PLXNA3 (plexin A3)

Gene

• Entrez ID: 55558
• Gene name: Plexin A3
• Gene symbol: PLXNA3
• Synonyms (NCBI Gene): 6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
• Chromosome: X
• Chromosome location: Xq28
• Summary: This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs202070666	G>A	Likely-pathogenic	Upstream transcript variant, genic upstream transcript variant, intron variant, non coding transcript variant, coding sequence variant, missense variant
rs782515431	G>C	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018079	hsa-miR-335-5p	Microarray	18185580
MIRT687218	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT687217	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT687216	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT687215	hsa-miR-5694	HITS-CLIP	23313552
MIRT687214	hsa-miR-154-3p	HITS-CLIP	23313552
MIRT687213	hsa-miR-487a-3p	HITS-CLIP	23313552
MIRT687212	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT687211	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT687210	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT687209	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT687208	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT687207	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT687206	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT687205	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT687204	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT687203	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT687202	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT687201	hsa-miR-612	HITS-CLIP	23313552
MIRT687200	hsa-miR-6860	HITS-CLIP	23313552
MIRT687199	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT687198	hsa-miR-661	HITS-CLIP	23313552
MIRT687197	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT687194	hsa-miR-7703	HITS-CLIP	23313552
MIRT687193	hsa-miR-4325	HITS-CLIP	23313552
MIRT645933	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT645932	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT645931	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT645930	hsa-miR-3183	HITS-CLIP	23824327
MIRT645929	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT645928	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT645927	hsa-miR-4469	HITS-CLIP	23824327
MIRT645926	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT645925	hsa-miR-4287	HITS-CLIP	23824327
MIRT645924	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645923	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT645922	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT645921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645919	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT645918	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645917	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT645916	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT645915	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645914	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645913	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT645912	hsa-miR-5691	HITS-CLIP	23824327
MIRT645911	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT645910	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT645909	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT645908	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT645907	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT645906	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT625925	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619210	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT687217	hsa-miR-508-5p	HITS-CLIP	27418678
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	27418678
MIRT687198	hsa-miR-661	HITS-CLIP	27418678
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	27418678
MIRT687205	hsa-miR-766-3p	HITS-CLIP	27418678
MIRT687194	hsa-miR-7703	HITS-CLIP	27418678
MIRT687206	hsa-miR-939-3p	HITS-CLIP	27418678
MIRT687218	hsa-miR-6512-5p	HITS-CLIP	23313552
MIRT687217	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT687216	hsa-miR-5586-3p	HITS-CLIP	23313552
MIRT687215	hsa-miR-5694	HITS-CLIP	23313552
MIRT687214	hsa-miR-154-3p	HITS-CLIP	23313552
MIRT687213	hsa-miR-487a-3p	HITS-CLIP	23313552
MIRT687212	hsa-miR-25-3p	HITS-CLIP	23313552
MIRT687211	hsa-miR-32-5p	HITS-CLIP	23313552
