PLXNA3 (plexin A3)

Gene

• Entrez ID: 55558
• Gene name: Plexin A3
• Gene symbol: PLXNA3
• Synonyms (NCBI Gene): 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs202070666	G>A	Likely-pathogenic	Upstream transcript variant, genic upstream transcript variant, intron variant, non coding transcript variant, coding sequence variant, missense variant
rs782515431	G>C	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018079	hsa-miR-335-5p	Microarray	18185580
MIRT687218	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT687217	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT687216	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT687215	hsa-miR-5694	HITS-CLIP	23313552
MIRT687214	hsa-miR-154-3p	HITS-CLIP	23313552
MIRT687213	hsa-miR-487a-3p	HITS-CLIP	23313552
MIRT687212	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT687211	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT687210	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT687209	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT687208	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT687207	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT687206	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT687205	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT687204	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT687203	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT687202	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT687201	hsa-miR-612	HITS-CLIP	23313552
MIRT687200	hsa-miR-6860	HITS-CLIP	23313552
MIRT687199	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT687198	hsa-miR-661	HITS-CLIP	23313552
MIRT687197	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT687194	hsa-miR-7703	HITS-CLIP	23313552
MIRT687193	hsa-miR-4325	HITS-CLIP	23313552
MIRT645933	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT645932	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT645931	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT645930	hsa-miR-3183	HITS-CLIP	23824327
MIRT645929	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT645928	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT645927	hsa-miR-4469	HITS-CLIP	23824327
MIRT645926	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT645925	hsa-miR-4287	HITS-CLIP	23824327
MIRT645924	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645923	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT645922	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT645921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645919	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT645918	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645917	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT645916	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT645915	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645914	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645913	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT645912	hsa-miR-5691	HITS-CLIP	23824327
MIRT645911	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT645910	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT645909	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT645908	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT645907	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT645906	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT625925	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619210	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT687217	hsa-miR-508-5p	HITS-CLIP	27418678
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	27418678
MIRT687198	hsa-miR-661	HITS-CLIP	27418678
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	27418678
MIRT687205	hsa-miR-766-3p	HITS-CLIP	27418678
MIRT687194	hsa-miR-7703	HITS-CLIP	27418678
MIRT687206	hsa-miR-939-3p	HITS-CLIP	27418678
MIRT687218	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT687217	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT687216	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT687215	hsa-miR-5694	HITS-CLIP	23313552
MIRT687214	hsa-miR-154-3p	HITS-CLIP	23313552
