Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	55454
Gene name	Chondroitin sulfate N-acetylgalactosaminyltransferase 2
Gene symbol	CSGALNACT2
Synonyms (NCBI Gene)	CHGN2ChGn-2GALNACT-2GALNACT2PRO0082beta4GalNAcT
Chromosome	10
Chromosome location	10q11.21
Summary	This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. Alternative splicing of this gene results in multiple transcript variants. Two rela

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024661	hsa-miR-215-5p	Microarray	19074876
MIRT026540	hsa-miR-192-5p	Microarray	19074876
MIRT029723	hsa-miR-26b-5p	Microarray	19088304
MIRT053743	hsa-miR-29b-3p	Microarray	22942087
MIRT639356	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT639356	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT911827	hsa-miR-125a-3p	CLIP-seq
MIRT911828	hsa-miR-1266	CLIP-seq
MIRT911829	hsa-miR-1299	CLIP-seq
MIRT911830	hsa-miR-2054	CLIP-seq
MIRT911831	hsa-miR-217	CLIP-seq
MIRT911832	hsa-miR-3127-5p	CLIP-seq
MIRT911833	hsa-miR-3180	CLIP-seq
MIRT911834	hsa-miR-3180-3p	CLIP-seq
MIRT911835	hsa-miR-3196	CLIP-seq
MIRT911836	hsa-miR-320a	CLIP-seq
MIRT911837	hsa-miR-320b	CLIP-seq
MIRT911838	hsa-miR-320c	CLIP-seq
MIRT911839	hsa-miR-320d	CLIP-seq
MIRT911840	hsa-miR-3665	CLIP-seq
MIRT911841	hsa-miR-4276	CLIP-seq
MIRT911842	hsa-miR-4429	CLIP-seq
MIRT911843	hsa-miR-4452	CLIP-seq
MIRT911844	hsa-miR-4518	CLIP-seq
MIRT911845	hsa-miR-4659a-3p	CLIP-seq
MIRT911846	hsa-miR-4659b-3p	CLIP-seq
MIRT911847	hsa-miR-4699-5p	CLIP-seq
MIRT911848	hsa-miR-4709-5p	CLIP-seq
MIRT911849	hsa-miR-4736	CLIP-seq
MIRT911850	hsa-miR-510	CLIP-seq
MIRT911851	hsa-miR-548ac	CLIP-seq
MIRT911852	hsa-miR-548ae	CLIP-seq
MIRT911853	hsa-miR-548aj	CLIP-seq
MIRT911854	hsa-miR-548am	CLIP-seq
MIRT911855	hsa-miR-548d-3p	CLIP-seq
MIRT911856	hsa-miR-548x	CLIP-seq
MIRT911857	hsa-miR-548z	CLIP-seq
MIRT911858	hsa-miR-583	CLIP-seq
MIRT911859	hsa-miR-873	CLIP-seq
MIRT911860	hsa-miR-875-3p	CLIP-seq
MIRT911861	hsa-miR-889	CLIP-seq
MIRT1921971	hsa-miR-4768-5p	CLIP-seq
MIRT911830	hsa-miR-2054	CLIP-seq
MIRT1970304	hsa-miR-2117	CLIP-seq
MIRT911832	hsa-miR-3127-5p	CLIP-seq
MIRT1970305	hsa-miR-371b-5p	CLIP-seq
MIRT1970306	hsa-miR-3942-3p	CLIP-seq
MIRT1970307	hsa-miR-4275	CLIP-seq
MIRT911841	hsa-miR-4276	CLIP-seq
MIRT1921971	hsa-miR-4768-5p	CLIP-seq
MIRT1970308	hsa-miR-499a-5p	CLIP-seq
MIRT911851	hsa-miR-548ac	CLIP-seq
MIRT911852	hsa-miR-548ae	CLIP-seq
MIRT911853	hsa-miR-548aj	CLIP-seq
MIRT911854	hsa-miR-548am	CLIP-seq
MIRT911855	hsa-miR-548d-3p	CLIP-seq
MIRT911856	hsa-miR-548x	CLIP-seq
MIRT911857	hsa-miR-548z	CLIP-seq
MIRT1970309	hsa-miR-888	CLIP-seq
MIRT1970310	hsa-miR-944	CLIP-seq
MIRT2206240	hsa-miR-1179	CLIP-seq
MIRT2206241	hsa-miR-1229	CLIP-seq
MIRT2206242	hsa-miR-130a	CLIP-seq
MIRT2206243	hsa-miR-130b	CLIP-seq
MIRT2206244	hsa-miR-188-3p	CLIP-seq
MIRT2206245	hsa-miR-2115	CLIP-seq
MIRT2206246	hsa-miR-301a	CLIP-seq
MIRT2206247	hsa-miR-301b	CLIP-seq
MIRT2206248	hsa-miR-342-3p	CLIP-seq
MIRT2206249	hsa-miR-3613-3p	CLIP-seq
MIRT2206250	hsa-miR-3666	CLIP-seq
MIRT1970305	hsa-miR-371b-5p	CLIP-seq
MIRT1970307	hsa-miR-4275	CLIP-seq
MIRT2206251	hsa-miR-4295	CLIP-seq
MIRT2206252	hsa-miR-454	CLIP-seq
MIRT2206253	hsa-miR-4671-3p	CLIP-seq
MIRT2206254	hsa-miR-4719	CLIP-seq
MIRT2206255	hsa-miR-4762-5p	CLIP-seq
MIRT2206256	hsa-miR-500a	CLIP-seq
MIRT2206257	hsa-miR-587	CLIP-seq
MIRT2206258	hsa-miR-630	CLIP-seq
MIRT2206259	hsa-miR-759	CLIP-seq
MIRT1970310	hsa-miR-944	CLIP-seq
MIRT2386511	hsa-miR-3663-5p	CLIP-seq
MIRT2386512	hsa-miR-4420	CLIP-seq
MIRT2386513	hsa-miR-4760-3p	CLIP-seq
MIRT2386514	hsa-miR-487b	CLIP-seq
MIRT2206258	hsa-miR-630	CLIP-seq
MIRT1970310	hsa-miR-944	CLIP-seq
MIRT2447727	hsa-miR-1324	CLIP-seq
MIRT2447728	hsa-miR-4661-3p	CLIP-seq
MIRT2447729	hsa-miR-4684-5p	CLIP-seq
MIRT1921971	hsa-miR-4768-5p	CLIP-seq
MIRT2447730	hsa-miR-543	CLIP-seq