MIRT687210	hsa-miR-363-3p	HITS-CLIP	23313552
MIRT687209	hsa-miR-367-3p	HITS-CLIP	23313552
MIRT687208	hsa-miR-92a-3p	HITS-CLIP	23313552
MIRT687207	hsa-miR-92b-3p	HITS-CLIP	23313552
MIRT687206	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT687205	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT687204	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT687203	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT687202	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT687201	hsa-miR-612	HITS-CLIP	23313552
MIRT687200	hsa-miR-6860	HITS-CLIP	23313552
MIRT687199	hsa-miR-4738-3p	HITS-CLIP	23313552
MIRT687198	hsa-miR-661	HITS-CLIP	23313552
MIRT687197	hsa-miR-196a-3p	HITS-CLIP	23313552
MIRT687196	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT687195	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT687194	hsa-miR-7703	HITS-CLIP	23313552
MIRT687193	hsa-miR-4325	HITS-CLIP	23313552
MIRT645933	hsa-miR-425-5p	HITS-CLIP	23824327
MIRT645932	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT645931	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT645930	hsa-miR-3183	HITS-CLIP	23824327
MIRT645929	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT645928	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT645927	hsa-miR-4469	HITS-CLIP	23824327
MIRT645926	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT645925	hsa-miR-4287	HITS-CLIP	23824327
MIRT645924	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645923	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT645922	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT645921	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT645920	hsa-miR-3124-3p	HITS-CLIP	23824327
MIRT645919	hsa-miR-3117-5p	HITS-CLIP	23824327
MIRT645918	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645917	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT645916	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT645915	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT645914	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT645913	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT645912	hsa-miR-5691	HITS-CLIP	23824327
MIRT645911	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT645910	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT645909	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT645908	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT645907	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT645906	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT625925	hsa-miR-5589-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619213	hsa-miR-1207-3p	HITS-CLIP	23824327
MIRT619212	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT619211	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT619210	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1243676	hsa-miR-1252	CLIP-seq
MIRT1243677	hsa-miR-125a-3p	CLIP-seq
MIRT1243678	hsa-miR-1273	CLIP-seq
MIRT1243679	hsa-miR-1321	CLIP-seq
MIRT1243680	hsa-miR-184	CLIP-seq
MIRT1243681	hsa-miR-3166	CLIP-seq
MIRT1243682	hsa-miR-3180	CLIP-seq
MIRT1243683	hsa-miR-3180-3p	CLIP-seq
MIRT1243684	hsa-miR-3196	CLIP-seq
MIRT1243685	hsa-miR-3199	CLIP-seq
MIRT1243686	hsa-miR-3654	CLIP-seq
MIRT1243687	hsa-miR-3665	CLIP-seq
MIRT1243688	hsa-miR-3675-5p	CLIP-seq
MIRT1243689	hsa-miR-3683	CLIP-seq
MIRT1243690	hsa-miR-4270	CLIP-seq
MIRT1243691	hsa-miR-4441	CLIP-seq
MIRT1243692	hsa-miR-4447	CLIP-seq
MIRT1243693	hsa-miR-4472	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT1243695	hsa-miR-4648	CLIP-seq
MIRT1243696	hsa-miR-4690-5p	CLIP-seq
MIRT1243697	hsa-miR-4699-3p	CLIP-seq
MIRT1243698	hsa-miR-4728-5p	CLIP-seq
MIRT1243699	hsa-miR-4736	CLIP-seq
MIRT1243700	hsa-miR-4739	CLIP-seq
MIRT1243701	hsa-miR-4756-5p	CLIP-seq
MIRT1243702	hsa-miR-4765	CLIP-seq
MIRT1243703	hsa-miR-4767	CLIP-seq
MIRT1243704	hsa-miR-4771	CLIP-seq
MIRT1243705	hsa-miR-4785	CLIP-seq
MIRT1243706	hsa-miR-4789-3p	CLIP-seq
MIRT1243707	hsa-miR-4790-3p	CLIP-seq
MIRT1243708	hsa-miR-4804-5p	CLIP-seq
MIRT1243709	hsa-miR-642b	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2072017	hsa-miR-124	CLIP-seq
MIRT2072018	hsa-miR-298	CLIP-seq
MIRT2072019	hsa-miR-3177-3p	CLIP-seq
MIRT2072020	hsa-miR-328	CLIP-seq
MIRT2072021	hsa-miR-3612	CLIP-seq
MIRT2072022	hsa-miR-3622a-5p	CLIP-seq
MIRT2072023	hsa-miR-3714	CLIP-seq
