TNFRSF19 (TNF receptor superfamily member 19)

Gene

• Entrez ID: 55504
• Gene name: TNF receptor superfamily member 19
• Gene symbol: TNFRSF19
• Synonyms (NCBI Gene): TAJ, TAJ-alpha, TRADE, TROY
• Chromosome: 13
• Chromosome location: 13q12.12
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1442980	hsa-miR-1206	CLIP-seq
MIRT1442981	hsa-miR-3656	CLIP-seq
MIRT1442982	hsa-miR-433	CLIP-seq
MIRT1442983	hsa-miR-4786-5p	CLIP-seq
MIRT1442984	hsa-miR-609	CLIP-seq
MIRT1442985	hsa-miR-769-5p	CLIP-seq
MIRT1442986	hsa-miR-1234	CLIP-seq
MIRT1442987	hsa-miR-1254	CLIP-seq
MIRT1442988	hsa-miR-1289	CLIP-seq
MIRT1442989	hsa-miR-3116	CLIP-seq
MIRT1442990	hsa-miR-3198	CLIP-seq
MIRT1442991	hsa-miR-3646	CLIP-seq
MIRT1442992	hsa-miR-3938	CLIP-seq
MIRT1442993	hsa-miR-4254	CLIP-seq
MIRT1442994	hsa-miR-4294	CLIP-seq
MIRT1442995	hsa-miR-4309	CLIP-seq
MIRT1442996	hsa-miR-4666-5p	CLIP-seq
MIRT1442997	hsa-miR-548an	CLIP-seq
MIRT1442998	hsa-miR-578	CLIP-seq
MIRT1442999	hsa-miR-670	CLIP-seq
MIRT1443000	hsa-miR-924	CLIP-seq
MIRT2132570	hsa-miR-1587	CLIP-seq
MIRT2132571	hsa-miR-4492	CLIP-seq
MIRT2132572	hsa-miR-4498	CLIP-seq
MIRT2132573	hsa-miR-4656	CLIP-seq
MIRT2132574	hsa-miR-4675	CLIP-seq
MIRT2132575	hsa-miR-4741	CLIP-seq
MIRT2132576	hsa-miR-548aa	CLIP-seq
MIRT2132577	hsa-miR-762	CLIP-seq
MIRT2353515	hsa-miR-105	CLIP-seq
MIRT2353516	hsa-miR-1207-3p	CLIP-seq
MIRT2353517	hsa-miR-130a	CLIP-seq
MIRT2353518	hsa-miR-130b	CLIP-seq
MIRT2353519	hsa-miR-149	CLIP-seq
MIRT2353520	hsa-miR-19a	CLIP-seq
MIRT2353521	hsa-miR-19b	CLIP-seq
MIRT2353522	hsa-miR-2113	CLIP-seq
MIRT2353523	hsa-miR-224	CLIP-seq
MIRT2353524	hsa-miR-24	CLIP-seq
MIRT2353525	hsa-miR-301a	CLIP-seq
MIRT2353526	hsa-miR-301b	CLIP-seq
MIRT2353527	hsa-miR-3064-5p	CLIP-seq
MIRT2353528	hsa-miR-3065-5p	CLIP-seq
MIRT2353529	hsa-miR-3120-5p	CLIP-seq
MIRT2353530	hsa-miR-33a	CLIP-seq
MIRT2353531	hsa-miR-33b	CLIP-seq
MIRT2353532	hsa-miR-3609	CLIP-seq
MIRT2353533	hsa-miR-3616-5p	CLIP-seq
MIRT2353534	hsa-miR-3647-5p	CLIP-seq
MIRT2353535	hsa-miR-3663-5p	CLIP-seq
MIRT2353536	hsa-miR-3666	CLIP-seq
MIRT2353537	hsa-miR-3671	CLIP-seq
MIRT2353538	hsa-miR-3688-5p	CLIP-seq
MIRT2353539	hsa-miR-3913-3p	CLIP-seq
MIRT2353540	hsa-miR-3919	CLIP-seq
MIRT2353541	hsa-miR-4284	CLIP-seq
MIRT2353542	hsa-miR-4290	CLIP-seq
MIRT2353543	hsa-miR-4295	CLIP-seq
MIRT2353544	hsa-miR-4474-3p	CLIP-seq
MIRT2353545	hsa-miR-4527	CLIP-seq
