MAML3 (mastermind like transcriptional coactivator 3)

Gene

• Entrez ID: 55534
• Gene name: Mastermind like transcriptional coactivator 3
• Gene symbol: MAML3
• Synonyms (NCBI Gene): CAGH3, ERDA3, GDN, MAM-2, MAM2, TNRC3, mam-3
• Chromosome: 4
• Chromosome location: 4q31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	20371350
MIRT508436	hsa-miR-1272	PAR-CLIP	20371350
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT508434	hsa-miR-4679	PAR-CLIP	20371350
MIRT508433	hsa-miR-4424	PAR-CLIP	20371350
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	20371350
MIRT508436	hsa-miR-1272	PAR-CLIP	20371350
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT508434	hsa-miR-4679	PAR-CLIP	20371350
MIRT508433	hsa-miR-4424	PAR-CLIP	20371350
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT547539	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547537	hsa-miR-485-3p	PAR-CLIP	21572407
MIRT547536	hsa-miR-539-3p	PAR-CLIP	21572407
MIRT547535	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT547534	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547539	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547537	hsa-miR-485-3p	PAR-CLIP	21572407
MIRT547536	hsa-miR-539-3p	PAR-CLIP	21572407
MIRT547535	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT547534	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT536193	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT536192	hsa-miR-651-3p	PAR-CLIP	22012620
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	22012620
MIRT536191	hsa-miR-5684	PAR-CLIP	22012620
MIRT508436	hsa-miR-1272	PAR-CLIP	22012620
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT508434	hsa-miR-4679	PAR-CLIP	22012620
MIRT508433	hsa-miR-4424	PAR-CLIP	22012620
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	22012620
MIRT536190	hsa-miR-4477b	PAR-CLIP	22012620
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	23446348
MIRT508436	hsa-miR-1272	PAR-CLIP	23446348
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT508434	hsa-miR-4679	PAR-CLIP	23446348
MIRT508433	hsa-miR-4424	PAR-CLIP	23446348
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	20371350
MIRT508436	hsa-miR-1272	PAR-CLIP	20371350
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT508434	hsa-miR-4679	PAR-CLIP	20371350
MIRT508433	hsa-miR-4424	PAR-CLIP	20371350
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	20371350
MIRT508436	hsa-miR-1272	PAR-CLIP	20371350
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	20371350
MIRT508434	hsa-miR-4679	PAR-CLIP	20371350
MIRT508433	hsa-miR-4424	PAR-CLIP	20371350
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	20371350
MIRT547539	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547537	hsa-miR-485-3p	PAR-CLIP	21572407
MIRT547536	hsa-miR-539-3p	PAR-CLIP	21572407
MIRT547535	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT547534	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547539	hsa-miR-144-3p	PAR-CLIP	21572407
MIRT547538	hsa-miR-101-3p	PAR-CLIP	21572407
MIRT547537	hsa-miR-485-3p	PAR-CLIP	21572407
MIRT547536	hsa-miR-539-3p	PAR-CLIP	21572407
MIRT547535	hsa-miR-576-3p	PAR-CLIP	21572407
MIRT547534	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT536193	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT536192	hsa-miR-651-3p	PAR-CLIP	22012620