MIRT911827	hsa-miR-125a-3p	CLIP-seq
MIRT911828	hsa-miR-1266	CLIP-seq
MIRT2509548	hsa-miR-1305	CLIP-seq
MIRT2206242	hsa-miR-130a	CLIP-seq
MIRT2206243	hsa-miR-130b	CLIP-seq
MIRT2509549	hsa-miR-142-3p	CLIP-seq
MIRT2509550	hsa-miR-1910	CLIP-seq
MIRT911830	hsa-miR-2054	CLIP-seq
MIRT2206246	hsa-miR-301a	CLIP-seq
MIRT2206247	hsa-miR-301b	CLIP-seq
MIRT2509551	hsa-miR-3140-5p	CLIP-seq
MIRT911833	hsa-miR-3180	CLIP-seq
MIRT911834	hsa-miR-3180-3p	CLIP-seq
MIRT911835	hsa-miR-3196	CLIP-seq
MIRT2509552	hsa-miR-3200-5p	CLIP-seq
MIRT2509553	hsa-miR-3607-3p	CLIP-seq
MIRT911840	hsa-miR-3665	CLIP-seq
MIRT2206250	hsa-miR-3666	CLIP-seq
MIRT2509554	hsa-miR-3686	CLIP-seq
MIRT2509555	hsa-miR-380	CLIP-seq
MIRT2509556	hsa-miR-3973	CLIP-seq
MIRT2509557	hsa-miR-4279	CLIP-seq
MIRT2206251	hsa-miR-4295	CLIP-seq
MIRT2509558	hsa-miR-4427	CLIP-seq
MIRT911844	hsa-miR-4518	CLIP-seq
MIRT2206252	hsa-miR-454	CLIP-seq
MIRT911845	hsa-miR-4659a-3p	CLIP-seq
MIRT911846	hsa-miR-4659b-3p	CLIP-seq
MIRT2206253	hsa-miR-4671-3p	CLIP-seq
MIRT2509559	hsa-miR-4680-3p	CLIP-seq
MIRT911847	hsa-miR-4699-5p	CLIP-seq
MIRT911849	hsa-miR-4736	CLIP-seq
MIRT2509560	hsa-miR-4738-3p	CLIP-seq
MIRT2509561	hsa-miR-4803	CLIP-seq
MIRT2206256	hsa-miR-500a	CLIP-seq
MIRT911850	hsa-miR-510	CLIP-seq
MIRT2509562	hsa-miR-520g	CLIP-seq
MIRT2509563	hsa-miR-520h	CLIP-seq
MIRT2509564	hsa-miR-548l	CLIP-seq
MIRT2509565	hsa-miR-656	CLIP-seq
MIRT1970309	hsa-miR-888	CLIP-seq
MIRT911861	hsa-miR-889	CLIP-seq
MIRT911827	hsa-miR-125a-3p	CLIP-seq
MIRT911828	hsa-miR-1266	CLIP-seq
MIRT2509548	hsa-miR-1305	CLIP-seq
MIRT911830	hsa-miR-2054	CLIP-seq
MIRT2678701	hsa-miR-3136-3p	CLIP-seq
MIRT2509551	hsa-miR-3140-5p	CLIP-seq
MIRT911833	hsa-miR-3180	CLIP-seq
MIRT911834	hsa-miR-3180-3p	CLIP-seq
MIRT911835	hsa-miR-3196	CLIP-seq
MIRT2509553	hsa-miR-3607-3p	CLIP-seq
MIRT911840	hsa-miR-3665	CLIP-seq
MIRT2678702	hsa-miR-3677-5p	CLIP-seq
MIRT2509554	hsa-miR-3686	CLIP-seq
MIRT2509555	hsa-miR-380	CLIP-seq
MIRT2509556	hsa-miR-3973	CLIP-seq
MIRT2509557	hsa-miR-4279	CLIP-seq
MIRT911844	hsa-miR-4518	CLIP-seq
MIRT911845	hsa-miR-4659a-3p	CLIP-seq
MIRT911846	hsa-miR-4659b-3p	CLIP-seq
MIRT911847	hsa-miR-4699-5p	CLIP-seq
MIRT911848	hsa-miR-4709-5p	CLIP-seq
MIRT911849	hsa-miR-4736	CLIP-seq
MIRT2509560	hsa-miR-4738-3p	CLIP-seq
MIRT2509561	hsa-miR-4803	CLIP-seq
MIRT2206256	hsa-miR-500a	CLIP-seq
MIRT911850	hsa-miR-510	CLIP-seq
MIRT2509562	hsa-miR-520g	CLIP-seq
MIRT2509563	hsa-miR-520h	CLIP-seq
MIRT2509564	hsa-miR-548l	CLIP-seq
MIRT2509565	hsa-miR-656	CLIP-seq
MIRT2678703	hsa-miR-663b	CLIP-seq
MIRT1970309	hsa-miR-888	CLIP-seq
MIRT911861	hsa-miR-889	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	NAS	11788602
GO:0000139	Component	Golgi membrane	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 33961781
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0008376	Function	Acetylgalactosaminyltransferase activity	IDA	11788602
GO:0008376	Function	Acetylgalactosaminyltransferase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030166	Process	Proteoglycan biosynthetic process	IDA	11788602
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0047237	Function	Glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IEA
GO:0047238	Function	Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IBA
GO:0047238	Function	Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IEA
GO:0047238	Function	Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	TAS
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IBA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IDA	11788602
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	IEA
GO:0050650	Process	Chondroitin sulfate proteoglycan biosynthetic process	TAS	11788602
GO:0050651	Process	Dermatan sulfate proteoglycan biosynthetic process	IDA	11788602
GO:0050651	Process	Dermatan sulfate proteoglycan biosynthetic process	TAS	11788602