MIRT2072024	hsa-miR-3910	CLIP-seq
MIRT2072025	hsa-miR-4257	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT2072026	hsa-miR-4640-5p	CLIP-seq
MIRT2072027	hsa-miR-4695-5p	CLIP-seq
MIRT2072028	hsa-miR-4726-5p	CLIP-seq
MIRT2072029	hsa-miR-4797-5p	CLIP-seq
MIRT2072030	hsa-miR-506	CLIP-seq
MIRT2072031	hsa-miR-564	CLIP-seq
MIRT2072032	hsa-miR-650	CLIP-seq
MIRT2299063	hsa-miR-122	CLIP-seq
MIRT2299064	hsa-miR-1224-5p	CLIP-seq
MIRT1243676	hsa-miR-1252	CLIP-seq
MIRT2299065	hsa-miR-1271	CLIP-seq
MIRT2299066	hsa-miR-141	CLIP-seq
MIRT2299067	hsa-miR-182	CLIP-seq
MIRT2299068	hsa-miR-200a	CLIP-seq
MIRT2299069	hsa-miR-3136-3p	CLIP-seq
MIRT1243681	hsa-miR-3166	CLIP-seq
MIRT1243682	hsa-miR-3180	CLIP-seq
MIRT1243683	hsa-miR-3180-3p	CLIP-seq
MIRT1243684	hsa-miR-3196	CLIP-seq
MIRT2299070	hsa-miR-34a	CLIP-seq
MIRT2299071	hsa-miR-34c-5p	CLIP-seq
MIRT2299072	hsa-miR-3659	CLIP-seq
MIRT1243687	hsa-miR-3665	CLIP-seq
MIRT1243688	hsa-miR-3675-5p	CLIP-seq
MIRT2299073	hsa-miR-3918	CLIP-seq
MIRT2299074	hsa-miR-449a	CLIP-seq
MIRT2299075	hsa-miR-449b	CLIP-seq
MIRT1243694	hsa-miR-4534	CLIP-seq
MIRT2299076	hsa-miR-4691-3p	CLIP-seq
MIRT1243697	hsa-miR-4699-3p	CLIP-seq
MIRT2299077	hsa-miR-4751	CLIP-seq
MIRT1243704	hsa-miR-4771	CLIP-seq
MIRT1243705	hsa-miR-4785	CLIP-seq
MIRT1243707	hsa-miR-4790-3p	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2299078	hsa-miR-96	CLIP-seq
MIRT2392721	hsa-miR-24	CLIP-seq
MIRT2392722	hsa-miR-3121-3p	CLIP-seq
MIRT2595951	hsa-miR-3123	CLIP-seq
MIRT2595952	hsa-miR-3148	CLIP-seq
MIRT2595953	hsa-miR-3907	CLIP-seq
MIRT2595954	hsa-miR-3919	CLIP-seq
MIRT2595955	hsa-miR-4290	CLIP-seq
MIRT2595956	hsa-miR-4293	CLIP-seq
MIRT2595957	hsa-miR-4687-5p	CLIP-seq
MIRT2595958	hsa-miR-4756-3p	CLIP-seq
MIRT2595959	hsa-miR-543	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2595960	hsa-miR-873	CLIP-seq
MIRT2595952	hsa-miR-3148	CLIP-seq
MIRT2595953	hsa-miR-3907	CLIP-seq
MIRT2595955	hsa-miR-4290	CLIP-seq
MIRT2595956	hsa-miR-4293	CLIP-seq
MIRT2595957	hsa-miR-4687-5p	CLIP-seq
MIRT2595959	hsa-miR-543	CLIP-seq
MIRT1243710	hsa-miR-764	CLIP-seq
MIRT2595960	hsa-miR-873	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002116	Component	Semaphorin receptor complex	IBA
GO:0002116	Component	Semaphorin receptor complex	TAS	19909241
GO:0005515	Function	Protein binding	IPI	20138877
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	ISS
GO:0007416	Process	Synapse assembly	IBA
GO:0008045	Process	Motor neuron axon guidance	IBA
GO:0016020	Component	Membrane	IEA
GO:0017154	Function	Semaphorin receptor activity	IBA
GO:0017154	Function	Semaphorin receptor activity	IEA
GO:0017154	Function	Semaphorin receptor activity	ISS
GO:0021537	Process	Telencephalon development	IEA
GO:0021612	Process	Facial nerve structural organization	IEA
GO:0021612	Process	Facial nerve structural organization	ISS
GO:0021628	Process	Olfactory nerve formation	IEA
GO:0021637	Process	Trigeminal nerve structural organization	IEA
GO:0021637	Process	Trigeminal nerve structural organization	ISS
GO:0021766	Process	Hippocampus development	IEA
GO:0021766	Process	Hippocampus development	ISS
GO:0021785	Process	Branchiomotor neuron axon guidance	IEA
GO:0021785	Process	Branchiomotor neuron axon guidance	ISS
GO:0021828	Process	Gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IEA
GO:0021860	Process	Pyramidal neuron development	IEA
GO:0021860	Process	Pyramidal neuron development	ISS
GO:0030334	Process	Regulation of cell migration	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0048675	Process	Axon extension	IEA
GO:0048841	Process	Regulation of axon extension involved in axon guidance	IEA
GO:0048843	Process	Negative regulation of axon extension involved in axon guidance	IEA
GO:0048846	Process	Axon extension involved in axon guidance	IEA
GO:0050770	Process	Regulation of axonogenesis	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0050919	Process	Negative chemotaxis	IEA
GO:0050920	Process	Regulation of chemotaxis	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	IEA
GO:0051495	Process	Positive regulation of cytoskeleton organization	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0071526	Process	Semaphorin-plexin signaling pathway	NAS	19909241
GO:0097485	Process	Neuron projection guidance	IEA
GO:0097485	Process	Neuron projection guidance	ISS
GO:1990138	Process	Neuron projection extension	IEA