MIRT687213	hsa-miR-487a-3p	HITS-CLIP	23313552
MIRT687212	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT687211	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT687210	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT687209	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT687208	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT687207	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT687206	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT687205	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT687204	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT687203	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT687202	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT687201	hsa-miR-612	HITS-CLIP	23313552
MIRT687200	hsa-miR-6860	HITS-CLIP	23313552
MIRT687199	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT687198	hsa-miR-661	HITS-CLIP	23313552
MIRT687197	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT687194	hsa-miR-7703	HITS-CLIP	23313552
MIRT687193	hsa-miR-4325	HITS-CLIP	23313552
MIRT645933	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT645932	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT645931	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT645930	hsa-miR-3183	HITS-CLIP	23824327
MIRT645929	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT645928	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT645927	hsa-miR-4469	HITS-CLIP	23824327
MIRT645926	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT645925	hsa-miR-4287	HITS-CLIP	23824327
MIRT645924	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645923	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT645922	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT645921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645919	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT645918	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645917	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT645916	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT645915	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645914	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645913	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT645912	hsa-miR-5691	HITS-CLIP	23824327
MIRT645911	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT645910	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT645909	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT645908	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT645907	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT645906	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT625925	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619210	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1243676	hsa-miR-1252	CLIP-seq
MIRT1243677	hsa-miR-125a-3p	CLIP-seq
MIRT1243678	hsa-miR-1273	CLIP-seq
MIRT1243679	hsa-miR-1321	CLIP-seq
MIRT1243680	hsa-miR-184	CLIP-seq
MIRT1243681	hsa-miR-3166	CLIP-seq
MIRT1243682	hsa-miR-3180	CLIP-seq
MIRT1243683	hsa-miR-3180-3p	CLIP-seq
MIRT1243684	hsa-miR-3196	CLIP-seq
MIRT1243685	hsa-miR-3199	CLIP-seq
MIRT1243686	hsa-miR-3654	CLIP-seq
MIRT1243687	hsa-miR-3665	CLIP-seq
MIRT1243688	hsa-miR-3675-5p	CLIP-seq
MIRT1243689	hsa-miR-3683	CLIP-seq
MIRT1243690	hsa-miR-4270	CLIP-seq
MIRT1243691	hsa-miR-4441	CLIP-seq
MIRT1243692	hsa-miR-4447	CLIP-seq
MIRT1243693	hsa-miR-4472	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT1243695	hsa-miR-4648	CLIP-seq
MIRT1243696	hsa-miR-4690-5p	CLIP-seq
MIRT1243697	hsa-miR-4699-3p	CLIP-seq
MIRT1243698	hsa-miR-4728-5p	CLIP-seq
MIRT1243699	hsa-miR-4736	CLIP-seq
MIRT1243700	hsa-miR-4739	CLIP-seq
MIRT1243701	hsa-miR-4756-5p	CLIP-seq
MIRT1243702	hsa-miR-4765	CLIP-seq
MIRT1243703	hsa-miR-4767	CLIP-seq
MIRT1243704	hsa-miR-4771	CLIP-seq
MIRT1243705	hsa-miR-4785	CLIP-seq
MIRT1243706	hsa-miR-4789-3p	CLIP-seq
MIRT1243707	hsa-miR-4790-3p	CLIP-seq
MIRT1243708	hsa-miR-4804-5p	CLIP-seq
MIRT1243709	hsa-miR-642b	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2072017	hsa-miR-124	CLIP-seq
MIRT2072018	hsa-miR-298	CLIP-seq
MIRT2072019	hsa-miR-3177-3p	CLIP-seq
MIRT2072020	hsa-miR-328	CLIP-seq
