Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	55437
Gene name Gene Name - the full gene name approved by the HGNC.	STE20 related adaptor beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	STRADB
Synonyms (NCBI Gene) Gene synonyms aliases	ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK, PRO1038
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q33.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a compl

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004339	hsa-miR-26a-5p	Western blot	18713946
MIRT016295	hsa-miR-193b-3p	Microarray	20304954
MIRT030416	hsa-miR-24-3p	Microarray	19748357
MIRT437591	hsa-miR-140-5p	Microarray, qRT-PCR	22815788
MIRT437639	hsa-miR-152-3p	Microarray, qRT-PCR	22815788
MIRT300108	hsa-miR-195-5p	Microarray, qRT-PCR	22815788
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT300116	hsa-miR-1297	PAR-CLIP	20371350
MIRT004339	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT300104	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT300120	hsa-miR-4465	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT565463	hsa-miR-1197	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT300116	hsa-miR-1297	PAR-CLIP	20371350
MIRT004339	hsa-miR-26a-5p	PAR-CLIP	20371350
MIRT300104	hsa-miR-26b-5p	PAR-CLIP	20371350
MIRT300120	hsa-miR-4465	PAR-CLIP	20371350
MIRT300101	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT300100	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT300107	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT300110	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT300112	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT300123	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT300108	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT300115	hsa-miR-548e-5p	PAR-CLIP	20371350
MIRT300118	hsa-miR-4428	PAR-CLIP	20371350
MIRT565463	hsa-miR-1197	PAR-CLIP	20371350
MIRT300122	hsa-miR-5697	PAR-CLIP	20371350
MIRT1399286	hsa-miR-200b	CLIP-seq
MIRT1399287	hsa-miR-200c	CLIP-seq
MIRT1399288	hsa-miR-26a	CLIP-seq
MIRT1399289	hsa-miR-26b	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT1399291	hsa-miR-3120-3p	CLIP-seq
MIRT1399292	hsa-miR-425	CLIP-seq
MIRT1399293	hsa-miR-429	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT1399295	hsa-miR-4502	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT1399298	hsa-miR-4724-5p	CLIP-seq
MIRT1399299	hsa-miR-4749-3p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT1399301	hsa-miR-4797-5p	CLIP-seq
MIRT1399302	hsa-miR-545	CLIP-seq
MIRT1399303	hsa-miR-548p	CLIP-seq
MIRT1399304	hsa-miR-759	CLIP-seq
MIRT1399305	hsa-miR-1305	CLIP-seq
MIRT1399306	hsa-miR-148a	CLIP-seq
MIRT1399307	hsa-miR-148b	CLIP-seq
MIRT1399308	hsa-miR-149	CLIP-seq
MIRT1399309	hsa-miR-152	CLIP-seq
MIRT1399310	hsa-miR-1825	CLIP-seq
MIRT1399311	hsa-miR-199a-5p	CLIP-seq
MIRT1399312	hsa-miR-199b-5p	CLIP-seq
MIRT1399286	hsa-miR-200b	CLIP-seq
MIRT1399287	hsa-miR-200c	CLIP-seq
MIRT1399313	hsa-miR-24	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT1399291	hsa-miR-3120-3p	CLIP-seq
MIRT1399314	hsa-miR-3613-3p	CLIP-seq
MIRT1399315	hsa-miR-371b-5p	CLIP-seq
MIRT1399316	hsa-miR-3925-3p	CLIP-seq
MIRT1399317	hsa-miR-4284	CLIP-seq
MIRT1399293	hsa-miR-429	CLIP-seq
MIRT1399318	hsa-miR-4461	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT1399298	hsa-miR-4724-5p	CLIP-seq
MIRT1399319	hsa-miR-4742-3p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT1399320	hsa-miR-498	CLIP-seq
MIRT1399302	hsa-miR-545	CLIP-seq
MIRT1399303	hsa-miR-548p	CLIP-seq
MIRT1399321	hsa-miR-582-3p	CLIP-seq
MIRT1399322	hsa-miR-767-5p	CLIP-seq
MIRT1399323	hsa-miR-892b	CLIP-seq
MIRT2119659	hsa-miR-1278	CLIP-seq
MIRT2119660	hsa-miR-1283	CLIP-seq
MIRT1399313	hsa-miR-24	CLIP-seq
MIRT1399288	hsa-miR-26a	CLIP-seq
