Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5537
Gene name Gene Name - the full gene name approved by the HGNC.
Protein phosphatase 6 catalytic subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPP6C
Synonyms (NCBI Gene) Gene synonyms aliases
PP6, PP6C
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q33.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provi
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs763733111 G>A Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027236 hsa-miR-103a-3p Sequencing 20371350
MIRT031938 hsa-miR-16-5p Proteomics 18668040
MIRT031938 hsa-miR-16-5p Sequencing 20371350
MIRT049228 hsa-miR-92a-3p CLASH 23622248
MIRT046636 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000082 Process G1/S transition of mitotic cell cycle TAS 9013334
GO:0000139 Component Golgi membrane IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IDA
GO:0004722 Function Protein serine/threonine phosphatase activity TAS
GO:0005515 Function Protein binding IPI 9647778, 16085932, 16769727, 17079228, 17384681, 18186651, 21187329, 24255178, 26496610, 28330616, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612725 9323 ENSG00000119414
Protein
UniProt ID O00743
Protein name Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]
Protein function Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956, PubMed:32474700). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-termin
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00149 Metallophos 46 241 Calcineurin-like phosphoesterase Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen. {ECO:0000269|PubMed:16769727, ECO:0000269|Pu
Sequence
Sequence length 305
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    COPII-mediated vesicle transport
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Carcinoma Carcinoma, Basal Cell rs121912654, rs555607708, rs786202962, rs1564055259 26950094
Lung carcinoma Squamous cell carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355
View all (44 more)
26619011
Melanoma melanoma, Cutaneous Melanoma rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340
View all (64 more)
22842228, 26619011
Associations from Text Mining
Disease Name Relationship Type References
Breast Diseases Inhibit 21451261
Breast Neoplasms Inhibit 21451261
Carcinoma Associate 24718460
Carcinoma Hepatocellular Associate 21481188
Colorectal Neoplasms Associate 35027503
Melanoma Associate 22817889, 22842228, 24336958, 25759478, 36071040
Mesothelioma Malignant Associate 20463022
Neoplasms Associate 22842228, 24336958, 31427592, 35027503, 36071040
Pancreatic Neoplasms Associate 33270085
Squamous Cell Carcinoma of Head and Neck Associate 31427592