MIRT2072021	hsa-miR-3612	CLIP-seq
MIRT2072022	hsa-miR-3622a-5p	CLIP-seq
MIRT2072023	hsa-miR-3714	CLIP-seq
MIRT2072024	hsa-miR-3910	CLIP-seq
MIRT2072025	hsa-miR-4257	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT2072026	hsa-miR-4640-5p	CLIP-seq
MIRT2072027	hsa-miR-4695-5p	CLIP-seq
MIRT2072028	hsa-miR-4726-5p	CLIP-seq
MIRT2072029	hsa-miR-4797-5p	CLIP-seq
MIRT2072030	hsa-miR-506	CLIP-seq
MIRT2072031	hsa-miR-564	CLIP-seq
MIRT2072032	hsa-miR-650	CLIP-seq
MIRT2299063	hsa-miR-122	CLIP-seq
MIRT2299064	hsa-miR-1224-5p	CLIP-seq
MIRT1243676	hsa-miR-1252	CLIP-seq
MIRT2299065	hsa-miR-1271	CLIP-seq
MIRT2299066	hsa-miR-141	CLIP-seq
MIRT2299067	hsa-miR-182	CLIP-seq
MIRT2299068	hsa-miR-200a	CLIP-seq
MIRT2299069	hsa-miR-3136-3p	CLIP-seq
MIRT1243681	hsa-miR-3166	CLIP-seq
MIRT1243682	hsa-miR-3180	CLIP-seq
MIRT1243683	hsa-miR-3180-3p	CLIP-seq
MIRT1243684	hsa-miR-3196	CLIP-seq
MIRT2299070	hsa-miR-34a	CLIP-seq
MIRT2299071	hsa-miR-34c-5p	CLIP-seq
MIRT2299072	hsa-miR-3659	CLIP-seq
MIRT1243687	hsa-miR-3665	CLIP-seq
MIRT1243688	hsa-miR-3675-5p	CLIP-seq
MIRT2299073	hsa-miR-3918	CLIP-seq
MIRT2299074	hsa-miR-449a	CLIP-seq
MIRT2299075	hsa-miR-449b	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT2299076	hsa-miR-4691-3p	CLIP-seq
MIRT1243697	hsa-miR-4699-3p	CLIP-seq
MIRT2299077	hsa-miR-4751	CLIP-seq
MIRT1243704	hsa-miR-4771	CLIP-seq
MIRT1243705	hsa-miR-4785	CLIP-seq
MIRT1243707	hsa-miR-4790-3p	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2299078	hsa-miR-96	CLIP-seq
MIRT2392721	hsa-miR-24	CLIP-seq
MIRT2392722	hsa-miR-3121-3p	CLIP-seq
MIRT2595951	hsa-miR-3123	CLIP-seq
MIRT2595952	hsa-miR-3148	CLIP-seq
MIRT2595953	hsa-miR-3907	CLIP-seq
MIRT2595954	hsa-miR-3919	CLIP-seq
MIRT2595955	hsa-miR-4290	CLIP-seq
MIRT2595956	hsa-miR-4293	CLIP-seq
MIRT2595957	hsa-miR-4687-5p	CLIP-seq
MIRT2595958	hsa-miR-4756-3p	CLIP-seq
MIRT2595959	hsa-miR-543	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2595960	hsa-miR-873	CLIP-seq
MIRT2595952	hsa-miR-3148	CLIP-seq
MIRT2595953	hsa-miR-3907	CLIP-seq
MIRT2595955	hsa-miR-4290	CLIP-seq
MIRT2595956	hsa-miR-4293	CLIP-seq
MIRT2595957	hsa-miR-4687-5p	CLIP-seq
MIRT2595959	hsa-miR-543	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2595960	hsa-miR-873	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002116	Component	Semaphorin receptor complex	IBA
GO:0002116	Component	Semaphorin receptor complex	TAS	19909241
GO:0005515	Function	Protein binding	IPI	20138877
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	ISS
GO:0007416	Process	Synapse assembly	IBA
GO:0008045	Process	Motor neuron axon guidance	IBA
GO:0016020	Component	Membrane	IEA
GO:0017154	Function	Semaphorin receptor activity	IBA
GO:0017154	Function	Semaphorin receptor activity	IEA
GO:0017154	Function	Semaphorin receptor activity	ISS
GO:0021537	Process	Telencephalon development	IEA
GO:0021612	Process	Facial nerve structural organization	IEA
GO:0021612	Process	Facial nerve structural organization	ISS
GO:0021628	Process	Olfactory nerve formation	IEA
GO:0021637	Process	Trigeminal nerve structural organization	IEA
GO:0021637	Process	Trigeminal nerve structural organization	ISS
GO:0021766	Process	Hippocampus development	IEA
GO:0021766	Process	Hippocampus development	ISS
GO:0021785	Process	Branchiomotor neuron axon guidance	IEA
GO:0021785	Process	Branchiomotor neuron axon guidance	ISS
GO:0021828	Process	Gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA
GO:0021860	Process	Pyramidal neuron development	IEA
GO:0021860	Process	Pyramidal neuron development	ISS
GO:0030334	Process	Regulation of cell migration	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0048675	Process	Axon extension	IEA
GO:0048841	Process	Regulation of axon extension involved in axon guidance	IEA
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	IEA
GO:0050770	Process	Regulation of axonogenesis	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0050920	Process	Regulation of chemotaxis	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	NAS	19909241
GO:0097485	Process	Neuron projection guidance	IEA
GO:0097485	Process	Neuron projection guidance	ISS
GO:1990138	Process	Neuron projection extension	IEA

