Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55576
Gene name Gene Name - the full gene name approved by the HGNC.	Stabilin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	STAB2
Synonyms (NCBI Gene) Gene synonyms aliases	FEEL2, FELE-2, FELL2, FEX2, HARE, SCARH1
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q23.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like do

Show/Hide all(5)

miRTarBase ID	miRNA	Experiments
MIRT2340361	hsa-miR-1293	CLIP-seq
MIRT2340362	hsa-miR-3120-3p	CLIP-seq
MIRT2340363	hsa-miR-4483	CLIP-seq
MIRT2340364	hsa-miR-541	CLIP-seq
MIRT2340365	hsa-miR-654-5p	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	NAS	12077138
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IBA	21873635
GO:0005041	Function	Low-density lipoprotein particle receptor activity	IDA	12077138
GO:0005044	Function	Scavenger receptor activity	IDA	12077138
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	18519035
GO:0005540	Function	Hyaluronic acid binding	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IDA	12077138
GO:0006897	Process	Endocytosis	ISS
GO:0006898	Process	Receptor-mediated endocytosis	TAS	12077138
GO:0007155	Process	Cell adhesion	NAS	12077138
GO:0009897	Component	External side of plasma membrane	ISS
GO:0015035	Function	Protein disulfide oxidoreductase activity	NAS	12077138
GO:0030169	Function	Low-density lipoprotein particle binding	IBA	21873635
GO:0030169	Function	Low-density lipoprotein particle binding	IDA	12077138
GO:0030214	Process	Hyaluronan catabolic process	TAS
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0042742	Process	Defense response to bacterium	IDA	12077138
GO:0050830	Process	Defense response to Gram-positive bacterium	IDA	11829752

MIM	HGNC	e!Ensembl
608561	18629	ENSG00000136011

Protein

UniProt ID

Q8WWQ8

Protein name

Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2

Protein function

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Also acts, in different species, as a primary systemic scavenger receptor for hepari

PDB

5N86

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12947	EGF_3	243 → 275	EGF domain	Domain
PF02469	Fasciclin	382 → 507	Fasciclin domain	Domain
PF02469	Fasciclin	526 → 654	Fasciclin domain	Domain
PF12947	EGF_3	917 → 951	EGF domain	Domain
PF12947	EGF_3	957 → 993	EGF domain	Domain
PF02469	Fasciclin	1005 → 1129	Fasciclin domain	Domain
PF02469	Fasciclin	1148 → 1267	Fasciclin domain	Domain
PF12947	EGF_3	1475 → 1511	EGF domain	Domain
PF12947	EGF_3	1517 → 1553	EGF domain	Domain
PF12947	EGF_3	1559 → 1595	EGF domain	Domain
PF02469	Fasciclin	1608 → 1726	Fasciclin domain	Domain
PF02469	Fasciclin	1751 → 1883	Fasciclin domain	Domain
PF12947	EGF_3	2086 → 2121	EGF domain	Domain
PF12947	EGF_3	2127 → 2164	EGF domain	Domain
PF00193	Xlink	2198 → 2290	Extracellular link domain	Domain
PF02469	Fasciclin	2333 → 2449	Fasciclin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macr

Sequence

MMLQHLVIFCLGLVVQNFCSPAETTGQARRCDRKSLLTIRTECRSCALNLGVKCPDGYTM
ITSGSVGVRDCRYTFEVRTYSLSLPGCRHICRKDYLQPRCCPGRWGPDCIECPGGAGSPC
NGRGSCAEGMEGNGTCSCQEGFGGTACETCADDNLFGPSCSSVCNCVHGVCNSGLDGDGT
CECYSAYTGPKCDKPIPECAALLCPENSRCSPSTEDENKLECKCLPNYRGDGKYCDPINP
CLRKICHPHAHCTYLGPNRHSCTCQEGYRGDGQVCLPVDPCQINFGNCPTKSTVCKYDGP
GQSHCECKEHYQNFVPGVGCSMTDICKSDNPCHRNANCTTVAPGRTECICQKGYVGDGLT
CYGNIMERLRELNTEPRGKWQGRLTSFISLLDKAYAWPLSKLGPFTVLLPTDKGLKGFNV
NELLVDNKAAQYFVKLHIIAGQMNIEYMNNTDMFYTLTGKSGEIFNSDKDNQIKLKLHGG
KKKVKIIQGDIIASNGLLHILDRAMDKLEPTFESNNEQTIMTMLQPRYSKFRSLLEETNL
GHALDEDGVGGPYTIFVPNNEALNNMKDGTLDYLLSPEGSRKLLELVRYHIVPFTQLEVA
TLISTPHIRSMANQLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGVLIPPSIVPI
LPHRCDETKREMKLGTCVSCSLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCARYCN
ATVKIPKCCKGFYGPDCNQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQFCSD
PNKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIH
ATCEYSNGTASCICKAGYEGDGTLCSEMDPCTGLTPGGCSRNAECIKTGTGTHTCVCQQG
WTGNGRDCSEINNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQ
TGKCHPLASCQSTSSGVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQ
PTLSATSNLTVLVPSQQATEDMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSS
DMLATSLQGNFLHLAKVDGNITIEGASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNL
LMRLEQMPDYSIFRGYIIQYNLANAIEAADAYTVFAPNNNAIENYIREKKVLSLEEDVLR
YHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLHNDQLYVNEAPINYTNVATDKGVIHG
LGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSLGNEKRRCIYTSYFMGRRTLF
IGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDGVNGTGVCECGEGFSG
TACETCTEGKYGIHCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNATTEDNCNGTC
HTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGRRVCTC
KAGYTGDGIVCLEINPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCL
TKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHF
VKDLVGPGPFTVFAPLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNA
TSLQGEPIVISVSQSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRI
LQNLTTLATNNGYIKFSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFN
QDNKDKLKEYLKFHVIRDAKVLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTC
RIVQRELLFDLGVAYGIDCLLIDPTLGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGV
KQKCLYNLPFKRNLEGCRERCSLVIQIPRCCKGYFGRDCQACPGGPDAPCNNRGVCLDQY
SATGECKCNTGFNGTACEMCWPGRFGPDCLPCGCSDHGQCDDGITGSGQCLCETGWTGPS
CDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGITCTVVDFCKQDNGGCAKVARCS
QKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMTGPGKHKCECKSHYVGD
GLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQYKLTFDKAREAC
ANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVDYGPRPN
KSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSAR
GRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTR
LGSKLLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGL
GAGIFFAIILVTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYE
STTSAPPEPSYDPFTDSEERQLEGNDPLRTL

Sequence length

2551

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis		Hyaluronan uptake and degradation Scavenging by Class H Receptors

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Non Small Cell Lung	Associate	34227915
Cluster Headache	Associate	36404298
Hemangioendothelioma	Associate	38206210
Hemangioma	Associate	38206210
Neoplasms	Associate	34227915, 35568949
Storm Syndrome	Associate	29178990
Venous Thromboembolism	Associate	20946148, 32457982
Venous Thrombosis	Associate	21980494

STAB2 (stabilin 2)