Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55558
Gene name Gene Name - the full gene name approved by the HGNC.
Plexin A3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLXNA3
Synonyms (NCBI Gene) Gene synonyms aliases
6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
Chromosome Chromosome number
X
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
Xq28
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs202070666 G>A Likely-pathogenic Upstream transcript variant, genic upstream transcript variant, intron variant, non coding transcript variant, coding sequence variant, missense variant
rs782515431 G>C Likely-pathogenic Coding sequence variant, non coding transcript variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT018079 hsa-miR-335-5p Microarray 18185580
MIRT687218 hsa-miR-6512-5p HITS-CLIP 23313552
MIRT687217 hsa-miR-508-5p HITS-CLIP 23313552
MIRT687216 hsa-miR-5586-3p HITS-CLIP 23313552
MIRT687215 hsa-miR-5694 HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002116 Component Semaphorin receptor complex IBA 21873635
GO:0002116 Component Semaphorin receptor complex TAS 19909241
GO:0004888 Function Transmembrane signaling receptor activity NAS 8570614
GO:0005515 Function Protein binding IPI 20138877
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
300022 9101 ENSG00000130827
Protein
UniProt ID P51805
Protein name Plexin-A3 (Plexin-4) (Semaphorin receptor SEX)
Protein function Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but n
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01403 Sema 35 469 Sema domain Family
PF01437 PSI 490 540 Plexin repeat Family
PF17960 TIG_plexin 545 636 TIG domain Domain
PF01437 PSI 637 685 Plexin repeat Family
PF18020 TIG_2 690 784 TIG domain found in plexin Domain
PF01833 TIG 840 932 IPT/TIG domain Domain
PF01833 TIG 935 1019 IPT/TIG domain Domain
PF01833 TIG 1023 1121 IPT/TIG domain Domain
PF01833 TIG 1126 1209 IPT/TIG domain Domain
PF08337 Plexin_cytopl 1293 1841 Plexin cytoplasmic RasGAP domain Family
Sequence
MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNL
TELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGIC
QFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPT
LSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLT
LQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKP
GLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGE
GTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAY
TYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDLLFS
PDHRHIYLLSE
KQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCV
QVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQ
ELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFY
NCSVLQSCMSCVGSPYPCHWCKYR
HTCTSRPHECSFQEGRVHSPEGCPE
ILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYE
CVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFR
ALLY
KCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHP
RITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEE
SLVPSPPPGPVELCVGDCSADFRTQSEQVYSF
VTPTFDQVSPSRGPASGGTRLTISGSSL
DAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTY
T
QDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCK
APGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTY
YPDPSFEPLGPSGVLDVKP
GSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGG
LEFWLGTLH
ISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQM
DNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKEL
DTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYAT
GLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLY
CAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNC
DSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLN
SLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITP
DQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTA
HRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHK
NSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMAS
ISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEI
LTALDRDASCRKHKLRQKL
EQIISLVSSDS
Sequence length 1871
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Axon guidance   Sema3A PAK dependent Axon repulsion
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
CRMPs in Sema3A signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Endometrial carcinoma Endometrial Carcinoma rs34612342, rs587776667, rs587776701, rs63750955, rs587776706, rs121434629, rs80359605, rs121913530, rs104894365, rs79184941, rs121913478, rs63750781, rs193922343, rs267608094, rs267608077
View all (247 more)
21933904
Associations from Text Mining
Disease Name Relationship Type References
ATR X syndrome Associate 34740135
Attention Deficit Disorder with Hyperactivity Associate 34740135
Autistic Disorder Associate 34740135
Developmental Disabilities Associate 34740135
Endometrial Neoplasms Inhibit 21933904
Growth Disorders Associate 30809043
Idiopathic Hypogonadotropic Hypogonadism Associate 33495532
Intellectual Disability Associate 34740135
Ovarian Neoplasms Inhibit 20124444
Personality Disorders Associate 34740135