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	22012620
MIRT536191	hsa-miR-5684	PAR-CLIP	22012620
MIRT508436	hsa-miR-1272	PAR-CLIP	22012620
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	22012620
MIRT508434	hsa-miR-4679	PAR-CLIP	22012620
MIRT508433	hsa-miR-4424	PAR-CLIP	22012620
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	22012620
MIRT536190	hsa-miR-4477b	PAR-CLIP	22012620
MIRT508437	hsa-miR-1255b-2-3p	PAR-CLIP	23446348
MIRT508436	hsa-miR-1272	PAR-CLIP	23446348
MIRT508435	hsa-miR-1273g-3p	PAR-CLIP	23446348
MIRT508434	hsa-miR-4679	PAR-CLIP	23446348
MIRT508433	hsa-miR-4424	PAR-CLIP	23446348
MIRT508432	hsa-miR-3682-3p	PAR-CLIP	23446348
MIRT1126939	hsa-miR-101	CLIP-seq
MIRT1126940	hsa-miR-1202	CLIP-seq
MIRT1126941	hsa-miR-1224-3p	CLIP-seq
MIRT1126942	hsa-miR-1288	CLIP-seq
MIRT1126943	hsa-miR-144	CLIP-seq
MIRT1126944	hsa-miR-18a	CLIP-seq
MIRT1126945	hsa-miR-18b	CLIP-seq
MIRT1126946	hsa-miR-1976	CLIP-seq
MIRT1126947	hsa-miR-2392	CLIP-seq
MIRT1126948	hsa-miR-302f	CLIP-seq
MIRT1126949	hsa-miR-3126-5p	CLIP-seq
MIRT1126950	hsa-miR-3140-3p	CLIP-seq
MIRT1126951	hsa-miR-3199	CLIP-seq
MIRT1126952	hsa-miR-370	CLIP-seq
MIRT1126953	hsa-miR-3944-5p	CLIP-seq
MIRT1126954	hsa-miR-3972	CLIP-seq
MIRT1126955	hsa-miR-4254	CLIP-seq
MIRT1126956	hsa-miR-4257	CLIP-seq
MIRT1126957	hsa-miR-4293	CLIP-seq
MIRT1126958	hsa-miR-4443	CLIP-seq
MIRT1126959	hsa-miR-4640-5p	CLIP-seq
MIRT1126960	hsa-miR-4641	CLIP-seq
MIRT1126961	hsa-miR-4645-5p	CLIP-seq
MIRT1126962	hsa-miR-4660	CLIP-seq
MIRT1126963	hsa-miR-4673	CLIP-seq
MIRT1126964	hsa-miR-4715-3p	CLIP-seq
MIRT1126965	hsa-miR-4726-5p	CLIP-seq
MIRT1126966	hsa-miR-4731-5p	CLIP-seq
MIRT1126967	hsa-miR-4733-3p	CLIP-seq
MIRT1126968	hsa-miR-4735-3p	CLIP-seq
MIRT1126969	hsa-miR-4755-3p	CLIP-seq
MIRT1126970	hsa-miR-4759	CLIP-seq
MIRT1126971	hsa-miR-4793-5p	CLIP-seq
MIRT1126972	hsa-miR-505	CLIP-seq
MIRT1126973	hsa-miR-548l	CLIP-seq
MIRT1126974	hsa-miR-619	CLIP-seq
MIRT1126975	hsa-miR-646	CLIP-seq
MIRT1126976	hsa-miR-7	CLIP-seq
MIRT1126977	hsa-miR-765	CLIP-seq
MIRT1126941	hsa-miR-1224-3p	CLIP-seq
MIRT1551022	hsa-miR-1226	CLIP-seq
MIRT1126942	hsa-miR-1288	CLIP-seq
MIRT1551023	hsa-miR-2467-3p	CLIP-seq
MIRT1126949	hsa-miR-3126-5p	CLIP-seq
MIRT1126951	hsa-miR-3199	CLIP-seq
MIRT1126955	hsa-miR-4254	CLIP-seq
MIRT1551024	hsa-miR-4530	CLIP-seq
MIRT1551025	hsa-miR-4688	CLIP-seq
MIRT1126964	hsa-miR-4715-3p	CLIP-seq
MIRT1126967	hsa-miR-4733-3p	CLIP-seq
MIRT1126974	hsa-miR-619	CLIP-seq
MIRT1551026	hsa-miR-634	CLIP-seq
MIRT1551027	hsa-miR-922	CLIP-seq
MIRT2035933	hsa-miR-1324	CLIP-seq
MIRT2035934	hsa-miR-1910	CLIP-seq
MIRT1126946	hsa-miR-1976	CLIP-seq
MIRT1551023	hsa-miR-2467-3p	CLIP-seq
MIRT2035935	hsa-miR-3183	CLIP-seq
MIRT2035936	hsa-miR-3615	CLIP-seq
MIRT1126952	hsa-miR-370	CLIP-seq
MIRT2035937	hsa-miR-3924	CLIP-seq
MIRT2035938	hsa-miR-4269	CLIP-seq
MIRT2035939	hsa-miR-4287	CLIP-seq
MIRT2035940	hsa-miR-4290	CLIP-seq
MIRT2035941	hsa-miR-4328	CLIP-seq
MIRT2035942	hsa-miR-4469	CLIP-seq
MIRT1126959	hsa-miR-4640-5p	CLIP-seq
MIRT1126961	hsa-miR-4645-5p	CLIP-seq
MIRT1126962	hsa-miR-4660	CLIP-seq
MIRT1126963	hsa-miR-4673	CLIP-seq
MIRT2035943	hsa-miR-4685-3p	CLIP-seq
MIRT2035944	hsa-miR-4691-5p	CLIP-seq
MIRT2035945	hsa-miR-4711-3p	CLIP-seq
MIRT1126964	hsa-miR-4715-3p	CLIP-seq
MIRT2035946	hsa-miR-4722-5p	CLIP-seq
MIRT2035947	hsa-miR-4723-3p	CLIP-seq