MIRT2353546	hsa-miR-454	CLIP-seq
MIRT2353547	hsa-miR-4652-3p	CLIP-seq
MIRT2353548	hsa-miR-4667-3p	CLIP-seq
MIRT2353549	hsa-miR-4687-5p	CLIP-seq
MIRT2353550	hsa-miR-4766-5p	CLIP-seq
MIRT2353551	hsa-miR-4794	CLIP-seq
MIRT2353552	hsa-miR-4795-5p	CLIP-seq
MIRT2353553	hsa-miR-488	CLIP-seq
MIRT2353554	hsa-miR-489	CLIP-seq
MIRT2353555	hsa-miR-518d-5p	CLIP-seq
MIRT2353556	hsa-miR-519a	CLIP-seq
MIRT2353557	hsa-miR-519b-3p	CLIP-seq
MIRT2353558	hsa-miR-519b-5p	CLIP-seq
MIRT2353559	hsa-miR-519c-3p	CLIP-seq
MIRT2353560	hsa-miR-519c-5p	CLIP-seq
MIRT2353561	hsa-miR-520c-5p	CLIP-seq
MIRT2353562	hsa-miR-520g	CLIP-seq
MIRT2353563	hsa-miR-520h	CLIP-seq
MIRT2353564	hsa-miR-526a	CLIP-seq
MIRT2353565	hsa-miR-548ah	CLIP-seq
MIRT2353566	hsa-miR-573	CLIP-seq
MIRT2353567	hsa-miR-600	CLIP-seq
MIRT2353568	hsa-miR-607	CLIP-seq
MIRT2353569	hsa-miR-892b	CLIP-seq
MIRT2353533	hsa-miR-3616-5p	CLIP-seq
MIRT2353534	hsa-miR-3647-5p	CLIP-seq
MIRT2353566	hsa-miR-573	CLIP-seq
MIRT2462059	hsa-miR-129-5p	CLIP-seq
MIRT2462060	hsa-miR-3189-5p	CLIP-seq
MIRT2462061	hsa-miR-3942-3p	CLIP-seq
MIRT2462062	hsa-miR-4758-3p	CLIP-seq
MIRT2462059	hsa-miR-129-5p	CLIP-seq
MIRT2462060	hsa-miR-3189-5p	CLIP-seq
MIRT2462061	hsa-miR-3942-3p	CLIP-seq
MIRT2462062	hsa-miR-4758-3p	CLIP-seq
MIRT2647697	hsa-miR-103b	CLIP-seq
MIRT2353515	hsa-miR-105	CLIP-seq
MIRT2647698	hsa-miR-1207-5p	CLIP-seq
MIRT2647699	hsa-miR-1229	CLIP-seq
MIRT2647700	hsa-miR-1238	CLIP-seq
MIRT2647701	hsa-miR-1251	CLIP-seq
MIRT2647702	hsa-miR-1257	CLIP-seq
MIRT2647703	hsa-miR-1261	CLIP-seq
MIRT2647704	hsa-miR-1276	CLIP-seq
MIRT2647705	hsa-miR-1283	CLIP-seq
MIRT2647706	hsa-miR-1294	CLIP-seq
MIRT2647707	hsa-miR-1299	CLIP-seq
MIRT2353517	hsa-miR-130a	CLIP-seq
MIRT2353518	hsa-miR-130b	CLIP-seq
MIRT2647708	hsa-miR-147	CLIP-seq
MIRT2647709	hsa-miR-15a	CLIP-seq
MIRT2647710	hsa-miR-15b	CLIP-seq
MIRT2647711	hsa-miR-16	CLIP-seq
MIRT2647712	hsa-miR-195	CLIP-seq
MIRT2353520	hsa-miR-19a	CLIP-seq
MIRT2353521	hsa-miR-19b	CLIP-seq
MIRT2647713	hsa-miR-2117	CLIP-seq
MIRT2647714	hsa-miR-2681	CLIP-seq
MIRT2353525	hsa-miR-301a	CLIP-seq
MIRT2353526	hsa-miR-301b	CLIP-seq
MIRT2353528	hsa-miR-3065-5p	CLIP-seq
MIRT2647715	hsa-miR-3164	CLIP-seq
MIRT2647716	hsa-miR-3186-3p	CLIP-seq
MIRT2647717	hsa-miR-3202	CLIP-seq
MIRT2647718	hsa-miR-337-3p	CLIP-seq
MIRT2353530	hsa-miR-33a	CLIP-seq
MIRT2353531	hsa-miR-33b	CLIP-seq
MIRT2353532	hsa-miR-3609	CLIP-seq