Other IDs

• MIM: 300022
• HGNC: 9101
• e!Ensembl: ENSG00000130827

Protein

• UniProt ID: P51805
• Protein name: Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)
• Protein function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but n
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01403	Sema	35 → 469	Sema domain	Family
  PF01437	PSI	490 → 540	Plexin repeat	Family
  PF17960	TIG_plexin	545 → 636	TIG domain	Domain
  PF01437	PSI	637 → 685	Plexin repeat	Family
  PF18020	TIG_2	690 → 784	TIG domain found in plexin	Domain
  PF01833	TIG	840 → 932	IPT/TIG domain	Domain
  PF01833	TIG	935 → 1019	IPT/TIG domain	Domain
  PF01833	TIG	1023 → 1121	IPT/TIG domain	Domain
  PF01833	TIG	1126 → 1209	IPT/TIG domain	Domain
  PF08337	Plexin_cytopl	1293 → 1841	Plexin cytoplasmic RasGAP domain	Family

• Sequence:

  MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNL
  TELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGIC
  QFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPT
  LSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLT
  LQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKP
  GLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGE
  GTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAY
  TYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDLLFSPDHRHIYLLSE
  KQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCV
  QVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQ
  ELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYR
  HTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYE
  CVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFR
  ALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHP
  RITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEE
  SLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSL
  DAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYT
  QDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCK
  APGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKP
  GSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGG
  LEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQM
  DNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKEL
  DTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYAT
  GLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLY
  CAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNC
  DSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLN
  SLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITP
  DQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTA
  HRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHK
  NSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMAS
  ISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKL
  EQIISLVSSDS

• Sequence length: 1871

Pathways

KEGG:

Axon guidance

Reactome:

Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Acute myeloid leukemia	Benign	rs5987265	RCV005935357
Adrenocortical carcinoma, hereditary	Uncertain significance	rs142270837	RCV005929167
Autism	Uncertain significance	rs2523076144, rs149367480	RCV003455874 RCV000477925
Cervical cancer	Uncertain significance; Benign	rs142270837, rs5987265	RCV005929168 RCV005935360
Childhood-onset schizophrenia	Benign	rs200042650	RCV000202331
Clear cell carcinoma of kidney	Benign	rs5987265	RCV005935361
Colon adenocarcinoma	Benign	rs5987265	RCV005935356
Disorder of sexual differentiation	Uncertain significance	rs2148244621	RCV001568329
Familial cancer of breast	Uncertain significance; Benign	rs146167713, rs150546014	RCV005932785 RCV005907648
Gastric cancer	Benign	rs5987265, rs150546014	RCV005935363 RCV005907650
Hepatocellular carcinoma	Benign	rs150546014	RCV005907649
Hypogonadotropic hypogonadism	Conflicting classifications of pathogenicity; Uncertain significance	rs5945430, rs2069048215, rs2069103152, rs150035406, rs782774035	RCV006279269 RCV001374681 RCV001374682 RCV001374683 RCV001374685
Lung cancer	Benign	rs5987265	RCV005935365
Malignant tumor of esophagus	Benign	rs5987265	RCV005935358
Microtia	Uncertain significance	rs149367480	RCV000477925
Neurodevelopmental disorder	Uncertain significance	rs782528486	RCV001262953
Nonpapillary renal cell carcinoma	Uncertain significance; Benign	rs200342725, rs5987265	RCV005932801 RCV005935359
PLXNA3-associated seizure disorder	Uncertain significance	rs2148244525	RCV001839114
PLXNA3-related disorder	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	rs782247717, rs35285799, rs781806360, rs200042650, rs144427846, rs202189139, rs150094168, rs372936004, rs782449636, rs201267859, rs139368340, rs781866776, rs376089205, rs373466863, rs369159707, rs142513042, rs138319096, rs200617248, rs148224862, rs145231103, rs199861985, rs376854661, rs782478483, rs142270837, rs781795304, rs143491103, rs782585263, rs201318025, rs374885337, rs782538859, rs141189623, rs782426462, rs149048914, rs150493678, rs201164440, rs369262880, rs781965411, rs200421034, rs1557205840, rs376423590, rs181269464, rs375752173, rs1557204266, rs782575034, rs376154383, rs148993102, rs184926947, rs1237660233, rs147960153, rs2523087298, rs371220483, rs375138921, rs200063870, rs781946606, rs146580781, rs368269282, rs368827077, rs199954840, rs371800667, rs200444772, rs146167713, rs149423704, rs143244763, rs782539165, rs1557208607, rs782543136, rs369435958, rs1255948130, rs897453344, rs782808493, rs370210706, rs375290922, rs201284044, rs2523085365, rs144336050, rs374335521, rs782229837, rs142245785, rs968688350, rs370812969, rs782464424, rs145244142, rs372123075, rs143007606, rs782056412, rs201983357, rs200060299, rs375016053, rs200342725, rs141311907, rs782602470, rs370979283, rs200868961, rs782248664, rs782347596, rs192841912, rs184056478, rs782042921, rs368907905, rs781890418, rs370470034, rs782092046, rs200093414, rs146456043, rs371665634, rs782573186, rs782276640, rs1449005376, rs367770095, rs949147044, rs200478230, rs2069158147, rs782556928, rs782775495, rs199780412, rs782767005, rs782226260, rs143354413, rs192776944, rs782506477, rs782189650, rs782760823, rs1206186201, rs1362648890, rs1261337185, rs782743853, rs782437535, rs782513820, rs137934756, rs782401505, rs35567597, rs199905351, rs781938991, rs782676452, rs782434703, rs371484357, rs782275281, rs782188114, rs782410957, rs143738443, rs201094369, rs782486790, rs782660964, rs1557208741, rs782004593, rs781949167, rs782311072, rs140141994, rs200880623, rs782794636, rs782554617, rs377575555, rs371806256, rs139166383, rs782458439, rs140776875, rs782708120, rs150235336, rs140476523, rs1349241842, rs139434525, rs781986296, rs372028579, rs1557205037, rs782492457, rs782635524, rs142516376, rs375310385, rs200721928, rs1027389