Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5546
Gene name Gene Name - the full gene name approved by the HGNC.	Proline rich mitotic checkpoint control factor
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PRCC
Synonyms (NCBI Gene) Gene synonyms aliases	RCCP1, TPRC
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q23.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein

Show/Hide all(129)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040762	hsa-miR-18a-3p	CLASH	23622248
MIRT039451	hsa-miR-421	CLASH	23622248
MIRT037286	hsa-miR-877-5p	CLASH	23622248
MIRT1259775	hsa-miR-1224-3p	CLIP-seq
MIRT1259776	hsa-miR-1225-3p	CLIP-seq
MIRT1259777	hsa-miR-1260	CLIP-seq
MIRT1259778	hsa-miR-1260b	CLIP-seq
MIRT1259779	hsa-miR-127-5p	CLIP-seq
MIRT1259780	hsa-miR-1280	CLIP-seq
MIRT1259781	hsa-miR-1972	CLIP-seq
MIRT1259782	hsa-miR-28-5p	CLIP-seq
MIRT1259783	hsa-miR-299-5p	CLIP-seq
MIRT1259784	hsa-miR-3127-3p	CLIP-seq
MIRT1259785	hsa-miR-3139	CLIP-seq
MIRT1259786	hsa-miR-3150a-3p	CLIP-seq
MIRT1259787	hsa-miR-3160-3p	CLIP-seq
MIRT1259788	hsa-miR-3175	CLIP-seq
MIRT1259789	hsa-miR-320e	CLIP-seq
MIRT1259790	hsa-miR-323-5p	CLIP-seq
MIRT1259791	hsa-miR-3612	CLIP-seq
MIRT1259792	hsa-miR-377	CLIP-seq
MIRT1259793	hsa-miR-4257	CLIP-seq
MIRT1259794	hsa-miR-4263	CLIP-seq
MIRT1259795	hsa-miR-4488	CLIP-seq
MIRT1259796	hsa-miR-4640-5p	CLIP-seq
MIRT1259797	hsa-miR-4680-3p	CLIP-seq
MIRT1259798	hsa-miR-4697-5p	CLIP-seq
MIRT1259799	hsa-miR-4726-5p	CLIP-seq
MIRT1259800	hsa-miR-4728-5p	CLIP-seq
MIRT1259801	hsa-miR-4731-3p	CLIP-seq
MIRT1259802	hsa-miR-4731-5p	CLIP-seq
MIRT1259803	hsa-miR-4755-3p	CLIP-seq
MIRT1259804	hsa-miR-4796-3p	CLIP-seq
MIRT1259805	hsa-miR-4801	CLIP-seq
MIRT1259806	hsa-miR-491-5p	CLIP-seq
MIRT1259807	hsa-miR-541	CLIP-seq
MIRT1259808	hsa-miR-548t	CLIP-seq
MIRT1259809	hsa-miR-576-5p	CLIP-seq
MIRT1259810	hsa-miR-637	CLIP-seq
MIRT1259811	hsa-miR-650	CLIP-seq
MIRT1259812	hsa-miR-654-5p	CLIP-seq
MIRT1259813	hsa-miR-708	CLIP-seq
MIRT1259814	hsa-miR-876-3p	CLIP-seq
MIRT1259815	hsa-miR-939	CLIP-seq
MIRT1259775	hsa-miR-1224-3p	CLIP-seq
MIRT1259776	hsa-miR-1225-3p	CLIP-seq
MIRT1259777	hsa-miR-1260	CLIP-seq
MIRT1259778	hsa-miR-1260b	CLIP-seq
MIRT1259780	hsa-miR-1280	CLIP-seq
MIRT2076558	hsa-miR-1323	CLIP-seq
MIRT2076559	hsa-miR-2110	CLIP-seq
MIRT1259784	hsa-miR-3127-3p	CLIP-seq
MIRT1259786	hsa-miR-3150a-3p	CLIP-seq
MIRT2076560	hsa-miR-3153	CLIP-seq
MIRT2076561	hsa-miR-3189-3p	CLIP-seq
MIRT1259791	hsa-miR-3612	CLIP-seq
MIRT2076562	hsa-miR-4271	CLIP-seq
MIRT2076563	hsa-miR-4311	CLIP-seq
MIRT2076564	hsa-miR-4725-3p	CLIP-seq
MIRT2076565	hsa-miR-532-3p	CLIP-seq
MIRT2076566	hsa-miR-548o	CLIP-seq
MIRT2076567	hsa-miR-548p	CLIP-seq
MIRT1259811	hsa-miR-650	CLIP-seq
MIRT2303154	hsa-miR-4436a	CLIP-seq
MIRT2303155	hsa-miR-665	CLIP-seq
MIRT2599834	hsa-miR-1206	CLIP-seq
MIRT1259775	hsa-miR-1224-3p	CLIP-seq
MIRT1259776	hsa-miR-1225-3p	CLIP-seq
MIRT1259777	hsa-miR-1260	CLIP-seq
MIRT1259778	hsa-miR-1260b	CLIP-seq
MIRT2599835	hsa-miR-1264	CLIP-seq
MIRT1259780	hsa-miR-1280	CLIP-seq
MIRT2599836	hsa-miR-1298	CLIP-seq
MIRT2076558	hsa-miR-1323	CLIP-seq
MIRT2599837	hsa-miR-2053	CLIP-seq
MIRT2599838	hsa-miR-2467-3p	CLIP-seq
MIRT1259782	hsa-miR-28-5p	CLIP-seq
MIRT1259784	hsa-miR-3127-3p	CLIP-seq
MIRT1259785	hsa-miR-3139	CLIP-seq
MIRT1259787	hsa-miR-3160-3p	CLIP-seq
MIRT1259791	hsa-miR-3612	CLIP-seq
MIRT2599839	hsa-miR-3653	CLIP-seq
MIRT2599840	hsa-miR-3658	CLIP-seq
MIRT2599841	hsa-miR-3671	CLIP-seq
MIRT1259792	hsa-miR-377	CLIP-seq
MIRT1259794	hsa-miR-4263	CLIP-seq
MIRT2303154	hsa-miR-4436a	CLIP-seq
MIRT1259797	hsa-miR-4680-3p	CLIP-seq
MIRT1259801	hsa-miR-4731-3p	CLIP-seq
MIRT1259805	hsa-miR-4801	CLIP-seq
MIRT2076565	hsa-miR-532-3p	CLIP-seq
MIRT2599842	hsa-miR-548c-3p	CLIP-seq
MIRT2076566	hsa-miR-548o	CLIP-seq
MIRT2076567	hsa-miR-548p	CLIP-seq
MIRT1259809	hsa-miR-576-5p	CLIP-seq
MIRT2599843	hsa-miR-621	CLIP-seq
MIRT1259811	hsa-miR-650	CLIP-seq
MIRT2303155	hsa-miR-665	CLIP-seq
MIRT1259813	hsa-miR-708	CLIP-seq
MIRT1259775	hsa-miR-1224-3p	CLIP-seq
MIRT1259776	hsa-miR-1225-3p	CLIP-seq
MIRT1259777	hsa-miR-1260	CLIP-seq
MIRT1259778	hsa-miR-1260b	CLIP-seq
MIRT2599835	hsa-miR-1264	CLIP-seq
MIRT1259780	hsa-miR-1280	CLIP-seq
MIRT2076558	hsa-miR-1323	CLIP-seq
MIRT2599837	hsa-miR-2053	CLIP-seq
MIRT1259782	hsa-miR-28-5p	CLIP-seq
MIRT1259784	hsa-miR-3127-3p	CLIP-seq
MIRT1259785	hsa-miR-3139	CLIP-seq
MIRT1259787	hsa-miR-3160-3p	CLIP-seq
MIRT1259791	hsa-miR-3612	CLIP-seq
MIRT2599839	hsa-miR-3653	CLIP-seq
MIRT2599840	hsa-miR-3658	CLIP-seq
MIRT1259792	hsa-miR-377	CLIP-seq
MIRT1259794	hsa-miR-4263	CLIP-seq
MIRT2303154	hsa-miR-4436a	CLIP-seq
MIRT1259797	hsa-miR-4680-3p	CLIP-seq
MIRT1259801	hsa-miR-4731-3p	CLIP-seq
MIRT1259805	hsa-miR-4801	CLIP-seq
MIRT2076565	hsa-miR-532-3p	CLIP-seq
MIRT2599842	hsa-miR-548c-3p	CLIP-seq
MIRT2076566	hsa-miR-548o	CLIP-seq
MIRT2076567	hsa-miR-548p	CLIP-seq
MIRT1259809	hsa-miR-576-5p	CLIP-seq
MIRT2599843	hsa-miR-621	CLIP-seq
MIRT1259811	hsa-miR-650	CLIP-seq
MIRT2303155	hsa-miR-665	CLIP-seq
MIRT1259813	hsa-miR-708	CLIP-seq