MIRT2353533	hsa-miR-3616-5p	CLIP-seq
MIRT2353534	hsa-miR-3647-5p	CLIP-seq
MIRT2647719	hsa-miR-3650	CLIP-seq
MIRT2353536	hsa-miR-3666	CLIP-seq
MIRT2647720	hsa-miR-3685	CLIP-seq
MIRT2647721	hsa-miR-3691-5p	CLIP-seq
MIRT2647722	hsa-miR-369-3p	CLIP-seq
MIRT2647723	hsa-miR-374c	CLIP-seq
MIRT2647724	hsa-miR-376a	CLIP-seq
MIRT2647725	hsa-miR-376b	CLIP-seq
MIRT2647726	hsa-miR-384	CLIP-seq
MIRT2647727	hsa-miR-3911	CLIP-seq
MIRT2353539	hsa-miR-3913-3p	CLIP-seq
MIRT2353540	hsa-miR-3919	CLIP-seq
MIRT2647728	hsa-miR-3929	CLIP-seq
MIRT2647729	hsa-miR-3941	CLIP-seq
MIRT2647730	hsa-miR-3977	CLIP-seq
MIRT2647731	hsa-miR-3978	CLIP-seq
MIRT2647732	hsa-miR-424	CLIP-seq
MIRT2647733	hsa-miR-4273	CLIP-seq
MIRT2647734	hsa-miR-4289	CLIP-seq
MIRT2353543	hsa-miR-4295	CLIP-seq
MIRT2647735	hsa-miR-4320	CLIP-seq
MIRT2647736	hsa-miR-4328	CLIP-seq
MIRT2647737	hsa-miR-4419b	CLIP-seq
MIRT2647738	hsa-miR-4436b-3p	CLIP-seq
MIRT2647739	hsa-miR-4461	CLIP-seq
MIRT2647740	hsa-miR-4478	CLIP-seq
MIRT2647741	hsa-miR-4496	CLIP-seq
MIRT2647742	hsa-miR-4501	CLIP-seq
MIRT2647743	hsa-miR-4524	CLIP-seq
MIRT2647744	hsa-miR-4533	CLIP-seq
MIRT2353546	hsa-miR-454	CLIP-seq
MIRT2647745	hsa-miR-4540	CLIP-seq
MIRT2647746	hsa-miR-4658	CLIP-seq
MIRT2647747	hsa-miR-4659a-3p	CLIP-seq
MIRT2647748	hsa-miR-4659b-3p	CLIP-seq
MIRT2647749	hsa-miR-466	CLIP-seq
MIRT2647750	hsa-miR-4672	CLIP-seq
MIRT2647751	hsa-miR-4682	CLIP-seq
MIRT2647752	hsa-miR-4704-5p	CLIP-seq
MIRT2647753	hsa-miR-4710	CLIP-seq
MIRT2647754	hsa-miR-4719	CLIP-seq
MIRT2647755	hsa-miR-4731-3p	CLIP-seq
MIRT2647756	hsa-miR-4752	CLIP-seq
MIRT2647757	hsa-miR-4758-5p	CLIP-seq
MIRT2647758	hsa-miR-4761-3p	CLIP-seq
MIRT2647759	hsa-miR-4762-5p	CLIP-seq
MIRT2647760	hsa-miR-4763-3p	CLIP-seq
MIRT2647761	hsa-miR-4782-5p	CLIP-seq
MIRT1442983	hsa-miR-4786-5p	CLIP-seq
MIRT2647762	hsa-miR-4792	CLIP-seq
MIRT2353552	hsa-miR-4795-5p	CLIP-seq
MIRT2647763	hsa-miR-4801	CLIP-seq
MIRT2647764	hsa-miR-485-5p	CLIP-seq
MIRT2647765	hsa-miR-487a	CLIP-seq
MIRT2353554	hsa-miR-489	CLIP-seq
MIRT2647766	hsa-miR-490-5p	CLIP-seq
MIRT2647767	hsa-miR-494	CLIP-seq
MIRT2647768	hsa-miR-497	CLIP-seq
MIRT2647769	hsa-miR-503	CLIP-seq
MIRT2647770	hsa-miR-516b	CLIP-seq
MIRT2353556	hsa-miR-519a	CLIP-seq
MIRT2353557	hsa-miR-519b-3p	CLIP-seq
MIRT2353559	hsa-miR-519c-3p	CLIP-seq
MIRT2353562	hsa-miR-520g	CLIP-seq
MIRT2353563	hsa-miR-520h	CLIP-seq
MIRT2647771	hsa-miR-543	CLIP-seq
