Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55529
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIP4P2
Synonyms (NCBI Gene) Gene synonyms aliases	TMEM55A
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

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miRTarBase ID	miRNA	Experiments	Reference
MIRT665752	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT665751	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT665750	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT665749	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT665748	hsa-miR-4466	HITS-CLIP	23824327
MIRT665747	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT665746	hsa-miR-7977	HITS-CLIP	23824327
MIRT665745	hsa-miR-6727-5p	HITS-CLIP	23824327
MIRT621792	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT621791	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT621790	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT621788	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT621787	hsa-miR-4427	HITS-CLIP	23824327
MIRT621786	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621785	hsa-miR-1200	HITS-CLIP	23824327
MIRT621784	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT621783	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT652393	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT652392	hsa-miR-5692a	HITS-CLIP	23824327
MIRT652391	hsa-miR-1295b-5p	HITS-CLIP	23824327
MIRT652390	hsa-miR-1912	HITS-CLIP	23824327
MIRT652389	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT652388	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT652387	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT652386	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT652385	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652384	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT652383	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT652382	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT652381	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT652380	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT652379	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652378	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652377	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT621792	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT621791	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT621790	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT621789	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT621788	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT621787	hsa-miR-4427	HITS-CLIP	23824327
MIRT621786	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621785	hsa-miR-1200	HITS-CLIP	23824327
MIRT621784	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT621783	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT621792	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT621791	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT621790	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT621789	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT621788	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT621787	hsa-miR-4427	HITS-CLIP	23824327
MIRT621786	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621785	hsa-miR-1200	HITS-CLIP	23824327
MIRT621784	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT621783	hsa-miR-7152-5p	HITS-CLIP	23824327

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 33961781, 37219487
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IBA
GO:0005765	Component	Lysosomal membrane	IDA	16365287
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030670	Component	Phagocytic vesicle membrane	IBA
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0030670	Component	Phagocytic vesicle membrane	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IDA	16365287
GO:0031902	Component	Late endosome membrane	IEA
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IBA
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IDA	16365287
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IEA
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IBA
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IDA	16365287
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IEA
GO:0050765	Process	Negative regulation of phagocytosis	IEA
GO:0050765	Process	Negative regulation of phagocytosis	ISS

MIM	HGNC	e!Ensembl
609864	25452	ENSG00000155099

Protein

UniProt ID

Q8N4L2

Protein name

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)

Protein function

Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosph

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09788	Tmemb_55A	6 → 250	Transmembrane protein 55A	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16365287}.

Sequence

MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRV
CQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPN
CRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKI
SSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIR
ACYWGAIRVSYPEHSFA

Sequence length

257

Interactions

View interactions

	KEGG
	Phosphatidylinositol signaling system

PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2)