Show/Hide all(7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11717438, 26871637
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	11717438
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0016607	Component	Nuclear speck	IDA
GO:0051726	Process	Regulation of cell cycle	IDA	11717438

MIM	HGNC	e!Ensembl
179755	9343	ENSG00000143294

Protein

UniProt ID

Q92733

Protein name

Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein)

Protein function

May regulate cell cycle progression through interaction with MAD2L2.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10253	PRCC	275 → 491	Mitotic checkpoint regulator, MAD2B-interacting	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous in fetal and adult tissues.

Sequence

MSLVAYASSDESEPDEAEPEPEEEEAVAPTSGPALGGLFASLPAPKGPALLPPPPQMLAP
AFPPPLLLPPPTGDPRLQPPPPLPFGLGGFPPPPGVSPAEAAGVGEGLGLGLPSPRGPGL
NLPPPIGGAGPPLGLPKPKKRKEPVKIAAPELHKGDSDSEEDEPTKKKTILQGSSEGTGL
SALLPQPKNLTVKETNRLLLPHAFSRKPSDGSPDTKPSRLASKTKTSSLAPVVGTTTTTP
SPSAIKAAAKSAALQVTKQITQEEDDSDEEVAPENFFSLPEKAEPPGVEPYPYPIPTVPE
ELPPGTEPEPAFQDDAANAPLEFKMAAGSSGAPWMPKPGDDYSYNQFSTYGDANAAGAYY
QDYYSGGYYPAQDPALVPPQEIAPDASFIDDEAFKRLQGKRNRGREEINFVEIKGDDQLS
GAQQWMTKSLTEEKTMKSFSKKKGEQPTGQQRRKHQITYLIHQAKERELELKNTWSENKL
SRRQTQAKYGF

Sequence length

491

Interactions

View interactions

	KEGG		Reactome
	Transcriptional misregulation in cancer Renal cell carcinoma		mRNA Splicing - Major Pathway

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Sjogren-Larsson Syndrome	Sjogren-Larsson Syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Calcinosis	Associate	29713041
Carcinogenesis	Associate	35396773
Carcinoma Renal Cell	Associate	28949976, 33019842, 35118587, 35396773, 40061565
Deafness X Linked 1	Associate	21602817
Lymphatic Metastasis	Associate	31348270
Mitochondrial Diseases	Associate	33019842
Neoplasms	Associate	21602817, 33019842, 35396773
Thyroid Cancer Papillary	Associate	29713041

PRCC (proline rich mitotic checkpoint control factor)