PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2)

Gene

• Entrez ID: 55529
• Gene name: Phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
• Gene symbol: PIP4P2
• Synonyms (NCBI Gene): TMEM55A
• Chromosome: 8
• Chromosome location: 8q21.3
• Summary: TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT665752	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT665751	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT665750	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT665749	hsa-miR-4746-3p	HITS-CLIP	23824327
MIRT665748	hsa-miR-4466	HITS-CLIP	23824327
MIRT665747	hsa-miR-675-5p	HITS-CLIP	23824327
MIRT665746	hsa-miR-7977	HITS-CLIP	23824327
MIRT665745	hsa-miR-6727-5p	HITS-CLIP	23824327
MIRT621792	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT621791	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT621790	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT621788	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT621787	hsa-miR-4427	HITS-CLIP	23824327
MIRT621786	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621785	hsa-miR-1200	HITS-CLIP	23824327
MIRT621784	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT621783	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT652393	hsa-miR-548c-3p	HITS-CLIP	23824327
MIRT652392	hsa-miR-5692a	HITS-CLIP	23824327
MIRT652391	hsa-miR-1295b-5p	HITS-CLIP	23824327
MIRT652390	hsa-miR-1912	HITS-CLIP	23824327
MIRT652389	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT652388	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT652387	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT652386	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT652385	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT652384	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT652383	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT652382	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT652381	hsa-miR-6802-3p	HITS-CLIP	23824327
MIRT652380	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT652379	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT652378	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT652377	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT621792	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT621791	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT621790	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT621789	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT621788	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT621787	hsa-miR-4427	HITS-CLIP	23824327
MIRT621786	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621785	hsa-miR-1200	HITS-CLIP	23824327
MIRT621784	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT621783	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT621792	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT621791	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT621790	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT621789	hsa-miR-4704-5p	HITS-CLIP	23824327
MIRT621788	hsa-miR-3140-5p	HITS-CLIP	23824327
MIRT621787	hsa-miR-4427	HITS-CLIP	23824327
MIRT621786	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT621785	hsa-miR-1200	HITS-CLIP	23824327
MIRT621784	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT621783	hsa-miR-7152-5p	HITS-CLIP	23824327

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005765	Component	Lysosomal membrane	IDA	16365287
GO:0005886	Component	Plasma membrane	ISS
GO:0016021	Component	Integral component of membrane	IEA
GO:0030670	Component	Phagocytic vesicle membrane	ISS
GO:0031902	Component	Late endosome membrane	IDA	16365287
GO:0034597	Function	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity	IDA	16365287
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IDA	16365287
GO:0050765	Process	Negative regulation of phagocytosis	ISS

Other IDs

• MIM: 609864
• HGNC: 25452
• e!Ensembl: ENSG00000155099

Protein

• UniProt ID: Q8N4L2
• Protein name: Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 2 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase II) (Transmembrane protein 55A)
• Protein function: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosph
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09788	Tmemb_55A	6 → 250	Transmembrane protein 55A	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:16365287}.
• Sequence:

  MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRV
  CQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPN
  CRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKI
  SSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIR
  ACYWGAIRVSYPEHSFA

• Sequence length: 257

Pathways

KEGG:

Phosphatidylinositol signaling system

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432, rs119451946, rs80356771, rs74500255, rs75822236, rs1141814, rs78973108, rs121908681, rs121908686, rs121908687, rs137853054, rs137853055, rs137853056, rs137853057, rs137853058, rs137853059, rs34424986, rs137853060, rs397518439, rs28938172, rs74315351, rs74315353, rs137853051, rs118192098, rs121918104, rs1589451049, rs104893877, rs104893878, rs188286943, rs387906863, rs387906864, rs774631197, rs199935023, rs397514694, rs398122403, rs398122404, rs398122405, rs104886460, rs409652, rs431905511, rs63751392, rs756677845, rs864309527, rs864309650, rs750014782, rs1554391082, rs864622011, rs869312810, rs869312809, rs869312811, rs369100678, rs879253853, rs869320761, rs747506979, rs879255630, rs886039854, rs191486604, rs781442277, rs1060499619, rs751037529, rs55777503, rs768091663, rs34208370, rs1553122929, rs772786691, rs754809877, rs1555907463, rs1557561340, rs781600849, rs141263564, rs1557901552, rs777160388, rs756783990, rs867929413, rs1237637353, rs1005937012, rs755000580, rs747427602, rs1578089802, rs771586218, rs748142049, rs1582953433, rs746646126, rs771529549, rs121918106	17052657