MIRT2132576	hsa-miR-548aa	CLIP-seq
MIRT2353565	hsa-miR-548ah	CLIP-seq
MIRT2647772	hsa-miR-548n	CLIP-seq
MIRT2647773	hsa-miR-548t	CLIP-seq
MIRT2647774	hsa-miR-554	CLIP-seq
MIRT2647775	hsa-miR-564	CLIP-seq
MIRT2353566	hsa-miR-573	CLIP-seq
MIRT2647776	hsa-miR-595	CLIP-seq
MIRT2647777	hsa-miR-606	CLIP-seq
MIRT2647778	hsa-miR-635	CLIP-seq
MIRT2647779	hsa-miR-644	CLIP-seq
MIRT2647780	hsa-miR-646	CLIP-seq
MIRT2647781	hsa-miR-655	CLIP-seq
MIRT1442985	hsa-miR-769-5p	CLIP-seq
MIRT2647782	hsa-miR-875-3p	CLIP-seq
MIRT2647783	hsa-miR-889	CLIP-seq
MIRT2647784	hsa-miR-935	CLIP-seq
MIRT2647697	hsa-miR-103b	CLIP-seq
MIRT2353515	hsa-miR-105	CLIP-seq
MIRT2647698	hsa-miR-1207-5p	CLIP-seq
MIRT2693701	hsa-miR-122	CLIP-seq
MIRT2647700	hsa-miR-1238	CLIP-seq
MIRT2647701	hsa-miR-1251	CLIP-seq
MIRT2647702	hsa-miR-1257	CLIP-seq
MIRT2647704	hsa-miR-1276	CLIP-seq
MIRT2647705	hsa-miR-1283	CLIP-seq
MIRT2647706	hsa-miR-1294	CLIP-seq
MIRT2647707	hsa-miR-1299	CLIP-seq
MIRT2353517	hsa-miR-130a	CLIP-seq
MIRT2353518	hsa-miR-130b	CLIP-seq
MIRT2647708	hsa-miR-147	CLIP-seq
MIRT2647709	hsa-miR-15a	CLIP-seq
MIRT2647710	hsa-miR-15b	CLIP-seq
MIRT2647711	hsa-miR-16	CLIP-seq
MIRT2647712	hsa-miR-195	CLIP-seq
MIRT2353520	hsa-miR-19a	CLIP-seq
MIRT2353521	hsa-miR-19b	CLIP-seq
MIRT2647713	hsa-miR-2117	CLIP-seq
MIRT2647714	hsa-miR-2681	CLIP-seq
MIRT2353525	hsa-miR-301a	CLIP-seq
MIRT2353526	hsa-miR-301b	CLIP-seq
MIRT2353528	hsa-miR-3065-5p	CLIP-seq
MIRT2647715	hsa-miR-3164	CLIP-seq
MIRT2647716	hsa-miR-3186-3p	CLIP-seq
MIRT2647717	hsa-miR-3202	CLIP-seq
MIRT2353530	hsa-miR-33a	CLIP-seq
MIRT2353531	hsa-miR-33b	CLIP-seq
MIRT2353532	hsa-miR-3609	CLIP-seq
MIRT2353533	hsa-miR-3616-5p	CLIP-seq
MIRT2353534	hsa-miR-3647-5p	CLIP-seq
MIRT2647719	hsa-miR-3650	CLIP-seq
MIRT2353536	hsa-miR-3666	CLIP-seq
MIRT2647721	hsa-miR-3691-5p	CLIP-seq
MIRT2647724	hsa-miR-376a	CLIP-seq
MIRT2647725	hsa-miR-376b	CLIP-seq
MIRT2647727	hsa-miR-3911	CLIP-seq
MIRT2353539	hsa-miR-3913-3p	CLIP-seq
MIRT2647728	hsa-miR-3929	CLIP-seq
MIRT2647729	hsa-miR-3941	CLIP-seq
MIRT2647730	hsa-miR-3977	CLIP-seq
MIRT2647731	hsa-miR-3978	CLIP-seq
MIRT2647732	hsa-miR-424	CLIP-seq
MIRT2647733	hsa-miR-4273	CLIP-seq
MIRT2647734	hsa-miR-4289	CLIP-seq
MIRT2353543	hsa-miR-4295	CLIP-seq
MIRT2647735	hsa-miR-4320	CLIP-seq
MIRT2647736	hsa-miR-4328	CLIP-seq
MIRT2647737	hsa-miR-4419b	CLIP-seq
MIRT2647738	hsa-miR-4436b-3p	CLIP-seq
MIRT2647739	hsa-miR-4461	CLIP-seq
MIRT2647740	hsa-miR-4478	CLIP-seq
MIRT2647741	hsa-miR-4496	CLIP-seq
MIRT2647742	hsa-miR-4501	CLIP-seq
MIRT2647743	hsa-miR-4524	CLIP-seq
MIRT2647744	hsa-miR-4533	CLIP-seq
MIRT2353546	hsa-miR-454	CLIP-seq
MIRT2647745	hsa-miR-4540	CLIP-seq
MIRT2647746	hsa-miR-4658	CLIP-seq
MIRT2647747	hsa-miR-4659a-3p	CLIP-seq
MIRT2647748	hsa-miR-4659b-3p	CLIP-seq
MIRT2647749	hsa-miR-466	CLIP-seq
MIRT2647750	hsa-miR-4672	CLIP-seq
MIRT2647751	hsa-miR-4682	CLIP-seq
MIRT2647752	hsa-miR-4704-5p	CLIP-seq
MIRT2647753	hsa-miR-4710	CLIP-seq
MIRT2647755	hsa-miR-4731-3p	CLIP-seq
MIRT2647756	hsa-miR-4752	CLIP-seq
MIRT2647757	hsa-miR-4758-5p	CLIP-seq
MIRT2647758	hsa-miR-4761-3p	CLIP-seq
MIRT2647759	hsa-miR-4762-5p	CLIP-seq
MIRT2647760	hsa-miR-4763-3p	CLIP-seq
MIRT2647761	hsa-miR-4782-5p	CLIP-seq
MIRT1442983	hsa-miR-4786-5p	CLIP-seq
MIRT2647762	hsa-miR-4792	CLIP-seq
MIRT2353552	hsa-miR-4795-5p	CLIP-seq
MIRT2647763	hsa-miR-4801	CLIP-seq
MIRT2647764	hsa-miR-485-5p	CLIP-seq
MIRT2647765	hsa-miR-487a	CLIP-seq
MIRT2353554	hsa-miR-489	CLIP-seq
MIRT2647768	hsa-miR-497	CLIP-seq
MIRT2647769	hsa-miR-503	CLIP-seq
MIRT2647770	hsa-miR-516b	CLIP-seq
MIRT2353556	hsa-miR-519a	CLIP-seq
MIRT2353557	hsa-miR-519b-3p	CLIP-seq
MIRT2353559	hsa-miR-519c-3p	CLIP-seq
MIRT2353562	hsa-miR-520g	CLIP-seq
MIRT2353563	hsa-miR-520h	CLIP-seq
MIRT2353565	hsa-miR-548ah	CLIP-seq
MIRT2647772	hsa-miR-548n	CLIP-seq
MIRT2647773	hsa-miR-548t	CLIP-seq
MIRT2647774	hsa-miR-554	CLIP-seq
MIRT2647775	hsa-miR-564	CLIP-seq
MIRT2353566	hsa-miR-573	CLIP-seq
MIRT2647776	hsa-miR-595	CLIP-seq
MIRT2647777	hsa-miR-606	CLIP-seq
MIRT2647778	hsa-miR-635	CLIP-seq
MIRT2647779	hsa-miR-644	CLIP-seq
MIRT2647780	hsa-miR-646	CLIP-seq
MIRT1442985	hsa-miR-769-5p	CLIP-seq
MIRT2647782	hsa-miR-875-3p	CLIP-seq
MIRT2647783	hsa-miR-889	CLIP-seq
MIRT2647784	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001942	Process	Hair follicle development	IEA
GO:0005031	Function	Tumor necrosis factor receptor activity	NAS	10809768
GO:0005515	Function	Protein binding	IPI	30337686, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	NAS	10809768
GO:0007254	Process	JNK cascade	NAS	10809768
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10809768
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0046330	Process	Positive regulation of JNK cascade	IBA
GO:0046330	Process	Positive regulation of JNK cascade	IEA

