Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	55437
Gene name	STE20 related adaptor beta
Gene symbol	STRADB
Synonyms (NCBI Gene)	ALS2CR2CALS-21ILPIPILPIPAPAPKPRO1038
Chromosome	2
Chromosome location	2q33.1
Summary	This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a compl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004339	hsa-miR-26a-5p	Western blot	18713946
MIRT016295	hsa-miR-193b-3p	Microarray	20304954
MIRT030416	hsa-miR-24-3p	Microarray	19748357
MIRT437591	hsa-miR-140-5p	MicroarrayqRT-PCR	22815788
MIRT437639	hsa-miR-152-3p	MicroarrayqRT-PCR	22815788
MIRT300108	hsa-miR-195-5p	MicroarrayqRT-PCR	22815788
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT300116	hsa-miR-1297	PAR-CLIP	20371350
MIRT004339	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT300104	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT300120	hsa-miR-4465	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT565463	hsa-miR-1197	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT300116	hsa-miR-1297	PAR-CLIP	20371350
MIRT004339	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT300104	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT300120	hsa-miR-4465	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT565463	hsa-miR-1197	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT1399286	hsa-miR-200b	CLIP-seq
MIRT1399287	hsa-miR-200c	CLIP-seq
MIRT1399288	hsa-miR-26a	CLIP-seq
MIRT1399289	hsa-miR-26b	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT1399291	hsa-miR-3120-3p	CLIP-seq
MIRT1399292	hsa-miR-425	CLIP-seq
MIRT1399293	hsa-miR-429	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT1399295	hsa-miR-4502	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT1399298	hsa-miR-4724-5p	CLIP-seq
MIRT1399299	hsa-miR-4749-3p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT1399301	hsa-miR-4797-5p	CLIP-seq
MIRT1399302	hsa-miR-545	CLIP-seq
MIRT1399303	hsa-miR-548p	CLIP-seq
MIRT1399304	hsa-miR-759	CLIP-seq
MIRT1399305	hsa-miR-1305	CLIP-seq
MIRT1399306	hsa-miR-148a	CLIP-seq
MIRT1399307	hsa-miR-148b	CLIP-seq
MIRT1399308	hsa-miR-149	CLIP-seq
MIRT1399309	hsa-miR-152	CLIP-seq
MIRT1399310	hsa-miR-1825	CLIP-seq
MIRT1399311	hsa-miR-199a-5p	CLIP-seq
MIRT1399312	hsa-miR-199b-5p	CLIP-seq
MIRT1399286	hsa-miR-200b	CLIP-seq
MIRT1399287	hsa-miR-200c	CLIP-seq
MIRT1399313	hsa-miR-24	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT1399291	hsa-miR-3120-3p	CLIP-seq
MIRT1399314	hsa-miR-3613-3p	CLIP-seq
MIRT1399315	hsa-miR-371b-5p	CLIP-seq
MIRT1399316	hsa-miR-3925-3p	CLIP-seq
MIRT1399317	hsa-miR-4284	CLIP-seq
MIRT1399293	hsa-miR-429	CLIP-seq
MIRT1399318	hsa-miR-4461	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT1399298	hsa-miR-4724-5p	CLIP-seq
MIRT1399319	hsa-miR-4742-3p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT1399320	hsa-miR-498	CLIP-seq
MIRT1399302	hsa-miR-545	CLIP-seq
MIRT1399303	hsa-miR-548p	CLIP-seq
MIRT1399321	hsa-miR-582-3p	CLIP-seq
MIRT1399322	hsa-miR-767-5p	CLIP-seq
MIRT1399323	hsa-miR-892b	CLIP-seq
MIRT2119659	hsa-miR-1278	CLIP-seq
MIRT2119660	hsa-miR-1283	CLIP-seq
MIRT1399313	hsa-miR-24	CLIP-seq
MIRT1399288	hsa-miR-26a	CLIP-seq
MIRT1399289	hsa-miR-26b	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT1399291	hsa-miR-3120-3p	CLIP-seq
MIRT2119661	hsa-miR-3126-5p	CLIP-seq
MIRT2119662	hsa-miR-3664-5p	CLIP-seq
MIRT1399316	hsa-miR-3925-3p	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT1399295	hsa-miR-4502	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT2119663	hsa-miR-4714-5p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT1399320	hsa-miR-498	CLIP-seq