426, rs188710474, rs781816637, rs782163370, rs140484283, rs782473883, rs781945902, rs140777906, rs144840211, rs370868352, rs202056396, rs1282567562, rs148059076, rs781810524, rs782120298, rs781912419, rs782071805, rs958950730, rs150337074, rs782195255, rs781996131, rs375560348, rs150039641, rs782688241, rs782046195, rs1557204442, rs375993377, rs143822288, rs376389948, rs146025967, rs1557206112, rs199705758, rs139270764, rs138811959, rs782436479, rs782023272, rs374284684, rs782590505, rs6643608, rs188830708, rs6643609, rs1557208815, rs782247826, rs373213513, rs146370191, rs377627483, rs782634194, rs782520547, rs199507126, rs143622764, rs199501544, rs201950962, rs369173697, rs199541567, rs202053669, rs142165702, rs369833329, rs150500748, rs201749397, rs144757857, rs148620908, rs143928608, rs781804704, rs147793684, rs139526851, rs144950198, rs782513809, rs145388937, rs146912790, rs201820066, rs782364397, rs149300616, rs782633521, rs139573527, rs782618267, rs148672767, rs200804384, rs201411324, rs2523060744, rs1478320804, rs191903829, rs140961230, rs782021071, rs57535644, rs150180614, rs5987265, rs782526970, rs201840250, rs782675595, rs374238497, rs151240042, rs781821504, rs149751983, rs140160422, rs199852866, rs200031701, rs143834428, rs148820056, rs201924446, rs782107582, rs782817783, rs148871846, rs782503035, rs782596274, rs782065498, rs374032775, rs150974296, rs781883186, rs150847200, rs142629148, rs782458950, rs145476494, rs181941264, rs201403408, rs782408788, rs149100691, rs145756790, rs1040005687, rs147390702, rs199982509, rs782417721, rs782264572, rs34401913, rs781844192, rs782400956, rs1557207155, rs2523062090, rs2069158301, rs782778301, rs782060714, rs200019038, rs370403729, rs376499905, rs374246725, rs202070666, rs35880504, rs147019078, rs79671454, rs142692328, rs113031143, rs140563543, rs141197316, rs139336954, rs56277624, rs144393472, rs149878050, rs34328761, rs146539077, rs142993803, rs5986980, rs148785068, rs139705497, rs36115591, rs35700706, rs138419530, rs151275064, rs782339269, rs145475407, rs149665008, rs201608832, rs782710505, rs147816954, rs369549579, rs34585333, rs782298917, rs370105284, rs150943884, rs781871529, rs782607201, rs186879417, rs781976607, rs190675077	RCV003900808 RCV003976066 RCV004743563 RCV003977502 RCV004744635 RCV003946349 RCV003918953 RCV003963731 RCV004744642 RCV003963741 RCV003918963 RCV003420451 RCV003420455 RCV003420458 RCV004741535 RCV003954016 RCV003420488 RCV003427647 RCV004741537 RCV003963764 RCV003936683 RCV003420509 RCV003420499 RCV003954026 RCV004741541 RCV003420502 RCV003395685 RCV004741543 RCV003395689 RCV003420534 RCV003427681 RCV003900925 RCV003928938 RCV003396940 RCV003919025 RCV004741565 RCV003395716 RCV004741563 RCV004741572 RCV003900996 RCV004741579 RCV003396980 RCV004741583 RCV004741585 RCV004741597 RCV003412017 RCV003399762 RCV003414117 RCV003405785 RCV003404362 RCV003392736 RCV003392740 RCV003408631 RCV003427839 RCV003427840 RCV003427858 RCV003427867 RCV003408688 RCV003402614 RCV003427891 RCV003392797 RCV003419237 RCV003419248 RCV003402877 RCV003402203 RCV003414517 RCV003427794 RCV003405983 RCV003414591 RCV003416646 RCV003419115 RCV003410664 RCV003397347 RCV003391273 RCV003410417 RCV003410455 RCV003403000 RCV003410777 RCV003410838 RCV003399841 RCV003414214 RCV003392801 RCV003418753 RCV003402654 RCV003402682 RCV003427898 RCV003402697 RCV003402982 RCV003420963 RCV003908972 RCV003919237 RCV003901081 RCV003966441 RCV003919238 RCV003908973 RCV004741607 RCV003966442 RCV003901082 RCV003946628 RCV003901083 RCV003946629 RCV003980953 RCV004741608 RCV004741609 RCV003901084 RCV003939043 RCV004741610 RCV003966443 RCV004741758 RCV003896512 RCV003896539 RCV003896712 RCV003898922 RCV003899060 RCV003896770 RCV003896811 RCV003896941 RCV003897089 RCV003897136 RCV003897142 RCV003894569 RCV003894652 RCV003894662 