Other IDs

• MIM: 606122
• HGNC: 11915
• e!Ensembl: ENSG00000127863

Protein

• UniProt ID: Q9NS68
• Protein name: Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)
• Protein function: Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00020	TNFR_c6	34 → 72	TNFR/NGFR cysteine-rich region	Domain
  PF00020	TNFR_c6	75 → 114	TNFR/NGFR cysteine-rich region	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
• Sequence:

  MALKVLLEQEKTFFTLLVLLGYLSCKVTCESGDCRQQEFRDRSGNCVPCNQCGPGMELSK
  ECGFGYGEDAQCVTCRLHRFKEDWGFQKCKPCLDCAVVNRFQKANCSATSDAICGDCLPG
  FYRKTKLVGFQDMECVPCGDPPPPYEPHCASKVNLVKIASTASSPRDTALAAVICSALAT
  VLLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSELSCFDRPQLHEYAHRACCQCRRD
  SVQTCGPVRLLPSMCCEEACSPNPATLGCGVHSAASLQARNAGPAGEMVPTFFGSLTQSI
  CGEFSDAWPLMQNPMGGDNISFCDSYPELTGEDIHSLNPELESSTSLDSNSSQDLVGGAV
  PVQSHSENFTAATDLSRYNNTLVESASTQDALTMRSQLDQESGAVIHPATQTSLQVRQRL
  GSL

• Sequence length: 423

Pathways

KEGG:

Cytokine-cytokine receptor interaction