MIRT2119664	hsa-miR-502-5p	CLIP-seq
MIRT2119665	hsa-miR-515-5p	CLIP-seq
MIRT1399302	hsa-miR-545	CLIP-seq
MIRT1399303	hsa-miR-548p	CLIP-seq
MIRT1399321	hsa-miR-582-3p	CLIP-seq
MIRT2119666	hsa-miR-766	CLIP-seq
MIRT1399305	hsa-miR-1305	CLIP-seq
MIRT1399306	hsa-miR-148a	CLIP-seq
MIRT1399307	hsa-miR-148b	CLIP-seq
MIRT1399309	hsa-miR-152	CLIP-seq
MIRT1399310	hsa-miR-1825	CLIP-seq
MIRT1399311	hsa-miR-199a-5p	CLIP-seq
MIRT1399312	hsa-miR-199b-5p	CLIP-seq
MIRT1399288	hsa-miR-26a	CLIP-seq
MIRT1399289	hsa-miR-26b	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT2341813	hsa-miR-3180-5p	CLIP-seq
MIRT2341814	hsa-miR-3646	CLIP-seq
MIRT2341815	hsa-miR-3670	CLIP-seq
MIRT1399316	hsa-miR-3925-3p	CLIP-seq
MIRT1399292	hsa-miR-425	CLIP-seq
MIRT1399318	hsa-miR-4461	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT2341816	hsa-miR-4490	CLIP-seq
MIRT1399295	hsa-miR-4502	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT1399319	hsa-miR-4742-3p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT2341817	hsa-miR-4774-5p	CLIP-seq
MIRT1399320	hsa-miR-498	CLIP-seq
MIRT2119664	hsa-miR-502-5p	CLIP-seq
MIRT2119665	hsa-miR-515-5p	CLIP-seq
MIRT2341818	hsa-miR-520a-5p	CLIP-seq
MIRT2341819	hsa-miR-525-5p	CLIP-seq
MIRT2341820	hsa-miR-532-3p	CLIP-seq
MIRT2341821	hsa-miR-662	CLIP-seq
MIRT2119666	hsa-miR-766	CLIP-seq
MIRT1399322	hsa-miR-767-5p	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000902	Process	Cell morphogenesis	IEA
GO:0004672	Function	Protein kinase activity	IDA	14517248
GO:0005515	Function	Protein binding	IPI	14676191, 20562859, 23414517, 32707033, 33961781, 34591612, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	14517248
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	14517248
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	14517248
GO:0006611	Process	Protein export from nucleus	IBA
GO:0006611	Process	Protein export from nucleus	IDA	14517248
GO:0007254	Process	JNK cascade	IEA
GO:0016235	Component	Aggresome	IDA
GO:0032147	Process	Activation of protein kinase activity	IDA	14517248
GO:0043539	Function	Protein serine/threonine kinase activator activity	IBA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IEA
GO:1902554	Component	Serine/threonine protein kinase complex	IBA
GO:1902554	Component	Serine/threonine protein kinase complex	ISS
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA

MIM	HGNC	e!Ensembl
607333	13205	ENSG00000082146

Q9C0K7

Protein name

STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2)

Protein function

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	58 → 369	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, testis, liver and colon. {ECO:0000269|PubMed:11161814, ECO:0000269|PubMed:12048196}.

Sequence

MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPSTRASEVLCSTNVSHYEL
QVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNIT
TYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGC
IHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQ
DLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESR
MKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA
SSLLSHVFFKQMKEESQDSILSLLPPAYNKPSISLPPVLPWTEPECDFPDEKDSYWEF

Sequence length

418

Interactions

View interactions

	KEGG		Reactome
	mTOR signaling pathway AMPK signaling pathway		Energy dependent regulation of mTOR by LKB1-AMPK

STRADB (STE20 related adaptor beta)