Other IDs

• MIM: 300022
• HGNC: 9101
• e!Ensembl: ENSG00000130827

Protein

• UniProt ID: P51805
• Protein name: Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)
• Protein function: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but n
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01403	Sema	35 → 469	Sema domain	Family
  PF01437	PSI	490 → 540	Plexin repeat	Family
  PF17960	TIG_plexin	545 → 636	TIG domain	Domain
  PF01437	PSI	637 → 685	Plexin repeat	Family
  PF18020	TIG_2	690 → 784	TIG domain found in plexin	Domain
  PF01833	TIG	840 → 932	IPT/TIG domain	Domain
  PF01833	TIG	935 → 1019	IPT/TIG domain	Domain
  PF01833	TIG	1023 → 1121	IPT/TIG domain	Domain
  PF01833	TIG	1126 → 1209	IPT/TIG domain	Domain
  PF08337	Plexin_cytopl	1293 → 1841	Plexin cytoplasmic RasGAP domain	Family

• Sequence:

  MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNL
  TELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGIC
  QFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPT
  LSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLT
  LQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKP
  GLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGE
  GTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAY
  TYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDLLFSPDHRHIYLLSE
  KQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCV
  QVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQ
  ELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYR
  HTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYE
  CVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFR
  ALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHP
  RITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEE
  SLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSL
  DAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYT
  QDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCK
  APGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKP
  GSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGG
  LEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQM
  DNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKEL
  DTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYAT
  GLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLY
  CAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNC
  DSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLN
  SLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITP
  DQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTA
  HRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHK
  NSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMAS
  ISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKL
  EQIISLVSSDS

• Sequence length: 1871

Pathways

KEGG:

Axon guidance

Reactome:

Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Schizophrenia	Childhood-onset schizophrenia	N/A	N/A	ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
ATR X syndrome	Associate	34740135
Attention Deficit Disorder with Hyperactivity	Associate	34740135
Autistic Disorder	Associate	34740135
Developmental Disabilities	Associate	34740135
Endometrial Neoplasms	Inhibit	21933904
Growth Disorders	Associate	30809043
Idiopathic Hypogonadotropic Hypogonadism	Associate	33495532
Intellectual Disability	Associate	34740135
Ovarian Neoplasms	Inhibit	20124444
Personality Disorders	Associate	34740135
Seizures	Associate	34740135
Tremor	Associate	34740135