RCV003907080 RCV003909468 RCV003921432 RCV003921436 RCV003921443 RCV003921530 RCV003921668 RCV003919819 RCV003923821 RCV003917298 RCV003929790 RCV003981619 RCV003983468 RCV003893650 RCV003893704 RCV003893755 RCV003896424 RCV003896440 RCV003893866 RCV003893874 RCV003893930 RCV003894022 RCV003894241 RCV003902136 RCV003902189 RCV003902224 RCV003892317 RCV003904153 RCV003906804 RCV003897407 RCV003912329 RCV003904316 RCV003904320 RCV003904353 RCV003904362 RCV003904396 RCV003904421 RCV003904539 RCV003904541 RCV003904552 RCV003904613 RCV003904655 RCV003974198 RCV003984754 RCV003984771 RCV003901483 RCV003901737 RCV003901766 RCV003901804 RCV003901811 RCV003899756 RCV003899842 RCV003899847 RCV003901978 RCV003902006 RCV003911806 RCV003903825 RCV003904109 RCV003911918 RCV003977094 RCV003899121 RCV003899124 RCV003899214 RCV003899250 RCV003899283 RCV003899290 RCV003899344 RCV003892260 RCV003899413 RCV003899464 RCV003899486 RCV003899646 RCV003899656 RCV003911590 RCV003913829 RCV003913852 RCV003913864 RCV003913891 RCV003913940 RCV003913941 RCV003913942 RCV003914050 RCV003914056 RCV003943932 RCV003944017 RCV003951882 RCV003951918 RCV003951975 RCV003952183 RCV003961673 RCV003961745 RCV003961830 RCV003947322 RCV003959505 RCV003959683 RCV003947409 RCV003962122 RCV003964105 RCV003964169 RCV003969853 RCV003954900 RCV003971892 RCV003971951 RCV003931481 RCV003929484 RCV003924541 RCV003949557 RCV003959237 RCV003959371 RCV003944500 RCV003961490 RCV003949294 RCV003951473 RCV003947069 RCV003947228 RCV003947231 RCV003949453 RCV003949492 RCV003958913 RCV003957034 RCV003957104 RCV003922071 RCV003931957 RCV003927390 RCV003942251 RCV003934304 RCV003949217 RCV003946779 RCV003946924 RCV003947005 RCV003947059 RCV003952302 RCV003944310 RCV003956840 RCV003979119 RCV003981850 RCV003983517 RCV003983555 RCV003983616 RCV003957336 RCV003957382 RCV003959453 RCV003959476 RCV003969529 RCV003954823 RCV003969560 RCV003969562 RCV003969574 RCV003969589 RCV003969661 RCV003969683 RCV003954872 RCV003969726 RCV003969792 RCV003967013 RCV003967073 RCV003967082 RCV003967155 RCV003967156 RCV003967219 RCV003969412 RCV003969418 RCV003969456 RCV003976518 RCV003976664 RCV003969062 RCV003966868 RCV003966885 RCV003966922 RCV003966949 RCV003981291 RCV003972204 RCV004741777 RCV004723597 RCV004741778 RCV004723598 RCV004723599 RCV004741779 RCV004741780 RCV004741781 RCV004741782 RCV004741785 RCV003960207 RCV003392576 RCV003915970 RCV003960647 RCV003933266 RCV003972933 RCV003962910 RCV003960832 RCV003926207 RCV003928547 RCV003906075 RCV003936157 RCV003910650 RCV003968053 RCV003957937 RCV003983251 RCV003910457 RCV003958152 RCV003932831 RCV003958098 RCV003958178 RCV003958153 RCV003932928 RCV003968392 RCV003968359 RCV003922956 RCV004742683 RCV003950498 RCV003968292 RCV003960443 RCV003970446 RCV003933068 RCV004743194 RCV003960440 RCV003923198 RCV003942877 RCV003933158 RCV003913186 RCV003960529 RCV003960475
Sarcoma	Benign	rs5987265	RCV005935362
Short stature	Conflicting classifications of pathogenicity; Uncertain significance	rs202070666, rs782515431	RCV000736201 RCV000736200
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs781931954	RCV005939403
Uterine carcinosarcoma	Benign	rs5987265	RCV005935364
Uterine corpus endometrial carcinoma	Benign	rs5987265	RCV005935366

Associations from Text Mining
Disease Name	Relationship Type	References
ATR X syndrome	Associate	34740135
Attention Deficit Disorder with Hyperactivity	Associate	34740135
Autistic Disorder	Associate	34740135
Developmental Disabilities	Associate	34740135
Endometrial Neoplasms	Inhibit	21933904
Growth Disorders	Associate	30809043
Idiopathic Hypogonadotropic Hypogonadism	Associate	33495532
Intellectual Disability	Associate	34740135
Ovarian Neoplasms	Inhibit	20124444
Personality Disorders	Associate	34740135
Seizures	Associate	34740135
Tremor	Associate	34740135