MIRT1399289	hsa-miR-26b	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT1399291	hsa-miR-3120-3p	CLIP-seq
MIRT2119661	hsa-miR-3126-5p	CLIP-seq
MIRT2119662	hsa-miR-3664-5p	CLIP-seq
MIRT1399316	hsa-miR-3925-3p	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT1399295	hsa-miR-4502	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT2119663	hsa-miR-4714-5p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT1399320	hsa-miR-498	CLIP-seq
MIRT2119664	hsa-miR-502-5p	CLIP-seq
MIRT2119665	hsa-miR-515-5p	CLIP-seq
MIRT1399302	hsa-miR-545	CLIP-seq
MIRT1399303	hsa-miR-548p	CLIP-seq
MIRT1399321	hsa-miR-582-3p	CLIP-seq
MIRT2119666	hsa-miR-766	CLIP-seq
MIRT1399305	hsa-miR-1305	CLIP-seq
MIRT1399306	hsa-miR-148a	CLIP-seq
MIRT1399307	hsa-miR-148b	CLIP-seq
MIRT1399309	hsa-miR-152	CLIP-seq
MIRT1399310	hsa-miR-1825	CLIP-seq
MIRT1399311	hsa-miR-199a-5p	CLIP-seq
MIRT1399312	hsa-miR-199b-5p	CLIP-seq
MIRT1399288	hsa-miR-26a	CLIP-seq
MIRT1399289	hsa-miR-26b	CLIP-seq
MIRT1399290	hsa-miR-3117-5p	CLIP-seq
MIRT2341813	hsa-miR-3180-5p	CLIP-seq
MIRT2341814	hsa-miR-3646	CLIP-seq
MIRT2341815	hsa-miR-3670	CLIP-seq
MIRT1399316	hsa-miR-3925-3p	CLIP-seq
MIRT1399292	hsa-miR-425	CLIP-seq
MIRT1399318	hsa-miR-4461	CLIP-seq
MIRT1399294	hsa-miR-4475	CLIP-seq
MIRT2341816	hsa-miR-4490	CLIP-seq
MIRT1399295	hsa-miR-4502	CLIP-seq
MIRT1399296	hsa-miR-4661-5p	CLIP-seq
MIRT1399297	hsa-miR-4704-5p	CLIP-seq
MIRT1399319	hsa-miR-4742-3p	CLIP-seq
MIRT1399300	hsa-miR-4762-3p	CLIP-seq
MIRT2341817	hsa-miR-4774-5p	CLIP-seq
MIRT1399320	hsa-miR-498	CLIP-seq
MIRT2119664	hsa-miR-502-5p	CLIP-seq
MIRT2119665	hsa-miR-515-5p	CLIP-seq
MIRT2341818	hsa-miR-520a-5p	CLIP-seq
MIRT2341819	hsa-miR-525-5p	CLIP-seq
MIRT2341820	hsa-miR-532-3p	CLIP-seq
MIRT2341821	hsa-miR-662	CLIP-seq
MIRT2119666	hsa-miR-766	CLIP-seq
MIRT1399322	hsa-miR-767-5p	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IEA
GO:0004672	Function	Protein kinase activity	IDA	14517248
GO:0005515	Function	Protein binding	IPI	14676191, 20562859, 23414517
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IDA	14517248
GO:0005737	Component	Cytoplasm	IDA	14517248
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	14517248
GO:0006611	Process	Protein export from nucleus	IDA	14517248
GO:0007050	Process	Cell cycle arrest	TAS
GO:0007254	Process	JNK cascade	IEA
GO:0016235	Component	Aggresome	IDA
GO:0032147	Process	Activation of protein kinase activity	IDA	14517248
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA

MIM	HGNC	e!Ensembl
607333	13205	ENSG00000082146

Protein

UniProt ID

Q9C0K7

Protein name

STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2)

Protein function

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformat

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	58 → 369	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, testis, liver and colon. {ECO:0000269|PubMed:11161814, ECO:0000269|PubMed:12048196}.

Sequence

MSLLDCFCTSRTQVESLRPEKQSETSIHQYLVDEPTLSWSRPSTRASEVLCSTNVSHYEL
QVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHPNIT
TYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQNGC
IHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPELLRQ
DLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQSESR
MKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA
SSLLSHVFFKQMKEESQDSILSLLPPAYNKPSISLPPVLPWTEPECDFPDEKDSYWEF

Sequence length

418

Interactions

View interactions

	KEGG		Reactome
	mTOR signaling pathway AMPK signaling pathway		Energy dependent regulation of mTOR by LKB1-AMPK

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Dermatitis	Dermatitis			GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Abnormalities Drug Induced	Associate	35648061

STRADB (STE20 related adaptor beta)