22012620
MIRT538944	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT538943	hsa-miR-4311	PAR-CLIP	22012620
MIRT538942	hsa-miR-551b-5p	PAR-CLIP	22012620
MIRT538941	hsa-miR-4693-3p	PAR-CLIP	22012620
MIRT538940	hsa-miR-1909-5p	PAR-CLIP	22012620
MIRT524747	hsa-miR-6771-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524746	hsa-miR-6885-3p	PAR-CLIP	23446348
MIRT512220	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512219	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512218	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT822378	hsa-miR-1305	CLIP-seq
MIRT822379	hsa-miR-181a	CLIP-seq
MIRT822380	hsa-miR-181b	CLIP-seq
MIRT822381	hsa-miR-181c	CLIP-seq
MIRT822382	hsa-miR-181d	CLIP-seq
MIRT822383	hsa-miR-298	CLIP-seq
MIRT822384	hsa-miR-3065-5p	CLIP-seq
MIRT822385	hsa-miR-3074-3p	CLIP-seq
MIRT822386	hsa-miR-3143	CLIP-seq
MIRT822387	hsa-miR-330-3p	CLIP-seq
MIRT822388	hsa-miR-3659	CLIP-seq
MIRT822389	hsa-miR-376a	CLIP-seq
MIRT822390	hsa-miR-376b	CLIP-seq
MIRT822391	hsa-miR-3944-5p	CLIP-seq
MIRT822392	hsa-miR-4262	CLIP-seq
MIRT822393	hsa-miR-4330	CLIP-seq
MIRT822394	hsa-miR-4427	CLIP-seq
MIRT822395	hsa-miR-4436a	CLIP-seq
MIRT822396	hsa-miR-4461	CLIP-seq
MIRT822397	hsa-miR-4658	CLIP-seq
MIRT822398	hsa-miR-4680-3p	CLIP-seq
MIRT822399	hsa-miR-4758-5p	CLIP-seq
MIRT822400	hsa-miR-4761-3p	CLIP-seq
MIRT822401	hsa-miR-543	CLIP-seq
MIRT822402	hsa-miR-558	CLIP-seq
MIRT822403	hsa-miR-574-5p	CLIP-seq
MIRT822404	hsa-miR-607	CLIP-seq
MIRT822405	hsa-miR-648	CLIP-seq
MIRT822406	hsa-miR-155	CLIP-seq
MIRT822407	hsa-miR-365	CLIP-seq
MIRT822408	hsa-miR-4424	CLIP-seq
MIRT822409	hsa-miR-4433	CLIP-seq
MIRT822410	hsa-miR-4653-3p	CLIP-seq
MIRT822411	hsa-miR-494	CLIP-seq
MIRT822412	hsa-miR-569	CLIP-seq
MIRT1943045	hsa-miR-129-5p	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT822411	hsa-miR-494	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq
MIRT822378	hsa-miR-1305	CLIP-seq
MIRT822393	hsa-miR-4330	CLIP-seq
MIRT822400	hsa-miR-4761-3p	CLIP-seq
MIRT822404	hsa-miR-607	CLIP-seq
MIRT822378	hsa-miR-1305	CLIP-seq
MIRT822393	hsa-miR-4330	CLIP-seq
MIRT822400	hsa-miR-4761-3p	CLIP-seq
MIRT822404	hsa-miR-607	CLIP-seq
MIRT2442013	hsa-miR-1264	CLIP-seq
MIRT2442014	hsa-miR-371-5p	CLIP-seq
MIRT2442015	hsa-miR-371b-5p	CLIP-seq
MIRT2442016	hsa-miR-513c	CLIP-seq
MIRT2442017	hsa-miR-514b-5p	CLIP-seq
MIRT2442018	hsa-miR-628-5p	CLIP-seq
MIRT2442019	hsa-miR-9	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT2444812	hsa-miR-4760-3p	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT2444812	hsa-miR-4760-3p	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq
MIRT1943046	hsa-miR-377	CLIP-seq
MIRT2444812	hsa-miR-4760-3p	CLIP-seq
MIRT1943047	hsa-miR-548e	CLIP-seq
MIRT1943048	hsa-miR-548f	CLIP-seq
MIRT1943049	hsa-miR-548g	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781, 35452674
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016740	Function	Transferase activity	IEA
GO:0019208	Function	Phosphatase regulator activity	IBA
GO:0019208	Function	Phosphatase regulator activity	IEA
GO:0030500	Process	Regulation of bone mineralization	IBA
GO:0030500	Process	Regulation of bone mineralization	IEA
GO:0035612	Function	AP-2 adaptor complex binding	IBA
GO:0045747	Process	Positive regulation of Notch signaling pathway	IBA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:2000369	Process	Regulation of clathrin-dependent endocytosis	IBA

MIM	HGNC	e!Ensembl
617648	18041	ENSG00000138756

Q9NSY1

Protein name

BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)

Protein function

May be involved in osteoblast differentiation.

PDB

4W9W , 4W9X , 5I3O , 5I3R , 5IKW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	51 → 314	Protein kinase domain	Domain
PF15282	BMP2K_C	893 → 1161	BMP-2-inducible protein kinase C-terminus	Family

Sequence

MKKFSRMPKSEGGSGGGAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEG
GFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSIS
DNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRD
LKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGG
KPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEP
DPEHRPDIFQVSYFAFKFAKKDCPVSNINNSSIPSALPEPMTASEAAARKSQIKARITDT
IGPTETSIAPRQRPKANSATTATPSVLTIQSSATPVKVLAPGEFGNHRPKGALRPGNGPE
ILLGQGPPQQPPQQHRVLQQLQQGDWRLQQLHLQHRHPHQQQQQQQQQQQQQQQQQQQQQ
QQQQQQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQQFLMHSVYQPQPSASQYPTMMPQY
QQAFFQQQMLAQHQPSQQQASPEYLTSPQEFSPALVSYTSSLPAQVGTIMDSSYSANRSV
ADKEAIANFTNQKNISNPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSD
KNVDSLSAPHNHPPEDPFGSVPFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKD
QRTGKKTSVQGQVQKGNDESESDFESDPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTEPE
NLGHRPLLMDSEDEEEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSA
QLSSDVAVETPKQEFDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTK
APFSKKVNVQECHAVGPEAHTIPGYPKSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFD
EITGSQQQKVKQRSLQKLSSRQRRTKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARR
HKKVGRRDSQSSNEFLTISDSKENISVALTDGKDRGNVLQPEESLLDPFGAKPFHSPDLS
WHPPHQGLSDIRADHNTVLPGRPRQNSLHGSFHSADVLKMDDFGAVPFTELVVQSITPHQ
SQQSQPVELDPFGAAPFPSKQ

Sequence length

1161

Interactions

View interactions

	KEGG
	Transcriptional misregulation in cancer

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GENERALIZED ANXIETY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colorectal Neoplasms	Associate	36765035	★★★★★ ★☆☆☆☆ Found in Text Mining only
COVID 19	Associate	35738348	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Associate	24455749	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastritis	Associate	37249580	★★★★★ ★☆☆☆☆ Found in Text Mining only
Helicobacter Infections	Associate	37249580	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myopia	Associate	19927351	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	35738348, 36765035	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	24455749	★★★★★ ★☆☆☆☆ Found in Text Mining only

BMP2K (BMP2 inducible kinase)