KLK15 (kallikrein related peptidase 15)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
55554
Gene name Gene Name - the full gene name approved by the HGNC.
Kallikrein related peptidase 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KLK15
Synonyms (NCBI Gene) Gene synonyms aliases
ACO, HSRNASPH
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(8)
miRTarBase ID miRNA Experiments Reference
MIRT1099020 hsa-miR-4264 CLIP-seq
MIRT1099021 hsa-miR-4488 CLIP-seq
MIRT1099022 hsa-miR-4688 CLIP-seq
MIRT1099023 hsa-miR-4697-5p CLIP-seq
MIRT1099024 hsa-miR-4704-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(13)
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IBA
GO:0004252 Function Serine-type endopeptidase activity IEA
GO:0004252 Function Serine-type endopeptidase activity NAS 11010966
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005576 Component Extracellular region IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
610601 20453 ENSG00000174562
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9H2R5
Protein name Kallikrein-15 (EC 3.4.21.-) (ACO protease)
Protein function Protease whose physiological substrate is not yet known.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 22 → 249 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Highest expression in the thyroid gland. Also expressed in the prostate, salivary, and adrenal glands and in the colon testis and kidney. {ECO:0000269|PubMed:11010966}.
Sequence
Sequence length 256
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Prostate cancer Prostate cancer, Prostate cancer (late onset) N/A N/A GWAS
Show/Hide Text Mining Associations (14)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 32592124
Adenoma Pleomorphic Associate 30120721
Ascites Associate 16557045
Breast Neoplasms Associate 12439720
Cap Myopathy Associate 20067463
Inflammation Associate 17823117
Lung Neoplasms Associate 19170196
Neoplasms Associate 17823117, 20067463, 23391636, 23894413
Neurodegenerative Diseases Associate 17823117
Ovarian Neoplasms Associate 16557045, 21457553, 29095848