MIM	HGNC	e!Ensembl
616616	24292	ENSG00000169826

Q8N6G5

Protein name

Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2)

Protein function

Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. {ECO:0000269|

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05679	CHGN	57 → 516	Chondroitin N-acetylgalactosaminyltransferase	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12433924, ECO:0000269|PubMed:12446672}.

Sequence

MPRRGLILHTRTHWLLLGLALLCSLVLFMYLLECAPQTDGNASLPGVVGENYGKEYYQAL
LQEQEEHYQTRATSLKRQIAQLKQELQEMSEKMRSLQERRNVGANGIGYQSNKEQAPSDL
LEFLHSQIDKAEVSIGAKLPSEYGVIPFESFTLMKVFQLEMGLTRHPEEKPVRKDKRDEL
VEVIEAGLEVINNPDEDDEQEDEEGPLGEKLIFNENDFVEGYYRTERDKGTQYELFFKKA
DLTEYRHVTLFRPFGPLMKVKSEMIDITRSIINIIVPLAERTEAFVQFMQNFRDVCIHQD
KKIHLTVVYFGKEGLSKVKSILESVTSESNFHNYTLVSLNEEFNRGRGLNVGARAWDKGE
VLMFFCDVDIYFSAEFLNSCRLNAEPGKKVFYPVVFSLYNPAIVYANQEVPPPVEQQLVH
KKDSGFWRDFGFGMTCQYRSDFLTIGGFDMEVKGWGGEDVHLYRKYLHGDLIVIRTPVPG
LFHLWHEKRCADELTPEQYRMCIQSKAMNEASHSHLGMLVFREEIETHLHKQAYRTNSEA
VG

Sequence length

542

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Metabolic pathways		Chondroitin sulfate biosynthesis

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Sarcoma	Uncertain significance	rs146092644	RCV005929112

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Carotid Body Tumor	Associate	30967136
Colorectal Neoplasms	Associate	30537927
Hirschsprung Disease	Associate	25310821
Lymphoma Non Hodgkin	Associate	24548782
Tourette Syndrome	Associate	35354918

CSGALNACT2 (chondroitin sulfate N-acetylgalactosaminyltransferase 2)