MIRT1126965	hsa-miR-4726-5p	CLIP-seq
MIRT1126966	hsa-miR-4731-5p	CLIP-seq
MIRT1126967	hsa-miR-4733-3p	CLIP-seq
MIRT1126969	hsa-miR-4755-3p	CLIP-seq
MIRT2035948	hsa-miR-4763-5p	CLIP-seq
MIRT2035949	hsa-miR-4768-3p	CLIP-seq
MIRT2035950	hsa-miR-486-3p	CLIP-seq
MIRT2035951	hsa-miR-486-5p	CLIP-seq
MIRT2035952	hsa-miR-579	CLIP-seq
MIRT2035953	hsa-miR-592	CLIP-seq
MIRT2035954	hsa-miR-599	CLIP-seq
MIRT2035955	hsa-miR-642a	CLIP-seq
MIRT1126975	hsa-miR-646	CLIP-seq
MIRT2035956	hsa-miR-942	CLIP-seq
MIRT2266310	hsa-miR-145	CLIP-seq
MIRT1126944	hsa-miR-18a	CLIP-seq
MIRT1126945	hsa-miR-18b	CLIP-seq
MIRT1126946	hsa-miR-1976	CLIP-seq
MIRT1126948	hsa-miR-302f	CLIP-seq
MIRT2266311	hsa-miR-3065-3p	CLIP-seq
MIRT2266312	hsa-miR-3691-5p	CLIP-seq
MIRT1126952	hsa-miR-370	CLIP-seq
MIRT2035941	hsa-miR-4328	CLIP-seq
MIRT1126959	hsa-miR-4640-5p	CLIP-seq
MIRT1126962	hsa-miR-4660	CLIP-seq
MIRT1126965	hsa-miR-4726-5p	CLIP-seq
MIRT1126966	hsa-miR-4731-5p	CLIP-seq
MIRT1126968	hsa-miR-4735-3p	CLIP-seq
MIRT2266313	hsa-miR-4752	CLIP-seq
MIRT1126969	hsa-miR-4755-3p	CLIP-seq
MIRT2266314	hsa-miR-499-3p	CLIP-seq
MIRT2266315	hsa-miR-548ac	CLIP-seq
MIRT2266316	hsa-miR-548ae	CLIP-seq
MIRT2266317	hsa-miR-548aj	CLIP-seq
MIRT2266318	hsa-miR-548am	CLIP-seq
MIRT2266319	hsa-miR-548d-3p	CLIP-seq
MIRT2266320	hsa-miR-548x	CLIP-seq
MIRT2266321	hsa-miR-548z	CLIP-seq
MIRT2266322	hsa-miR-640	CLIP-seq
MIRT1126975	hsa-miR-646	CLIP-seq
MIRT1126946	hsa-miR-1976	CLIP-seq
MIRT1126952	hsa-miR-370	CLIP-seq
MIRT1126959	hsa-miR-4640-5p	CLIP-seq
MIRT1126962	hsa-miR-4660	CLIP-seq
MIRT1126965	hsa-miR-4726-5p	CLIP-seq
MIRT1126966	hsa-miR-4731-5p	CLIP-seq
MIRT1126969	hsa-miR-4755-3p	CLIP-seq
MIRT1126975	hsa-miR-646	CLIP-seq
MIRT1126947	hsa-miR-2392	CLIP-seq
MIRT2453639	hsa-miR-3613-3p	CLIP-seq
MIRT2565471	hsa-miR-1229	CLIP-seq
MIRT2565472	hsa-miR-1254	CLIP-seq
MIRT2565473	hsa-miR-1913	CLIP-seq
MIRT1126947	hsa-miR-2392	CLIP-seq
MIRT2565474	hsa-miR-3116	CLIP-seq
MIRT2565475	hsa-miR-3127-3p	CLIP-seq
MIRT2565476	hsa-miR-3176	CLIP-seq
MIRT2565477	hsa-miR-324-3p	CLIP-seq
MIRT2453639	hsa-miR-3613-3p	CLIP-seq
MIRT2565478	hsa-miR-3667-3p	CLIP-seq
MIRT2565479	hsa-miR-378g	CLIP-seq
MIRT2565480	hsa-miR-3922-3p	CLIP-seq
MIRT2035938	hsa-miR-4269	CLIP-seq
MIRT1126961	hsa-miR-4645-5p	CLIP-seq
MIRT1126963	hsa-miR-4673	CLIP-seq
MIRT1126964	hsa-miR-4715-3p	CLIP-seq
MIRT2565481	hsa-miR-4722-3p	CLIP-seq
MIRT1126967	hsa-miR-4733-3p	CLIP-seq
MIRT2565482	hsa-miR-4749-3p	CLIP-seq
MIRT1126971	hsa-miR-4793-5p	CLIP-seq
MIRT2565483	hsa-miR-661	CLIP-seq
MIRT1126947	hsa-miR-2392	CLIP-seq
MIRT2453639	hsa-miR-3613-3p	CLIP-seq
MIRT1126972	hsa-miR-505	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	12370315
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	12370315
GO:0005634	Component	Nucleus	IDA	12370315
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0007219	Process	Notch signaling pathway	IDA	12370315
GO:0007219	Process	Notch signaling pathway	IEA
GO:0007221	Process	Positive regulation of transcription of Notch receptor target	IBA
GO:0007221	Process	Positive regulation of transcription of Notch receptor target	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0016607	Component	Nuclear speck	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	12370315
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA

Other IDs

• MIM: 608991
• HGNC: 16272
• e!Ensembl: ENSG00000196782

Protein

• UniProt ID: Q96JK9
• Protein name: Mastermind-like protein 3 (Mam-3)
• Protein function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09596	MamL-1	68 → 125	MamL-1 domain	Domain

• Sequence:

  MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAPSSNHPAAGGCGGSGGP
  GGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQLELERRDTVSLYQRTLEQ
  RAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQETVKRKLEGARSPLNGDQQNGA
  CDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPLHQLDLKPSLPLQNSGTHTPGLL
  EDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQEPLDDPTCIDTSETSLSNQNKLFS
  DINLNDQEWQELIDELANTVPEDDIQDLFNEDFEEKKEPEFSQPATETPLSQESASVKSD
  PSHSPFAHVSMGSPQARPSSSGPPFSTVSTATSLPSVASTPAAPNPASSPANCAVQSPQT
  PNQAHTPGQAPPRPGNGYLLNPAAVTVAGSASGPVAVPSSDMSPAEQLKQMAAQQQQRAK
  LMQQKQQQQQQQQQQQQQQQQQQQQQQQQQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSP
  MMYPQAFNNQNPIVPPMANNLQKTTMNNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYG
  NTKPLTHFNADLSQRMTPPVANPNKNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPR
  AHLSEDQKRLLLMKQKGVMNQPMAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVS
  GASPAGPGFLGSQPQAAIMKQMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQ
  QSHLPRQHLQPQRNPYPVQQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGP
  SQNPGTMATAAAQSEMGLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGP
  RQPASGQGVGMVSGFGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGA
  QSWQQRSLQGMPGRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRT
  LNPAAMGRQMMPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQ
  SQAYERNAPQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP

• Sequence length: 1138

Pathways

KEGG:

Notch signaling pathway
Th1 and Th2 cell differentiation
Human papillomavirus infection

Reactome:

Pre-NOTCH Transcription and Translation
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription